Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy 2017
2017 GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway 2017
2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy 2017
2017 Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls 2017
2016 IgA nephropathy enigma 2016
2016 Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes 2016
2016 The origin and activities of IgA1-containing immune complexes in IGA nephropathy 2016
2016 Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge 2016
2016 Galactose-Deficient IgA1 as a Candidate Urinary Polypeptide Marker of IgA Nephropathy? 2016
2014 18. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs: Reflections and commentary a decade later: Original Research Article: Biodegradable block copolymers for delivery and proteins water-insoluble drugs, 2001 2014
2014 Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection 2014
2014 Enzymatic sialylation of IgA1 O-glycans: Implications for studies of IgA nephropathy 2014
2014 Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes 2014
2014 Humoral Immune Responses to HIV in the Mucosal Secretions and Sera of HIV-Infected Women 2014
2014 Origin of galactose-deficient immunoglobulin G in gingival crevicular fluid in periodontitis 2014
2013 Biomarkers in IgA nephropathy: Relationship to pathogenetic hits 2013
2013 The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells 2013
2013 IgA nephropathy: Molecular mechanisms of the disease 2013
2012 Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy. 2012
2012 Comparative evaluation of HIV-1 neutralization in external secretions and sera of HIV-1-infected women 2012
2012 In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells 2012
2012 The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression 2012
2012 Serum galactose-deficient IgA1 level is not associated with proteinuria in children with IgA nephropathy 2012
2012 Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy 2012
2011 IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells 2011
2011 The pathophysiology of IgA nephropathy 2011
2011 Aberrant glycosylation of iga1 and anti-glycan antibodies in iga nephropathy: Role of mucosal immune system 2011
2011 Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women 2011
2011 Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions 2011
2011 Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis 2011
2010 Galactose-deficient IgA1 in African Americans with IgA nephropathy: Serum levels and heritability 2010
2010 Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: A comparative binding study. 2010
2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition 2010
2010 Antibody-mediated protection and the mucosal immune system of the genital tract: Relevance to vaccine design 2010
2010 Expression of homing receptors on IgA1 and IgA2 plasmablasts in blood reflects differential distribution of IgA1 and IgA2 in various body fluids 2010
2010 Familial IgA nephropathy in southeastern Kentucky. 2010
2010 Familial IgA nephropathy in southeastern Kentucky 2010
2009 P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques 2009
2009 Effect of flash-heat treatment on immunoglobulins in breast milk 2009
2009 Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity 2009
2009 Mucosal antibody responses to HIV 2009
2009 Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection 2009
2008 Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy 2008
2008 Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses 2008
2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 2008
2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of iga nephropathy 2008
2007 Electrophoretic methods for analysis of urinary polypeptides in lgA-associated renal diseases 2007
2007 Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura 2007
2007 Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice 2007
2007 Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels 2007
2007 IgA nephropathy and henoch-schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells 2007
2007 IgA nephropathy: A clinical overview 2007
2007 IgA nephropathy: Characterization of IgG antibodies specific for galactose-deficient IgA1 2007
2007 IgA nephropathy: Current views of immune complex formation 2007
2007 Identification and Characterization of CMP-NeuAc:GalNAc-IgA1 α2,6-Sialyltransferase in IgA1-producing Cells 2007
2007 Reactivities of N-acetylgalactosamine-specific lectins with human IgA1 proteins 2007
2007 Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins 2007
2006 IgA-containing immune complexes in the urine of IgA nephropathy patients 2006
2005 Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunity 2005
2005 Immunologic uniqueness of the genital tract: Challenge for vaccine development 2005
2005 Immune response versus mucosal tolerance to mucosally administered antigens 2005
2005 Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals 2005
2004 Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals 2004
2004 Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein 2004
2004 Oral tolerance in humans: Failure to suppress an existing immune response by oral antigen administration 2004
2004 Oral tolerance in humans: failure to suppress an existing immune response by oral antigen administration 2004
2003 Intramuscular immunization with poliovirus replicons primes for a humoral and cellular immune response to soluble antigen 2003
2002 SIVcpz in wild chimpanzees 2002
2002 Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells 2002
2001 Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccine 2001
2001 Biodegradable block copolymers for delivery of proteins and water-insoluble drugs 2001
2001 A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects 2001
2001 Mechanisms of immune tolerance to food antigens in humans 2001
2000 Strategies of immunization against mucosal infections 2000
2000 High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice 2000
