Selected Publications

Academic Article

Year Title Altmetric
2021 Diabetes, obesity, and inflammation: Impact on clinical and radiographic features of breast cancerInternational Journal of Molecular Sciences.  22:1-15. 2021
2021 Molecular imaging of inflammatory diseaseBiomedicines.  9:1-23. 2021
2021 The neutral red assay can be used to evaluate cell viability during autophagy or in an acidic microenvironment in vitro 2021
2020 Actively targeted nanodelivery of echinomycin induces autophagy-mediated death in chemoresistant pancreatic cancer in vivoCancers.  12:1-17. 2020
2020 Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristicsInternational Journal of Cancer.  146:2784-2796. 2020
2020 Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progressionOncogene.  39:4077-4091. 2020
2020 Identification of distinct heterogenic subtypes and molecular signatures associated with african ancestry in triple negative breast cancer using quantified genetic ancestry models in admixed race populationsCancers.  12. 2020
2020 TBCRC 002: A phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancerBreast Cancer Research.  22. 2020
2020 Hallmarks and Determinants of Oncogenic Translation Revealed by Ribosome Profiling in Models of Breast CancerTranslational Oncology.  13:452-470. 2020
2019 Inclusiveness and ethical considerations for observational, translational, and clinical cancer health disparity researchCancer.  125:4452-4461. 2019
2019 Issues in the use of human tissues to support precision medicineJournal of Health Care for the Poor and Underserved.  30:66-78. 2019
2019 Self-Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsyCancer Medicine.  8:6915-6922. 2019
2019 Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))Immunity.  51:411-412. 2019
2019 Biobank: What's in a Name?Biopreservation and Biobanking.  17:204-208. 2019
2019 Biological, medical, and other tissue variables affecting biospecimen utilizationBiopreservation and Biobanking.  17:259-263. 2019
2019 Biospecimen utilization: A critical challenge in global bioresource/biobanking operationsBiopreservation and Biobanking.  17:201-203. 2019
2019 Commentary on improving biospecimen utilization by classic biobanks: Identifying past and minimizing future mistakesBiopreservation and Biobanking.  17:243-247. 2019
2019 The importance of human tissue bioresources in advancing biomedical researchBiopreservation and Biobanking.  17:209-212. 2019
2019 The utilization of biospecimens: Impact of the choice of biobanking modelBiopreservation and Biobanking.  17:230-242. 2019
2018 Lessons Learned During Three Decades of Operations of Two Prospective BioresourcesBiopreservation and Biobanking.  16:483-492. 2018
2018 Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticleBiomaterials.  182:114-126. 2018
2018 Comprehensive Molecular Characterization of the Hippo Signaling Pathway in CancerCell Reports.  25:1304-1317.e5. 2018
2018 A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β SuperfamilyCell Systems.  7:422-437.e7. 2018
2018 A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer ProgressionNeoplasia.  20:894-904. 2018
2018 Nitrocellulose tissue prints: An innovative approach to preparing high quality DNA and RNA from prostate biopsies without compromising the cores for pathology diagnosisTranslational andrology and urology.  7:S514-S518. 2018
2018 Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200cCancer Letters.  431:1-10. 2018
2018 Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 PatientsCancer Cell.  34:211-224.e6. 2018
2018 Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))Cell.  174:1034-1035. 2018
2018 Factors that drive the increasing use of FFPE tissue in basic and translational cancer research 2018
2018 Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))Cell Reports.  23:3698. 2018
2018 AR negative triple negative or “Quadruple Negative” breast cancers in African American women have an enriched basal and immune signaturePLoS ONE.  13. 2018
2018 Reply to "phase II prospective randomized trial of weight loss prior to radical prostatectomyProstate Cancer and Prostatic Diseases.  21:293-294. 2018
2018 Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition 2018
2018 The Immune Landscape of CancerImmunity.  48:812-830.e14. 2018
2018 A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast CancersCancer Cell.  33:690-705.e9. 2018
2018 Genomic and Functional Approaches to Understanding Cancer AneuploidyCancer Cell.  33:676-689.e3. 2018
2018 lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in CancerCancer Cell.  33:706-720.e9. 2018
2018 A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient SamplesCell.  173:386-399.e12. 2018
2018 An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome AnalyticsCell.  173:400-416.e11. 2018
2018 Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of CancerCell.  173:291-304.e6. 2018
2018 Comprehensive Characterization of Cancer Driver Genes and MutationsCell.  173:371-385.e18. 2018
2018 Machine Learning Identifies Stemness Features Associated with Oncogenic DedifferentiationCell.  173:338-354.e15. 2018
2018 Oncogenic Signaling Pathways in The Cancer Genome AtlasCell.  173:321-337.e10. 2018
2018 Pathogenic Germline Variants in 10,389 Adult CancersCell.  173:355-370.e14. 2018
2018 Perspective on Oncogenic Processes at the End of the Beginning of Cancer GenomicsCell.  173:305-320.e10. 2018
2018 Driver Fusions and Their Implications in the Development and Treatment of Human CancersCell Reports.  23:227-238.e3. 2018
2018 Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome AtlasCell Reports.  23:239-254.e6. 2018
2018 Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous CarcinomasCell Reports.  23:194-212.e6. 2018
2018 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer TypesCell Reports.  23:213-226.e3. 2018
2018 Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome AtlasCell Reports.  23:172-180.e3. 2018
2018 Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human CancersCell Reports.  23:255-269.e4. 2018
2018 Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor ContextCell Reports.  23:297-312.e12. 2018
2018 Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer TypesCell Reports.  23:282-296.e4. 2018
2018 Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology ImagesCell Reports.  23:181-193.e7. 2018
2018 Systematic Analysis of Splice-Site-Creating Mutations in CancerCell Reports.  23:270-281.e3. 2018
2018 The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell CarcinomaCell Reports.  23:313-326.e5. 2018
2018 Shifting sands: the complexities and uncertainties of the evolving US regulatory, policy, and scientific landscape for biospecimen researchDiagnostic Histopathology.  24:136-148. 2018
2018 Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome AtlasCell Systems.  6:282-300.e2. 2018
2018 Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic PipelinesCell Systems.  6:271-281.e7. 2018
2018 Standard PREanalytical Code Version 3.0Biopreservation and Biobanking.  16:9-12. 2018
2017 Epigenetic risk score improves prostate cancer risk assessment 2017
2017 Translational dysregulation in cancer: Molecular insights and potential clinical applications in biomarker developmentFrontiers in Oncology.  7. 2017
2017 Noninvasive imaging of colitis using multispectral optoacoustic tomographyJournal of Nuclear Medicine.  58:1009-1012. 2017
2017 Erratum: Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer. [BMC Cancer, 16 (2016) (61)]BMC Cancer.  17. 2017
