• Dr. Holman trained in general and cardiothoracic surgery at Duke University under Dr. David Sabiston. During his residency, he performed research in the laboratory of Dr. James Cox. Dr. Holman was an instructor in cardiac surgery at UAB under Dr. Albert Pacifico and joined the faculty in 1988. Since that time, Dr. Holman has performed adult cardiothoracic operations at UAB and the Birmingham VA Medical Center. In addition, he worked in several areas of research including cardiac arrhythmias, ischemia-reperfusion injury and outcomes analysis for patients with heart assist devices. He has been awarded grants from the NIH, American Heart Association (including an Established Investigator award), VA, and industry. He has been a member of NIH and VA study sections and is currently the chairman of the American Heart Association (AHA) Surgery Study Section.

    When Dr. Holman began work at UAB, he started the ventricular assist device program. He has been the local principal investigator for numerous FDA Investigational New Device trials of ventricular assist devices. He has been a member or chairman of several data safety monitoring boards for new surgical devices.

    In 2007, Dr. Holman expanded his involvement at the Birmingham VA Medical Center to become the chief of surgical services. He has been involved in the expansion of existing services and the establishment of new services at the VA. Advances in the VA clinical programs culminated in promotion of the Birmingham VA Medical Center from a 1B to a 1A facility in 2014.

    Dr. Holman’s clinical interests include adult cardiac surgery (coronary artery bypass grafting and heart valve surgery) and surgery for heart failure (mechanical circulatory support devices). His research interests include topics in mechanical circulatory support and surgery for heart failure. He also has interests in surgical education and myocardial ischemia-reperfusion injury (heart attacks). Dr. Holman participated in the training of five NIH funded resident researchers and numerous clinical trainees in cardiothoracic surgery.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Innovation in Medical Devices-Lessons from the Past, Planning for the Future: Hastings Lecture 2019ASAIO Journal.  65:e82-e85. 2019
    2019 Long-term clinical outcome and graft patency of radial artery and saphenous vein grafts in multiple arterial revascularizationJournal of Thoracic and Cardiovascular Surgery.  158:442-450. 2019
    2019 Invited CommentaryAnnals of Thoracic Surgery.  108:44. 2019
    2019 Effect of Calcium-Channel Blocker Therapy on Radial Artery Grafts After Coronary Bypass SurgeryJournal of the American College of Cardiology.  73:2299-2306. 2019
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture modelThe Journal of heart transplantation.  38:456-465. 2019
    2019 Use of computed tomography in preoperative planning for heartware left ventricular assist device placementASAIO Journal.  65:70-76. 2019
    2018 Utility of nuclear stress imaging in predicting long-term outcomes one-year post CABG SurgeryJournal of Nuclear Cardiology2018
    2017 INTERMACS Analysis of Stroke During Support With Continuous-Flow Left Ventricular Assist Devices: Risk Factors and OutcomesJACC: Heart Failure.  5:703-711. 2017
    2016 Ventricular Assist Device in Acute Myocardial InfarctionJournal of the American College of Cardiology.  67:1871-1880. 2016
    2015 Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP deviceThe Journal of heart transplantation.  34:1549-1560. 2015
    2015 Assessment and management of right ventricular failure in left ventricular assist device patientsCirculation Journal.  79:478-486. 2015
    2015 Changes over time in risk profiles of patients who undergo coronary artery bypass graft surgery: The Veterans Affairs Surgical Quality Improvement Program (VASQIP)JAMA Surgery.  150:308-315. 2015
    2015 Octreotide in the management of recurrent gastrointestinal bleed in patients supported by continuous flow left ventricular assist devicesASAIO Journal.  61:107-109. 2015
