• Dr. Holman trained in general and cardiothoracic surgery at Duke University under Dr. David Sabiston. During his residency, he performed research in the laboratory of Dr. James Cox. Dr. Holman was an instructor in cardiac surgery at UAB under Dr. Albert Pacifico and joined the faculty in 1988. Since that time, Dr. Holman has performed adult cardiothoracic operations at UAB and the Birmingham VA Medical Center. In addition, he worked in several areas of research including cardiac arrhythmias, ischemia-reperfusion injury and outcomes analysis for patients with heart assist devices. He has been awarded grants from the NIH, American Heart Association (including an Established Investigator award), VA, and industry. He has been a member of NIH and VA study sections and is currently the chairman of the American Heart Association (AHA) Surgery Study Section.

    When Dr. Holman began work at UAB, he started the ventricular assist device program. He has been the local principal investigator for numerous FDA Investigational New Device trials of ventricular assist devices. He has been a member or chairman of several data safety monitoring boards for new surgical devices.

    In 2007, Dr. Holman expanded his involvement at the Birmingham VA Medical Center to become the chief of surgical services. He has been involved in the expansion of existing services and the establishment of new services at the VA. Advances in the VA clinical programs culminated in promotion of the Birmingham VA Medical Center from a 1B to a 1A facility in 2014.