2017 Genomic regulation of invasion by STAT3 in triple negative breast cancerOncotarget.  8:8226-8238. 2017
2017 Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signalingOncotarget.  8:69264-69280. 2017
2017 Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancerBritish Journal of Cancer.  117:1303-1313. 2017
2016 Effects of Cold Ischemia on Gene Expression: A Review and CommentaryBiopreservation and Biobanking.  14:548-558. 2016
2016 Construction and validation of a multi-institutional tissue microarray of invasive ductal carcinoma from racially and ethnically diverse populationsCancer Control : Journal of the Moffitt Cancer Center.  23:383-389. 2016
2016 IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells 2016
2016 RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4Molecular Oncology.  10:1169-1182. 2016
2016 Exploring effects of presurgical weight loss among women with stage 0-II breast cancer: Protocol for a randomised controlled feasibility trialBMJ Open.  6. 2016
2016 Occult Metastases in Pelvic Lymphadenectomy Specimens From Patients With Urothelial Carcinoma of the BladderUrology.  94:161-166. 2016
2016 Current and emerging clinical applications of multispectral optoacoustic tomography (MSOT) in oncologyClinical Cancer Research.  22:3432-3439. 2016
2016 A standard tissue as a control for histochemical and immunohistochemical staining 2016
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCancer Research.  76:3978-3988. 2016
2016 Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy 2016
2016 Expression of the MHC class II pathway in triple-negative breast cancer tumor cells is associated with a good prognosis and infiltrating lymphocytesCancer Immunology Research.  4:390-399. 2016
2016 Preservation of Biospecimens at Ambient Temperature: Special Focus on Nucleic Acids and Opportunities for the Biobanking CommunityBiopreservation and Biobanking.  14:89-98. 2016
2016 SPARC-independent delivery of nab-paclitaxel without depleting tumor stroma in patient-derived pancreatic Cancer xenograftsMolecular Cancer Therapeutics.  15:680-688. 2016
2016 Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancerBMC Cancer.  16. 2016
2016 Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancerProteomics.  16:516-531. 2016
2016 Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974Laboratory Investigation.  96:249-259. 2016
2016 A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell linesBMC Complementary and Alternative Medicine.  16. 2016
2016 Factors affecting the use of human tissues in biomedical research: Implications in the design and operation of a biorepositoryMethods in Molecular Biology.  1381:1-38. 2016
2016 The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancerOncotarget.  7:73739-73753. 2016
2016 The rank pathway in advanced breast cancer: Does Src play a role?Applied Immunohistochemistry and Molecular Morphology.  24:42-50. 2016
2015 Missed Opportunities and Lost Lives: Consequences of Some Proposed Changes to Regulations on Research with Human Tissues-LetterClinical Cancer Research.  21:5404-5405. 2015
2015 Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomographyJournal of Nanobiotechnology.  13. 2015
2015 Targeting acidity in pancreatic Adenocarcinoma: Multispectral Optoacoustic tomography detects ph-low insertion peptide probes in vivoClinical Cancer Research.  21:4576-4585. 2015
2015 Small molecule inhibitors of IRES-mediated translationCancer Biology and Therapy.  16:1471-1485. 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypesPLoS ONE.  10. 2015
2015 TBCRC 019: A phase II trial of nanoparticle albumin-bound paclitaxel with or without the anti-death receptor 5 monoclonal antibody tigatuzumab in patients with triple-negative breast cancerClinical Cancer Research.  21:2722-2729. 2015
2015 Clinical implications of rabphillin-3A-like gene alterations in breast cancerPLoS ONE.  10. 2015
2015 Quality management of biorepositoriesBiopreservation and Biobanking.  13:183-194. 2015
2015 The protective effect of p16 INK4a in oral cavity carcinomas: p16 Ink4A dampens tumor invasion-integrated analysis of expression and kinomics pathwaysModern Pathology.  28:631-653. 2015
2015 PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancersBreast Cancer Research and Treatment.  150:569-579. 2015
2015 Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activityOncogene.  34:1499-1509. 2015
2015 S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinaseScientific Reports.  5. 2015
2014 A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regressionInternational Journal of Nanomedicine.  9:5093-5102. 2014
2014 An autoregulatory mechanism governing mucociliary transport is sensitive to mucus loadAmerican Journal of Respiratory Cell and Molecular Biology.  51:485-493. 2014
2014 The effects of frozen tissue storage conditions on the integrity of RNA and protein 2014
2014 Pazopanib combined with radiation: In vivo model of interactionCancer Biotherapy and Radiopharmaceuticals.  29:247-250. 2014
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγtNature Communications.  5. 2014
2014 Erythropoietin upregulation in pulmonary arterial hypertensionPulmonary Circulation.  4:269-279. 2014
2014 Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signalingOncogene.  33:2620-2628. 2014
2014 Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthoodMolecular and Cellular Endocrinology.  387:35-43. 2014
2014 Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort studyPLoS ONE.  9. 2014
2014 Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse modelBritish Journal of Cancer.  110:2000-2010. 2014
2014 Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancerPLoS ONE.  9. 2014
2014 A framework for biobank sustainabilityBiopreservation and Biobanking.  12:60-68. 2014
2014 A functional anatomic defect of the cystic fibrosis airwayAmerican Journal of Respiratory and Critical Care Medicine.  190:421-432. 2014
2014 Effect of niclosamide on basal-like breast cancersMolecular Cancer Therapeutics.  13:800-811. 2014
2014 Exosomes: A novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesionsAmerican Journal of Pathology.  184:28-41. 2014
2014 L-Methionine inhibits growth of human pancreatic cancer cells 2014
2014 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1Oncotarget.  5:3512-3525. 2014
2014 NSAIDs inhibit tumorigenesis, but how?Clinical Cancer Research.  20:1104-1113. 2014
2014 Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomasClinical and Experimental Metastasis.  31:497-510. 2014
2014 Recurrent read-through fusion transcripts in breast cancerBreast Cancer Research and Treatment.  146:287-297. 2014
2013 COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugsFrontiers in Oncology.  3 JUL. 2013
2013 The effect of antigen retrieval on cells fixed in 10% neutral buffered formalin followed by transfer to 70% ethanolPLoS ONE.  8. 2013
2013 Retargeting of gene expression using endothelium specific hexon modified adenoviral vectorVirology.  447:312-325. 2013
2013 It is primarily the control of transcription and post-transcriptional processing that are critical to the development and progression of sporadic neoplasias 2013
2013 Post-transcriptional processing of genetic information and its relation to cancer 2013
2013 Lung resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic marker for advanced ovarian serous carcinomaAnnals of Surgical Oncology.  20:3059-3065. 2013
2013 Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress wnt/β-catenin signalingMolecular Cancer Therapeutics.  12:1848-1858. 2013