    2014 Completeness of coronary revascularization and survival: Impact of age and off-pump surgeryJournal of Thoracic and Cardiovascular Surgery.  148:1307-1315.e1. 2014
    2014 Perioperative outcomes after onand off-pump coronary artery bypass graftingTexas Heart Institute Journal.  41:144-151. 2014
    2013 Consequences of radial artery harvest: Results of a prospective, randomized, multicenter trialJAMA Surgery.  148:1020-1023. 2013
    2013 Trends over time in the relative use and associated mortality of on-pump and off-pump coronary artery bypass grafting in the Veterans Affairs SystemJAMA Surgery.  148:1031-1036. 2013
    2013 Gastrointestinal bleeding in patients with ventricular assist devices is highest immediately after implantationASAIO Journal.  59:480-485. 2013
    2013 Use of retrospectively gated CT angiography to diagnose systolic LVAD inflow obstructionASAIO Journal.  59:542-546. 2013
    2013 Performing coronary artery bypass grafting off-pump may compromise long-term survival in a veteran populationAnnals of Thoracic Surgery.  95:1952-1960. 2013
    2013 Berlin heart EXCOR pediatric ventricular assist device for bridge to heart transplantation in US childrenCirculation.  127:1702-1711. 2013
    2013 Durability of left ventricular assist devices: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 2006 to 2011Journal of Thoracic and Cardiovascular Surgery.  146. 2013
    2012 Continuous-flow devices and percutaneous site infections: Clinical outcomesThe Journal of heart transplantation.  31:1151-1157. 2012
    2012 Perceptions and expectations of cardiothoracic residents and attending surgeonsJournal of Surgical Research.  177. 2012
    2012 Utility of nuclear stress imaging for detecting coronary artery bypass graft diseaseBMC Cardiovascular Disorders.  12. 2012
    2012 Coronary artery bypass graft patency: Residents versus attending surgeonsAnnals of Thoracic Surgery.  94:482-488. 2012
    2012 Invited commentaryAnnals of Thoracic Surgery.  94:467. 2012
    2012 Invited commentaryAnnals of Thoracic Surgery.  94:264. 2012
    2012 Comparison of observed survival after ventricular assist device placement versus predicted survival without assist device using the seattle heart failure modelASAIO Journal.  58:93-97. 2012
    2012 Implantation of the HeartWare HVAD in a child after a recent thromboembolic strokeAnnals of Thoracic Surgery.  93:977-978. 2012
    2012 Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS): what have we learned and what will we learn?Circulation.  126:1401-1406. 2012
    2011 Costs and quality of life associated with radial artery and saphenous vein cardiac bypass surgery: Results from a Veterans Affairs multisite trialAmerican Journal of Surgery.  202:532-535. 2011
    2011 Incremental value of live/real time three-dimensional transesophageal echocardiography over the two-dimensional technique in the assessment of sinus of Valsalva aneurysm ruptureEchocardiography.  28:918-920. 2011
    2011 Surgical site infection prevention: Time to move beyond the surgical care improvement programAnnals of Surgery.  254:494-501. 2011
    2011 Improvement in 2-year survival for ventricular assist device patients after implementation of an intensive surveillance protocolThe Journal of heart transplantation.  30:879-887. 2011
    2011 Perceptions regarding cardiothoracic surgical training at Veterans Affairs hospitalsJournal of Thoracic and Cardiovascular Surgery.  141:1107-1113. 2011
    2011 DiscussionJournal of The American College of Surgeons.  212:467-469. 2011
    2011 The generalizability of participants in Veterans Affairs Cooperative Studies Program 474, a multi-site randomized cardiac bypass surgery trialControlled Clinical Trials.  32:260-266. 2011
    2011 Radial artery grafts vs saphenous vein grafts in coronary artery bypass surgery: A randomized trialJournal of the American Medical Association.  305:167-174. 2011