    Dr. Holman’s clinical interests include adult cardiac surgery (coronary artery bypass grafting and heart valve surgery) and surgery for heart failure (mechanical circulatory support devices). His research interests include topics in mechanical circulatory support and surgery for heart failure. He also has interests in surgical education and myocardial ischemia-reperfusion injury (heart attacks). Dr. Holman participated in the training of five NIH funded resident researchers and numerous clinical trainees in cardiothoracic surgery.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Long-term clinical outcome and graft patency of radial artery and saphenous vein grafts in multiple arterial revascularization 2019
    2019 Invited Commentary 2019
    2019 Effect of Calcium-Channel Blocker Therapy on Radial Artery Grafts After Coronary Bypass Surgery 2019
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model 2019
    2019 Use of computed tomography in preoperative planning for heartware left ventricular assist device placement 2019
    2018 Utility of nuclear stress imaging in predicting long-term outcomes one-year post CABG Surgery 2018
    2017 INTERMACS Analysis of Stroke During Support With Continuous-Flow Left Ventricular Assist Devices: Risk Factors and Outcomes 2017
    2016 Ventricular Assist Device in Acute Myocardial Infarction 2016
    2015 Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device 2015
    2015 Assessment and management of right ventricular failure in left ventricular assist device patients 2015
    2015 Changes over time in risk profiles of patients who undergo coronary artery bypass graft surgery: The Veterans Affairs Surgical Quality Improvement Program (VASQIP) 2015
    2015 Octreotide in the management of recurrent gastrointestinal bleed in patients supported by continuous flow left ventricular assist devices 2015
    2014 Completeness of coronary revascularization and survival: Impact of age and off-pump surgery 2014
    2014 Perioperative outcomes after onand off-pump coronary artery bypass grafting 2014
    2013 Consequences of radial artery harvest: Results of a prospective, randomized, multicenter trial 2013
    2013 Trends over time in the relative use and associated mortality of on-pump and off-pump coronary artery bypass grafting in the Veterans Affairs System 2013
    2013 Gastrointestinal bleeding in patients with ventricular assist devices is highest immediately after implantation 2013
    2013 Use of retrospectively gated CT angiography to diagnose systolic LVAD inflow obstruction 2013
    2013 Performing coronary artery bypass grafting off-pump may compromise long-term survival in a veteran population 2013
    2013 Berlin heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US children 2013
    2013 Durability of left ventricular assist devices: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 2006 to 2011 2013
    2012 Continuous-flow devices and percutaneous site infections: Clinical outcomes 2012
    2012 Perceptions and expectations of cardiothoracic residents and attending surgeons 2012
    2012 Utility of nuclear stress imaging for detecting coronary artery bypass graft disease 2012
    2012 Coronary artery bypass graft patency: Residents versus attending surgeons 2012
    2012 Invited commentary 2012
    2012 Invited commentary 2012
    2012 Comparison of observed survival after ventricular assist device placement versus predicted survival without assist device using the seattle heart failure model 2012
    2012 Implantation of the HeartWare HVAD in a child after a recent thromboembolic stroke 2012
    2012 Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS): what have we learned and what will we learn? 2012
    2011 Costs and quality of life associated with radial artery and saphenous vein cardiac bypass surgery: Results from a Veterans Affairs multisite trial 2011
    2011 Incremental value of live/real time three-dimensional transesophageal echocardiography over the two-dimensional technique in the assessment of sinus of Valsalva aneurysm rupture 2011
    2011 Surgical site infection prevention: Time to move beyond the surgical care improvement program 2011
    2011 Improvement in 2-year survival for ventricular assist device patients after implementation of an intensive surveillance protocol 2011
    2011 Perceptions regarding cardiothoracic surgical training at Veterans Affairs hospitals 2011
    2011 Discussion 2011
    2011 The generalizability of participants in Veterans Affairs Cooperative Studies Program 474, a multi-site randomized cardiac bypass surgery trial 2011
    2011 Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: A randomized trial 2011
    2011 Use of a vascular plug to percutaneously occlude the outflow conduit of a dysfunctional left ventricular assist device 2011
    2011 Use of gated cardiac computed tomography angiography in the assessment of left ventricular assist device dysfunction 2011
    2011 Working formulation for the standardization of definitions of infections in patients using ventricular assist devices 2011
    2010 Highlights of the American society for artificial internal organs 2010 conference 2010
    2010 Device related infections: Are we making progress? 2010
    2010 Invited Commentary 2010
    2010 Infection after implantation of pulsatile mechanical circulatory support devices 2010
    2009 INTERMACS: Interval Analysis of Registry Data 2009
    2009 Clot lifespan model analysis of the effects of warfarin on thrombus growth and fibrinolysis: Role of contact protein and tissue factor initiation 2009
    2009 Predictors of Death and Transplant in Patients With a Mechanical Circulatory Support Device: A Multi-institutional Study 2009
    2009 Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flow 2009
    2008 Patency of internal jugular vein following repair after ECMO stabilization prior to Berlin heart implantation: Utility of repaired vein for subsequent cardiac catheterization and biopsy 2008
    2008 Patient With Hypofibrinolysis-mediated Thromboembolism Converted to a Hypercoagulable/Hyperfibrinolytic State via Ventricular Assist Device Placement 2008
    2008 Mechanical circulatory device thrombosis: A new paradigm linking hypercoagulation and hypofibrinolysis 2008
    2008 Invited Commentary 2008
    2008 Use of an Intraperitoneal Ventricular Assist Device With a Polytetrafluoroethylene Barrier Decreases Infections 2008
    2008 The effects of a soluble polymer and bone wax on sternal healing in an animal model. Invited commentary. 2008
    2007 Surgical Management of a Giant Thoracic Angiomyolipoma 2007
    2007 Sodium-Hydrogen Exchange Inhibition and β-Blockade Additively Decrease Infarct Size 2007
    2007 Thrombelastographic method to quantify the contribution of factor XIII to coagulation kinetics 2007