2013 Use of human specimens in research: The evolving United States regulatory, policy, and scientific landscapeDiagnostic Histopathology.  19:322-330. 2013
2013 An undesired effect of chemotherapy: Gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factorκb- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4Journal of Biological Chemistry.  288:21197-21207. 2013
2013 The prognostic value of MicroRNAs varies with patient race/ethnicity and stage of colorectal cancerClinical Cancer Research.  19:3955-3965. 2013
2013 Frequencies of mtDNA mutations in primary tissue of colorectal adenopolypsFrontiers in bioscience (Elite edition).  5 E:809-813. 2013
2013 Mouse model findings and the future of human tissue in disease researchBiopreservation and Biobanking.  11:135-136. 2013
2013 An Extensive Targeted Proteomic Analysis of Disease-Related Protein Biomarkers in Urine from Healthy DonorsPLoS ONE.  8. 2013
2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to SepsisPLoS ONE.  8. 2013
2013 A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagyMolecular Cancer Therapeutics.  12:663-674. 2013
2013 Preservation of immunorecognition by transferring cells from 10% neutral buffered formalin to 70% ethanol 2013
2013 Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cellsJournal of Immunology.  190:3579-3589. 2013
2013 Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesisAmerican Journal of Pathology.  182:646-667. 2013
2013 Return of research results from genomic biobanks: A call for dataGenetics in Medicine.  15:159-160. 2013
2013 Return of research results from genomic biobanks: Cost mattersGenetics in Medicine.  15:103-105. 2013
2013 Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence TomographyPLoS ONE.  8. 2013
2013 Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53 2013
2012 CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: Implications for bidirectional tumor-stromal interactionsJournal of Biological Chemistry.  287:39115-39124. 2012
2012 Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: Potential role in castration resistanceCarcinogenesis.  33:1149-1157. 2012
2012 Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cellsAmerican Journal of Pathology.  181:1836-1846. 2012
2012 Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and humanProteomics.  12:3393-3402. 2012
2012 A critical need for increased understanding of the use of human tissues in biomedical researchJournal of Cancer Science and Therapy.  4. 2012
2012 Modern age pathology of pulmonary arterial hypertensionAmerican Journal of Respiratory and Critical Care Medicine.  186:261-272. 2012
2012 A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung diseasePLoS ONE.  7. 2012
2012 A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activityCancer Prevention Research.  5:822-833. 2012
2012 Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancerBMC Research Notes.  5. 2012
2012 18F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts 2012
2012 Exosomes and immune surveillance of neoplastic lesions: A review 2012
2012 Practical implementation issues and challenges for biobanks in the return of individual research resultsGenetics in Medicine.  14:478-483. 2012
2012 Clinical and biological significance of KISS1 expression in prostate cancerAmerican Journal of Pathology.  180:1170-1178. 2012
2012 Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73Cancer Cell.  21:196-211. 2012
2012 Predictors of long-term outcome from intraperitoneal radioimmunotherapy for ovarian cancerCancer Biotherapy and Radiopharmaceuticals.  27:36-40. 2012
2012 Corrigendum: Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brainMolecular Therapy.  20:239. 2012
2012 MiRNAs are stable in colorectal cancer archival tissue blocksFrontiers in bioscience (Elite edition).  4 E:1937-1940. 2012
2012 Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progressionAmerican Journal of Pathology.  180:390-398. 2012
2011 Biomarkers and the genetics of early neoplastic lesionsCancer Biomarkers.  9:41-64. 2011
2011 Development and progression of colorectal neoplasiaCancer Biomarkers.  9:235-265. 2011
2011 Issues in collecting, processing and storing human tissues and associated information to support biomedical researchCancer Biomarkers.  9:531-549. 2011
2011 The biology of incipient, pre-invasive or intraepithelial neoplasiaCancer Biomarkers.  9:21-39. 2011
2011 Translational pathology of early cancerCancer Biomarkers.  9:1-4. 2011
2011 Translational pathology of neoplasiaCancer Biomarkers.  9:7-20. 2011
2011 MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cellsCarcinogenesis.  32:1832-1839. 2011
2011 Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteinsJournal of Cellular Physiology.  226:3355-3367. 2011
2011 What are the most oppressing legal and ethical issues facing biorepositories and what are some strategies to address themBiopreservation and Biobanking.  9:317-319. 2011
2011 Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy 2011
2011 The human face of biobank networks for translational researchBiopreservation and Biobanking.  9:279-285. 2011
2011 MiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMTOncogene.  30:3440-3453. 2011
2011 Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancerInternational Journal of Oncology.  39:373-381. 2011
2011 Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathwayMolecular Carcinogenesis.  50:516-527. 2011
2011 Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cellsInternational Journal of Oncology.  39:111-119. 2011
2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 miceArthritis and Rheumatism.  63:2038-2048. 2011
2011 PCCR: Pancreatic cancer collaborative registryCancer Informatics.  10:83-91. 2011
2011 Early therapy evaluation of combined cetuximab and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic resonance imagingMolecular Imaging.  10:153-167. 2011
2011 Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer 2011
2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophagesBlood.  117:4796-4804. 2011
2011 CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashionWorld Journal of Surgical Oncology.  9. 2011
2011 CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashionInternational Journal of Oncology.  38:1279-1285. 2011
2011 LL-37 as a therapeutic target for late stage prostate cancer 2011
2011 Self-calibrated warping for mass spectra alignmentCancer Informatics.  10:65-82. 2011
2011 Exosomes and cancer: A newly described pathway of immune suppressionClinical Cancer Research.  17:959-964. 2011
2011 L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cellsJournal of Cancer Research and Clinical Oncology.  137:441-453. 2011
2011 Serum biomarker panels for the detection of pancreatic cancerClinical Cancer Research.  17:805-816. 2011
2011 DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 Therapy 2011
2011 A migration signature and plasma biomarker panel for pancreatic adenocarcinomaCancer Prevention Research.  4:137-149. 2011
2011 Author's replyAmerican Journal of Pathology.  178:1404-1405. 2011
2011 Erratum: Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples (Journal of Biomedical Optics (2010) 15 (067005))Journal of Biomedical Optics.  16. 2011
2011 The national lung screening trial: Overview and study designRadiology.  258:243-253. 2011
2011 Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brainMolecular Therapy.  19:1769-1779. 2011
