Selected Publications

Academic Article

Year Title Altmetric
2020 PhenylethanolamineN-methyltransferase gene polymorphisms associate with crisis pain in sickle cell disease patientsPharmacogenomics.  21:269-278. 2020
2019 Spinal and afferent PKC signaling mechanisms that mediate chronic pain in sickle cell diseaseNeuroscience Letters.  706:56-60. 2019
2018 Genetic variants of GCH1 associate with chronic and acute crisis pain in African Americans with sickle cell diseaseExperimental Hematology.  66:42-49. 2018
2018 Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell diseasePharmacogenomics.  19:1003-1011. 2018
2018 AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependenceNeuropharmacology.  137:50-58. 2018
2018 Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell diseasePharmacogenomics.  19:401-411. 2018
2016 CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic micePAIN.  157:2798-2806. 2016
2016 IL1A rs1800587 associates with chronic noncrisis pain in sickle cell diseasePharmacogenomics.  17:1999-2006. 2016
2016 PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease modelJournal of Clinical Investigation.  126:3053-3057. 2016
2015 Prevalence of pain-related single nucleotide polymorphisms in patients of African origin with sickle cell diseasePharmacogenomics.  16:1795-1806. 2015
2015 Nociceptor Beta II, Delta, and Epsilon Isoforms of PKC Differentially Mediate Paclitaxel-Induced Spontaneous and Evoked Pain 2015
2014 Dopamine D3 Receptor Ser9Gly and Catechol-O-Methyltransferase Val158Met Polymorphisms and Acute Pain in Sickle Cell DiseaseAnesthesia and Analgesia.  119:1201-1207. 2014
2014 Mechanism-driven phase I translational study of trifluoperazine in adults with sickle cell disease 2014
2013 Constitutive  -Opioid Receptor Activity Leads to Long-Term Endogenous Analgesia and DependenceScience.  341:1394-1399. 2013
2012 Negative Reinforcement Reveals Non-Evoked Ongoing Pain in Mice With Tissue or Nerve InjuryJournal of Pain.  13:598-607. 2012
2012 Determination of the enantioselectivity of six chiral aryloxy aminopropanol drugs transport across Caco-2 cell monolayers 2012
2012 The beta-lactam antibiotic, ceftriaxone, inhibits the development of opioid-induced hyperalgesia in miceNeuroscience Letters.  509:69-71. 2012
2011 Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.Biochemical Pharmacology.  81:170-177. 2011
2010 Regulation of Opioid Tolerance by let-7 Family MicroRNA Targeting the   Opioid Receptor 2010
2010 Transport characteristics of rutin deca (H-) sulfonate sodium across Caco-2 cell monolayers†Journal of Pharmacy and Pharmacology.  57:1297-1303. 2010
2010 Reversed-phase high-performance liquid chromatographic analysis of seven pairs of chiral drug enantiomers in transport medium after chiral derivatizationJournal of Chinese Pharmaceutical Sciences.  19. 2010
2009 Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction 2009
2007 Stereoselective regulation of MDR1 expression in Caco-2 cells by cetirizine enantiomers 2007
2006 Determination of the stereoselectivity of chiral drug transport across Caco-2 cell monolayers 2006
2004 Simultaneous determination of the enantiomers of esmolol and its acid metabolite in human plasma by reversed phase liquid chromatography with solid-phase extraction 2004
2004 Stereoselective RP-HPLC determination of esmolol enantiomers in human plasma after pre-column derivatization 2004
Beta2-Adrenergic Receptor Polymorphisms and Haplotypes Associate With Chronic Pain in Sickle Cell DiseaseFrontiers in Pharmacology.  10.
Let-7 microRNAs and Opioid ToleranceFrontiers in Genetics.  3.
S100B single nucleotide polymorphisms exhibit sex-specific associations with chronic pain in sickle cell disease in a largely African-American cohortPLoS ONE.  15:e0232721-e0232721.
Vasopressin SNP pain factors and stress in sickle cell diseasePLoS ONE.  14:e0224886-e0224886.

Research Overview

  • Molecular pharmacology of chronic pain and opioid addiction
    Pain in sickle cell disease, cancer
    Epigenetic mechanisms of hemoglobinopathies, chronic pain, and drug addiction
  • Education And Training

  • Doctor of Psychology in Pharmaceutical Sciences, University of Illinois at Chicago 2012
  • Master of Physical Sciences, Zhejiang University 2006
  • Bachelor of Pharmacy in Pharmacy, Pharmaceutical Sciences, and Administration, Zhejiang University 2003
  • University of Illinois at Chicago, Postdoctoral Fellowship 2014
  • Full Name

  • Ying He