Positions

Overview

  • Dr. Jaroslaw Zmijewski completed his undergraduate education in Biology, graduating from the University of Gdansk. He than completed his PhD training in University of Gdansk Department of Biotechnology, a department dedicated to the research integration between the University of Gdansk and Medical School in Gdansk. Dr. Zmijewski undertook postdoctoral training in the Department of Pathology at UAB and thereafter joined the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine as an Assistant Professor and subsequently Associate Professor.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injuryJCI insight.  4. 2019
    2018 Erratum to: Metformin reverses established lung fibrosis in a bleomycin model (Nature Medicine, (2018), 24, 8, (1121-1127), 10.1038/s41591-018-0087-6)Nature Medicine.  24:1627. 2018
    2018 Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDSEuropean Respiratory Journal.  52. 2018
    2018 Metformin reverses established lung fibrosis in a bleomycin modelNature Medicine.  24:1121-1131. 2018
    2017 Melatonin, mitochondria, and the skinCellular and Molecular Life Sciences.  74:3913-3925. 2017
    2017 Mitochondrial dysfunction and immune cell metabolism in sepsisInfection and Chemotherapy.  49:10-21. 2017
    2017 Frontline science: D1 dopaminergic receptor signaling activates the AMPK-bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxininduced ALIJournal of Leukocyte Biology.  101:357-365. 2017
    2017 Frontline science: HMGB1 induces neutrophil dysfunction in experimental sepsis and in patients who survive septic shockJournal of Leukocyte Biology.  101:1281-1287. 2017
    2016 The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injuryFederation proceedings.  30:2135-2150. 2016
    2016 Generation of Reactive Oxygen Species Mediated by 1-Hydroxyphenazine, a Virulence Factor of Pseudomonas aeruginosaChemical Research in Toxicology.  28:175-181. 2016
    2016 Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironmentOncotarget.  7:75407-75424. 2016
    2016 N-cadherin coordinates AMP kinase-mediated lung vascular repairAJP - Lung Cellular and Molecular Physiology.  310:L71-L85. 2016
    2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
    2015 AMP-activated protein kinase and glycogen synthase kinase 3β modulate the severity of sepsis-induced lung injuryMolecular Medicine.  21:937-950. 2015
    2015 Metabolic reprogramming is required for myofibroblast contractility and differentiationJournal of Biological Chemistry.  290:25427-25438. 2015
    2015 Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinaseCellular Signalling.  27:1186-1197. 2015
    2015 Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology.  135:413-424.e15. 2015
    2014 Interaction of the cell adhesion molecule CHL1 with vitronectin, Integrins, And the plasminogen activator inhibitor-2 promotes CHL1-induced neurite outgrowth and neuronal migrationJournal of Neuroscience.  34:14606-14623. 2014
    2014 Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injuryJournal of Immunology.  192:4795-4803. 2014
    2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsivenessLaboratory Investigation.  94:1312-1325. 2014
    2014 GSK3β-Dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injuryAJP - Lung Cellular and Molecular Physiology.  307:L735-L745. 2014
    2014 Heat-shock response increases lung injury caused by pseudomonas aeruginosa via an Interleukin-10-dependent mechanism in miceAnesthesiology.  120:1450-1462. 2014
    2013 Activation of AMPK enhances neutrophil chemotaxis and bacterial killingMolecular Medicine.  19:387-398. 2013
    2013 Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injuryAJP - Lung Cellular and Molecular Physiology.  305. 2013
    2013 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathwaysCancer Research.  73:6609-6620. 2013
    2013 Mitochondria and AMP-activated protein kinase-dependent mechanism of efferocytosisJournal of Biological Chemistry.  288:26013-26026. 2013
    2013 HMGB1 Accelerates Alveolar Epithelial Repair via an IL-1β- and αvβ6 Integrin-dependent Activation of TGF-β1PLoS ONE.  8. 2013
    2013 Erratum: Elevated levels of NO are localized to distal airways in asthma (Free Radical Biology and Medicine (2011) 50 (1679-1688))Free Radical Biology and Medicine.  58:45. 2013
    2013 HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4AJP - Lung Cellular and Molecular Physiology.  304. 2013
    2013 Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophagesJournal of Immunology.  190:2273-2281. 2013
    2012 Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathwaysAmerican Journal of Respiratory Cell and Molecular Biology.  46:790-796. 2012
    2012 Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killingAmerican Journal of Physiology - Cell Physiology.  302. 2012
    2012 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism.Molecular Medicine.  18:659-668. 2012
    2011 AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophilsFederation proceedings.  25:4358-4368. 2011