2010 Bax expression is a candidate prognostic and predictive marker of colorectal cancer.Journal of Gastrointestinal Oncology.  1:76-89. 2010
2010 KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse modelClinical and Experimental Metastasis.  27:591-600. 2010
2010 A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseasesClinical Cancer Research.  16:5277-5287. 2010
2010 CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposideInternational Journal of Cancer.  127:2020-2030. 2010
2010 Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samplesJournal of Biomedical Optics.  15. 2010
2010 Standards for immunohistochemical imaging: A protein reference device for biomarker quantitation 2010
2010 Analysis of mtDNA sequence variants in colorectal adenomatous polypsDiagnostic Pathology.  5. 2010
2010 CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashionJournal of Ovarian Research.  3. 2010
2010 Gli1 promotes cell survival and is predictive of a poor outcome in ERα-negative breast cancerBreast Cancer Research and Treatment.  123:59-71. 2010
2010 Prognostic value of mucin 4 expression in colorectal adenocarcinomasCancer.  116:3577-3586. 2010
2010 CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasionWorld Journal of Surgical Oncology.  8. 2010
2010 Comparison of the predictive qualities of three prognostic models of colorectal cancerFrontiers in bioscience (Elite edition).  2 E:849-856. 2010
2010 Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRESExperimental and Molecular Pathology.  88:341-352. 2010
2010 Suppression by L-methionine of cell cycle progression in LNCaP and MCF-7 cells but not benign cells 2010
2010 A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomesMolecular Therapy.  18:1606-1614. 2010
2010 Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cellsAmerican Journal of Pathology.  176:2490-2499. 2010
2010 NSAIDs: Old drugs reveal new anticancer targetsPharmaceuticals.  3:1652-1667. 2010
2010 Organizational issues in providing high-quality human tissues and clinical information for the support of biomedical research.Methods in Molecular Biology.  576:1-30. 2010
2010 TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomesAmerican Journal of Pathology.  177:1606-1610. 2010
2010 The deployment of a tissue request tracking system for the CHTN: A case study in managing change in informatics for biobanking operationsBMC Medical Informatics and Decision Making.  10. 2010
2009 Immature myeloid cells induced by a high-fat diet contribute to liver inflammationHepatology.  50:1412-1420. 2009
2009 Dual effects of TGF-β On ERα-mediated estrogenic transcriptional activity in breast cancerMolecular Cancer.  8. 2009
2009 Combined effects of formalin fixation and tissue processing on immunorecognition Fixation effects on immunostaining 2009
2009 Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulatedCell Cycle.  8:3770-3776. 2009
2009 Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell linesInternational Journal of Cancer.  125:2288-2295. 2009
2009 Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistanceDiabetes.  58:2498-2505. 2009
2009 Experimental cancer therapy using restoration of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expressionMolecular Cancer Therapeutics.  8:3130-3139. 2009
2009 CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental gliomaCancer Gene Therapy.  16:794-805. 2009
2009 Combined effects of formalin fixation and tissue processing on immunorecognition. 2009
2009 Special symposium: fixation and tissue processing models. 2009
2009 Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesionCancer Letters.  283:29-35. 2009
2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritisScandinavian Journal of Immunology.  70:309-316. 2009
2009 Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer modelInternational Journal of Gynecological Cancer.  19:814-819. 2009
2009 Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1Molecular Pharmacology.  76:81-90. 2009
2009 How to efficiently obtain human tissues to support specific biomedical research projectsCancer Epidemiology, Biomarkers and Prevention.  18:1676-1679. 2009
2009 Induction of myeloid-derived suppressor cells by tumor exosomesInternational Journal of Cancer.  124:2621-2633. 2009
2009 Regulation of p53 by TopBP1: A potential mechanism for p53 inactivation in cancerMolecular and Cellular Biology.  29:2673-2693. 2009
2009 Prognostic significance of p53 Codon 72 polymorphism differs with race in colorectal adenocarcinomaClinical Cancer Research.  15:2406-2416. 2009
2009 Immunohistochemical expression of rabphilin -3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas 2009
2009 CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growthMolecular Cancer Therapeutics.  8:178-184. 2009
2009 Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancerInternational Journal of Women's Health.  1:131-137. 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary SyndromeGastroenterology.  136:1070-1080. 2009
2009 Standard operating procedures for serum and plasma collection: Early detection research network consensus statement standard operating procedure integration working groupJournal of Proteome Research.  8:113-117. 2009
2009 Timing of consent for the research use of surgically removed tissue is postoperative consenting acceptable?Cancer.  115:4-9. 2009
2008 Erratum: The efficient operation of the surgical pathology gross room (Biotechnic and Histochemistry vol. 82(3) (71-82)) 2008
2008 Immunohistochemistry in the evaluation of neovascularization in tumor xenografts 2008
2008 Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer 2008
2008 Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenograftsby diffusion-weighted magnetic resonance imagingCancer Research.  68:8369-8376. 2008
2008 Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancerJournal of Gastrointestinal Surgery.  12:1683-1690. 2008
2008 Breast tumor xenografts: Diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibodyRadiology.  248:844-851. 2008
2008 mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age differenceDiagnostic Pathology.  3. 2008
2008 Vascular endothelial growth factor reduces tamoxifen efficacy and promotes metastatic colonization and desmoplasia in breast tumorsCancer Research.  68:6232-6240. 2008
2008 Quality Assurance in Tissue Resources Supporting Biomedical Research.Cell Preservation Technology.  6:113-118. 2008
2008 Quality assurance in tissue resources supporting biomedical researchCell Preservation Technology.  6:113-118. 2008
2008 Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinomaFrontiers in Bioscience.  13:1050-1061. 2008
2008 Effect of exercise and calorie restriction on biomarkers of aging in mice 2008
2008 Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeBiochemical Journal.  411:361-369. 2008
2008 Antibody responses of variable lymphocyte receptors in the lampreyNature Immunology.  9:319-327. 2008
2008 The efficient operation of the surgical pathology gross room 2008
2008 p53 nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior 2008
2008 A standards based ontological approach to information handling for use by organizations providing human tissue for researchCancer Informatics.  6:127-137. 2008
2008 Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: Sources of sample bias 2008
2008 Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer modelGynecologic Oncology.  108:591-597. 2008
2008 Immunohistochemical detection of EGFR, p185erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women 2008