    2011 Use of a vascular plug to percutaneously occlude the outflow conduit of a dysfunctional left ventricular assist deviceThe Journal of heart transplantation.  30:733-734. 2011
    2011 Use of gated cardiac computed tomography angiography in the assessment of left ventricular assist device dysfunctionASAIO Journal.  57:32-37. 2011
    2011 Working formulation for the standardization of definitions of infections in patients using ventricular assist devicesThe Journal of heart transplantation.  30:375-384. 2011
    2010 Highlights of the American society for artificial internal organs 2010 conferenceArtificial Organs.  34:795-797. 2010
    2010 Device related infections: Are we making progress?Journal of Cardiac Surgery.  25:478-483. 2010
    2010 Invited CommentaryAnnals of Thoracic Surgery.  89:1510. 2010
    2010 Infection after implantation of pulsatile mechanical circulatory support devicesJournal of Thoracic and Cardiovascular Surgery.  139. 2010
    2009 INTERMACS: Interval Analysis of Registry DataJournal of The American College of Surgeons.  208:755-761. 2009
    2009 Clot lifespan model analysis of the effects of warfarin on thrombus growth and fibrinolysis: Role of contact protein and tissue factor initiationASAIO Journal.  55:33-40. 2009
    2009 Predictors of Death and Transplant in Patients With a Mechanical Circulatory Support Device: A Multi-institutional StudyThe Journal of heart transplantation.  28:44-50. 2009
    2009 Successful cardiac transplant after Berlin Heart bridge in a single ventricle heart: Use of aortopulmonary shunt as a supplementary source of pulmonary blood flowJournal of Thoracic and Cardiovascular Surgery.  137. 2009
    2008 Patency of internal jugular vein following repair after ECMO stabilization prior to Berlin heart implantation: Utility of repaired vein for subsequent cardiac catheterization and biopsyCongenital Heart Disease.  3:411-414. 2008
    2008 Patient With Hypofibrinolysis-mediated Thromboembolism Converted to a Hypercoagulable/Hyperfibrinolytic State via Ventricular Assist Device PlacementThe Journal of heart transplantation.  27:1169-1171. 2008
    2008 Mechanical circulatory device thrombosis: A new paradigm linking hypercoagulation and hypofibrinolysisASAIO Journal.  54:351-358. 2008
    2008 Invited CommentaryAnnals of Thoracic Surgery.  85:1780. 2008
    2008 Use of an Intraperitoneal Ventricular Assist Device With a Polytetrafluoroethylene Barrier Decreases InfectionsThe Journal of heart transplantation.  27:268-271. 2008
    2008 The effects of a soluble polymer and bone wax on sternal healing in an animal model. Invited commentary.Annals of Thoracic Surgery.  85:1780. 2008
    2007 Surgical Management of a Giant Thoracic AngiomyolipomaAnnals of Thoracic Surgery.  83:2201-2203. 2007
    2007 Sodium-Hydrogen Exchange Inhibition and β-Blockade Additively Decrease Infarct SizeAnnals of Thoracic Surgery.  83:1121-1127. 2007
    2007 Thrombelastographic method to quantify the contribution of factor XIII to coagulation kineticsBlood Coagulation and Fibrinolysis.  18:145-150. 2007
    2007 Xenograft calcification in Reiter's syndromeJournal of Heart Valve Disease.  16:159-161. 2007
    2007 Invited commentaryAnnals of Thoracic Surgery.  83:509. 2007
    2007 Is Early Too Early? Effect of Shorter Stays After Bypass SurgeryAnnals of Thoracic Surgery.  83:100-107. 2007
    2007 Microbiology of infection in mechanical circulatory supportLife support systems : the journal of the European Society for Artificial Organs.  30:764-770. 2007
    2006 Trends in postoperative length of stay after bypass surgeryAmerican Heart Journal.  152:1194-1200. 2006
    2006 Mechanical circulatory support therapy as a bridge to transplant or recovery (new advances)Current Opinion in Cardiology.  21:120-126. 2006
    2006 Native aortic valve insufficiency in patients with left ventricular assist devicesAnnals of Thoracic Surgery.  81. 2006
    2006 Portable coronary active perfusion system for off-pump coronary artery bypass grafting: Invited commentaryAnnals of Thoracic Surgery.  81:710-711. 2006
