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Zhao Ph.D., Xinyang
Associate Professor
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E-mail
zhaox88@uab.edu
Office Address
SHEL 703
RICHARD C & ANNETTE N SHELBY INTERDISCIPLINARY BIOMEDICAL RESH B
Birmingham, AL 35294-2182
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Map of Science
Co-investigator Network
Zhao Ph.D., Xinyang
Associate Professor
Positions
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Associate Professor (P)
,
Biochemistry & Molecular Genetics
,
Academic Joint Departments
2011 -
Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2019
Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus: The Role of Protein O-GlcNAc Modification
.
Arteriosclerosis, Thrombosis, and Vascular Biology
. 39:1911-1924.
2019
2019
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD
1
acute myeloid leukemia
.
Blood
. 134:548-560.
2019
2019
Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis
.
Journal of Neuro-Oncology
. 141:289-301.
2019
2018
Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1
.
Blood Advances
. 2:2829-2836.
2018
2017
Splicing factor SF3B1
K700E
mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
.
PLoS ONE
. 12.
2017
2017
The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand
.
Journal of Biological Chemistry
. 292:10390-10397.
2017
2016
The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation
.
EMBO Reports
. 17:887-900.
2016
2015
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
.
eLife
. 4.
2015
2015
Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis
.
British Journal of Haematology
. 170:859-873.
2015
2015
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: Synthesis and biological evaluation
.
Journal of Medicinal Chemistry
. 58:1228-1243.
2015
2014
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
.
Cell Reports
. 9:1841-1855.
2014
2014
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1
.
Journal of Medicinal Chemistry
. 57:2611-2622.
2014
2014
Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
.
Journal of Neuro-Oncology
. 118:61-72.
2014
2013
PRMT4 blocks myeloid differentiation by assembling a Methyl-RUNX1-dependent repressor complex
.
Cell Reports
. 5:1625-1638.
2013
2013
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
.
Journal of Experimental Medicine
. 210:2641-2659.
2013
2012
Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus
.
Science Signaling
. 5.
2012
2012
ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
.
Cancer Cell
. 22:180-193.
2012
2012
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential
.
Blood
. 119:4953-4962.
2012
2011
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
.
Blood
. 118:6544-6552.
2011
2011
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation
.
Science
. 333:765-769.
2011
2011
The Mef/Elf4 transcription factor fine tunes the DNA damage response
.
Cancer Research
. 71:4857-4865.
2011
2011
Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
.
Cancer Cell
. 20:11-24.
2011
2011
JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
.
Cancer Cell
. 19:283-294.
2011
2011
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
.
Nature Chemical Biology
. 7:818-826.
2011
2010
Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: Possible role in 20q - Polycythemia vera
.
Blood
. 116:2812-2821.
2010
2009
Post-translational modifications of Runx1 regulate its activity in the cell
.
Blood Cells, Molecules and Diseases
. 43:30-34.
2009
2008
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
.
Genes and Development
. 22:640-653.
2008
2007
CHD8 associates with human staf and contributes to efficient U6 RNA polymerase III transcription
.
Molecular and Cellular Biology
. 27:8729-8738.
2007
2001
A positioned nucleosome on the human U6 promoter allows recruitment of SNAP
c
by the Oct-1 POU domain
.
Molecular Cell
. 7:539-549.
2001
1997
The evolution of hantaviruses
.
Immunological communications
. 26:191-197.
1997
Research
Principal Investigator On
The Functions of Antisense RNA AS-RBM15 in Hematopoiesis
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2020
Targeting PRMTl as a Curative Therapy for Acute Myeloid Leukemia
awarded by
Pardee (Elsa U.) Foundation
2018 - 2020
PRMT1-Mediated Metabolic Reprogramming in Leukemia Progression
awarded by
National Cancer Institute/NIH/DHHS
2016 - 2019
Targeting PRMT1 in Acute Megakaryocytic Leukemia
awarded by
Leukemia Research Foundation
2016 - 2017
Investigator On
Targeting PRMT5 in Cancer Initiating Cells as a New Therapy for Glioblastoma
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2015 - 2020
Teaching
Teaching Activities
GBSC710 - Advanced Chromatin Biology (Fall Term 2019)
2019
GBSC710 - Advanced Chromatin Biology (Fall Term 2018)
2018
GBSC735 - Discoveries in Mol Bio (Fall Term 2018)
2018
GBSC710 - Advanced Chromatin Biology (Fall Term 2017)
2017
GBSC710 - Advanced Chromatin Biology (Fall Term 2016)
2016
GBS788 - Special Topics (Fall Term 2015)
2015
GBSC710 - Advanced Chromatin Biology (Fall Term 2015)
2015
GBSC710 - Advanced Chromatin Biology (Fall Term 2014)
2014
Background
Education And Training
Doctor of Philosophy in Microbiology,
State University of New York System : Buffalo
1996
Master of Science in Microbiology,
State University of New York System : Buffalo
1995
Contact
Full Name
Xinyang
Zhao