• Dr. Yan Sanders received her medical degree from Hunan Medical University, China. Then she went to graduate school at University of Arkansas for Medical Sciences. She completed a postdoctoral research fellowship at the National Center for Toxicological Research before she joined UAB at pediatric pulmonary, late she joined the faculty of medicine at the rank of Assistant Professor in 2011.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell AgingAmerican Journal of Respiratory and Critical Care Medicine.  206:459-475. 2022
    2022 Circular RNA Methylation: A New Twist in Lung FibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  66:471-472. 2022
    2022 DNA methylation in pulmonary fibrosis and lung cancerExpert Review of Respiratory Medicine.  16:519-528. 2022
    2022 Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged miceTheranostics.  12:530-541. 2022
    2021 Transglutaminase-2: Nature’s glue in lung fibrosis?American Journal of Respiratory Cell and Molecular Biology.  65:243-244. 2021
    2021 Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice 2021
    2020 MeCP2 epigenetically regulates alpha-smooth muscle actin in human lung fibroblastsJournal of Cellular Biochemistry.  121:3616-3625. 2020
    2020 New clue: Prediction from cell-free DNAJournal of Clinical Medicine.  9:1-3. 2020
    2020 Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged miceJCI insight.  5. 2020
    2019 Inhibition of glutaminase 1 attenuates experimental pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  61:492-500. 2019
    2019 Betting on novel treatments for asthma: Bromodomain 4 inhibitorsAmerican Journal of Respiratory Cell and Molecular Biology.  60:7-8. 2019
    2019 Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  60:49-57. 2019
    2019 HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosisTherapeutic Advances in Chronic Disease.  10. 2019
    2018 Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activationJournal of Biological Chemistry.  293:1218-1228. 2018
    2017 DNA methylation regulated gene expression in organ fibrosisBBA: Molecular Basis of Disease.  1863:2389-2397. 2017
    2017 Epigenetic regulation of caveolin-1 gene expression in lung fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  56:50-61. 2017
    2016 Novel mechanisms for the antifibrotic action of nintedanibAmerican Journal of Respiratory Cell and Molecular Biology.  54:51-59. 2016
    2015 SMAD-independent down-regulation of caveolin-1 by TGF-β: Effects on proliferation and survival of myofibroblastsPLoS One.  10. 2015
    2015 Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescenceFree Radical Biology and Medicine.  79:197-205. 2015
    2014 TGF-beta downregulation of distinct chloride channels in cystic fibrosis-affected epitheliaPLoS One.  9. 2014
    2014 Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in miceEuropean Respiratory Journal.  43:1448-1458. 2014
    2014 Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalanceScience Translational Medicine.  6. 2014
    2013 Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblastsInternational Journal of Molecular Sciences.  14:19605-19617. 2013
    2013 Histone modifications in senescence-associated resistance to apoptosis by oxidative stressRedox Biology.  1:8-16. 2013
    2012 Altered DNA methylation profile in idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine.  186:525-535. 2012
    2012 Participation of miR-200 in pulmonary fibrosisAmerican Journal of Pathology.  180:484-493. 2012
    2011 Absence of Thy-1 results in TGF-Β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblastsLaboratory Investigation.  91:1206-1218. 2011
    2011 Epigenetic regulation of Thy-1 by histone deacetylase inhibitor in rat lung fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  45:16-23. 2011
    2008 Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosisAmerican Journal of Respiratory Cell and Molecular Biology.  39:610-618. 2008
    2007 Enhanced myofibroblastic differentiation and survival in thy-1(-) lung fibroblastsAmerican Journal of Respiratory Cell and Molecular Biology.  36:226-235. 2007
    2006 Increased levels of NAD(P)H: Quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreasCell Biology and Toxicology: an international journal devoted to research at the cellular level.  22:73-80. 2006
    2003 Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responsesMolecular and Cellular Biology.  23:2362-2378. 2003
    2002 Increased expression of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP) in pancreatic tissue from smokers and pancreatic tumor cellsCancer Letters.  183:215-220. 2002
    2001 Specific site methylation in the 5′-flanking region of CYP1A2: Interindividual differences in human liversLife Sciences.  69:839-845. 2001


    Year Title Altmetric
    2014 Signaling Networks Controlling Cellular Senescence.  67-83. 2014

    Research Overview

  • Dr. Sanders' main research interests are on the epigenetics aspects of lung injury, repair, aging, and aging related diseases. The main focuses of this research are the roles of histone modifications and DNA methylation in aging related diseases, such as pulmonary fibrosis. Ongoing projects include exploring epigenetic alterations in idiopathic pulmonary fibrosis (IPF), examining the effects of histone modifiers on fibrotic lung fibroblasts, determining the epigenetic mechanisms of cellular senescence, aging and age-related chronic diseases, specifically histone modifications and DNA methylation.
  • Education And Training

  • Doctor of Medicine in Pediatrics Residency Program, Central South University 1992
  • Full Name

  • Yan Sanders