2008 Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervixNutrition.  24:94-99. 2008
2008 SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer 2008
2008 Thymus exosomes-like particles induce regulatory T cellsJournal of Immunology.  181:5242-5248. 2008
2007 Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: Implications for the molecular analysis of clinically available biopsiesDiagnostic Molecular Pathology.  16:229-237. 2007
2007 Phosphorylated LIM kinases colocalize with γ-tubulin in centrosomes during early stages of mitosisCell Cycle.  6:2944-2952. 2007
2007 Role of microvascular density in nonlocalizing parathyroid sestamibi scans 2007
2007 TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growthMolecular Cancer Therapeutics.  6:3198-3207. 2007
2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 miceMechanisms of Ageing and Development.  128:672-680. 2007
2007 Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70Cancer Research.  67:9407-9416. 2007
2007 Combination treatment with TRA-8 anti-death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancerClinical Cancer Research.  13. 2007
2007 Assessment of biomarker expression in predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer [1] 2007
2007 Erratum: SIRT1 is significantly elevated in mouse and human prostate cancer (Cancer Research (2007) 67, (6612-6618))Cancer Research.  67:8423. 2007
2007 Inactivation of Smad4 accelerates KrasG12D-mediated pancreatic neoplasiaCancer Research.  67:8121-8130. 2007
2007 SIRT1 is significantly elevated in mouse and human prostate cancerCancer Research.  67:6612-6618. 2007
2007 Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity 2007
2007 Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancerMolecular Cancer.  6. 2007
2007 Tumor exosomes inhibit differentiation of bone marrow dendritic cellsJournal of Immunology.  178:6867-6875. 2007
2007 Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing hostBlood.  109:4336-4342. 2007
2007 Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice modelGynecologic Oncology.  105:291-298. 2007
2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodiesJournal of Immunology.  178:5357-5365. 2007
2007 Plasma protein profiles differ between women diagnosed with cervical intraepithelial neoplasia (cin) 1 and 3.Cancer Informatics.  2:345-349. 2007
2007 Novel approaches to smoothing and comparing SELDI TOF spectraCancer Informatics.  1:78-85. 2007
2007 The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysisCancer Informatics.  1:86-97. 2007
2007 Discrimination between benign and malignant prostate tissue using chromatin texture analysis in 3-D by confocal laser scanning microscopy 2007
2007 Methionine inhibits cellular growth dependent on the p53 status of cells 2007
2007 Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1 2007
2007 African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: An epidemiologic reviewCancer Biomarkers.  3:301-313. 2007
2007 Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker databaseCancer Informatics.  3:115-122. 2007
2006 Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM)Journal of Neuro-Oncology.  80:261-274. 2006
2006 Oncolytic HSV-1 for the treatment of brain tumours 2006
2006 Mucinous expression in benign and neoplastic glandular lesions of the uterine cervixArchives of Pathology and Laboratory Medicine.  130:1510-1515. 2006
2006 Celecoxib Inhibits Cellular Growth, Decreases Ki-67 Expression and Modifies Apoptosis in Ovarian Cancer Cell LinesArchives of Medical Research.  37:689-695. 2006
2006 Erratum: A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death (Journal of Immunology (2006) 176 (7385-7393))Journal of Immunology.  177:2025. 2006
2006 Ovarian expression of markers associated with proliferation or apoptosis in women with diminished ovarian reserveFertility and Sterility.  86:176-185. 2006
2006 Phenotypic expression of Bax is a predictive marker of 5-fluorouracil treatment in colorectal cancer.Journal of Clinical Oncology.  24:3605. 2006
2006 A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell deathJournal of Immunology.  176:7385-7393. 2006
2006 Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer modelGynecologic Oncology.  101:46-54. 2006
2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell functionJournal of Immunology.  176:1375-1385. 2006
2006 19 Role of Immunohistochemical Expression of Lewis Y Antigen in Ovarian CarcinomaHandbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas.  4:465-471. 2006
2006 Cell density influences the effect of celecoxib in two carcinoma cell lines 2006
2006 JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-αAmerican Journal of Pathology.  169:889-902. 2006
2006 Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesisCancer Biomarkers.  2:259-266. 2006
2006 Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array. Application to Hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma 2006
2006 Ovarian biopsy in infertile patients with ovarian dysfunction 2006
2006 Plasma protein profiles differ between women diagnosed with cervical intraepithelial neoplasia (CIN) 1 and 3Cancer Informatics.  2:421-425. 2006
2005 Development of 3D chromatin texture analysis using confocal laser scanning microscopy 2005
2005 Implementation of accurate and fast DNA cytometry by confocal microscopy in 3D 2005
2005 Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis 2005
2005 Selective cyclooxygenase-2 inhibition produces heterogeneous erythema response to ultraviolet irradiation [3]Journal of Investigative Dermatology.  125:1317-1319. 2005
2005 Phase I study of90Y-CC49 monoclonal antibody therapy in patients with advanced non-small cell lung cancer: Effect of chelating agents and paclitaxel co-administrationCancer Biotherapy and Radiopharmaceuticals.  20:467-478. 2005
2005 Feasibility of performing chemoprevention trials in women at elevated risk of ovarian carcinoma: Initial examination of celecoxib as a chemopreventive agentGynecologic Oncology.  98:376-382. 2005
2005 Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumorsOncogene.  24:5589-5605. 2005
2005 Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-α-positive breast cancer cellsJournal of Biological Chemistry.  280:27022-27028. 2005
2005 Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors 2005
2005 High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomasCancer.  103:2163-2170. 2005
2005 Best practices for repositories I: Collection, storage, and retrieval of human biological materials for researchCell Preservation Technology.  3:5-48. 2005
2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of miceScandinavian Journal of Immunology.  61:128-138. 2005
2005 Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancerClinical Cancer Research.  11:1073-1085. 2005
2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptorCancer Gene Therapy.  12:26-34. 2005
2005 Cholangiocyte endothelin 1 and transforming growth factor β1 production in rat experimental hepatopulmonary syndromeGastroenterology.  129:682-695. 2005
2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblastsAmerican Journal of Pathology.  167:705-719. 2005
2005 Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancerCancer Biology and Therapy.  4:72-76. 2005
2005 Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer.Cancer Biology and Therapy.  4:65-69. 2005
2005 Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility 2005
2005 Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humansDisease Markers.  21:147-151. 2005
