Selected Publications

Academic Article

Year Title Altmetric
2020 MRLR: Unraveling high-resolution meiotic recombination by linked reads 2020
2019 Multi-platform discovery of haplotype-resolved structural variation in human genomes 2019
2019 Scalable De Novo Genome Assembly Using a Pregel-Like Graph-Parallel System. 2019
2019 Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2 2019
2018 Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection 2018
2018 Identification of meiotic recombination through gamete genome reconstruction using whole genome linked-reads 2018
2018 Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes 2018
2018 Regenerative potential of neonatal porcine hearts 2018
2018 Structural variant breakpoint detection with novoBreak 2018
2017 A murine preclinical syngeneic transplantation model for breast cancer precision medicine 2017
2017 Integrated genomic and molecular characterization of cervical cancer 2017
2017 A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines 2017
2017 An Organismal CNV Mutator Phenotype Restricted to Early Human Development 2017
2017 novoBreak: local assembly for breakpoint detection in cancer genomes. 2017
2016 Single-cell isolation by a modular single-cell pipette for RNA-sequencing. 2016
2016 Functional annotation of rare gene aberration drivers of pancreatic cancer 2016
2016 Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types 2016
2015 An integrated map of structural variation in 2,504 human genomes 2015
2015 A global reference for human genetic variation 2015
2015 ClinSeK: a targeted variant characterization framework for clinical sequencing 2015
2015 Clinical actionability enhanced through deep targeted sequencing of solid tumors 2015
2015 Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia 2015
2015 Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutations 2015
2015 TransVar: a multilevel variant annotator for precision genomics 2015
2014 Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. 2014
2014 Towards accurate characterization of clonal heterogeneity based on structural variation 2014
2014 Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions 2014
2013 The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster. 2013
2013 Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals 2013
2013 Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology 2013
2013 Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism 2013
2012 Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads 2012
2011 Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. 2011

Education And Training

  • Doctor of Social or Behavioral Sciences in Genome Sciences / Genomics, Chinese Academy of Medical Sciences and Peking Union Medical College 2013
  • Univeristy of Texas MD Anderson Cancer Center Bioinformatics and Computational Biology, Postdoctoral Fellowship 2017
  • Full Name

  • Zechen Chong