2000 Role of nuclear factor-κB in the expression by tumor necrosis factor-α of the human polymeric immunoglobulin receptor (pIgR) gene 2000
1999 Induction of immune responses to SIV antigens by mucosally administered vaccines 1999
1999 Heterosubtypic immunity to lethal influenza A virus infection is associated with virus-specific CD8+ cytotoxic T lymphocyte responses induced in mucosa-associated tissues 1999
1998 Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: Evidence for compartmentalization within the common mucosal immune system in humans 1998
1998 Vitamin A is required for regulation of polymeric immunoglobulin receptor (plgR) expression by interleukin-4 and interferon-γ in a human intestinal epithelial cell line 1998
1998 Mucosal immunity in the female reproductive tract: Correlation of immunoglobulins, cytokines, and reproductive hormones in human cervical mucus around the time of ovulation 1998
1998 Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes 1998
1998 Demonstration of the specificity of poliovirus encapsidation using a novel replicon which encodes enzymatically active firefly luciferase 1998
1998 CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus 1998
1997 Current options for vaccine delivery systems by mucosal routes 1997
1997 Immunization of mice with poliovirus replicons expressing the C-fragment of tetanus toxin protects against lethal challenge with tetanus toxin 1997
1997 Characterization of the expression and immunogenicity of poliovirus replicons that encode Simian immunodeficiency virus SIV(mac)239 gag or envelope SU proteins 1997
1997 Immunoglobulin J chain. An early differentiation marker of human B cells 1997
1997 Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. 1997
1996 Antigen delivery systems for induction of influenza virus-specific cytotoxic lymphocytes (CTLs) in MICE 1996
1996 Induction of genital tract immune responses by oral immunization 1996
1996 Mucosally activated circulating human T-cells express the gut homing receptor α4β7 1996
1996 Multiple mechanisms of oral tolerance to food antigens in humans 1996
1996 Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice 1996
1995 Compartmentalization within the common mucosal immune system 1995
1995 Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeys 1995
1995 Ig-Secreting and interferon-γ-producing cells in mice mucosally immunized with influenza virus 1995
1995 Oral immunization studies with streptococcus mutans and influenza vaccines in rhesus macaque monkeys 1995
1994 Oral tolerance in humans: T cell but not B cell tolerance after antigen feeding 1994
1994 Biodegradable microspheres for the delivery of oral vaccines 1994
1994 Characterization of Poliovirus Replicons Encoding Carcinoembryonic Antigen 1994
1994 Mucosal immunity and strategies for novel microbial vaccines 1994
1994 New approaches for mucosal vaccines for AIDS: Encapsidation and serial passage of poliovirus replicons that express HIV-1 proteins on infection 1994
1993 Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. 1993
1993 Interactions of cell-surface galactosyltransferase with immunoglobulins 1993
1993 Murine model for evaluation of protective immunity to influenza virus 1993
1993 Oral immunization with influenza virus in biodegradable microspheres 1993
1992 Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: A comparison between intravenously and genitally inoculated Rhesus macaques 1992
1992 IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy 1992
1992 Isotype of anti-SIV responses in infected rhesus macaques and in animals immunized by mucosal routes 1992
1989 Analysis of human IgG and IgA subclass antibody-secreting cells from localized chronic inflammatory tissue 1989
1989 Bacteroides-specific IgG and IgA subclass antibody-secreting cells isolated from chronically inflamed gingival tissues 1989
1989 Biodegradable microspheres: vaccine delivery system for oral immunization. 1989
1989 Cellular analysis of functional mononuclear cells from chronically inflamed gingival tissue. 1989
1989 Immune responses to influenza virus in orally and systemically immunized mice. 1989
1989 Systemic immunization for the induction of IgA responses. 1989
1989 The role of the liver in catabolism of mouse and human iga 1989
1988 A novel two colour ELISPOT assay. I. Simultaneous detection of distinct types of antibody-secreting cells 1988
1988 Binding of IgA to erythrocytes from patients with IgA nephropathy 1988
1988 The sites of catabolism of murine monomeric IgA 1988
1987 IgA on the surface of erythrocytes from IgA nephropathy patients. 1987
1986 Detection and specificity of antibodies secreted by spleen cells in mice immunized with Streptococcus mutans 1986
1985 Activation of human splenic lymphocytes with T cell lectins increase FcαR+ T cell populations and support in vitro IgA responses 1985
1985 Activity of rheumatoid factors of different molecular sizes: Comparison of autologous monomeric and polymeric monoclonal IgA rheumatoid factors 1985
1985 Major site(s) of mIgA catabolism in BALB/c mice 1985
1984 Cellular origins of human polymeric and monomeric IgA: Intracellular and secreted forms of IgA 1984
1984 Receptors for secretory and serum IgA in human liver 1984
1983 Ultrastructural studies of human lymphoid cells: µ and J chain expression as a function of B cell differentiation 1983
1983 Biosynthesis of J-chain in human lymphoid cells producing immunoglobulins of various isotypes 1983

Chapter

Year Title Altmetric
2016 Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy.  53-68. 2016
2005 Collection and processing of external secretions and tissues of mouse origin.  1841-1852. 2005
2005 Collection and processing of human mucosal secretions.  1829-1839. 2005
1998 Principles of oral tolerance.  90-9. 1998
1997 Therapeutic applications of oral tolerance for human disease.  209-23. 1997

Teaching Activities

Full Name

  • Zina Moldoveanu