Zina Moldoveanu

Zina Moldoveanu
Professor

Professor (P), Microbiology , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2017	Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy. PLoS ONE. 12. 2017
2017	GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. PLoS Genetics. 13. 2017
2017	Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy. Kidney International Reports. 2:1194-1207. 2017
2017	Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls. International Journal of Nephrology. 2017. 2017
2016	IgA nephropathy enigma. Clinical Immunology. 172:72-77. 2016
2016	Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes. Vaccine. 34:3171-3177. 2016
2016	The origin and activities of IgA1-containing immune complexes in IGA nephropathy. Frontiers in Immunology. 7. 2016
2016	Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge. Mucosal Immunology. 9:13-23. 2016
2016	Galactose-Deficient IgA1 as a Candidate Urinary Polypeptide Marker of IgA Nephropathy?. Disease Markers. 2016. 2016
2014	18. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs: Reflections and commentary a decade later: Original Research Article: Biodegradable block copolymers for delivery and proteins water-insoluble drugs, 2001. Journal of Controlled Release. 190:63-64. 2014
2014	Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection. AIDS Research and Therapy. 11. 2014
2014	Enzymatic sialylation of IgA1 O-glycans: Implications for studies of IgA nephropathy. PLoS ONE. 9. 2014
2014	Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. Journal of Biological Chemistry. 289:5330-5339. 2014
2014	Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women. American Journal of Reproductive Immunology. 71:600-607. 2014
2014	Origin of galactose-deficient immunoglobulin G in gingival crevicular fluid in periodontitis. Journal of Periodontology. 85:1779-1785. 2014
2013	Biomarkers in IgA nephropathy: Relationship to pathogenetic hits. Expert Opinion on Medical Diagnostics. 7:615-627. 2013
2013	The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells. PLoS Pathogens. 9. 2013
2013	IgA nephropathy: Molecular mechanisms of the disease. Annual Review of Pathology: Mechanisms of Disease. 8:217-240. 2013
2012	Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy.. Clinical Nephrology. 78:465-469. 2012
2012	Comparative evaluation of HIV-1 neutralization in external secretions and sera of HIV-1-infected women. Open AIDS Journal. 6:293-302. 2012
2012	In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells. Results in Immunology. 2:166-172. 2012
2012	The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression. Kidney International. 82:790-796. 2012
2012	Serum galactose-deficient IgA1 level is not associated with proteinuria in children with IgA nephropathy. International Journal of Nephrology. 2012. 2012
2012	Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy. Clinical Nephrology. 78:465-469. 2012
2011	IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells. Nephrology Dialysis Transplantation. 26:3451-3457. 2011
2011	The pathophysiology of IgA nephropathy. Journal of the American Society of Nephrology. 22:1795-1803. 2011
2011	Aberrant glycosylation of iga1 and anti-glycan antibodies in iga nephropathy: Role of mucosal immune system 2011
2011	Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women. AIDS Research and Human Retroviruses. 27:469-486. 2011
2011	Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions. American Journal of Reproductive Immunology. 65:361-367. 2011
2011	Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis. Kidney International. 80:79-87. 2011
2010	Galactose-deficient IgA1 in African Americans with IgA nephropathy: Serum levels and heritability. Clinical Journal of the American Society of Nephrology. 5:2069-2074. 2010
2010	Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: A comparative binding study.. Biochemistry. 49:5671-5682. 2010
2010	Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition. Journal of Biological Chemistry. 285:20860-20869. 2010
2010	Antibody-mediated protection and the mucosal immune system of the genital tract: Relevance to vaccine design. Journal of Reproductive Immunology. 85:81-85. 2010
2010	Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids 2010
2010	Familial IgA nephropathy in southeastern Kentucky.. Clinical Nephrology. 73:115-121. 2010
2010	Familial IgA nephropathy in southeastern Kentucky. Clinical Nephrology. 73:115-121. 2010
2009	P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques. Retrovirology. 6. 2009
2009	Effect of flash-heat treatment on immunoglobulins in breast milk 2009
2009	Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. Journal of Clinical Investigation. 119:1668-1677. 2009
2009	Mucosal antibody responses to HIV. Methods in Molecular Biology. 485:333-345. 2009
2009	Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection. Journal of Reproductive Immunology. 83:196-200. 2009
2008	Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy. Journal of the American Society of Nephrology. 19:1008-1014. 2008
2008	Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses. Vaccine. 26:1541-1551. 2008
2008	IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. Journal of Clinical Investigation. 118:629-639. 2008
2008	Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of iga nephropathy. Kidney and Blood Pressure Research. 31:29-37. 2008
