• Jarred Younger completed postdoctoral fellowships at Arizona State University and the Stanford University School of Medicine before taking an Assistant Professor position at Stanford.

    He has recently joined the UAB faculty in Psychology, with secondary appointments in Anesthesiology and Rheumatology. He is currently funded by the National Institutes of Health and the Department of Defense to study new techniques for diagnosing and treating neuroinflammation.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Corrigendum: Repeatability and Reproducibility of in-vivo Brain Temperature Measurements (Front. Hum. Neurosci., (2020) ,14, (598435), 10.3389/fnhum.2020.598435)Frontiers in Human Neuroscience.  15. 2021
    2021 Boston biorepository, recruitment and integrative network (BBRAIN): A resource for the Gulf War Illness scientific communityLife Sciences.  284. 2021
    2021 Yoga is effective in treating symptoms of Gulf War illness: A randomized clinical trialJournal of Psychiatric Research.  143:563-571. 2021
    2021 Production of [89Zr]Oxinate4 and cell radiolabeling for human useJournal of Labelled Compounds and Radiopharmaceuticals.  64:209-216. 2021
    2021 A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for gulf war illness: Reishi mushroom (ganoderma lucidum), stinging nettle (urtica dioica), and epimedium (epimedium sagittatum)International Journal of Environmental Research and Public Health.  18. 2021
    2021 A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for gulf war illness: Curcumin (curcuma longa), boswellia (boswellia serrata), and french maritime pine bark (pinus pinaster)International Journal of Environmental Research and Public Health.  18:1-15. 2021
    2021 A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for gulf war illness: Resveratrol (polygonum cuspidatum), luteolin, and fisetin (rhus succedanea)International Journal of Environmental Research and Public Health.  18:1-14. 2021
    2021 Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury 2021
    2021 Low-dose dextromethorphan for the treatment of fibromyalgia pain: Results from a longitudinal, single-blind, placebo-controlled pilot trialJournal of Pain Research.  14:189-200. 2021
    2020 Repeatability and Reproducibility of in-vivo Brain Temperature MeasurementsFrontiers in Human Neuroscience.  14. 2020
    2020 Reproducibility of whole-brain temperature mapping and metabolite quantification using proton magnetic resonance spectroscopyNMR in Biomedicine.  33. 2020
    2020 No evidence of abnormal metabolic or inflammatory activity in the brains of patients with rheumatoid arthritis: results from a preliminary study using whole-brain magnetic resonance spectroscopic imaging (MRSI)Clinical Rheumatology.  39:1765-1774. 2020
    2020 Cognitive Effects of a Ketogenic Diet on Neurocognitive Impairment in Adults Aging With HIV: A Pilot StudyJournal of the Association of Nurses in AIDS Care.  31:312-324. 2020
    2020 Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy 2020
    2019 Effects of cannabinoid administration for pain: A meta-analysis and meta-regressionExperimental and Clinical Psychopharmacology.  27:370-382. 2019
    2018 Thermal Stimulation Changes Diffusivity of the Spinothalamic TractSpine.  43:E697-E702. 2018
    2018 Daily opioid analgesic use reduces blood insulin levels 2018
    2018 Daily Fluctuations of Progesterone and Testosterone Are Associated With Fibromyalgia Pain SeverityJournal of Pain.  19:410-417. 2018
    2018 Meta-analysis of cognitive performance in fibromyalgiaJournal of Clinical and Experimental Neuropsychology.  40:698-714. 2018
    2017 Cytokine signature associated with disease severity in chronic fatigue syndrome patients 2017
    2017 Brief Report: IL-1β Levels Are Associated with Chronic Multisite Pain in People Living with HIV 2017
    2017 Reduced pro-inflammatory cytokines after eight weeks of low-dose naltrexone for FibromyalgiaBiomedicines.  5. 2017
    2016 One month of oral morphine decreases gray matter volume in the right amygdala of individuals with low back pain: Confirmation of previously reported magnetic resonance imaging resultsPain Medicine.  17:1497-1504. 2016
    2016 Association of leptin with body pain in womenJournal of Women's Health.  25:752-760. 2016
    2016 Development of the Sensory Hypersensitivity Scale (SHS): a self-report tool for assessing sensitivity to sensory stimuliJournal of Behavioral Medicine.  39:537-550. 2016
    2016 Identification and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome: Small Intestinal Bacterial Overgrowth and Obstructive Sleep ApneaA&A Case Reports.  6:272-276. 2016
    2015 Pain Duration and Resolution following Surgery: An Inception Cohort StudyPain Medicine.  16:2386-2396. 2015
    2015 Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring dataBMC Immunology.  16. 2015
    2015 Acute opioid withdrawal is associated with increased neural activity in reward-processing centers in healthy men: A functional magnetic resonance imaging studyDrug and Alcohol Dependence.  153:314-322. 2015
    2015 Being female is a risk factor for chronic pain. Are inflammatory processes to blame?Brain, Behavior, and Immunity.  46:33-34. 2015
    2015 Relationship of pain and ancestry in African American womenEuropean Journal of Pain.  19:601-610. 2015
    2014 Erratum:“A control systems engineering approach for adaptive behavioral interventions: illustration with a fibromyalgia intervention” [Translational Behavioral Medicine, Volume 4, Issue 3, pp 275–289][Behav. Med. Pract. Policy Res., DOI 10.1007/s13142-014-0282-z]Translational Behavioral Medicine.  4:439. 2014
    2014 Optimized treatment of fibromyalgia using system identification and hybrid model predictive controlControl Engineering Practice.  33:161-173. 2014
    2014 A control systems engineering approach for adaptive behavioral interventions: illustration with a fibromyalgia interventionTranslational Behavioral Medicine.  4:275-289. 2014