    2006 Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibitionBBA - Molecular Basis of Disease.  1762:223-231. 2006
    2005 Multiple treatment approach to limit cardiac ischemia-reperfusion injuryAnnals of Thoracic Surgery.  80:1408-1416. 2005
    2005 Human leukocyte antigen sensitization in ventricular assist device recipients: A lesser risk with the DeBakey axial pump - CommentaryAnnals of Thoracic Surgery.  80:948-949. 2005
    2005 Managing device infections: Are we progressing or is infection an insurmountable obstacle?ASAIO Journal.  51:452-455. 2005
    2005 Automatic intraaortic balloon pump timing using an intrabeat dicrotic notch prediction algorithm: Invited CommentaryAnnals of Thoracic Surgery.  79:1022. 2005
    2005 Left ventricular assist devices as destination therapy: A new look at survivalJournal of Thoracic and Cardiovascular Surgery.  129:9-17. 2005
    2005 MagScrew total artificial heart in vivo performance above 200 beats per minute: Invited commentaryAnnals of Thoracic Surgery.  79:1383. 2005
    2004 Infection in permanent circulatory support: Experience from the REMATCH trialThe Journal of heart transplantation.  23:1359-1365. 2004
    2004 Left ventricular assist device performance with long-term circulatory support: Lessons from the REMATCH trialAnnals of Thoracic Surgery.  78:2123-2130. 2004
    2004 Clinical experience with the mini-extracorporeal circulation system: An evolution or a revolution? Invited commentaryAnnals of Thoracic Surgery.  77:2176. 2004
    2004 Does the Use of Routine Duodenotomy (DUODX) Affect Rate of Cure, Development of Liver Metastases, or Survival in Patients with Zollinger-Ellison Syndrome?Annals of Surgery.  239:617-626. 2004
    2004 Epicardial organization of human ventricular fibrillationHeart Rhythm.  1:14-23. 2004
    2004 Alabama Coronary Artery Bypass Grafting Project: Results from Phase II of a Statewide Quality Improvement InitiativeAnnals of Surgery.  239:99-109. 2004
    2004 Outcomes of early extubation after bypass surgery in the elderlyAnnals of Thoracic Surgery.  77:781-788. 2004
    2003 The hemodynamic effects of compliance, bulging, and curvature in a saphenous vein coronary artery bypass graft modelTechnology and Health Care.  11:443-455. 2003
    2003 Intra-myocyte ion homeostasis during ischemia-reperfusion injury: Effects of pharmacologic preconditioning and controlled reperfusionAnnals of Thoracic Surgery.  76:1252-1258. 2003
    2003 Hemodynamic evaluation of normally functioning sulzer carbomedics prosthetic valvesUltrasound in Medicine and Biology.  29:649-657. 2003
    2003 Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulationAnesthesia and Analgesia.  96:956-958. 2003
    2003 Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injuryJournal of Thoracic and Cardiovascular Surgery.  125:863-871. 2003
    2003 Amiodarone in cardiothoracic surgery patients: What is a surgeon to do?Journal of Thoracic and Cardiovascular Surgery.  125:463-464. 2003
    2003 A flow visualization study of an anatomic coronary artery anastomosis model with an implantTechnology and Health Care.  11:21-39. 2003
    2003 Beneficial effect of autologous cell transplantation on infarcted heart function: Comparison between bone marrow stromal cells and heart cellsAnnals of Thoracic Surgery.  75:169-177. 2003
    2002 Mechanical circulatory support for myocarditis: How much recovery should occur before device removal?The Journal of heart transplantation.  21:1246-1249. 2002
    2002 The effects of acute and chronic amiodarone on activation patterns and defibrillation threshold during ventricular fibrillation in dogsJournal of the American College of Cardiology.  40:375-383. 2002
    2002 Effect of a flow-streamlining implant at the distal anastomosis of a coronary artery bypass graftAnnals of Biomedical Engineering.  30:917-926. 2002
