Positions

Overview

  • Dr. Zhou obtained his MD degree from Wuhan University in China and his PhD from Kyshu University in Japan. He completed his postdoctoral studies in the area of TGF-beta, matrix biology, and lung fibrosis at the University of Alabama at Birmingham, where he later became a Department of Pathology faculty member. In 2009, Dr. Zhou was recruited to the Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, where he is now an Associate Professor of Medicine. Dr. Zhou has received many prestigious awards, including the International Colloquium on Lung and Airway Fibrosis (ICLAF) Young Investigator Award, the American Thoracic Society (ATS) Recognition Award for Outstanding Early Career Investigator, and the UAB School of Medicine Dean's Excellence Award in Mentoring.Dr. Zhou currently serves as a PLOS ONE editorial board member, a grant reviewer for the American Heart Association (AHA), and a grant reviewer for the Department of Defense (DoD). He has served on ATS International Conferences as chair, co-chair, and facilitator and has also served on the program committee of the ATS Assembly on Respiratory Structure and Function (RSF).
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Rosiglitazone treatment prevents postoperative fibrosis in a rabbit model of glaucoma filtration surgery 2019
    2019 The immunomodulatory role of interleukin-35 in fibrotic diseases 2019
    2019 Beyond fibroblast heterogeneity: What single-cell RNA sequencing tells us 2019
    2019 Cigarette Smoke Extract Promotes Human Lung Myofibroblast Differentiation by the Induction of Endoplasmic Reticulum Stress 2019
    2018 Extracellular matrix in lung development, homeostasis and disease 2018
    2018 Reversing mechanoinductive DSP expression by CRISPR/dCas9–mediated epigenome editing 2018
    2018 α6-Integrin alternative splicing: Distinct cytoplasmic variants in stem cell fate specification and niche interaction 2018
    2018 Most good, least harm: Isoform-specific targeting of ROCK in pulmonary fibrosis 2018
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β 2017
    2017 miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions 2017
    2017 MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence 2017
    2017 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. 2017
    2016 Tristetraprolin down-regulation contributes to persistent TNF-alpha expression induced by cigarette smoke extract through a post- transcriptional mechanism 2016
    2016 Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis 2016
    2016 Alveolar epithelial disintegrity in pulmonary fibrosis 2016
    2016 Image-based quantification of fiber alignment within electrospun tissue engineering scaffolds is related to mechanical anisotropy 2016
    2016 The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury 2016
    2016 Nanofiber alignment regulates NIH3T3 cell orientation and cytoskeletal gene expression on electrospun PCL+gelatin nanofibers 2016
    2015 High-magnitude and/or high-frequency mechanical strain promotes peripapillary scleral myofibroblast differentiation 2015
    2015 Noninvasive imaging of experimental lung fibrosis 2015
    2015 Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis 2015
    2015 Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus 2015
    2014 Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis 2014
    2014 Negative regulation of NADPH oxidase 4 by Hydrogen peroxide-inducible clone 5 (Hic-5) protein 2014
    2014 A far-upstream AP-1/Smad binding box regulates human NOX4 promoter activation by transforming growth factor-β 2014
    2014 Fibrosis: Ultimate and proximate causes 2014
    2014 Matrix biology of idiopathic pulmonary fibrosis: A workshop report of the national heart, lung, and blood institute 2014
    2013 Erratum: Myofibroblast differentiation and enhanced Tgf-B signaling in cystic fibrosis lung disease (PLoS ONE (2013) 8 (8)) 2013
    2013 Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease 2013
    2013 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis 2013
    2012 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle action filaments during myofibroblast differentiation 2012
    2012 Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction 2012
    2011 Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis 2011
    2011 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis 2011
    2010 Thy-1-integrin αvβ5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-β1 activation and myofibroblast differentiation 2010
    2009 Latent transforming growth factor-β-binding protein-4 regulates transforming growth factor-β1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin 2009
    2006 Thrombospondin 1 mediates angiotensin II induction of TGF-β activation by cardiac and renal cells under both high and low glucose conditions 2006
    2004 Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-β in response to fibrogenic stimuli 2004
    2002 Growth-associated Gene Expression Profiles by Microarray Analysis of Trophoblast of Molar Pregnancies and Normal Villi 2002
    2002 Identification of FOXC1 as a TGF-β1 responsive gene and its involvement in negative regulation of cell growth 2002
    2001 Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers 2001
    2000 Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of the DCC gene 2000
    1999 Involvement of mutations in the DPC4 promoter in endometrial carcinoma development 1999
    1998 Genetics of gestational trophoblastic diseases 1998

    Research Overview

  • Dr. Zhou's lab also works to determine cellular responses to intraocular pressure-generated mechanical strain that drive ECM remodeling in lamina cribosa cells and scleral fibroblasts harvested from clinical-records-confirmed normal and glaucomatous human donor eyes. Progressive remodeling of load-bearing connective tissues, like lamina cribosa and sclera, at the optic nerve head, is a defining feature of glaucoma. This remodeling alters the microenvironment of the retinal ganglion cell (RGC) axons traversing the ONH and is believed to be a direct cause of the axon loss and death of RGCs. Intraocular pressure is currently the only known modifiable risk factor for glaucoma. Dr. Zhou's Lab is currently funded by the NIH/NHLBI, AHA, ATS, and the EyeSight Foundation of Alabama (ESFA).
  • Full Name

  • Yong Zhou