    2014 Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brainJournal of Pain.  15:197-203. 2014
    2014 Multivariate classification of structural MRI data detects chronic low back painCerebral Cortex.  24:1037-1044. 2014
    2014 Preoccupation in an early-romantic relationship predicts experimental pain reliefPain Medicine.  15:947-953. 2014
    2014 Self-loathing aspects of depression reduce postoperative opioid cessation ratePain Medicine.  15:954-964. 2014
    2014 The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic painClinical Rheumatology.  33:451-459. 2014
    2013 Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: Evidence of inflammatory pathologyJournal of Translational Medicine.  11. 2013
    2013 Pain in chronic medical illnessPain Research and Treatment.  2013. 2013
    2013 Perioperative interventions to reduce chronic postsurgical painJournal of Reconstructive Microsurgery.  29:213-222. 2013
    2013 Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levelsArthritis and Rheumatism.  65:529-538. 2013
    2013 A pilot functional MRI study of the effects of prefrontal rTMS on pain perceptionPain Medicine.  14:999-1009. 2013
    2013 Identification of affine linear parameter varying models for adaptive interventions in fibromyalgia treatment 2013
    2012 Development of the Stanford Expectations of Treatment Scale (SETS): A tool for measuring patient outcome expectancy in clinical trialsClinical Trials.  9:767-776. 2012
    2012 A pilot cohort study of the determinants of longitudinal opioid use after surgeryAnesthesia and Analgesia.  115:694-702. 2012
    2011 Visualization of painful experiences believed to trigger the activation of affective and emotional brain regions in subjects with low back painPLoS ONE.  6. 2011
    2011 Towards a physiology-based measure of pain: Patterns of human brain activity distinguish painful from non-painful thermal stimulationPLoS ONE.  6. 2011
    2011 Prescription opioid analgesics rapidly change the human brainPAIN.  152:1803-1810. 2011
    2011 A control engineering approach for designing an optimized treatment plan for fibromyalgia 2011
    2010 Viewing pictures of a romantic partner reduces experimental pain: Involvement of neural reward systemsPLoS ONE.  5. 2010
    2010 Chronic myofascial temporomandibular pain is associated with neural abnormalities in the trigeminal and limbic systemsPAIN.  149:222-228. 2010
    2010 Pain quality predicts lidocaine analgesia among patients with suspected neuropathic painPain Medicine.  11:617-621. 2010
    2009 Fibromyalgia symptoms are reduced by low-dose naltrexone: A pilot studyPain Medicine.  10:663-672. 2009
    2009 Effects of naltrexone on pain sensitivity and mood in fibromyalgia: No evidence for endogenous opioid pathophysiologyPLoS ONE.  4. 2009
    2009 Pain outcomes: A brief review of instruments and techniquesCurrent Pain and Headache Reports.  13:39-43. 2009
    2009 Randomized clinical trial of acupuncture for myofascial pain of the jaw muscles 2009
    2008 Reduced cold pain tolerance in chronic pain patients following opioid detoxificationPain Medicine.  9:1158-1163. 2008
    2008 Personal mastery predicts pain, stress, fatigue, and blood pressure in adults with rheumatoid arthritis 2008
    2008 Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: Implications for fatigueBrain, Behavior, and Immunity.  22:24-32. 2008
    2007 Hypnotizability and somatic complaints: A gender-specific phenomenonInternational Journal of Clinical and Experimental Hypnosis.  55:1-13. 2007
    2006 Effects of naltrexone on repressive coping and disclosure of emotional material: A test of the opioid-peptide hypothesis of repression and hypertensionPsychosomatic Medicine.  68:734-741. 2006
    2006 Anatomy of a hypnotic response: Self-report estimates, actual behavior, and physiological response to the hypnotic suggestion for arm rigidityInternational Journal of Clinical and Experimental Hypnosis.  54:186-205. 2006
    2006 Effects of naltrexone on repressive coping and disclosure of emotional material: A test of the opioid-peptide hypothesis of repression and hypertensionPsychosomatic Medicine.  68:734-741. 2006
    2006 The role of adult attachment style in forgiveness following an interpersonal offenseJournal of Counseling and Development.  84:493-502. 2006
    2005 The Harvard Group Scale of Hypnotic Susceptibility: Accuracy of self-report and the memory for itemsInternational Journal of Clinical and Experimental Hypnosis.  53:306-320. 2005
    2005 Spirituality predicts Health and cardiovascular responses to stress in young adult womenJournal of Religion and Health.  44:161-171. 2005
    2005 The unique effects of forgiveness on health: An exploration of pathwaysJournal of Behavioral Medicine.  28:157-167. 2005
    2004 Dimensions of forgiveness: The views of laypersonsJournal of Social and Personal Relationships.  21:837-855. 2004
    2004 Perceived links between physical problems and stress may be clouded by dissociative processesJournal of Trauma and Dissociation.  5:121-127. 2004
    2004 The computer-assisted cognitive/imagery system for use in the management of painPain Research and Management.  9:157-162. 2004
    2003 A change of heart: Cardiovascular correlates of forgiveness in response to interpersonal conflictJournal of Behavioral Medicine.  26:373-393. 2003
    2002 Theobiology: An analysis of spirituality, cardiovascular responses, stress, mood, and physical healthJournal of Religion and Health.  41:347-362. 2002
    2000 An alternative approach for achieving cardiovascular baseline: Viewing an aquatic videoInternational Journal of Psychophysiology.  37:207-217. 2000
    2000 Forgiveness: Physiological and psychological correlatesPsychosomatic Medicine.  62:101-101. 2000
    2000 Physiological and psychological correlates of attachment style and family marital status in forgiveness recall interviewsPsychosomatic Medicine.  62:118-118. 2000


