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William Harris
Associate Professor
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wtharris@uab.edu
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William Harris
Associate Professor
Positions
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Associate Professor (P)
,
Pediatric - Pulmonary & Sleep Medicine
,
Pediatrics
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
Overview
Publications
Research
Background
Contact
Overview
Overview
CF researcher
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2021
Tobacco smoke exposure limits the therapeutic benefit of tezacaftor/ivacaftor in pediatric patients with cystic fibrosis
.
Journal of Cystic Fibrosis
. 20:612-617.
2021
2020
Tobacco smoke exposure and socioeconomic factors are independent predictors of pulmonary decline in pediatric cystic fibrosis
.
Journal of Cystic Fibrosis
. 19:783-790.
2020
2020
Tobacco smoke exposure in pediatric cystic fibrosis: A qualitative study of clinician and caregiver perspectives on smoking cessation
.
Pediatric Pulmonology
. 55:2330-2340.
2020
2020
Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates
.
Pediatric Research
. 88:293-299.
2020
2019
An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2–5 years (KLIMB)
.
Journal of Cystic Fibrosis
. 18:838-843.
2019
2019
Area deprivation as a risk factor for methicillin-resistant Staphylococcus aureus infection in pediatric cystic fibrosis
2019
2019
CFTR dysfunction increases endoglin and TGF-β signaling in airway epithelia
.
Physiological Reports
. 7.
2019
2019
Objective versus self-reported adherence to airway clearance therapy in cystic fibrosis
2019
2019
Reply to Finotti et al.
.
American Journal of Respiratory and Critical Care Medicine
. 199:1444-1445.
2019
2018
MicroRNA-145 antagonism reverses TGF-b inhibition of F508del CFTR correction in airway Epithelia
.
American Journal of Respiratory and Critical Care Medicine
. 197:632-643.
2018
2017
Airway microbiota across age and disease spectrum in cystic fibrosis.
.
European Respiratory Journal
. 50.
2017
2017
Pulmonary complications post hematopoietic stem cell transplant in dyskeratosis congenita: Analysis of oxidative stress in lung fibroblasts
.
Bone Marrow Transplantation
. 52:765-768.
2017
2017
Effect of prenatal versus postnatal Vitamin D deficiency on pulmonary structure and function in mice
.
American Journal of Respiratory Cell and Molecular Biology
. 56:383-392.
2017
2016
Constrictive bronchiolitis in cystic fibrosis adolescents with refractory pulmonary decline
.
Annals of the American Thoracic Society
. 13:2174-2183.
2016
2016
Risk stratification model to detect early pulmonary disease in infants with cystic fibrosis diagnosed by newborn screening
.
Pediatric pulmonology. Supplement
. 51:1168-1176.
2016
2016
Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-years with cystic fibrosis and a CFTR gating mutation (KIWI): An open-label, single-arm study
2016
2016
Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor
.
Journal of Cystic Fibrosis
. 15:67-73.
2016
2015
Adherence to airway clearance therapy in pediatric cystic fibrosis: Socioeconomic factors and respiratory outcomes
.
Pediatric pulmonology. Supplement
. 50:1244-1252.
2015
2015
Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis
.
Pediatric Nephrology
. 30:1879-1888.
2015
2014
Acute Kidney Injury in Hospitalized Children With Cystic Fibrosis
2014
2014
TGF-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia
.
PLoS One
. 9.
2014
2014
Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients
.
Clinical and Translational Science
. 7:336-341.
2014
2013
Erratum: Myofibroblast differentiation and enhanced Tgf-B signaling in cystic fibrosis lung disease (PLoS ONE (2013) 8 (8))
.
PLoS One
. 8.
2013
2013
IP-10 Is a Potential Biomarker of Cystic Fibrosis Acute Pulmonary Exacerbations
.
PLoS One
. 8.
2013
2013
Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease
.
PLoS One
. 8.
2013
2013
Crohn's disease with pulmonary manifestations in children: 2 case reports and review of the literature
.
Journal of Crohn's and Colitis
. 7.