    2011 Intracellular HMGB1 Negatively regulates efferocytosisJournal of Immunology.  187:4686-4694. 2011
    2011 Free radical-producing myeloid-derived regulatory cells: Potent activators and suppressors of lung inflammation and airway hyperresponsivenessMucosal Immunology.  4:503-518. 2011
    2011 Inhibition of neutrophil apoptosis by PAI-1AJP - Lung Cellular and Molecular Physiology.  301. 2011
    2011 Elevated levels of NO are localized to distal airways in asthmaFree Radical Biology and Medicine.  50:1679-1688. 2011
    2011 Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overloadJournal of Molecular and Cellular Cardiology.  50:147-156. 2011
    2010 Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinaseJournal of Biological Chemistry.  285:33154-33164. 2010
    2010 Modulation of SCFβ-TrCP-dependent IκBα ubiquitination by hydrogen peroxideJournal of Biological Chemistry.  285:2665-2675. 2010
    2009 S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal functionJournal of Biological Chemistry.  284:22213-22221. 2009
    2009 Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injuryAmerican Journal of Respiratory Cell and Molecular Biology.  41:237-245. 2009
    2009 Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  179:694-704. 2009
    2009 Participation of mitochondrial respiratory complex III in neutrophil activation and lung injuryAJP - Lung Cellular and Molecular Physiology.  296. 2009
    2009 Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxideProceedings of the National Academy of Sciences.  106:4671-4676. 2009
    2008 Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injuryAJP - Lung Cellular and Molecular Physiology.  295. 2008
    2008 PAI-1 inhibits neutrophil efferocytosisProceedings of the National Academy of Sciences.  105:11784-11789. 2008
    2008 Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injuryAmerican Journal of Respiratory and Critical Care Medicine.  178:168-179. 2008
    2008 Role of extracellular superoxide in neutrophil activation: Interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine productionAmerican Journal of Physiology - Cell Physiology.  294. 2008
    2008 HMGB1 develops enhanced proinflammatory activity by binding to cytokinesJournal of Immunology.  180:2531-2537. 2008
    2007 Binding of MmeI restriction-modification enzyme to its specific recognition sequence is stimulated by S-adenosyl-L-methionineMolecular Biotechnology.  37:127-135. 2007
    2007 Exposure to hydrogen peroxide diminishes NF-κB activation, IκB-α degradation, and proteasome activity in neutrophilsAmerican Journal of Physiology - Cell Physiology.  293. 2007
    2006 Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen speciesAJP - Heart and Circulatory Physiology.  290. 2006
    2006 Activation of mitogen-activated protein kinases by lysophosphatidylcholine- induced mitochondrial reactive oxygen species generation in endothelial cellsAmerican Journal of Pathology.  168:1737-1748. 2006
    2005 Cell signalling by oxidized lipids and the role of reactive oxygen species in the endotheliumBiochemical Society Transactions.  33:1385-1389. 2005
    2005 Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cellsAJP - Heart and Circulatory Physiology.  289. 2005
    2004 Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblastsAging Cell.  3:309-317. 2004
    2004 Stress- and cell cycle-associated regulation of RGS2 mRNA levelsNeuroscience Research Communications.  34:72-81. 2004
    2002 Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damageProceedings of the National Academy of Sciences.  99:7951-7955. 2002
    2001 Second messengers regulate RGS2 expression which is targeted to the nucleusBiochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1541:201-211. 2001
    2001 Oxidative stress and heat shock stimulate RGS2 expression in 1321N1 astrocytoma cellsArchives of Biochemistry and Biophysics.  392:192-196. 2001
    2001 RGS2: Regulation of expression and nuclear localizationBiochemical and Biophysical Research Communications.  283:102-106. 2001
    2000 Meaning of opening form of internal cervical opening in prognosis of cervical insufficiencyGinekologia Polska.  71:279-283. 2000

    Research Overview

  • Dr. Zmijewski is a member of the Center for Free Radical Biology at UAB, an editorial board member of the American Journal of Clinical and Experimental Immunology, and research Director of the Translational Program for Acute Respiratory Syndrome (TP-ARDS) at UAB. Dr. Zmijewski has broad expertise in molecular biology and biochemistry, protein interaction, redox signalling, assessment of numerous enzymatic activities, metabolism, ubiquitin/proteasome systems, and mitochondrial function in cultured cells and experimental models of lung injury.
  • Education And Training

  • Doctor of Philosophy Level Degree in Biological and Biomedical Sciences, University of Gdansk 1999
  • Full Name

  • Jaroslaw Zmijewski