Selected Publications

Academic Article

Year Title Altmetric
2021 Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complicationsCurrent Opinion in Pharmacology.  57:1-12. 2021
2021 Association of a four-gene model with allergic diseases: Two-year follow-up of a birth cohort studyImmunity, Inflammation and Disease.  9:239-245. 2021
2020 Effects of environmental PM2.5 exposure on airway inflammatory diseases 2020
2020 The role of basophils in asthma 2020
2020 Reprint of: Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complicationsCurrent Opinion in Pharmacology.  54:209-220. 2020
2020 Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia 2020
2020 Differential effects of REV-ERB/ agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption 2020
2020 Role and Mechanisms of Mitophagy in Liver DiseasesCells.  9. 2020
2020 MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure 2020
2020 Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and functionAutophagy2020
2020 Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart BeatingAnnual Review of Physiology.  82:79-101. 2020
2020 Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β productionCellular and Molecular Immunology2020
2020 Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotectiveAutophagy2020
2019 Acute increases in O-glcNAc indirectly impair mitochondrial bioenergetics through dysregulation of lonp1-mediated mitochondrial protein complex turnover 2019
2019 GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2Gastroenterology.  156:2297-2312. 2019
2019 Association between the PAI-1 4G/5G gene polymorphism and the risk of systemic lupus erythematosus/lupus nephritisCritical Reviews in Eukaryotic Gene Expression.  29:85-94. 2019
2019 Bioenergetics and translational metabolism: Implications for genetics, physiology and precision medicine 2019
2018 Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in VitroACS Chemical Biology.  13:2048-2057. 2018
2017 Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neuronsAutophagy.  13:1828-1840. 2017
2017 Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart FailureCirculation: Heart Failure.  10. 2017
2017 O-GlcNAcylation and neurodegenerationBrain Research Bulletin.  133:80-87. 2017
2017 Oxidative stress and neurodegenerationBrain Research Bulletin.  133:1-3. 2017
2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolismFree Radical Biology and Medicine.  100:94-107. 2016
2016 Differential regulation of autophagy and mitophagy in pulmonary diseases 2016
2016 Metabolic, autophagic, and mitophagic activities in cancer initiation and progressionBiomedical Journal.  39:98-106. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
2016 The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: Implications for neurodegenerative diseasesAging and Disease.  7:150-162. 2016
2015 Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355))Biochemical Journal.  471:431. 2015
2015 KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicityBiochemical Journal.  469:347-355. 2015
2015 Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammationFree Radical Biology and Medicine.  85:83-94. 2015
2014 SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signalingCancer Research.  74:6318-6329. 2014
2014 Aging and energetics' 'Top 40' future research opportunities 2010-2013F1000Research.  3. 2014
2014 Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeuticsFree Radical Biology and Medicine.  71:196-207. 2014
2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research.Clinical Science.  127:367-373. 2014
2014 The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cellsAutophagy.  10:986-1003. 2014
2013 Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cellsAutophagy.  9:1996-2008. 2013
2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells 2013
2013 Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblastsBiochemical Journal.  454:249-257. 2013
2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeuticsBiochemical Society Transactions.  41:127-133. 2013
2013 Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease, Redox Biology 2 (2014) 82–90 2013
2013 Cellular metabolic and autophagic pathways: Traffic control by redox signalingFree Radical Biology and Medicine.  63:207-221. 2013
2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cellsAmerican Journal of Physiology-Endocrinology and Metabolism 305 (5), E585-.  599. 2013
2013 Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neuronsFree Radical Biology and Medicine.  65:1215-1228. 2013
2013 Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation productsFree Radical Biology and Medicine.  59:56-68. 2013
2012 Integration of cellular bioenergetics with mitochondrial quality control and autophagy 2012
2012 Genetically engineered mouse models of Parkinson's diseaseBrain Research Bulletin.  88:13-32. 2012
2012 Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy.  8:445-544. 2012
2012 Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy 2012
2012 Autophagy, mitochondria and oxidative stress: Cross-talk and redox signallingBiochemical Journal.  441:523-540. 2012
2012 Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heartAutophagy.  8:707-708. 2012
2011 Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stressFree Radical Biology and Medicine.  51:2007-2017. 2011
2011 Assessing bioenergetic function in response to oxidative stress by metabolic profilingFree Radical Biology and Medicine.  51:1621-1635. 2011
2011 Systems biology of the autophagy-lysosomal pathwayAutophagy.  7:477-489. 2011
2008 The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapyFrontiers in Bioscience.  13:718-736. 2008
2007 Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicinCell Research.  17:735-736. 2007
2007 The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosisInsect Molecular Biology.  16:93-105. 2007
2006 Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1 and D3 receptorsAnnals of the New York Academy of Sciences.  1074:1-12. 2006
2005 Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1Cardiovascular Research.  65:719-727. 2005
2004 Molecular genetic probing of dopamine receptors in drug addictionCurrent Opinion in Drug Discovery and Development.  7:703-708. 2004
2004 Bioconductor: open software development for computational biology and bioinformatics.Genome Biology.  5. 2004
2002 Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditionsBiochemical and Biophysical Research Communications.  297:537-544. 2002
2002 Identification of chronic cocaine-induced gene expression through dopamine D1 receptors by using cDNA microarraysAnnals of the New York Academy of Sciences.  965:1-9. 2002
2001 DNA fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell deathBiochemical and Biophysical Research Communications.  285:1143-1149. 2001
2000 Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45-deficient thymocytes upon activation of apoptosisBiochemical and Biophysical Research Communications.  274:225-229. 2000
2000 DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control miceBrain Research.  867:70-79. 2000
2000 Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptorBrain Research.  852:198-207. 2000
2000 DNA fragmentation in apoptosisCell Research.  10:205-211. 2000
2000 Probing the role of the dopamine D1 receptor in psychostimulant addictionAnnals of the New York Academy of Sciences.  914:13-21. 2000
1995 Association of an activator with an RNA polymerase II holoenzymeGenes and Development.  9. 1995
1995 Association of an activator with an RNA polymerase II holoenzymeGenes and Development.  9:897-910. 1995