    Year Title Altmetric
    2012 Hypnosis and mind-body interactions 2012
    2007 Arthritis - Psychological.  261-264. 2007

    Research Overview

  • The Neuroinflammation, Pain and Fatigue Laboratory uses neuroimaging, pharmaceutical, and immunological techniques to understand and treat chronic diseases. We believe that low-level inflammation of the brain drives pain, fatigue, depression, and cognitive decline in millions of people. Low-level inflammation may also drive memory problems and fatigability as people age. We also investigate the impact that addictive drugs (such as opioid pain medications) have on the human brain. We use magnetic resonance imaging (MRI), pharmacologic MRI (phfMRI), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS) neuroimaging techniques.

    Neuroinflammation, pain, anesthesiology, rheumatology
  • Principal Investigator On

  • Assessing Neuroinflammation in Gulf War Illness with Whole-Brain Magnetic Resonance Spectroscopy  awarded by DOD - Department of Defense
  • Brain Thermometry: A Non-Invasive Method for Detecting Neuroinflammation in RA  awarded by RHEUMATOLOGY RESEARCH FOUNDATION
  • Daily Immune Monitoring in Chronic Fatigue Syndrome  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Detecting Neuroinflammation in Fibromyalgia with the Positron Emission Tomography (PET) Radioligand [18] DPA-714  awarded by American Fibromyalgia Syndrome Association
  • Identifying Immune Drivers of Gulf War Illness Using a Novel Daily Sampling Approach  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • MRSt and brain imaging in ME/CFS  awarded by SOLVE ME/CFS
  • Measuring Neuroinflammation in Chronic Fatigue Syndrome with Whole-brain Magnetic Resonance Spectroscopy  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Moral Elevation and the Brain  awarded by Fetzer Institute
  • Neuroimmodulatory Pharmacotherapy in Pain: Therapy and Outcomes  awarded by International Association for the Study of Pain
  • Private Grant  awarded by KARIUS INC.
  • The Innate Central Nervous System Immune Response To An Experimental Immune Challenge In People With Fibromyalgia  awarded by American Fibromyalgia Syndrome Association
  • Treating Gulf War Illness with Novel Anti-Inflammatories: A Screening of Botanical Microglia Modulators  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Viability Testing of Immune Cells Extracted from Human Blood Samples  awarded by ME RESEARCH UK
  • Education And Training

  • Doctor of Philosophy in Agriculture, Agriculture Operations, and Related Sciences, Maryville College 2003
  • Full Name

  • Jarred Younger