    2002 Treatment of end-stage heart disease with outpatient ventricular assist devicesAnnals of Thoracic Surgery.  73:1489-1494. 2002
    2002 Long-term follow-up of patients treated with an implantable left ventricular assist device as an extended bridge to heart transplantationThe Journal of heart transplantation.  21:604-607. 2002
    2002 Ischemic preconditioning and Na+/H+ exchange inhibition improve reperfusion ion homeostasisAnnals of Thoracic Surgery.  73:569-574. 2002
    2002 Long-term follow-up of thoratec ventricular assist device bridge-to-recovery patients successfully removed from support after recovery of ventricular functionThe Journal of heart transplantation.  21:516-521. 2002
    2001 Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantationJournal of Thoracic and Cardiovascular Surgery.  122:1186-1195. 2001
    2001 Mechanical circulatory support: Expanding knowledge and experience in a challenging patient subsetIntensive Care Medicine.  27:1245-1246. 2001
    2001 Albumin versus hydroxyethyl starch in cardiopulmonary surgery: A meta-analysis of postoperative bleedingbypass: Invited commentaryAnnals of Thoracic Surgery.  72:534. 2001
    2001 Cardiomyopathy in a carrier of Duchenne's muscular dystrophyThe Journal of heart transplantation.  20:781-784. 2001
    2001 Invited commentaryAnnals of Thoracic Surgery.  72:112-113. 2001
    2001 Alabama coronary artery bypass grafting project: Results of a statewide quality improvement initiativeJournal of the American Medical Association.  285:3003-3010. 2001
    2001 A new method of monitoring recovery and weaning the Thoratec left ventricular assist deviceAnnals of Thoracic Surgery.  71:215-218. 2001
    2001 Cell volume and ionic transport systems after cold preservation of coronary endothelial cells: Invited commentaryAnnals of Thoracic Surgery.  71:1295. 2001
    2001 Discussion of economics of devicesAnnals of Thoracic Surgery.  71:S202-S203. 2001
    2001 How to run an outpatient VAD program: OverviewASAIO Journal.  47:588-589. 2001
    2001 Infection with clinical ventricular assist devices: Clinical therapyASAIO Journal.  47:195-196. 2001
    2000 Right thoracotomy for mitral reoperatron: Analysis of technique and outcomeAnnals of Thoracic Surgery.  70:1970-1973. 2000
    2000 Aortic dissection with intimal intussusception: Diagnosis and managementJournal of Cardiovascular Surgery.  41:613-615. 2000
    2000 Controlled postcardioplegia reperfusion: Mechanism for attenuation of reperfusion injuryJournal of Thoracic and Cardiovascular Surgery.  119:1093-1101. 2000
    2000 Cost-benefit analysis of extended antifungal prophylaxis in ventricular assist devicesASAIO Journal.  46:587-589. 2000
    2000 Fungal infections in ventricular assist devicesASAIO Journal.  46. 2000
    2000 Novel methods to evaluate controlled reperfusion techniques in cardiac surgery.International journal of surgical investigation.  1:397-407. 2000
    2000 Pneumoperitoneum after concomitant resection of the right middle and lower lobes (bilobectomy)Annals of Thoracic Surgery.  70:942-946. 2000
    2000 Prophylactic value of preincision intra-aortic balloon pump: Analysis of a statewide experienceJournal of Thoracic and Cardiovascular Surgery.  120:1112-1119. 2000
    1999 Outcome after myocardial revascularization and renal transplantation: A 25-year single-institution experienceAnnals of Surgery.  230:232-241. 1999
    1998 Arrest duration influences postcardioplegia electrophysiologic recovery and reperfusion arrhythmiasAnnals of Thoracic Surgery.  65:1003-1008. 1998
    1998 Evaluation of complex mediastinal masses by magnetic resonance imagingJournal of Cardiovascular Surgery.  39:117-119. 1998
    1998 A prospective algorithm for the management of air leaks after pulmonary resectionAnnals of Thoracic Surgery.  66:1726-1730. 1998
    1998 Gene polymorphisms for PAI-1 are associated with the angiographic Extent of coronary artery diseaseJournal of Thrombosis and Thrombolysis.  5:143-150. 1998
