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Zechen Chong
Assistant Professor
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E-mail
zchong@uab.edu
zchong@uabmc.edu
Phone
205-801-7590
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Zechen Chong
Assistant Professor
Positions
Scientist (C)
,
Informatics Institute
,
School of Medicine
2017 -
Assistant Professor (P)
,
Genetics
,
Academic Joint Departments
2017 -
Associate Scientist (C)
,
Minority Health & Research Center
,
General Clinical Research Center
2019 -
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2020 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2020
The effects of common structural variants on 3D chromatin structure
.
BMC Genomics
. 21.
2020
2020
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
.
Nature Genetics
. 52:306-319.
2020
2020
Pan-cancer analysis of whole genomes
.
Nature
. 578:82-93.
2020
2020
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population
2020
2020
MRLR: Unraveling high-resolution meiotic recombination by linked reads
.
Bioinformatics
. 36:10-16.
2020
2020
Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies
.
Journal of Alzheimer's Disease
. 76:807-824.
2020
2019
Multi-platform discovery of haplotype-resolved structural variation in human genomes
.
Nature Communications
. 10.
2019
2019
Human-specific tandem repeat expansion and differential gene expression during primate evolution
2019
2019
Scalable De Novo Genome Assembly Using a Pregel-Like Graph-Parallel System.
.
IEEE/ACM Transactions on Computational Biology and Bioinformatics
.
2019
2019
Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2
.
Cell
. 176:1310-1324.e10.
2019
2018
Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection
.
Genome Biology
. 19.
2018
2018
Identification of meiotic recombination through gamete genome reconstruction using whole genome linked-reads
2018
2018
Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes
.
Human Mutation
. 39:939-946.
2018
2018
Regenerative potential of neonatal porcine hearts
.
Circulation
. 138:2809-2816.
2018
2018
Structural variant breakpoint detection with novoBreak
.
Methods in Molecular Biology
. 1833:129-141.
2018
2017
A murine preclinical syngeneic transplantation model for breast cancer precision medicine
.
Science Advances
. 3:e1600957-e1600957.
2017
2017
Integrated genomic and molecular characterization of cervical cancer
.
Nature
. 543:378-384.
2017
2017
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines
.
Cell Systems
. 5:485-497.e3.
2017
2017
An Organismal CNV Mutator Phenotype Restricted to Early Human Development
.
Cell
. 168:830-842.
2017
2017
novoBreak: local assembly for breakpoint detection in cancer genomes.
.
Nature methods
. 14:65-67.
2017
2016
Single-cell isolation by a modular single-cell pipette for RNA-sequencing.
2016
2016
Functional annotation of rare gene aberration drivers of pancreatic cancer
.
Nature Communications
. 7.
2016
2016
Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types
.
BMC Genomics
. 17:394-394.
2016
2015
An integrated map of structural variation in 2,504 human genomes
.
Nature
. 526:75-81.
2015
2015
A global reference for human genetic variation
.
Nature
. 526:68-74.
2015
2015
ClinSeK: a targeted variant characterization framework for clinical sequencing
.
Genome Medicine
. 7:34-34.
2015
2015
Clinical actionability enhanced through deep targeted sequencing of solid tumors
.
Clinical Chemistry
. 61:544-553.
2015
2015
Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia
.
Oncotarget
. 6:6535-6535.
2015
2015
Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutations
.
Cancer Research
. 75:5341-5354.
2015
2015
TransVar: a multilevel variant annotator for precision genomics
.
Nature methods
. 12:1002-1003.
2015
2014
Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.
.
Cell Research
. 24:532-541.
2014
2014
Towards accurate characterization of clonal heterogeneity based on structural variation
.
BMC Bioinformatics
. 15:299-299.
2014
2014
Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions
.
Cell Stem Cell
. 14:632-643.
2014
2013
The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster.
.
Molecular Biology and Evolution
. 30:2699-2708.
2013
2013
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
.
Journal of the American Chemical Society
. 135:10396-10403.
2013
2013
Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology
.
BMC Genomics
. 14:711-711.
2013
2013
Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism
.
Nucleic Acids Research
. gkt1090-gkt1090.
2013
2012
Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads
.
Bioinformatics
.
2012
2011
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.
2011
Research
Principal Investigator On
Structural Variation Analysis with and without a Reference Genome
awarded by
National Institute of General Medical Sciences/NIH/DHHS
2020 - 2025
Study the Contribution of Structural Variations to Cardiovascular Diseases on the BioData Catalyst Platform
awarded by
University of North Carolina at Chapel Hill
2020 - 2021
Investigator On
Circadian Regulation of Vascular Aging
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2022
AHA-Data Grant Fellowship
awarded by
American Heart Association
2017 - 2019
Genomic Diagnosis in Children with Developmental Delay: South-seq: DNA Sequencing for Newborn Nurseries in the South
awarded by
HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY
2013 - 2017
Teaching
Teaching Activities
INFO601 - Introduction to Bioinformatics (Fall Term 2019)
2019
INFO701 - Introduction to Bioinformatics (Fall Term 2019)
2019
INFO701 - Introduction to Bioinformatics (Fall Term 2018)
2018
Background
Education And Training
Doctor of Social or Behavioral Sciences in Genome Sciences / Genomics,
Chinese Academy of Medical Sciences and Peking Union Medical College
2013
Univeristy of Texas MD Anderson Cancer Center Bioinformatics and Computational Biology, Postdoctoral Fellowship
2017
Contact
Full Name
Zechen
Chong