Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Metabolic Stress and Cardiovascular Disease in Diabetes Mellitus: The Role of Protein O-GlcNAc Modification.  Arteriosclerosis, Thrombosis, and Vascular Biology.  39:1911-1924. 2019
2019 PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD1 acute myeloid leukemia.  Blood.  134:548-560. 2019
2019 Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis.  Journal of Neuro-Oncology.  141:289-301. 2019
2018 Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.  Blood Advances.  2:2829-2836. 2018
2017 Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.  PLoS ONE.  12. 2017
2017 The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-related apoptosis-inducing ligand.  Journal of Biological Chemistry.  292:10390-10397. 2017
2016 The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.  EMBO Reports.  17:887-900. 2016
2015 Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.  eLife.  4. 2015
2015 Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.  British Journal of Haematology.  170:859-873. 2015
2015 Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: Synthesis and biological evaluation.  Journal of Medicinal Chemistry.  58:1228-1243. 2015
2014 DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia.  Cell Reports.  9:1841-1855. 2014
2014 Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.  Journal of Medicinal Chemistry.  57:2611-2622. 2014
2014 Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro.  Journal of Neuro-Oncology.  118:61-72. 2014
2013 PRMT4 blocks myeloid differentiation by assembling a Methyl-RUNX1-dependent repressor complex.  Cell Reports.  5:1625-1638. 2013
2013 Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.  Journal of Experimental Medicine.  210:2641-2659. 2013
2012 Akt phosphorylates the transcriptional repressor Bmi1 to block its effects on the tumor-suppressing Ink4a-Arf locus.  Science Signaling.  5. 2012
2012 ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression.  Cancer Cell.  22:180-193. 2012
2012 PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.  Blood.  119:4953-4962. 2012
2011 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.  Blood.  118:6544-6552. 2011
2011 The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.  Science.  333:765-769. 2011
2011 The Mef/Elf4 transcription factor fine tunes the DNA damage response.  Cancer Research.  71:4857-4865. 2011
2011 Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation.  Cancer Cell.  20:11-24. 2011
2011 JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation.  Cancer Cell.  19:283-294. 2011
2011 Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.  Nature Chemical Biology.  7:818-826. 2011
2010 Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: Possible role in 20q - Polycythemia vera.  Blood.  116:2812-2821. 2010
2009 Post-translational modifications of Runx1 regulate its activity in the cell.  Blood Cells, Molecules and Diseases.  43:30-34. 2009
2008 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.  Genes and Development.  22:640-653. 2008
2007 CHD8 associates with human staf and contributes to efficient U6 RNA polymerase III transcription.  Molecular and Cellular Biology.  27:8729-8738. 2007
2001 A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.  Molecular Cell.  7:539-549. 2001
1997 The evolution of hantaviruses.  Immunological communications.  26:191-197. 1997

Education And Training

  • Doctor of Philosophy in Microbiology, State University of New York System : Buffalo 1996
  • Master of Science in Microbiology, State University of New York System : Buffalo 1995

    • Full Name

  • Xinyang Zhao