    1998 Usefulness of transesophageal echocardiography in diagnosing valve leakage of left ventricular assist deviceEchocardiography.  15:703-707. 1998
    1997 Simultaneous use of an implanted defibrillator and ventricular assist deviceAnnals of Thoracic Surgery.  64:1156-1158. 1997
    1997 Ventricular assist devices as a bridge to cardiac transplantation: A prelude to destination therapyAnnals of Surgery.  225:695-706. 1997
    1997 MEDOS HIA-VAD biventricular assist device for bridge to recovery in fulminant myocarditis: Invited commentaryAnnals of Thoracic Surgery.  63:1146. 1997
    1997 Platypnea and orthodeoxia: Shunting associated with an aortic aneurysmJournal of Thoracic and Cardiovascular Surgery.  113:955-956. 1997
    1997 Preoperative and postoperative comparison of patients with univentricular and biventricular support with the thoratec ventricular assist device as a bridge to cardiac transplantationJournal of Thoracic and Cardiovascular Surgery.  113:202-209. 1997
    1997 Replacement of an intracorporeal left ventricular assist deviceAnnals of Thoracic Surgery.  64:839-841. 1997
    1996 Measurement of percent oxyhemoglobin by optical densitometry in perfluorocarbon supplemented bloodASAIO Journal.  42. 1996
    1996 Extensive pulmonary metastasis of an intracranial meningioma with repeated recurrence: Radiographic and pathologic featuresSouthern Medical Journal.  89:313-318. 1996
    1996 Coronary vascular regulation during postcardioplegia reperfusionJournal of Thoracic and Cardiovascular Surgery.  112:1054-1063. 1996
    1996 Infections during extended circulatory support: University of Alabama at Birmingham experience 1989 to 1994Annals of Thoracic Surgery.  61:366-371. 1996
    1996 Resection of multiple pulmonary metastases from a recurrent intracranial meningiomaAnnals of Thoracic Surgery.  61:1823-1824. 1996
    1996 Usefulness of transesophageal echocardiography in diagnosing and guiding correct placement of a right ventricular assist device malpositioned in the left atriumEchocardiography.  13:159-163. 1996
    1995 Circulatory support for myocardial infarction with ventricular arrhythmiasAnnals of Thoracic Surgery.  59:1230-1231. 1995
    1995 Incremental Value of Three‐Dimensional Echocardiography Over Transesophageal Multiplane Two‐Dimensional Echocardiography in Qualitative and Quantitative Assessment of Cardiac Masses and DefectsEchocardiography.  12:619-628. 1995
    1995 Left atrial or ventricular cannulation beyond 30 days for a Thoratec ventricular assist deviceASAIO Journal.  41. 1995
    1995 Mechanisms of transplant right ventricular dysfunctionAnnals of Surgery.  221:666-676. 1995
    1995 Perfluorocarbons are effective oxygen carriers in cardiopulmonary bypassASAIO Journal.  41. 1995
    1995 Tissue oxygenation with graded dissolved oxygen delivery during cardiopulmonary bypassJournal of Thoracic and Cardiovascular Surgery.  110:774-785. 1995
    1995 Transesophageal Echocardiographic Detection of Sinus of Valsalva DissectionEchocardiography.  12:99-102. 1995
    1994 Effect of postcardioplegia reperfusion rhythm or myocardial blood flowAnnals of Thoracic Surgery.  58:351-358. 1994
    1994 Treatment of recurrent heart rejection with mycophenolate mofetil (RS- 61443): Initial clinical experienceThe Journal of heart transplantation.  13:444-450. 1994
    1994 Anatomic definition of a vulnerable extranodal site in AV node reentryAnnals of Thoracic Surgery.  57:1273-1280. 1994
    1994 Cardiac amyloidoma with IgM-κ gammopathyArchives of Pathology and Laboratory Medicine.  118:1148-1150. 1994
    1994 Effect of hemoglobin concentration on oxyhemoglobin dissociation during hypothermic blood cardioplegic arrestJournal of Thoracic and Cardiovascular Surgery.  108:664-671. 1994
    1994 Influence of longer term left ventricular assist device support on valvular regurgitationASAIO Journal.  40. 1994
    1994 Perfluorocarbon oxygen transport: A comparative study of four oxygenator designsASAIO Journal.  40. 1994