2007	Electrophoretic methods for analysis of urinary polypeptides in lgA-associated renal diseases. ELECTROPHORESIS. 28:4469-4483. 2007
2007	Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura. Pediatric Nephrology. 22:2067-2072. 2007
2007	Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice. Vaccine. 25:6359-6366. 2007
2007	Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney International. 71:1148-1154. 2007
2007	IgA nephropathy and henoch-schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contributions to Nephrology. 157:134-138. 2007
2007	IgA nephropathy: A clinical overview. Contributions to Nephrology. 157:19-26. 2007
2007	IgA nephropathy: Characterization of IgG antibodies specific for galactose-deficient IgA1. Contributions to Nephrology. 157:129-133. 2007
2007	IgA nephropathy: Current views of immune complex formation. Contributions to Nephrology. 157:56-63. 2007
2007	Identification and Characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-Sialyltransferase in IgA1-producing Cells. Journal of Molecular Biology. 369:69-78. 2007
2007	Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins. Molecular Immunology. 44:2598-2604. 2007
2007	Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. Virology. 360:218-234. 2007
2006	IgA-containing immune complexes in the urine of IgA nephropathy patients. Nephrology Dialysis Transplantation. 21:2478-2484. 2006
2005	Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunity. Journal of Immunology. 175:4127-4136. 2005
2005	Immune response versus mucosal tolerance to mucosally administered antigens. Vaccine. 23:1800-1803. 2005
2005	Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals. AIDS. 19:381-389. 2005
2005	Immunologic uniqueness of the genital tract: Challenge for vaccine development. American Journal of Reproductive Immunology. 53:208-214. 2005
2004	Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals. AIDS Research and Human Retroviruses. 20:972-988. 2004
2004	Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. Journal of Infectious Diseases. 189:1221-1231. 2004
2004	Oral tolerance in humans: Failure to suppress an existing immune response by oral antigen administration. Annals of the New York Academy of Sciences. 1029:299-309. 2004
2004	Oral tolerance in humans: failure to suppress an existing immune response by oral antigen administration. Annals of the New York Academy of Sciences. 1029:299-309. 2004
2003	Intramuscular immunization with poliovirus replicons primes for a humoral and cellular immune response to soluble antigen. Viral Immunology. 16:169-182. 2003
2002	SIVcpz in wild chimpanzees. Science. 295:465. 2002
2002	Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5⁺ cells. Nature Medicine. 8:150-156. 2002
2001	Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccine. Journal of Reproductive Immunology. 52:61-75. 2001
2001	Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. Journal of Controlled Release. 72:203-215. 2001
2001	A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Vaccine. 19:3033-3042. 2001
2001	Mechanisms of immune tolerance to food antigens in humans. Clinical Immunology. 101:158-168. 2001
2000	Strategies of immunization against mucosal infections. Vaccine. 19. 2000
2000	High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice 2000
2000	Role of nuclear factor-κB in the expression by tumor necrosis factor-α of the human polymeric immunoglobulin receptor (pIgR) gene. Immunogenetics. 51:289-295. 2000
1999	Induction of immune responses to SIV antigens by mucosally administered vaccines. AIDS Research and Human Retroviruses. 15:1469-1476. 1999
1999	Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8⁺ cytotoxic T lymphocyte responses induced in mucosa-associated tissues. Virology. 254:50-60. 1999
1998	Mucosal immunity in the female reproductive tract: Correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation. AIDS Research and Human Retroviruses. 14. 1998
1998	Demonstration of the specificity of poliovirus encapsidation using a novel replicon which encodes enzymatically active firefly luciferase. Virology. 243:1-11. 1998
1998	CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine. 16:1216-1224. 1998
1998	Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: Evidence for compartmentalization within the common mucosal immune system in humans. Infection and Immunity. 66:5630-5635. 1998
1998	Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8⁺ cytotoxic T lymphocytes. Journal of Virology. 72:4534-4536. 1998
1998	Vitamin A is required for regulation of polymeric immunoglobulin receptor (plgR) expression by interleukin-4 and interferon-γ in a human intestinal epithelial cell line 1998
1997	Current options for vaccine delivery systems by mucosal routes. Journal of Controlled Release. 48:243-257. 1997
1997	Immunization of mice with poliovirus replicons expressing the C-fragment of tetanus toxin protects against lethal challenge with tetanus toxin. Vaccine. 15:257-264. 1997
1997	Characterization of the expression and immunogenicity of poliovirus replicons that encode Simian immunodeficiency virus SIV(mac)239 gag or envelope SU proteins. AIDS Research and Human Retroviruses. 13:53-62. 1997
1997	Immunoglobulin J chain. An early differentiation marker of human B cells. Annals of the New York Academy of Sciences. 815:111-113. 1997
1997	Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.. Behring Institute Mitteilungen. 33-43. 1997
