• Dr Edwards holds a PhD and an MS in Bioinformatics from Birkbeck College, University of London, United Kingdom and a BS in Biochemistry and Pharmacology from Kings College, University of London, United Kingdom.

    Dr Edwards has over 20 years of leadership experience in Bioinformatics research and development environments in world class organizations such as the National Institutes of Health, National Cancer Institute, Bethesda, Maryland. Dr Edwards has expertise in the application of next-generation sequencing technologies to study genetic variation in human health and disease at the genome, transcriptome, and proteome levels. Dr Edwards has a track record of making highly recognized research contributions and enabling next generation sequencing technologies to support clinical research to study various types of cancers, (pancreatic, ovarian, breast, melanoma, renal, colorectal, cervical), and other complex medical conditions such as Cystic Fibrosis, COPD, Cystic Kidney Disease, metabolic syndromes, deafness syndromes and HIV infectious disease. She has experience in management and scientific leadership of small- to medium-sized groups to successfully deliver complex, cross-functional informatics projects. Dr Edwards is a scientific contributor of over 50 peer-reviewed PubMed publications. Furthermore, she has co-authored an additional 50 book reviews, book chapters, conference abstracts and presentations. Dr Edwards is a reviewer for several Genomics and Bioinformatics journals and serves as an Associate Editor and Editorial Board member for Briefings in Bioinformatics ranked #1 in the Mathematical and Computational Biology category, Impact Factor 13.994. Dr Edwards has secondary appointment with the Department of Cell, Developmental and Integrative Biology and scientific membership with the Gregory Fleming James Cystic Fibrosis Research Center and the O’Neal Comprehensive Cancer Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferretsRespiratory Research.  23. 2022
    2022 UBE2T promotes breast cancer tumor growth by suppressing DNA replication stressNAR Cancer.  4. 2022
    2022 Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome 2022
    2022 Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma CellsFrontiers in Oncology.  12. 2022
    2021 Defining the influence of the a12.2 subunit on transcription elongation and termination by rna polymerase i in vivoGenes.  12. 2021
    2021 Erratum: JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting? (Am J Physiol Cell Physiol (2020) 319 (C667–C674) DOI: 10.1152/ajpcell.00436.2019) 2021
    2021 Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosisOncogenesis.  10. 2021
    2021 Spt4 promotes pol i processivity and transcription elongationGenes.  12. 2021
    2021 Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cellsJournal of Biological Chemistry.  296. 2021
    2020 Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCsScientific Reports.  10. 2020
    2020 Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.Journal of Biological Chemistry.  296:100034. 2020
    2020 Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells 2020
    2020 JAGN1, tetraspanins, and Erv proteins: Is common topology indicative of common function in cargo sorting? 2020
    2019 Cutting edge: Early attrition of memory T cells during inflammation and costimulation blockade is regulated concurrently by proapoptotic proteins Fas and BimJournal of Immunology.  202:647-651. 2019
    2019 Oncogenic pathways and loss of the Rab11 GTPase synergize to alter metabolism in Drosophila 2019
    2018 CRISPR-delivery particles targeting nuclear receptor–interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditureJournal of Biological Chemistry.  293:17291-17305. 2018
    2018 The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involutionCell Death and Differentiation.  25:1702-1715. 2018
    2018 CRISPR delivery particles for developing therapeutic strategies in metabolic disease 2018
    2018 The cJUN NH 2 -terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiationeLife.  7. 2018
    2018 Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and ThermogenesisCell Metabolism.  27:195-209.e6. 2018
    2018 Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanomaJournal of Clinical Investigation.  128:294-308. 2018
    2017 Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress CardiomyopathyFrontiers in Cardiovascular Medicine.  4. 2017
    2016 Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behaviorRNA.  22:1492-1499. 2016
    2016 An alternative splicing program promotes adipose tissue thermogenesiseLife.  5. 2016
    2016 Endothelial mitogen-activated protein kinase kinase kinase kinase 4 is critical for lymphatic vascular development and functionMolecular and Cellular Biology.  36:1740-1749. 2016
    2016 Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 InactivationCell Reports.  16:9-18. 2016
    2013 Correction: Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. (PLoS ONE)PLoS One.  8. 2013