Year Title Altmetric
2017 ROS and epigenetics.  519-533. 2017
2013 Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology.  17-22. 2013
2012 Mitochondrial dysfunction in neurodegenerative disease: Protein aggregation, autophagy, and oxidative stress.  95-111. 2012
2009 Apoptosis in neurodegenerative diseases.  479-504. 2009
2006 Cell Death and Transcription.  431-444. 2006
2006 Comparative Genomics of Tissue Specific Gene Expression.  393-408. 2006

Investigator On

  • Comparative Bioenergetics of Aging  awarded by National Institute on Aging/NIH/DHHS 2020 - 2025
  • Regulation of Skeletal Muscle Mitochondrial Quality Control Parameters and Systemic Metabolism  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2022
  • Aberrant Circadian Regulation Of Autophagy In The Heart During Diabetes  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2022
  • Role of Rab27b in Synucleinopathies  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2020 - 2021
  • Comparative Energetics and Aging  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • Comparative Energetics and Aging - Comparative Molecular Energetics Analysis Core D  awarded by National Institute on Aging/NIH/DHHS 2015 - 2020
  • HDL and Cellular Repair Mechanisms  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2020
  • IPA - Sirtuins in Lung Aging and Fibrosis (Jianhua Zhang)  awarded by VETERANS ADMINISTRATION 2015 - 2018
  • UAB Nutrition Obesity Research Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2018
  • Utilizing Transcriptional Pathways to Enhance Mitochondrial Health in Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2017
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • Mitochondrial Bioenergetic Dysfunction and Chlorine Toxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2015
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, University of Texas System : Southwestern Medical Center at Dallas 1991
  • Full Name

  • Jianhua Zhang