Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases 2021
2021 Transcriptional programming in arteriosclerotic,disease; A Multifaceted Function of the Runx2 (Runt-Related Transcription Factor 2) 2021
2020 Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation.  Laboratory Investigation.  100:777-785. 2020
2020 Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization 2020
2019 Metabolic stress and cardiovascular disease in diabetes mellitus: The role of protein O -GlcNAc modification 2019
2019 PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD1 acute myeloid leukemia.  Blood.  134:548-560. 2019
2019 Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis.  Journal of Neuro-Oncology.  141:289-301. 2019
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.  Blood Advances.  2:2829-2836. 2018
2017 The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand.  Journal of Biological Chemistry.  292:10390-10397. 2017
2017 Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.  PLoS ONE.  12. 2017
2016 Mifepristone inhibites the migration of endometrial cancer cells through regulating H19 methylation 2016
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.  EMBO Reports.  17:887-900. 2016
2016 Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.  Oncogene.  35:1468-1474. 2016
2015 Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.  eLife.  4. 2015
2015 Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.  British Journal of Haematology.  170:859-873. 2015
2015 Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation.  Oncogene.  34:3076-3084. 2015
2015 Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: Synthesis and biological evaluation.  Journal of Medicinal Chemistry.  58:1228-1243. 2015
2014 DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia.  Cell Reports.  9:1841-1855. 2014
2014 Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.  Journal of Medicinal Chemistry.  57:2611-2622. 2014
2014 Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro.  Journal of Neuro-Oncology.  118:61-72. 2014
2013 PRMT4 blocks myeloid differentiation by assembling a Methyl-RUNX1-dependent repressor complex.  Cell Reports.  5:1625-1638. 2013
2013 Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.  Journal of Experimental Medicine.  210:2641-2659. 2013
2012 Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus.  Science Signaling.  5. 2012
2012 ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.  Cancer Cell.  22:180-193. 2012
2012 PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.  Blood.  119:4953-4962. 2012
2011 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.  Blood.  118:6544-6552. 2011
2011 The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.  Science.  333:765-769. 2011
2011 The Mef/Elf4 transcription factor fine tunes the DNA damage response.  Cancer Research.  71:4857-4865. 2011
2011 Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation.  Cancer Cell.  20:11-24. 2011
2011 JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation.  Cancer Cell.  19:283-294. 2011
2011 Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.  Nature Chemical Biology.  7:818-826. 2011
2010 Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: Possible role in 20q - Polycythemia vera.  Blood.  116:2812-2821. 2010
2009 Post-translational modifications of Runx1 regulate its activity in the cell.  Blood Cells, Molecules and Diseases.  43:30-34. 2009
2008 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.  Genes and Development.  22:640-653. 2008
2007 CHD8 associates with human staf and contributes to efficient U6 RNA polymerase III transcription.  Molecular and Cellular Biology.  27:8729-8738. 2007
2001 A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.  Molecular Cell.  7:539-549. 2001
1997 The evolution of hantaviruses 1997

Education And Training

  • Doctor of Philosophy in Microbiology, State University of New York System : Buffalo 1996
  • Master of Science in Microbiology, State University of New York System : Buffalo 1995

    • Full Name

  • Xinyang Zhao