2013
2011
Plasma TGF-β
1
in pediatric cystic fibrosis: Potential biomarker of lung disease and response to therapy
.
Pediatric pulmonology. Supplement
. 46:688-695.
2011
2010
Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas
.
Pediatric pulmonology. Supplement
. 45:281-290.
2010
2009
Transforming growth factor-β
1
in bronchoalveolar lavage fluid from children with cystic fibrosis
.
Pediatric pulmonology. Supplement
. 44:1057-1064.
2009
2009
Experience of the school-aged child with tracheostomy
.
International Journal of Pediatric Otorhinolaryngology
. 73:975-980.
2009
2009
Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis
.
Pediatric pulmonology. Supplement
. 44:503-511.
2009
2006
Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough
.
Pediatric pulmonology. Supplement
. 41:709-719.
2006
Research
Research Overview
Cystic Fibrosis, Pediatric Lung Disease, TGF-beta signaling, Airway Remodeling, miRNA
Principal Investigator On
Bronchoalveolar Lavage Fluid (BALF) Specimen Bank and Lower Airway Microbiome Analysis in Children and Adults With and Without Cystic Fibrosis (CF)
awarded by
University of Colorado
Effect of Vitamin D Deficiency on Murine Lung Development and Function
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
Losartan as Anti-Inflammatory Therapy to Augment F508del CFTR Recovery
awarded by
University of Miami
Mechanisms of Pulmonary Fibrosis in CF Lung Disease
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
MiR-145 Mediated TGF-Beta Pathobiology in CF
awarded by
Cystic Fibrosis Foundation ^
Myofibroblast Differentiation in Cystic Fibrosis
awarded by
Cystic Fibrosis Foundation ^
Myofibroblast Proliferation in Cystic Fibrosis: A Novel Mechanism of Disease Modification
awarded by
KAUL PEDIATRIC RESEARCH INSTITUTE
Oligotherapeutics to Enhance CFTR Correction
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Overcoming Barriers to F508del CFTR Correction
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
Gilead Sciences ^
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
miR-145 Inhibition: A Novel Strategy to Improve CFTR Therapeutics
awarded by
Cystic Fibrosis Foundation ^
miR-145 Target Site Blockade is a Selective Strategy to Enhance CFTR Restoration and Readthrough
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
miR-145 Target Site Blockade to Amplify CFTR Correction
awarded by
Cystic Fibrosis Foundation ^
Investigator On
Non-Invasive Oscillometry to Measure Lung Mechanics, Response to Treatments, and Predict Longer-Term Pulmonary Outcomes Among Preterm Infants: A Prospective Cohort Study
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Pediatric Physician Training in Translational Research
awarded by
National Institute of Child Health and Human Development/NIH/DHHS
Prevalence and Significance of Staphylococcus Aureus Small–Colony Variants
awarded by
SEATTLE CHILDREN'S RESEARCH INSTITUTE
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
GRIFOLS, INC
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
N30 PHARMACEUTICALS, LLC
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
N30 PHARMACEUTICALS, LLC
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
PROQR THERAPEUTICS
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
Private Grant
awarded by
VERTEX PHARMACEUTICALS, INC.
The Genetic Contribution to Drug Induced Renal lnjury:The Drug Induced Renal Injury Consortium (DIRECT)
awarded by
INTERNATIONAL SAE CONSORTIOUM, LTD
Therapeutics Development Center Award
awarded by
Cystic Fibrosis Foundation ^
Therapeutics Development Center Award
awarded by
Cystic Fibrosis Foundation ^
Translational Therapeutic Development Center
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Cystic Fibrosis Center for Care, Teaching, and Research
awarded by
Cystic Fibrosis Foundation ^
UAB Therapeutic Development Network Center
awarded by
Cystic Fibrosis Foundation ^
Background
Education And Training
Johns Hopkins Hospital, Residency
University of North Carolina Hospital, Postdoctoral Fellowship
Doctor of Medicine,
Southwestern University
1999
Bachelor of Engineering in Materials Engineering,
Rice University
1994
Contact
Full Name
William
Harris