2005 Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinomaCancer Biomarkers.  1:241-250. 2005
2004 Expression and functional role of CCR9 in prostate cancer cell migration and invasionClinical Cancer Research.  10:8743-8750. 2004
2004 Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancerMolecular Therapy.  10:1059-1070. 2004
2004 CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasionLaboratory Investigation.  84:1666-1676. 2004
2004 Spontaneous pregnancy in a woman with premature ovarian failure: A case report 2004
2004 Confocal 3D DNA cytometry: Assessment of required coefficient of variation by computer simulation 2004
2004 Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulatorClinical Cancer Research.  10:5403-5417. 2004
2004 Clarification in the point/counterpoint discussion related to surface-enhanced laser desorption/ionisation time-of-flight mass spectrometric identification of patients with adenocarcinomas of the prostate [3] (multiple letters) 2004
2004 Promoter hypermethylation profile of kidney cancerClinical Cancer Research.  10:3972-3979. 2004
2004 Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinomaCancer.  101:66-76. 2004
2004 The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the ratHepatology.  39:1593-1602. 2004
2004 Nuclear Localization of KLF4 Is Associated with An Aggressive Phenotype in Early-Stage Breast CancerClinical Cancer Research.  10:2709-2719. 2004
2004 Establishing a tumour bank: Banking, informatics and ethicsBritish Journal of Cancer.  90:1115-1119. 2004
2004 Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy: Long-Term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single FactorCancer Research.  64:1781-1787. 2004
2004 Expression of sperm protein 17 (Sp17) in ovarian cancerInternational Journal of Cancer.  108:805-811. 2004
2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte ProliferationJournal of Immunology.  172:2909-2916. 2004
2004 Prognostic Significance of p27kip-1 Expression in Colorectal Adenocarcinomas Is Associated with Tumor StageClinical Cancer Research.  10:1743-1752. 2004
2004 Intratumor heterogeneity of biomarker expression in breast carcinomas 2004
2004 Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells 2004
2004 p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomasDisease Markers.  19:11-17. 2004
2003 MUC1 and MUC2 Expression in Pancreatic Ductal Carcinoma Obtained by Fine-Needle AspirationCancer.  99:365-371. 2003
2003 Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer modelClinical Cancer Research.  9:3731-3741. 2003
2003 LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: Implications in prostate cancerJournal of Biological Chemistry.  278:36868-36875. 2003
2003 Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model.Clinical Cancer Research.  9:3731-3741. 2003
2003 Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma 2003
2003 Inhibition of tumorigenicity by the 5′-untranslated RNA of the human c-myc P0 transcriptExperimental Cell Research.  288:131-142. 2003
2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422))Scandinavian Journal of Immunology.  58:118. 2003
2003 Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicityClinical Cancer Research.  9:2701-2710. 2003
2003 Cellular mechanism of thymic involutionScandinavian Journal of Immunology.  57:410-422. 2003
2003 Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: A potential mechanism in experimental hepatopulmonary syndromeJournal of Hepatology.  38:556-563. 2003
2003 Smad4 as a transcription corepressor for estrogen receptor αJournal of Biological Chemistry.  278:15192-15200. 2003
2003 Cancer incidence among triazine herbicide manufacturing workers [1] (multiple letters)Journal of Occupational and Environmental Medicine.  45:343-344. 2003
2003 Aging, immunity, and tumor susceptibilityImmunology and Allergy Clinics of North America.  23:83-102. 2003
2003 Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)Cancer Causes and Control.  14:37-42. 2003
2003 The efficacy of 9-Cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: Results of a randomized double-blind clinical trialCancer Epidemiology, Biomarkers and Prevention.  12:114-119. 2003
2003 The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP 2003
2003 The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines 2003
2003 Analysis of Pulmonary Heme Oxygenase-1 and Nitric Oxide Synthase Alterations in Experimental Hepatopulmonary SyndromeGastroenterology.  125:1441-1451. 2003
2003 Expression of CEA, Tag-72, and Lewis-Y Antigen in Primary and Metastatic Lesions of Ovarian CarcinomaHuman Pathology.  34:1016-1021. 2003
2003 Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokersChest.  123:181-186. 2003
2003 Receiver operating characteristic (ROC) to determine cut-off points of biomarkers in lung cancer patientsDisease Markers.  19:273-278. 2003
2003 Risk biomarker assessment for breast cancer progression: Replication precision of nuclear morphometry 2003
2003 Serum protein expression profiling for cancer detection: Validation of a SELDI-based approach for prostate cancerDisease Markers.  19:185-195. 2003
2002 Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation 2002
2002 Cancer incidence among triazine herbicide manufacturing workersJournal of Occupational and Environmental Medicine.  44:1048-1058. 2002
2002 A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumorsClinical Cancer Research.  8:3092-3099. 2002
2002 A phase II breast cancer chemoprevention trial of oral α-difluoromethylornithine: Breast tissue, imaging, and serum and urine biomarkersClinical Cancer Research.  8:3105-3117. 2002
2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor modelInternational Journal of Cancer.  101:270-279. 2002
2002 The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity 2002
2002 Transforming growth factor-α: A surrogate endpoint biomarker?Journal of The American College of Surgeons.  195:149-158. 2002
2002 Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lungClinical Cancer Research.  8:734-744. 2002
2002 Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancerJournal of Biological Chemistry.  277:25431-25438. 2002
2002 Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal womenInternational Journal of Cancer.  98:118-127. 2002
2002 Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: A sensitive method for assessing 5-fluorocytosine toxicity in VitroAnalytical Biochemistry.  301:189-199. 2002
2002 Molecular staging of colorectal cancer in African-American and caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 and p27kip-1International Journal of Cancer.  97:403-409. 2002
2002 10 Role of global methylation of dma in lung carcinomaHandbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas.  1:181-187. 2002
2002 A phase I study of combined modality90Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancerClinical Cancer Research.  8:2806-2811. 2002
2002 A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesisGynecologic Oncology.  87:57-63. 2002
2002 Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology 2002
2002 Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: Preclinical evaluation of NSAIDs as chemopreventive agentsClinical Cancer Research.  8:202-209. 2002
2002 Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in miceRadiology.  223:417-425. 2002
2002 Paradigms for primary prevention of ovarian carcinomaCA: A Cancer Journal for Clinicians.  52:216-225. 2002
2002 Review of the 2002 annual meeting of the biological stain commission 2002