    1994 Use of current generation perfluorocarbon emulsions in cardiac surgeryArtificial Cells, Blood Substitutes and Biotechnology.  22:979-990. 1994
    1994 Ventricular assist: experience with a pulsatile heterotopic device.Seminars in Thoracic and Cardiovascular Surgery.  6:147-153. 1994
    1993 Duration of asystolic reperfusion and reperfusate electrolyte composition influence postcardioplegia ventricular fibrillationJournal of Thoracic and Cardiovascular Surgery.  106:511-519. 1993
    1993 External pulsatile circulatory supportAnnals of Thoracic Surgery.  55:257-260. 1993
    1993 Sinus of Valsalva aneurysms and application of surgical science to their repairAnnals of Thoracic Surgery.  55:545-550. 1993
    1993 The ivory tower from outside and in: A survey of Minnesota surgeonsSurgery.  114:436-441. 1993
    1993 The monosialoganglioside, GM1, reduces neurologic injury associated with hypothermic circulatory arrestSurgery.  114:324-333. 1993
    1993 Use of expanded polytetrafluoroethylene pericardial substitute with ventricular assist devicesAnnals of Thoracic Surgery.  55:181-183. 1993
    1992 Operative results after unsuccessful radiofrequency ablation for Wolff-Parkinson-White syndromeAmerican Journal of Cardiology.  70:1490-1491. 1992
    1992 Electrical instability during reperfusionAnnals of Thoracic Surgery.  54:1245-1246. 1992
    1992 Long-term results of coronary artery bypass graftingCurrent Opinion in Cardiology.  7:990-996. 1992
    1992 Quantitation of mapping uncertainty in Wolff-Parkinson-White syndrome: Implications for anatomic characterization and surgical division of accessory atrioventricular connectionsJournal of Thoracic and Cardiovascular Surgery.  104:1045-1052. 1992
    1992 Successful mechanical circulatory support for noncoronary shockThe Journal of heart transplantation.  11:129-135. 1992
    1992 Variation in cryolesion penetration due to probe size and tissue thermal conductivityAnnals of Thoracic Surgery.  53:123-126. 1992
    1992 Wolff-Parkinson-White syndrome: A quantitative morphometric analysis of surgical anatomyJournal of Thoracic and Cardiovascular Surgery.  104:802-811. 1992
    1991 Case report: Circulatory support for seventy days with resolution of acute heart failure [2]Journal of Thoracic and Cardiovascular Surgery.  102:932-934. 1991
    1991 Agglutination of blood cardioplegia by cold reacting autoantibodiesAnnals of Thoracic Surgery.  51:833-836. 1991
    1991 Intermediate septal accessory pathways: Electrocardiographic characteristics, electrophysiologic observations and their surgical implicationsJournal of the American College of Cardiology.  17:1570-1578. 1991
    1991 Removal of massive right atrial thrombus guided by transesophageal echocardiographyAnnals of Thoracic Surgery.  52:313-315. 1991
    1991 Usefulness of transesophageal echocardiography in assessment of aortic dissectionCirculation.  84:1903-1914. 1991
    1990 Combined use of transesophageal echocardiography and endocardial mapping to localize the site of origin of ectopic atrial tachycardiaAmerican Journal of Cardiology.  65:1284-1286. 1990
    1990 Coronary artery bypass grafting with unanticipated fibrosing mediastinitisAnnals of Thoracic Surgery.  49:321-322. 1990
    1990 Transesophageal Echocardiographic Evaluation of Mechanical Biventricular Assist DeviceEchocardiography.  7:561-566. 1990
    1989 The Blalock‐Taussig Shunt: An Analysis of Trends and Techniques in the Fourth DecadeJournal of Cardiac Surgery.  4:113-124. 1989
    1988 Cryosurgical ablation of atrioventricular nodal reentry: Histologic localization of the proximal common pathwayCirculation.  77:1356-1362. 1988
    1987 Cryosurgical treatment of atrioventricular node reentrant tachycardiaCirculation.  76:1329-1336. 1987
    1986 The effects of cardioplegic potassium concentration and myocardial temperature on electrical activity in the heart during elective cardioplegic arrestJournal of Thoracic and Cardiovascular Surgery.  92:755-765. 1986
