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Xu Feng Ph.D.
Professor
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E-mail
xufeng@uab.edu
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Co-investigator Network
Xu Feng Ph.D.
Professor
Positions
Senior Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
2000 -
Scientist (C)
,
Integrative Center for Aging Research
,
School of Medicine
2001 -
Associate Scientist (C)
,
Cell Adhesion & Matrix Research Center
,
Pathology
2001 -
Scientist (C)
,
Biomatrix Eng Regen Med (BERM) Center
,
Biomedical Engineering
2006 -
Scientist (C)
,
Center for Biophysical Sciences and Engineering (CBSE)
,
School of Optometry
2008 -
Senior Scientist (C)
,
Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC)
,
School of Medicine
2015 -
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
2019 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2020
Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection
.
Journal of Leukocyte Biology
. 108:1037-1050.
2020
2020
Frontline Science: Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.
.
Journal of Leukocyte Biology
. 108:1037-1050.
2020
2020
Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection
.
Journal of Periodontal Research
. 55:410-425.
2020
2019
Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis
.
Journal of Bone and Mineral Research
. 34:1938-1951.
2019
2018
C/EBPα transcription factor is regulated by the RANK cytoplasmic 535IVVY538 motif and stimulates osteoclastogenesis more strongly than c-Fos.
.
Journal of Biological Chemistry
. 293:1480-1492.
2018
2016
CCAAT/enhancer-binding protein α (C/EBPα) is important for osteoclast differentiation and activity
.
Journal of Biological Chemistry
. 291:16390-16403.
2016
2015
IL-1R/TLR2 through MyD88 divergently modulates osteoclastogenesis through regulation of nuclear factor of activated T cells c1 (NFATc1) and B lymphocyte-induced maturation protein-1 (Blimp1)
.
Journal of Biological Chemistry
. 290:30163-30174.
2015
2015
The IVVY motif and tumor necrosis factor receptor-associated factor (TRAF) sites in the cytoplasmic domain of the receptor activator of nuclear factor κB (RANK) cooperate to induce osteoclastogenesis
.
Journal of Biological Chemistry
. 290:23738-23750.
2015
2014
RANK-and c-Met-mediated signal network promotes prostate cancer metastatic colonization
.
Endocrine-Related Cancer
. 21:311-326.
2014
2013
Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process
.
Biochemical and Biophysical Research Communications
. 440:545-550.
2013
2013
Osteoclasts: New Insights.
.
Bone Research
. 1:11-26.
2013
2013
Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer
.
Cancer Research
. 73:672-682.
2013
2013
IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells
.
BMC Cancer
. 13.
2013
2012
Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: Evidence from an animal model
2012
2012
Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis
.
Journal of Biological Chemistry
. 287:15728-15738.
2012
2012
Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis
.
Journal of Interferon and Cytokine Research
. 32:34-45.
2012
2011
Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis
.
Journal of Cellular Biochemistry
. 112:3385-3392.
2011
2011
Nucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators
.
Journal of Bone and Mineral Research
. 26:1913-1925.
2011
2011
TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-κB
.
Journal of Biological Chemistry
. 286:24159-24169.
2011
2011
A simplified method for the generation of human osteoclasts in vitro
.
International Journal of Biochemistry and Molecular Biology
. 2:183-189.
2011
2011
APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner
.
Journal of Bone and Mineral Research
. 26:1084-1098.
2011
2011
Disorders of bone remodeling
.
Annual Review of Pathology: Mechanisms of Disease
. 6:121-145.
2011
2011
Development of cell-based high-throughput assays for the identification of inhibitors of receptor activator of nuclear factor-kappa B signaling
.
ASSAY and Drug Development Technologies
. 9:40-49.
2011
2010
Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer
.
Cancer Gene Therapy
. 17:893-905.
2010
2010
Erratum: Arming a replicating adenovirus with osteoprotegerin reduces the tumor burden in a murine model of osteolytic bone metastases of breast cancer (Cancer Gene Therapy (2010) 17 (893-905))
.
