Positions

Overview

  • Yvonne holds a PhD and an MS in Computational Molecular and Structural Biology (Bioinformatics) from Birkbeck College, University of London, United Kingdom and a BS in Biochemistry and Pharmacology from Kings College, University of London, United Kingdom.

    Yvonne has over 20 years of leadership experience in Bioinformatics research and development environments in world class organizations such as the NIH NCI, Center for Cancer Research. Yvonne has expertise in the application of next-generation sequencing to study genetic variation in human health and disease at the genome, transcriptome and proteome levels. Yvonne has a track record of achievement in scientific collaborations as well as making highly-recognized research contributions and enabling next generation sequencing technologies to support clinical research in the areas of cancer diseases, metabolic syndromes, cardiovascular disorders, neuropathies, premature aging, ophthalmologic disorders, deafness syndrome and HIV infectious disease. She has experience in management and scientific leadership of small- to medium-sized groups to successfully deliver complex, cross-functional informatics projects. Yvonne is a noted scientific contributor of 40+ peer-reviewed PubMed publications. Furthermore, she has co-authored an additional 40+ book reviews, book chapters, conference abstracts and presentations; plus, she is a reviewer for several Bioinformatics journals.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila 2019
    2019 Cutting edge: Early attrition of memory T cells during inflammation and costimulation blockade is regulated concurrently by proapoptotic proteins Fas and Bim 2019
    2018 The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution 2018
    2018 CRISPR delivery particles for developing therapeutic strategies in metabolic disease 2018
    2018 The cJUN NH 2 -terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation 2018
    2018 Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis 2018
    2018 Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma 2018
    2018 CRISPR-delivery particles targeting nuclear receptor–interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure 2018
    2017 Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. 2017
    2016 Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior 2016
    2016 An alternative splicing program promotes adipose tissue thermogenesis 2016
    2016 Endothelial mitogen-activated protein kinase kinase kinase kinase 4 is critical for lymphatic vascular development and function 2016
    2016 Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation 2016
    2013 Correction: Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. (PLoS ONE) 2013
    2012 Whole-Exome Sequencing Efficiently Detects Rare Mutations in Autosomal Recessive Nonsyndromic Hearing Loss 2012
    2012 Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss 2012
    2012 Challenges in whole exome sequencing: An example from hereditary deafness 2012
    2011 Comparison of three targeted enrichment strategies on the Solid sequencing platform 2011
    2011 Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach 2011
    2011 Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family 2011
    2011 Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa 2011
    2010 The mtDNA mutation spectrum of the progeroid polg mutator mouse includes abundant control region multimers 2010
    2010 Recurrent and private MYO15A mutations are associated with deafness in the Turkish population 2010
    2009 Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data 2009
    2008 A meta-analysis of microarray gene expression in mouse stem cells: Redefining stemness 2008
    2007 Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: Evidence from comparative genomic analysis 2007
    2006 Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies 2006
    2005 Highly conserved non-coding sequences are associated with vertebrate development 2005
    2004 A Fugu-human genome synteny viewer: Web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes 2004
    2004 Molecular characterisation of the sand protein family: A study based on comparative genomics, structural bioinformatics and phylogeny 2004
    2003 Fugu ESTs: New resources for transcription analysis and genome annotation 2003
    2003 AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals 2003
    2003 Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence 2003
    2003 Bioinformatics methods to predict protein structure and function: A practical approach 2003
    2003 Cultural Connection and transformation: Substance abuse treatment at friendship house 2003
    2002 Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes 2002
    2002 Fugu orthologues of human major histocompatibility complex genes: A genome survey 2002
    2001 Finding genes in genomic nucleotide sequences by using bioinformatics. 2001
    2001 Prediction of protein structure and function by using bioinformatics. 2001
    2001 SAND, a new protein family: From nucleic acid to protein structure and function prediction 2001
    1999 Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: Implications for the activity of factor B 1999
    1999 Sequence scanning chicken cosmids: A methodology for genome screening 1999
    1999 Generation and analysis of 25 mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning 1999
    1999 Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation 1999
    1998 The identification and characterization of microsatellites in the compact genome of the Japanese Pufferfish, Fugu rubripes: Perspectives in functional and comparative genomic analyses 1998
    1996 Assessment of protein fold predictions from sequence information: The predicted α/β doubly wound fold of the von Willebrand factor type a domain is similar to its crystal structure 1996
    1995 The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted β-sheet flanked by α-helices found in human ras-p21 1995

    Chapter

    Year Title Altmetric
    1994 The Effects of Local Environments on the Pattern of Amino-Acid Substitution in Homologous Prote Instructures: The Role of Side-Chain to Main-Chain Van Der Waals Interactions.  405-412. 1994

    Research Overview

  • Bioinformatics to study Complex Biological Systems and Disease; Precision Medicine

    • Education And Training

    Full Name

  • Yvonne Edwards