• Dr. Wang’s current research focuses on identifying human antibody-mediated target antigens on pig kidney/liver/skin cells using CRISPR/cas 9 gene editing, including carbohydrate xenoantigens, SLA Class I and Class II, developing a novel strategy for inducing human T-cell tolerance to pig xenotransplantation to humans, and understanding the mechanisms by porcine liver sinusoidal cells to phagocytose human platelets, thereby alleviating the lethal thrombocytopenia observed after pig liver xenotransplantion, as well as characterizing RBC from gene-editing pigs for pig-to-primate xenotransfuion. In summary, his experience and expertise in the field of immunology and xenoimmunology have prepared him for xenotransplantation research.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 HLA class i-sensitized renal transplant patients have antibody binding to SLA Class i epitopes 2019
    2018 Crispr/Cas and recombinase-based human-to-pig orthotopic gene exchange for xenotransplantation 2018
    2018 Examining the biosynthesis and xenoantigenicity of Class II swine leukocyte antigen proteins 2018
    2018 Swine Leukocyte Antigen Class II Is a Xenoantigen 2018
    2017 Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination 2017
    2017 Eliminating xenoantigen expression on swine rbc 2017
    2016 Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response 2016
    2016 The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs 2016
    2016 Immunogenicity of renal microvascular endothelial cells from genetically modified pigs 2016
    2015 Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection 2015
    2015 Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein 2015
    2014 Erythrocytes from GGTA1/CMAH knockout pigs: Implications for xenotransfusion and testing in non-human primates 2014
    2013 Fibronectin from alpha 1,3-galactosyltransferase knockout pigs is a xenoantigen 2013
    2013 N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens 2013
    2013 Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation 2013
    2012 Immortalized porcine liver sinusoidal endothelial cells: An in vitro model of xenotransplantation-induced thrombocytopenia 2012
    2012 Identification of human preformed antibody targets in GTKO pigs 2012
    2011 Primary porcine kupffer cell phagocytosis of human platelets involves the CD18 receptor 2011

    Education And Training

  • Doctor of Philosophy in Medicine, Kobe University 2002
  • Full Name

  • Zheng-Yu Wang