Positions

Overview

  • My lab is looking for postdocs and/or graduate students.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro.  ACS Chemical Biology.  13:2048-2057. 2018
    2017 Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons.  Autophagy.  13:1828-1840. 2017
    2017 Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.  Circulation: Heart Failure.  10. 2017
    2017 O-GlcNAcylation and neurodegeneration.  Brain Research Bulletin.  133:80-87. 2017
    2017 Oxidative stress and neurodegeneration.  Brain Research Bulletin.  133:1-3. 2017
    2017 Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.  Annals of Oncology.  28:83-89. 2017
    2017 Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up.  Annals of Oncology.  28:75-82. 2017
    2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.  Free Radical Biology and Medicine.  100:94-107. 2016
    2016 Differential regulation of autophagy and mitophagy in pulmonary diseases.  AJP - Lung Cellular and Molecular Physiology.  311:L433-L452. 2016
    2016 Metabolic, autophagic, and mitophagic activities in cancer initiation and progression.  Biomedical Journal.  39:98-106. 2016
    2016 Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.  Cell.  164:550-563. 2016
    2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).  Autophagy.  12:1-222. 2016
    2016 Novel mechanisms for the antifibrotic action of nintedanib.  American Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
    2016 The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: Implications for neurodegenerative diseases.  Aging and Disease.  7:150-162. 2016
    2015 Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355)).  Biochemical Journal.  471:431. 2015
    2015 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.  Biochemical Journal.  469:347-355. 2015
    2015 Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.  Free Radical Biology and Medicine.  85:83-94. 2015
    2014 SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling.  Cancer Research.  74:6318-6329. 2014
    2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013.  F1000Research.  3. 2014
    2014 Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics.  Free Radical Biology and Medicine.  71:196-207. 2014
    2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research..  Clinical Science.  127:367-373. 2014
    2014 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.  Autophagy.  10:986-1003. 2014
    2013 Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells.  Autophagy.  9:1996-2008. 2013
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells.  AJP - Endocrinology and Metabolism.  305. 2013
    2013 Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.  Biochemical Journal.  454:249-257. 2013
    2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeutics.  Biochemical Society Transactions.  41:127-133. 2013
    2013 Cellular metabolic and autophagic pathways: Traffic control by redox signaling.  Free Radical Biology and Medicine.  63:207-221. 2013
    2013 Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.  Free Radical Biology and Medicine.  65:1215-1228. 2013
    2013 Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products.  Free Radical Biology and Medicine.  59:56-68. 2013
    2012 Genetically engineered mouse models of Parkinson's disease.  Brain Research Bulletin.  88:13-32. 2012
    2012 Guidelines for the use and interpretation of assays for monitoring autophagy.  Autophagy.  8:445-544. 2012
    2012 Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy.  AJP - Heart and Circulatory Physiology.  302. 2012
    2012 Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling.  Biochemical Journal.  441:523-540. 2012
    2012 Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart.  Autophagy.  8:707-708. 2012
    2011 Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress.  Free Radical Biology and Medicine.  51:2007-2017. 2011
    2011 Assessing bioenergetic function in response to oxidative stress by metabolic profiling.  Free Radical Biology and Medicine.  51:1621-1635. 2011
    2011 Systems biology of the autophagy-lysosomal pathway.  Autophagy.  7:477-489. 2011
    2008 The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapy.  Frontiers in Bioscience.  13:718-736. 2008
    2007 Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin.  Cell Research.  17:735-736. 2007
    2005 Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1.  Cardiovascular Research.  65:719-727. 2005
    2004 Molecular genetic probing of dopamine receptors in drug addiction.  Current Opinion in Drug Discovery and Development.  7:703-708. 2004
    2002 Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditions.  Biochemical and Biophysical Research Communications.  297:537-544. 2002
    2001 DNA fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell death.  Biochemical and Biophysical Research Communications.  285:1143-1149. 2001
    2000 Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosis.  Biochemical and Biophysical Research Communications.  274:225-229. 2000
    2000 DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control mice.  Brain Research.  867:70-79. 2000
    2000 Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.  Brain Research.  852:198-207. 2000
    2000 DNA fragmentation in apoptosis.  Cell Research.  10:205-211. 2000
    2000 Probing the role of the dopamine D1 receptor in psychostimulant addiction.  Annals of the New York Academy of Sciences.  914:13-21. 2000
    1995 Association of an activator with an RNA polymerase II holoenzyme.  Genes and Development.  9. 1995

    Book

    Year Title Altmetric
    2013 Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease, Redox Biology 2 (2014) 82–90 2013

    Chapter

    Year Title Altmetric
    2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
    2012 Mitochondrial dysfunction in neurodegenerative disease: Protein aggregation, autophagy, and oxidative stress.  95-111. 2012
    2009 Apoptosis in neurodegenerative diseases.  479-504. 2009

    Research Overview

  • My research focus is to understand the cellular and molecular mechanisms responsible for autophagy, mitophagy and lysosomal functions, how these are linked to redox biology and bioenergetics, and how these mechanisms play important roles in Parkinson’s disease pathogenesis and provide opportunities for therapeutics development. These mechanisms are also important for understanding cell differentiation, proliferation, function and survival, in the context of cancer, diabetes, aging, cardiovascular, lung, liver and Alzheimer’s diseases. We are approaching this by using state of the art genetic models and advanced biochemical, omics, metabolic and redox related technologies.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Texas System : Southwestern Medical Center at Dallas 1991

    • Full Name

  • Jianhua Zhang