Cancer Gene Therapy
. 17:906.
2010
2010
Receptor activator of NF-κB (RANK) cytoplasmic IVVY
535-538
motif plays an essential role in tumor necrosis factor-α (TNF)-mediated osteoclastogenesis
.
Journal of Biological Chemistry
. 285:37427-37435.
2010
2010
Selective targeting of RANK signaling pathways as new therapeutic strategies for osteoporosis
.
Expert Opinion on Therapeutic Targets
. 14:923-934.
2010
2009
Chemical and biochemical basis of cell-bone matrix interaction in health and disease
.
Current Chemical Biology
. 3:189-196.
2009
2009
Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis
.
Journal of Biological Chemistry
. 284:14667-14675.
2009
2009
Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
.
Journal of Biological Chemistry
. 284:12512-12523.
2009
2008
Phospholipase Cγ2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
.
Journal of Biological Chemistry
. 283:29593-29601.
2008
2008
HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE
.
Journal of Bone and Mineral Research
. 23:1084-1096.
2008
2008
R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
.
FEBS Letters
. 582:643-650.
2008
2007
c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages.
.
Journal of Biological Chemistry
. 282:18980-18990.
2007
2006
Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing
.
BMC Biotechnology
. 6.
2006
2006
Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators
.
Journal of Biological Chemistry
. 281:35686-35698.
2006
2006
Regulation of osteoclast function and bone mass by RAGE
.
Journal of Experimental Medicine
. 203:1067-1080.
2006
2006
High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals
.
Journal of Leukocyte Biology
. 79:686-695.
2006
2006
A novel receptor activator of NF-κB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage
.
Journal of Biological Chemistry
. 281:4678-4690.
2006
2005
Receptor activator of NF-κB (RANK) cytoplasmic motif,
369
PFQEP
373
, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4
.
Journal of Biological Chemistry
. 280:43064-43072.
2005
2005
Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells
.
Journal of Cellular Biochemistry
. 96:716-727.
2005
2005
Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis
.
Arthritis and Rheumatism
. 52:3257-3268.
2005
2005
Erratum: Osteoclastogenesis: The role of calcium and calmodulin (Critical Reviews in Eukaryotic Gene Expession)
.
Critical Reviews in Eukaryotic Gene Expression
. 15.
2005
2005
RANKing intracellular signaling in osteoclasts
2005
2005
Regulatory roles and molecular signaling of TNF family members in osteoclasts
.
Gene
. 350:1-13.
2005
2005
Osteoclastogenesis: The role of calcium and calmodulin
.
Critical Reviews in Eukaryotic Gene Expression
. 15:1-13.
2005
2004
Functional identification of three receptor activator of NF-κB cytoplasmic motifs mediating osteoclast differentiation and function
.
Journal of Biological Chemistry
. 279:54759-54769.
2004
2004
YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation
.
Gene
. 343:117-126.
2004
2004
Development of a chimaeric receptor approach to study signalling by tumour necrosis factor receptor family members
.
Biochemical Journal
. 383:219-225.
2004
2004
Glucose up-regulates thrombospondin 1 gene transcription and transforming growth factor-β activity through antagonism of cGMP-dependent protein kinase repression via upstream stimulatory factor 2
.
Journal of Biological Chemistry
. 279:34311-34322.
2004
2004
AZT enhances osteoclastogenesis and bone loss
.
AIDS Research and Human Retroviruses
. 20:608-620.
2004
2003
Osteoclast Apoptosis: The Role of Fas in Vivo and in Vitro
.
Endocrinology
. 144:5545-5555.
2003
2003
PYK2 and FAK in osteoclasts
.
Frontiers in Bioscience
. 8.
2003
2003
The role of calmodulin in the regulation of osteoclastogenesis
.
Endocrinology
. 144:4536-4543.
2003
2003
Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiation.
.
Journal of Biological Chemistry
. 278:20603-20611.
2003
2003
PYK2 and FAK in osteoclasts.
.
Frontiers in Bioscience
. 8.