    2012 Whole-Exome Sequencing Efficiently Detects Rare Mutations in Autosomal Recessive Nonsyndromic Hearing LossPLoS One.  7. 2012
    2012 Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing lossAmerican Journal of Human Genetics.  91:872-882. 2012
    2012 Challenges in whole exome sequencing: An example from hereditary deafnessPLoS One.  7. 2012
    2011 Comparison of three targeted enrichment strategies on the Solid sequencing platformPLoS One.  6. 2011
    2011 Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approachPLoS One.  6. 2011
    2011 Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth familyAnnals of Neurology.  69:464-470. 2011
    2011 Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosaAmerican Journal of Human Genetics.  88:201-206. 2011
    2010 The mtDNA mutation spectrum of the progeroid polg mutator mouse includes abundant control region multimersCell Metabolism.  12:675-682. 2010
    2010 Recurrent and private MYO15A mutations are associated with deafness in the Turkish populationGenetic Testing and Molecular Biomarkers.  14:543-550. 2010
    2009 Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression dataGenome Biology.  10. 2009
    2008 A meta-analysis of microarray gene expression in mouse stem cells: Redefining stemnessPLoS One.  3. 2008
    2007 Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: Evidence from comparative genomic analysisPhysiological Genomics.  32:1-15. 2007
    2006 Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies 2006
    2005 Highly conserved non-coding sequences are associated with vertebrate developmentPLoS Biology.  3. 2005
    2004 A Fugu-human genome synteny viewer: Web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genesNucleic Acids Research.  32:2618-2622. 2004
    2004 Molecular characterisation of the sand protein family: A study based on comparative genomics, structural bioinformatics and phylogeny 2004
    2003 Fugu ESTs: New resources for transcription analysis and genome annotationGenome Research.  13:2747-2753. 2003
    2003 AP1 genes in Fugu indicate a divergent transcriptional control to that of mammalsMammalian Genome.  14:514-525. 2003
    2003 Theatre: A software tool for detailed comparative analysis and visualization of genomic sequenceNucleic Acids Research.  31:3510-3517. 2003
    2003 Bioinformatics methods to predict protein structure and function: A practical approachMolecular Biotechnology.  23:139-166. 2003
    2002 Whole-genome shotgun assembly and analysis of the genome of Fugu rubripesScience.  297:1301-1310. 2002
    2002 Fugu orthologues of human major histocompatibility complex genes: A genome surveyImmunogenetics.  54:367-380. 2002
    2001 Finding genes in genomic nucleotide sequences by using bioinformatics.Methods in Molecular Biology.  175:235-247. 2001
    2001 Prediction of protein structure and function by using bioinformatics.Methods in Molecular Biology.  175:341-375. 2001
    2001 SAND, a new protein family: From nucleic acid to protein structure and function predictionGene Function and Disease.  2:226-235. 2001
    1999 Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: Implications for the activity of factor BJournal of Molecular Biology.  294:587-599. 1999
    1999 Sequence scanning chicken cosmids: A methodology for genome screeningGene.  227:223-230. 1999
    1999 Generation and analysis of 25 mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanningGenome Research.  9:960-971. 1999
    1999 Structural and functional modelling of von Willebrand factor type A domains in complement and coagulationBiochemical Society Transactions.  27:815-820. 1999
    1998 The identification and characterization of microsatellites in the compact genome of the Japanese Pufferfish, Fugu rubripes: Perspectives in functional and comparative genomic analysesJournal of Molecular Biology.  278:843-854. 1998
    1996 Assessment of protein fold predictions from sequence information: The predicted α/β doubly wound fold of the von Willebrand factor type a domain is similar to its crystal structureJournal of Molecular Biology.  260:277-285. 1996
    1995 The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted β-sheet flanked by α-helices found in human ras-p21FEBS Letters.  358:283-286. 1995


    Year Title Altmetric
    2001 Finding Genes in Genomic Nucleotide Sequences by Using Bioinformatics.  235-247. 2001
    2001 Prediction of Protein Structure and Function by Using Bioinformatics.  341-375. 2001
    1994 The Effects of Local Environments on the Pattern of Amino-Acid Substitution in Homologous Prote Instructures: The Role of Side-Chain to Main-Chain Van Der Waals Interactions.  405-412. 1994

    Education And Training

  • Doctor of Philosophy in Bioinformatics, University of London - Birkbeck 1995
  • Master of Science in Bioinformatics, University of London - Birkbeck 1990
  • Bachelor of Science or Mathematics in Biochemistry, King's College London 1989
  • Full Name

  • Yvonne Edwards