Positions

Overview

  • Dr Edwards holds a PhD and an MS in Bioinformatics from Birkbeck College, University of London, United Kingdom and a BS in Biochemistry and Pharmacology from Kings College, University of London, United Kingdom.
    Dr Edwards has over 20 years of leadership experience in Bioinformatics research and development environments in world class organizations such as the National Institutes of Health, National Cancer Institute, Bethesda, Maryland. Dr Edwards has expertise in the application of next-generation sequencing technologies to study genetic variation in human health and disease at the genome, transcriptome and proteome levels. Dr Edwards has a track record of making highly-recognized research contributions and enabling next generation sequencing technologies to support clinical research in the areas of cancer diseases, metabolic syndromes, cardiovascular disorders, neuropathies, premature aging, ophthalmologic disorders, deafness syndromes, HIV infectious disease and cystic fibrosis. She has experience in management and scientific leadership of small- to medium-sized groups to successfully deliver complex, cross-functional informatics projects. Dr Edwards is a scientific contributor of 40+ peer-reviewed PubMed publications. Furthermore, she has co-authored an additional 40+ book reviews, book chapters, conference abstracts and presentations. She is a reviewer for several Genomics and Bioinformatics journals. Dr Edwards is affiliated with The Department of Cell, Developmental and Integrative Biology and The Gregory Fleming James Cystic Fibrosis Research Center and The O’Neal Comprehensive Cancer Center.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Cutting edge: Early attrition of memory T cells during inflammation and costimulation blockade is regulated concurrently by proapoptotic proteins Fas and Bim.  Journal of Immunology.  202:647-651. 2019
    2019 Oncogenic pathways and loss of the Rab11 GTPase synergize to alter metabolism in Drosophila.  Genetics.  212:1227-1239. 2019
    2018 The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.  Cell Death and Differentiation.  25:1702-1715. 2018
    2018 CRISPR delivery particles for developing therapeutic strategies in metabolic disease 2018
    2018 The cJUN NH 2 -terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation.  eLife.  7. 2018
    2018 Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.  Cell Metabolism.  27:195-209.e6. 2018
    2018 Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.  Journal of Clinical Investigation.  128:294-308. 2018
    2018 CRISPR-delivery particles targeting nuclear receptor–interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.  Journal of Biological Chemistry.  293:17291-17305. 2018
    2017 Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy..  Frontiers in Cardiovascular Medicine.  4:49. 2017
    2016 Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior.  RNA.  22:1492-1499. 2016
    2016 An alternative splicing program promotes adipose tissue thermogenesis.  eLife.  5. 2016
    2016 Endothelial mitogen-activated protein kinase kinase kinase kinase 4 is critical for lymphatic vascular development and function.  Molecular and Cellular Biology.  36:1740-1749. 2016
    2016 Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation.  Cell Reports.  16:9-18. 2016
    2013 Correction: Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. (PLoS ONE).  PLoS ONE.  8. 2013
    2012 Whole-Exome Sequencing Efficiently Detects Rare Mutations in Autosomal Recessive Nonsyndromic Hearing Loss.  PLoS ONE.  7. 2012
    2012 Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.  American Journal of Human Genetics.  91:872-882. 2012
    2012 Challenges in whole exome sequencing: An example from hereditary deafness.  PLoS ONE.  7. 2012
    2011 Comparison of three targeted enrichment strategies on the Solid sequencing platform.  PLoS ONE.  6. 2011
    2011 Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.  PLoS ONE.  6. 2011
    2011 Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family.  Annals of Neurology.  69:464-470. 2011
    2011 Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa.  American Journal of Human Genetics.  88:201-206. 2011
    2010 The mtDNA mutation spectrum of the progeroid polg mutator mouse includes abundant control region multimers.  Cell Metabolism.  12:675-682. 2010
    2010 Recurrent and private MYO15A mutations are associated with deafness in the Turkish population.  Genetic Testing.  14:543-550. 2010
    2009 Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.  Genome Biology.  10. 2009
    2008 A meta-analysis of microarray gene expression in mouse stem cells: Redefining stemness.  PLoS ONE.  3. 2008
    2007 Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: Evidence from comparative genomic analysis.  Physiological Genomics.  32:1-15. 2007
    2006 Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies.  Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics.  1:46-58. 2006
    2005 Highly conserved non-coding sequences are associated with vertebrate development.  PLoS Biology.  3. 2005
    2004 A Fugu-human genome synteny viewer: Web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes.  Nucleic Acids Research.  32:2618-2622. 2004
    2004 Molecular characterisation of the sand protein family: A study based on comparative genomics, structural bioinformatics and phylogeny.  Cellular and Molecular Biology Letters.  9:739-753. 2004
    2003 Fugu ESTs: New resources for transcription analysis and genome annotation.  PCR methods and applications.  13:2747-2753. 2003
    2003 AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals.  Mammalian Genome.  14:514-525. 2003
    2003 Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence.  Nucleic Acids Research.  31:3510-3517. 2003
    2003 Bioinformatics methods to predict protein structure and function: A practical approach.  Molecular Biotechnology.  23:139-166. 2003
    2003 Cultural Connection and transformation: Substance abuse treatment at friendship house.  Journal of Psychoactive Drugs.  35:53-58. 2003
    2002 Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.  Science.  297:1301-1310. 2002
    2002 Fugu orthologues of human major histocompatibility complex genes: A genome survey.  Immunogenetics.  54:367-380. 2002
    2001 Finding genes in genomic nucleotide sequences by using bioinformatics..  Methods in Molecular Biology.  175:235-247. 2001
    2001 Prediction of protein structure and function by using bioinformatics..  Methods in Molecular Biology.  175:341-375. 2001
    2001 SAND, a new protein family: From nucleic acid to protein structure and function prediction.  Comparative and Functional Genomics.  2:226-235. 2001
    1999 Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: Implications for the activity of factor B.  Journal of Molecular Biology.  294:587-599. 1999
    1999 Sequence scanning chicken cosmids: A methodology for genome screening.  Gene.  227:223-230. 1999
    1999 Generation and analysis of 25 mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning.  PCR methods and applications.  9:960-971. 1999
    1999 Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation.  Biochemical Society Transactions.  27:815-820. 1999
    1998 The identification and characterization of microsatellites in the compact genome of the Japanese Pufferfish, Fugu rubripes: Perspectives in functional and comparative genomic analyses.  Journal of Molecular Biology.  278:843-854. 1998
    1996 Assessment of protein fold predictions from sequence information: The predicted α/β doubly wound fold of the von Willebrand factor type a domain is similar to its crystal structure.  Journal of Molecular Biology.  260:277-285. 1996
    1995 The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted β-sheet flanked by α-helices found in human ras-p21.  FEBS Letters.  358:283-286. 1995

    Chapter

    Year Title Altmetric
    1994 The Effects of Local Environments on the Pattern of Amino-Acid Substitution in Homologous Prote Instructures: The Role of Side-Chain to Main-Chain Van Der Waals Interactions.  405-412. 1994

    Research Overview

  • Bioinformatics to study Complex Biological Systems and Disease; Precision Medicine

    • Education And Training

  • Doctor of Philosophy in Molecular Biology, University of London - Birkbeck 1995
  • Master of Science in Molecular Biology, University of London - Birkbeck 1990
  • Bachelor of Science or Mathematics in Molecular Pharmacology, University of London - Birkbeck 1989

    • Full Name

  • Yvonne Edwards