1996	Antigen delivery systems for induction of influenza virus-specific cytotoxic lymphocytes (CTLs) in MICE. The FASEB Journal. 10. 1996
1996	Induction of genital tract immune responses by oral immunization. The FASEB Journal. 10. 1996
1996	Mucosally activated circulating human T-cells express the gut homing receptor α4β7. The FASEB Journal. 10. 1996
1996	Multiple mechanisms of oral tolerance to food antigens in humans. The FASEB Journal. 10. 1996
1996	Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice 1996
1995	Compartmentalization within the common mucosal immune system. Advances in Experimental Medicine and Biology. 371:97-101. 1995
1995	Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeys. Advances in Experimental Medicine and Biology. 371:1035-1038. 1995
1995	Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virus. Advances in Experimental Medicine and Biology. 371:1587-1590. 1995
1995	Oral immunization studies with streptococcus mutans and influenza vaccines in rhesus macaque monkeys. Advances in Experimental Medicine and Biology. 371:1423-1429. 1995
1994	Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding. Journal of Immunology. 152:4663-4670. 1994
1994	Biodegradable microspheres for the delivery of oral vaccines. Journal of Controlled Release. 28:131-141. 1994
1994	Characterization of Poliovirus Replicons Encoding Carcinoembryonic Antigen. Cancer Research. 54:6359-6364. 1994
1994	Mucosal immunity and strategies for novel microbial vaccines. Pediatrics International. 36:537-544. 1994
1994	New approaches for mucosal vaccines for AIDS: Encapsidation and serial passage of poliovirus replicons that express HIV-1 proteins on infection. AIDS Research and Human Retroviruses. 10. 1994
1993	Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy.. Contributions to Nephrology. 104:172-182. 1993
1993	Interactions of cell-surface galactosyltransferase with immunoglobulins. Molecular Immunology. 30:265-275. 1993
1993	Murine model for evaluation of protective immunity to influenza virus. Vaccine. 11:55-60. 1993
1993	Oral immunization with influenza virus in biodegradable microspheres. Journal of Infectious Diseases. 167:84-90. 1993
1992	Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: A comparison between intravenously and genitally inoculated Rhesus macaques. Clinical and Experimental Immunology. 88:520-526. 1992
1992	IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy. Clinical and Experimental Immunology. 89:315-320. 1992
1992	Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes. AIDS Research and Human Retroviruses. 8:1389. 1992
1989	Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue. Journal of Immunology. 142:1150-1158. 1989
1989	Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues. Clinical and Experimental Immunology. 76:103-110. 1989
1989	Biodegradable microspheres: vaccine delivery system for oral immunization.. Current Topics in Microbiology and Immunology. 146:59-66. 1989
1989	Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue.. Regional immunology. 2:103-110. 1989
1989	Immune responses to influenza virus in orally and systemically immunized mice.. Current Topics in Microbiology and Immunology. 146:91-99. 1989
1989	Systemic immunization for the induction of IgA responses.. Current Topics in Microbiology and Immunology. 146:161-168. 1989
1989	The role of the liver in catabolism of mouse and human iga 1989
1988	A novel two colour ELISPOT assay. I. Simultaneous detection of distinct types of antibody-secreting cells. Journal of Immunological Methods. 115:31-37. 1988
1988	Binding of IgA to erythrocytes from patients with IgA nephropathy. Clinical immunology and immunopathology. 48:1-9. 1988
1988	The sites of catabolism of murine monomeric IgA. Journal of Immunology. 141:208-213. 1988
1987	IgA on the surface of erythrocytes from IgA nephropathy patients.. Advances in Experimental Medicine and Biology. 216 B:1577-1581. 1987
1986	Detection and specificity of antibodies secreted by spleen cells in mice immunized with Streptococcus mutans. Infection and Immunity. 53:317-323. 1986
1985	Activation of human splenic lymphocytes with T cell lectins increase FcαR+ T cell populations and support in vitro IgA responses. The FASEB Journal. 44. 1985
1985	Activity of rheumatoid factors of different molecular sizes: Comparison of autologous monomeric and polymeric monoclonal IgA rheumatoid factors. Journal of Immunology. 134:1469-1474. 1985
1985	Major site(s) of mIgA catabolism in BALB/c mice. The FASEB Journal. 44. 1985
1984	Cellular origins of human polymeric and monomeric IgA: Intracellular and secreted forms of IgA. Journal of Immunology. 133:3156-3162. 1984
1984	Receptors for secretory and serum IgA in human liver. The FASEB Journal. 43. 1984
1983	Ultrastructural studies of human lymphoid cells: µ and J chain expression as a function of B cell differentiation. Journal of Experimental Medicine. 158:1993-2006. 1983
1983	Biosynthesis of J-chain in human lymphoid cells producing immunoglobulins of various isotypes. Molecular Immunology. 20:967-976. 1983

Chapter

Year	Title	Altmetric
2016	Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy. 53-68. 2016
2005	Collection and processing of external secretions and tissues of mouse origin. 1841-1852. 2005
2005	Collection and processing of human mucosal secretions. 1829-1839. 2005
1998	Principles of oral tolerance. 90-9. 1998
1997	Therapeutic applications of oral tolerance for human disease. 209-23. 1997