    2007 Xenograft calcification in Reiter's syndrome 2007
    2007 Invited commentary 2007
    2007 Is Early Too Early? Effect of Shorter Stays After Bypass Surgery 2007
    2007 Microbiology of infection in mechanical circulatory support 2007
    2006 Trends in postoperative length of stay after bypass surgery 2006
    2006 Mechanical circulatory support therapy as a bridge to transplant or recovery (new advances) 2006
    2006 Native aortic valve insufficiency in patients with left ventricular assist devices 2006
    2006 Portable coronary active perfusion system for off-pump coronary artery bypass grafting: Invited commentary 2006
    2006 Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition 2006
    2005 Multiple treatment approach to limit cardiac ischemia-reperfusion injury 2005
    2005 Human leukocyte antigen sensitization in ventricular assist device recipients: A lesser risk with the DeBakey axial pump - Commentary 2005
    2005 Managing device infections: Are we progressing or is infection an insurmountable obstacle? 2005
    2005 Automatic intraaortic balloon pump timing using an intrabeat dicrotic notch prediction algorithm: Invited Commentary 2005
    2005 Left ventricular assist devices as destination therapy: A new look at survival 2005
    2005 MagScrew total artificial heart in vivo performance above 200 beats per minute: Invited commentary 2005
    2004 Infection in permanent circulatory support: Experience from the REMATCH trial 2004
    2004 Left ventricular assist device performance with long-term circulatory support: Lessons from the REMATCH trial 2004
    2004 Clinical experience with the mini-extracorporeal circulation system: An evolution or a revolution? Invited commentary 2004
    2004 Does the Use of Routine Duodenotomy (DUODX) Affect Rate of Cure, Development of Liver Metastases, or Survival in Patients with Zollinger-Ellison Syndrome? 2004
    2004 Epicardial organization of human ventricular fibrillation 2004
    2004 Alabama Coronary Artery Bypass Grafting Project: Results from Phase II of a Statewide Quality Improvement Initiative 2004
    2004 Outcomes of early extubation after bypass surgery in the elderly 2004
    2003 The hemodynamic effects of compliance, bulging, and curvature in a saphenous vein coronary artery bypass graft model 2003
    2003 Intra-myocyte ion homeostasis during ischemia-reperfusion injury: Effects of pharmacologic preconditioning and controlled reperfusion 2003
    2003 Hemodynamic evaluation of normally functioning sulzer carbomedics prosthetic valves 2003
    2003 Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation 2003
    2003 Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury 2003
    2003 Amiodarone in cardiothoracic surgery patients: What is a surgeon to do? 2003
    2003 A flow visualization study of an anatomic coronary artery anastomosis model with an implant 2003
    2003 Beneficial effect of autologous cell transplantation on infarcted heart function: Comparison between bone marrow stromal cells and heart cells 2003
    2002 Mechanical circulatory support for myocarditis: How much recovery should occur before device removal? 2002
    2002 The effects of acute and chronic amiodarone on activation patterns and defibrillation threshold during ventricular fibrillation in dogs 2002
    2002 Effect of a flow-streamlining implant at the distal anastomosis of a coronary artery bypass graft 2002
    2002 Treatment of end-stage heart disease with outpatient ventricular assist devices 2002
    2002 Long-term follow-up of patients treated with an implantable left ventricular assist device as an extended bridge to heart transplantation 2002
    2002 Ischemic preconditioning and Na+/H+ exchange inhibition improve reperfusion ion homeostasis 2002
    2002 Long-term follow-up of thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular function 2002
    2001 Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation 2001
    2001 Mechanical circulatory support: Expanding knowledge and experience in a challenging patient subset 2001
    2001 Albumin versus hydroxyethyl starch in cardiopulmonary surgery: A meta-analysis of postoperative bleedingbypass: Invited commentary 2001
    2001 Cardiomyopathy in a carrier of Duchenne's muscular dystrophy 2001
    2001 Invited commentary 2001
    2001 Alabama coronary artery bypass grafting project: Results of a statewide quality improvement initiative 2001
    2001 A new method of monitoring recovery and weaning the Thoratec left ventricular assist device 2001
    2001 Cell volume and ionic transport systems after cold preservation of coronary endothelial cells: Invited commentary 2001
    2001 Discussion of economics of devices 2001
    2001 How to run an outpatient VAD program: Overview 2001
    2001 Infection with clinical ventricular assist devices: Clinical therapy 2001
    2000 Right thoracotomy for mitral reoperatron: Analysis of technique and outcome 2000
    2000 Aortic dissection with intimal intussusception: Diagnosis and management 2000
    2000 Controlled postcardioplegia reperfusion: Mechanism for attenuation of reperfusion injury 2000
    2000 Cost-benefit analysis of extended antifungal prophylaxis in ventricular assist devices 2000
    2000 Fungal infections in ventricular assist devices 2000
    2000 Novel methods to evaluate controlled reperfusion techniques in cardiac surgery. 2000
    2000 Pneumoperitoneum after concomitant resection of the right middle and lower lobes (bilobectomy) 2000
    2000 Prophylactic value of preincision intra-aortic balloon pump: Analysis of a statewide experience 2000
    1999 Outcome after myocardial revascularization and renal transplantation: A 25-year single-institution experience 1999
    1998 Arrest duration influences postcardioplegia electrophysiologic recovery and reperfusion arrhythmias 1998
    1998 Evaluation of complex mediastinal masses by magnetic resonance imaging 1998
    1998 A prospective algorithm for the management of air leaks after pulmonary resection 1998
    1998 Gene polymorphisms for PAI-1 are associated with the angiographic Extent of coronary artery disease 1998
    1998 Usefulness of transesophageal echocardiography in diagnosing valve leakage of left ventricular assist device 1998
    1997 Simultaneous use of an implanted defibrillator and ventricular assist device 1997
    1997 Ventricular assist devices as a bridge to cardiac transplantation: A prelude to destination therapy 1997
    1997 MEDOS HIA-VAD biventricular assist device for bridge to recovery in fulminant myocarditis: Invited commentary 1997
    1997 Platypnea and orthodeoxia: Shunting associated with an aortic aneurysm 1997
    1997 Preoperative and postoperative comparison of patients with univentricular and biventricular support with the thoratec ventricular assist device as a bridge to cardiac transplantation 1997
