Positions

Overview

  • Dr. Wang’s current research focuses on identifying human antibody-mediated target antigens on pig kidney/liver/skin cells using CRISPR/cas 9 gene editing, including carbohydrate xenoantigens, SLA Class I and Class II, developing a novel strategy for inducing human T-cell tolerance to pig xenotransplantation to humans, and understanding the mechanisms by porcine liver sinusoidal cells to phagocytose human platelets, thereby alleviating the lethal thrombocytopenia observed after pig liver xenotransplantion, as well as characterizing RBC from gene-editing pigs for pig-to-primate xenotransfuion. In summary, his experience and expertise in the field of immunology and xenoimmunology have prepared him for xenotransplantation research.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes.Transplantation.  103:1620-1629. 2019
    2018 Crispr/Cas and recombinase-based human-to-pig orthotopic gene exchange for xenotransplantationJournal of Surgical Research.  229:28-40. 2018
    2018 Examining the biosynthesis and xenoantigenicity of Class II swine leukocyte antigen proteinsJournal of Immunology.  200:2957-2964. 2018
    2018 Swine Leukocyte Antigen Class II Is a XenoantigenTransplantation.  102:249-254. 2018
    2017 Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombinationJournal of Surgical Research.  212:238-245. 2017
    2017 Eliminating xenoantigen expression on swine rbcTransplantation.  101:517-523. 2017
    2016 Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell responseTransplant Immunology.  35:47-51. 2016
    2016 The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organsJournal of Surgical Research.  200:698-706. 2016
    2016 Immunogenicity of renal microvascular endothelial cells from genetically modified pigsTransplantation.  100:533-537. 2016
    2015 Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 proteinXenotransplantation.  22:203-210. 2015
    2014 Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selectionXenotransplantation2014
    2014 Erythrocytes from GGTA1/CMAH knockout pigs: Implications for xenotransfusion and testing in non-human primatesXenotransplantation.  21:376-384. 2014
    2013 Fibronectin from alpha 1,3-galactosyltransferase knockout pigs is a xenoantigenJournal of Surgical Research.  184:1123-1133. 2013
    2013 N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigensXenotransplantation.  20:277-291. 2013
    2013 Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantationXenotransplantation.  20:27-35. 2013
    2012 Immortalized porcine liver sinusoidal endothelial cells: An in vitro model of xenotransplantation-induced thrombocytopeniaXenotransplantation.  19:249-255. 2012
    2012 Identification of human preformed antibody targets in GTKO pigsXenotransplantation.  19:92-101. 2012
    2011 Primary porcine kupffer cell phagocytosis of human platelets involves the CD18 receptorTransplantation.  92:739-744. 2011

    Education And Training

  • Doctor of Philosophy in Medicine, Kobe University 2002
  • Full Name

  • Zheng-Yu Wang