2001 Altered subcellular localization of Suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomasClinical Cancer Research.  7:3495-3503. 2001
2001 Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivoNature Biotechnology.  19:838-842. 2001
2001 Intraperitoneal radioimmunochemotherapy of ovarian cancer: A phase I studyCancer Biotherapy and Radiopharmaceuticals.  16:305-315. 2001
2001 Genetic dissection of age-related changes of immune function in miceScandinavian Journal of Immunology.  54:10-20. 2001
2001 Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2 and p53Annals of Surgery.  233:630-638. 2001
2001 Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer.Urology.  57:220-223. 2001
2001 Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention. 2001
2001 Molecular characterization of colorectal neoplasia in translational researchArchives of Pathology and Laboratory Medicine.  125:91-98. 2001
2001 Advanced concepts in fixation: 1. Effects of fixation on immunohistochemistry, reversibility of fixation and recovery of proteins, nucleic acids, and other molecules from fixed and processed tissues. 2. Developmental methods of fixationJournal of Histotechnology.  24:201-210. 2001
2001 Altered global methylation of DNA: An epigenetic difference in susceptibility for lung cancer is associated with its progressionHuman Pathology.  32:856-862. 2001
2001 Avoiding biohazards in medical, veterinary and research laboratories 2001
2001 Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancerUrology.  57:220-223. 2001
2001 Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancersMolecular Therapy.  3:385-394. 2001
2001 Effects of time and temperature during attachment of sections to microscope slides on immunohistochemical detection of antigens 2001
2001 Fatty acid synthase: An early molecular marker of progression of prostatic adenocarcinoma to androgen independence 2001
2001 Immunohistochemical expression of molecular markers in an avian model: A potential model for preclinical evaluation of agents for ovarian cancer chemopreventionGynecologic Oncology.  81:373-379. 2001
2001 Introduction to the theory and practice of fixation of tissuesJournal of Histotechnology.  24:173-190. 2001
2001 Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands 2001
2001 Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiationJournal of Investigative Dermatology.  117:1412-1420. 2001
2001 The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen 2001
2001 The effects of tissue processing variables other than fixation on histochemical staining and immunohistochemical detection of antigensJournal of Histotechnology.  24:213-219. 2001
2001 The use of fixatives in diagnostic pathologyJournal of Histotechnology.  24:151-152. 2001
2000 Increase of GKLF messenger RNA and protein expression during progression of breast cancerCancer Research.  60:6488-6495. 2000
2000 Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomasClinical Cancer Research.  6:4017-4025. 2000
2000 BC1-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomasInternational Journal of Cancer.  89:423-430. 2000
2000 Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas.International Journal of Cancer.  89:423-430. 2000
2000 Methods of antigen recovery vary in their usefulness in unmasking specific antigens in immunohistochemistryApplied Immunohistochemistry and Molecular Morphology.  8:236-243. 2000
2000 Longitudinal analysis of mammary cancer multiplicity in chemoprevention studies 2000
2000 Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumorsCancer Research.  60:4305-4310. 2000
2000 The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNACancer.  89:171-176. 2000
2000 Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high-affinity peptide radiolabeled with 99mTc or 188ReJournal of Nuclear Medicine.  41:887-895. 2000
2000 The p44(S10) locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanomaOncogene.  19:1419-1427. 2000
2000 A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivoMolecular Therapy.  2:562-578. 2000
2000 Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models 2000
2000 Immunohistochemical evaluation of global DNA methylation: Comparison with in vitro radiolabeled methyl incorporation assay 2000
2000 Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation 2000
2000 The expression of Ep-CAM (17-1A) in squamous cell cancers of the lungHuman Pathology.  31:482-487. 2000
2000 The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lungHuman Pathology.  31:1068-1073. 2000
1999 Phase II study of interferon-enhanced 131I-labeled high affinity CC49 monoclonal antibody therapy in patients with metastatic prostate cancer.Clinical Cancer Research.  5:3254s-3258s. 1999
1999 Transforming growth factor α (TGF-α) expression in dysplastic oral leukoplakia: Modulation by 13-cis retinoic acid 1999
1999 Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinomaInternational Journal of Cancer.  82:424-429. 1999
1999 Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue 1999
1999 Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF 1999
1999 Evaluation of biomarker modulation by fenretinide in prostate cancer patientsEuropean Urology.  35:429-438. 1999
1999 Recommended policies for uses of human tissue in research, education, and quality controlArchives of Pathology and Laboratory Medicine.  123:296-300. 1999
1999 Changes in cyclin dependent kinase inhibitors p21 and p27 during the castration induced regression of the CWR22 model of prostatic adenocarcinoma 1999
1999 Combined modality therapy of A431 human epidermoid cancer using anti- EGFR antibody C225 and radiationCancer Biotherapy and Radiopharmaceuticals.  14:451-463. 1999
1999 Ep-CAM levels in prostatic adenocarcinoma and prostatic intraepithelial neoplasia 1999
1999 Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectorsCancer Gene Therapy.  6:209-219. 1999
1998 Nuclear accumulation of p53 in colorectal adenocarcinoma prognostic importance differs with race and location of the tumorCancer.  83:2456-2467. 1998
1998 Genetic induction of antigens and receptors as targets for cancer radiotherapyTumor Targeting.  3:122-137. 1998
1998 Providing human tissues for research: How to establish a programArchives of Pathology and Laboratory Medicine.  122:1065-1076. 1998
1998 Radiosensitization mediated by a transfected anti-ERBB-2 single-chain antibody in vitro and in vivo 1998
1998 Chimeric antibodies with specificity for tumor antigens: Demonstration of in situ localization to tumors after antibody therapy 1998
1998 Models for early chemoprevention trials in breast cancer 1998
1997 Ductal distribution of annexin IIIThe FASEB Journal.  11. 1997
1997 Hormone levels and mammary epithelial cell proliferation in rats treated with a regimen of estradiol and progesterone that mimics the preventive effect of pregnancy against mammary cancer 1997
1997 Hormone levels and mammary epithelial cell proliferation in rats treated with a regimen of estradiol and progesterone that mimics the preventive effect of pregnancy against mammary cancer. 1997
1997 Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinomaInternational Journal of Cancer.  74:346-358. 1997
1997 A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrowHuman Gene Therapy.  8:157-170. 1997
1997 Aging alters zonation in the adrenal cortex of menJournal of Clinical Endocrinology and Metabolism.  82:3898-3901. 1997
1997 Assessment of genomic damage in colorectal cancer by DNA fingerprinting: Prognostic applicationsJournal of Clinical Oncology.  15:3230-3240. 1997