    1997 Replacement of an intracorporeal left ventricular assist device 1997
    1996 Measurement of percent oxyhemoglobin by optical densitometry in perfluorocarbon supplemented blood 1996
    1996 Extensive pulmonary metastasis of an intracranial meningioma with repeated recurrence: Radiographic and pathologic features 1996
    1996 Coronary vascular regulation during postcardioplegia reperfusion 1996
    1996 Infections during extended circulatory support: University of Alabama at Birmingham experience 1989 to 1994 1996
    1996 Resection of multiple pulmonary metastases from a recurrent intracranial meningioma 1996
    1996 Usefulness of transesophageal echocardiography in diagnosing and guiding correct placement of a right ventricular assist device malpositioned in the left atrium 1996
    1995 Circulatory support for myocardial infarction with ventricular arrhythmias 1995
    1995 Incremental Value of Three‐Dimensional Echocardiography Over Transesophageal Multiplane Two‐Dimensional Echocardiography in Qualitative and Quantitative Assessment of Cardiac Masses and Defects 1995
    1995 Left atrial or ventricular cannulation beyond 30 days for a Thoratec ventricular assist device 1995
    1995 Mechanisms of transplant right ventricular dysfunction 1995
    1995 Perfluorocarbons are effective oxygen carriers in cardiopulmonary bypass 1995
    1995 Tissue oxygenation with graded dissolved oxygen delivery during cardiopulmonary bypass 1995
    1995 Transesophageal Echocardiographic Detection of Sinus of Valsalva Dissection 1995
    1994 Effect of postcardioplegia reperfusion rhythm or myocardial blood flow 1994
    1994 Treatment of recurrent heart rejection with mycophenolate mofetil (RS- 61443): Initial clinical experience 1994
    1994 Anatomic definition of a vulnerable extranodal site in AV node reentry 1994
    1994 Cardiac amyloidoma with IgM-κ gammopathy 1994
    1994 Effect of hemoglobin concentration on oxyhemoglobin dissociation during hypothermic blood cardioplegic arrest 1994
    1994 Influence of longer term left ventricular assist device support on valvular regurgitation 1994
    1994 Perfluorocarbon oxygen transport: A comparative study of four oxygenator designs 1994
    1994 Use of current generation perfluorocarbon emulsions in cardiac surgery 1994
    1994 Ventricular assist: experience with a pulsatile heterotopic device. 1994
    1993 Duration of asystolic reperfusion and reperfusate electrolyte composition influence postcardioplegia ventricular fibrillation 1993
    1993 External pulsatile circulatory support 1993
    1993 Sinus of Valsalva aneurysms and application of surgical science to their repair 1993
    1993 The ivory tower from outside and in: A survey of Minnesota surgeons 1993
    1993 The monosialoganglioside, GM1, reduces neurologic injury associated with hypothermic circulatory arrest 1993
    1993 Use of expanded polytetrafluoroethylene pericardial substitute with ventricular assist devices 1993
    1992 Operative results after unsuccessful radiofrequency ablation for Wolff-Parkinson-White syndrome 1992
    1992 Electrical instability during reperfusion 1992
    1992 Long-term results of coronary artery bypass grafting 1992
    1992 Quantitation of mapping uncertainty in Wolff-Parkinson-White syndrome: Implications for anatomic characterization and surgical division of accessory atrioventricular connections 1992
    1992 Successful mechanical circulatory support for noncoronary shock 1992
    1992 Variation in cryolesion penetration due to probe size and tissue thermal conductivity 1992
    1992 Wolff-Parkinson-White syndrome: A quantitative morphometric analysis of surgical anatomy 1992
    1991 Case report: Circulatory support for seventy days with resolution of acute heart failure [2] 1991
    1991 Agglutination of blood cardioplegia by cold reacting autoantibodies 1991
    1991 Intermediate septal accessory pathways: Electrocardiographic characteristics, electrophysiologic observations and their surgical implications 1991
    1991 Removal of massive right atrial thrombus guided by transesophageal echocardiography 1991
    1991 Usefulness of transesophageal echocardiography in assessment of aortic dissection 1991
    1990 Combined use of transesophageal echocardiography and endocardial mapping to localize the site of origin of ectopic atrial tachycardia 1990
    1990 Coronary artery bypass grafting with unanticipated fibrosing mediastinitis 1990
    1990 Transesophageal Echocardiographic Evaluation of Mechanical Biventricular Assist Device 1990
    1989 The Blalock‐Taussig Shunt: An Analysis of Trends and Techniques in the Fourth Decade 1989
    1988 Cryosurgical ablation of atrioventricular nodal reentry: Histologic localization of the proximal common pathway 1988
    1987 Cryosurgical treatment of atrioventricular node reentrant tachycardia 1987
    1986 The effects of cardioplegic potassium concentration and myocardial temperature on electrical activity in the heart during elective cardioplegic arrest 1986
    1986 Cryosurgical modification of retrograde atrioventricular conduction: Implications for the surgical treatment of atrioventricular nodal reentry tachycardia 1986
    1986 Cardiac cryosurgery: Regional myocardial blood flow of ventricular cryolesions 1986
    1986 Surgical Treatment of H-Type Tracheoesophageal Fistula Diagnosed in an Adult 1986
    1985 Surgical treatment of supraventricular tachyarrhythmias 1985
    1984 Alteration of antegrade atrioventricular conduction by cryoablation of peri-atrioventricular nodal tissue: Implications for the surgical treatment of atrioventricular nodal reentry tachycardia 1984
    1984 The electrophysiologic effects of discrete cryosurgery for the treatment of supraventricular tachycardia due to av nodal reentry 1984
    1983 Supraventricular conduction abnormalities following cardiac operations. A complication of inadequate atrial preservation 1983
    1983 Cardiac cryosurgery: Effects of myocardial temperature on cryolesion size 1983
    1983 Cryosurgery for cardiac arrhythmias: Acute and chronic effects on coronary arteries 1983
    1983 Quantitation of cardiac cryolesion size by regional tissue resistance 1983
    1983 Ventricular Cryosurgery: Short-term Effects on Intramural Electrophysiology 1983
    1982 Elective prolongation of atrioventricular conduction by multiple discrete cryolesions. A new technique for the treatment of paroxysmal supraventricular tachycardia 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. I. Electrophysiological effects 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. II. Effects on regional myocardial blood flow 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. III. Effects on regional left ventricular function 1982
    1982 Effects of cardioplegic infusion rate and topical hypothermia on elective cardiac arrest 1982