2003
2002
Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function
.
Endocrinology
. 143:4868-4874.
2002
2001
Identification of the type II Na
+
-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice
.
BONE
. 29:467-476.
2001
2001
A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function.
.
Journal of Clinical Investigation
. 107:1137-1144.
2001
2001
Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression.
.
Journal of Biological Chemistry
. 276:10119-10125.
2001
2000
Transforming growth factor-beta up-regulates the beta 5 integrin subunit expression via Sp1 and Smad signaling.
.
Journal of Biological Chemistry
. 275:36400-36406.
2000
2000
Sp1/Sp3 and PU.1 differentially regulate beta(5) integrin gene expression in macrophages and osteoblasts.
.
Journal of Biological Chemistry
. 275:8331-8340.
2000
2000
Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells.
.
Journal of Cellular Biochemistry
. 77:265-276.
2000
2000
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.
.
Journal of Clinical Investigation
. 105:433-440.
2000
1999
Cloning of the murine beta5 integrin subunit promoter. Identification of a novel sequence mediating granulocyte-macrophage colony-stimulating factor-dependent repression of beta5 integrin gene transcription.
.
Journal of Biological Chemistry
. 274:1366-1374.
1999
1996
Competition for a unique response element mediates retinoic acid inhibition of vitamin D3-stimulated transcription.
.
Journal of Biological Chemistry
. 271:20650-20654.
1996
Chapter
Filter
Year
Title
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2014
MetaboLic Bone Disease II
. 829-837.
2014
2005
Osteoclast biology
. 71-94.
2005
Research
Principal Investigator On
Development of Targeted Drugs for Osteoporosis
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2019 - 2022
Development of Novel Therapeutics for Bone Erosion in Rheumatoid Arthritis
awarded by
RHEUMATOLOGY RESEARCH FOUNDATION
2018 - 2021
Discovery of Novel Drug Targets for Breast Cancer
awarded by
National Cancer Institute/NIH/DHHS
2018 - 2021
Development Of Targeted Drugs For Treating Breast Cancer Bone Metastasis
awarded by
METAVIVOR
2019 - 2021
Prostate Cancer Bone Metastasis Biology and Targeting
awarded by
Cedars - Sinai Medical Center
2015 - 2020
RANK Signaling in Osteoclast Differentiation and Function
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2012 - 2018
Potential Role of CD68 in Breast Cancer Bone Metastasis
awarded by
DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
2011 - 2013
RANK Signaling in Osteoclast Differentiation and Function
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2006 - 2012
Cell-based Assays for Identifying Anti-RANK Signaling Agents
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2007 - 2011
In Vivo Validation of Novel Therapeutic Targets for Arthritic Bone Erosion
awarded by
American College of Rheumatology
2008 - 2010
Investigator On
Role of Osteoclast Precursors in Periodontal Bone Loss
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
2017 - 2022
Characterizing the Mechanism by which Endogenous Negative Regulators of Osteoclasts Control Bone Homeostasis under Physiological and Pathological Conditions in Mouse Models
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2017 - 2022
Targeted Stem Cell Therapy Coupling Angiogenesis and Osteogenesis for Bone Defect
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2011 - 2019
Molecular Mechanisms of the Innate Regulation of Osteoclastogenesis
awarded by
National Institute of Dental and Craniofacial Research/NIH/DHHS
2012 - 2015
Teaching
Teaching Activities
IBS700 - Biological Chem/Cell Physiol (Fall Term 2009)
2009
NEUR711 - Princ of Cell Neurosci-Mod I (Fall Term 2009)
2009
IBS700 - Biological Chem/Cell Physiol (Fall Term 2008)
2008
NEUR711 - Princ of Cell Neurosci-Mod I (Fall Term 2008)
2008
Background
Education And Training
Doctor of Philosophy in Zoology / Animal Biology,
University of Vermont
1994
Bachelor of Science or Mathematics in Biology,
Fudan University
1987
Contact
Full Name
Xu
Feng