    1986 Cryosurgical modification of retrograde atrioventricular conduction: Implications for the surgical treatment of atrioventricular nodal reentry tachycardiaJournal of Thoracic and Cardiovascular Surgery.  91:826-834. 1986
    1986 Cardiac cryosurgery: Regional myocardial blood flow of ventricular cryolesionsJournal of Surgical Research.  41:524-528. 1986
    1986 Surgical Treatment of H-Type Tracheoesophageal Fistula Diagnosed in an AdultAnnals of Thoracic Surgery.  41:453-454. 1986
    1985 Surgical treatment of supraventricular tachyarrhythmiasSurgical Clinics of North America.  65:553-570. 1985
    1984 Alteration of antegrade atrioventricular conduction by cryoablation of peri-atrioventricular nodal tissue: Implications for the surgical treatment of atrioventricular nodal reentry tachycardiaJournal of Thoracic and Cardiovascular Surgery.  88:67-75. 1984
    1984 The electrophysiologic effects of discrete cryosurgery for the treatment of supraventricular tachycardia due to av nodal reentryCirculation Journal.  48:127-135. 1984
    1983 Supraventricular conduction abnormalities following cardiac operations. A complication of inadequate atrial preservationJournal of Thoracic and Cardiovascular Surgery.  85:105-115. 1983
    1983 Cardiac cryosurgery: Effects of myocardial temperature on cryolesion sizeSurgery.  93:268-272. 1983
    1983 Cryosurgery for cardiac arrhythmias: Acute and chronic effects on coronary arteriesAmerican Journal of Cardiology.  51:149-155. 1983
    1983 Quantitation of cardiac cryolesion size by regional tissue resistanceSurgical Forum -Chicago-.  VOL. 34:348-350. 1983
    1983 Ventricular Cryosurgery: Short-term Effects on Intramural ElectrophysiologyAnnals of Thoracic Surgery.  35:386-393. 1983
    1982 Elective prolongation of atrioventricular conduction by multiple discrete cryolesions. A new technique for the treatment of paroxysmal supraventricular tachycardiaJournal of Thoracic and Cardiovascular Surgery.  84:554-559. 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. I. Electrophysiological effectsJournal of Thoracic and Cardiovascular Surgery.  83:840-849. 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. II. Effects on regional myocardial blood flowJournal of Thoracic and Cardiovascular Surgery.  83:850-856. 1982
    1982 Encircling endocardial ventriculotomy for refractory ischemic ventricular tachycardia. III. Effects on regional left ventricular functionJournal of Thoracic and Cardiovascular Surgery.  83:857-864. 1982
    1982 Effects of cardioplegic infusion rate and topical hypothermia on elective cardiac arrestAmerican Journal of Cardiology.  49:894. 1982


    Year Title Altmetric
    2012 Complications of mechanical circulatory support devices.  718-721. 2012
    2012 INTERMACS.  730-732. 2012

    Research Overview

  • adult cardiac surgery, surgery for heart failure, mechanical circulatory support and surgery for heart failure, surgical education
  • Principal Investigator On

  • Private Grant  awarded by HEARTWARE, INC. 2015 - 2017
  • Private Grant  awarded by ABIOMED, INC. 2013 - 2015
  • Private Grant  awarded by ACORN CARDIOVASCULAR, INC. 2008 - 2014
  • Private Grant  awarded by BERLIN HEART, INC. 2008 - 2013
  • Investigator On

  • Private Grant  awarded by SUNSHINE HEART, INC. 2009 - 2016
  • Private Grant  awarded by EVAHEART, INC. 2011 - 2016
  • Private Grant  awarded by SUNSHINE HEART, INC. 2013 - 2016
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2014 - 2015
  • Randomized Evaluation of VAD Intervention before Inotropic Therapy (REVIVE-IT) Pilot Trial  awarded by University of Michigan 2013 - 2015
  • Private Grant  awarded by VENTRACOR, INC. 2007 - 2012
  • Private Grant  awarded by VENTRACOR, INC. 2007 - 2012
  • Education And Training

  • Doctor of Medicine, Cornell University 1978
  • Bachelor's Degree, Williams College 1974
  • Duke University Medical Center, Internship 1979
  • Duke University Medical Center, Residency 1987
  • UAB Hospital, Postdoctoral Fellowship 1988
  • Full Name

  • William Holman