    Year Title Altmetric
    2012 Complications of mechanical circulatory support devices.  718-721. 2012
    2012 INTERMACS.  730-732. 2012

    Research Overview

  • adult cardiac surgery, surgery for heart failure, mechanical circulatory support and surgery for heart failure, surgical education
  • Principal Investigator On

  • Private Grant  awarded by HEARTWARE, INC. 2015 - 2017
  • Private Grant  awarded by ABIOMED, INC. 2013 - 2015
  • Private Grant  awarded by ACORN CARDIOVASCULAR, INC. 2008 - 2014
  • Private Grant  awarded by BERLIN HEART, INC. 2008 - 2013
  • Investigator On

  • Private Grant  awarded by SUNSHINE HEART, INC. 2009 - 2016
  • Private Grant  awarded by EVAHEART, INC. 2011 - 2016
  • Private Grant  awarded by SUNSHINE HEART, INC. 2013 - 2016
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2014 - 2015
  • Randomized Evaluation of VAD Intervention before Inotropic Therapy (REVIVE-IT) Pilot Trial  awarded by University of Michigan 2013 - 2015
  • Private Grant  awarded by VENTRACOR, INC. 2007 - 2012
  • Private Grant  awarded by VENTRACOR, INC. 2007 - 2012
  • Education And Training

  • Duke University Medical Center, Internship 1979
  • Duke University Medical Center, Residency 1987
  • UAB Hospital, Postdoctoral Fellowship 1988
  • Full Name

  • William Holman