1997 Expression of nitric oxide synthase III in human thyroid follicular cells: Evidence for increased expression in hyperthyroidismEuropean Journal of Endocrinology.  136:649-655. 1997
1997 Intraperitoneal radioimmunotherapy of ovarian cancer with 177Lu- CC49: A phase I/II studyGynecologic Oncology.  65:94-101. 1997
1997 Re: loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. 1997
1997 The use of biomarker expression to characterize neoplastic processes 1997
1996 The effects of dihydrotestosterone on the expression of p185(erbB-2) and c-erbB-2 mRNA in the prostatic cell line LNCaP 1996
1996 Elevated serum levels of p105(erbB-2) in patients with advanced-stage prostatic adenocarcinomaInternational Journal of Cancer.  69:398-402. 1996
1996 Phase II study of dual 131I-labeled monoclonal antibody therapy with interferon in patients with metastatic colorectal cancerClinical Cancer Research.  2:1811-1818. 1996
1996 The pathologist's role in the use of human tissues in research - Legal, ethical, and other issuesArchives of Pathology and Laboratory Medicine.  120:909-912. 1996
1996 CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagusInternational Journal of Cancer.  69:254-258. 1996
1996 Intraperitoneal radioimmunotherapy of ovarian cancer with lutetium-177- CC49Journal of Nuclear Medicine.  37:1491-1496. 1996
1996 CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagus.International Journal of Cancer.  69:254-258. 1996
1996 Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene 1996
1996 Effects of mutation and growth rates on patterns of microsatellite instabilityAmerican Journal of Pathology.  148:1757-1761. 1996
1996 Dissociation of cyclic inositol phosphohydrolase activity from annexin IIIJournal of Biological Chemistry.  271:8295-8299. 1996
1996 Lymphoplasmacytic aortitis and acute aortic dissection: An uncommon associationArchives of Pathology and Laboratory Medicine.  120:402-404. 1996
1996 Biomarker expression in prostatic intraepithelial neoplasiaEuropean Urology.  30:153-166. 1996
1996 Effects of fixation and tissue processing on immunohistochemical demonstration of specific antigens 1996
1996 Expression of nm23-H1 in prostatic intraepithelial neoplasia and adenocarcinomaHuman Pathology.  27:1021-1024. 1996
1996 Silver staining methods to identify cells of the dispersed neuroendocrine systemJournal of Histotechnology.  19:225-234. 1996
1996 Theory and practice of silver staining in histopathologyJournal of Histotechnology.  19:183-195. 1996
1995 Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells.Journal of Clinical Endocrinology and Metabolism.  80:1027-1031. 1995
1995 Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomasBiochemical and molecular medicine.  56:104-107. 1995
1995 Erratum: Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells (Journal of Clinical Endocrinology and Metabolism (1995) 80 (1027-1031))Journal of Clinical Endocrinology and Metabolism.  80:1971. 1995
1995 Expression of tumor-associated glycoprotein 72 in prostatic intraepithelial neoplasia and prostatic adenocarcinomaModern Pathology.  8:260-265. 1995
1995 Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice 1995
1995 Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cellsJournal of Clinical Endocrinology and Metabolism.  80:1027-1031. 1995
1995 Immunohistochemical evaluation of the cellular localization and ontogeny of 3βhydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal GlandEndocrine Research.  21:69-80. 1995
1995 Lewis Y Antigen as Detected by the Monoclonal Antibody BR96 is Expressed Strongly in Prostatic Adenocarcinoma 1995
1995 Nesidioblastosis causing reversal of insulin-dependent diabetes and development of hyperinsulinemic hypoglycemiaDiabetes Care.  18:1379-1380. 1995
1995 Prognostic Biomarkers in Breast Cancer: Factors Affecting Immunohistochemical Evaluation 1995
1994 Expression of p160erbb-3 and p185erbb-2 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma 1994
1994 Evaluation of thyroid nodules: Clinical considerations 1994
1994 Interactions between TGF-beta and adrenocorticotropin in growth regulation of human adrenal fetal zone cells.American Journal of Physiology.  266:E495-E500. 1994
1994 Accumulation of the p53 protein occurs more frequently in metastatic than in localized prostatic adenocarcinomas 1994
1994 Counter-regulatory hormone responses to insulin-induced acute hypoglycemia in hypopituitary patientsHormone and Metabolic Research.  26:276-282. 1994
1994 Evaluation of biomarkers in breast and prostate cancerJournal of Cellular Biochemistry.  56:259-266. 1994
1994 FDA regulation of immunochemicals used in immunohistochemistry: Our view 1994
1994 Immunohistochemical localization of dehydroepiandrosterone sulfotransferase in human fetal tissuesJournal of Clinical Endocrinology and Metabolism.  78:234-236. 1994
1994 Interactions between TGF-β and adrenocorticotropin in growth regulation of human adrenal fetal zone cellsAmerican Journal of Physiology.  266. 1994
1994 Interactions between TGF-β and adrenocorticotropin in growth regulation of human adrenal fetal zone cellsAmerican Journal of Physiology.  266. 1994
1994 Retinoid modulation of biomarkers in oral leukoplakia/dysplasiaJournal of Cellular Biochemistry.  56:270-277. 1994
1994 The effects of coumarin and suramin on the growth of malignant renal and prostatic cell linesJournal of Cancer Research and Clinical Oncology.  120. 1994
1994 The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitaryMolecular and Cellular Endocrinology.  106:145-149. 1994
1994 Thyroid dysfunction in nonpregnant women 1994
1994 Thyroid function screening in newly admitted psychiatric inpatientsAnnals of Clinical Psychiatry.  6:7-12. 1994
1994 Treatment of metastatic prostate carcinoma with radiolabeled antibody CC49Journal of Nuclear Medicine.  35:1017-1022. 1994
1993 Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasiaModern Pathology.  6:733-737. 1993
1993 A Phase I Clinical Trial of Murine Monoclonal Antibody D612 in Patients with Metastatic Gastrointestinal CancerCancer Research.  53:4555-4562. 1993
1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells.American Journal of Physiology.  264:R1101-R1110. 1993
1993 Direct localization comparison of murine and chimeric B72.3 antibodies in patients with colon cancerHuman Antibodies.  4:190-197. 1993
1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cellsAmerican Journal of Physiology.  264. 1993
1993 The cooperative human tissue network. An updateCancer.  71:1391-1394. 1993
1992 Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanomaHuman Antibodies.  3:19-24. 1992
1991 Identification of bile acid-CoA:amino acid N-acyltransferase in rat kidneyBiochemical Journal.  280:821-824. 1991
1991 Systemic absorption of insulin delivered topically to the rat eyeInvestigative Ophthalmology and Visual Science.  32:3021-3027. 1991
1990 Alterations in dietary sodium affect isoproterenol-induced cardiac hypertrophyJournal of Molecular and Cellular Cardiology.  22:1135-1145. 1990
1990 Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma 1990
1989 Receptors for insulin and insulin-like growth factor-I in the human adrenal glandBiochemical and Biophysical Research Communications.  165:204-211. 1989
1989 Colonic absorption of insulin: An in vitro and in vivo evaluationJournal of Pharmacology and Experimental Therapeutics.  248:567-572. 1989
1989 Cushing's syndrome. Diagnosis of the atypical patientArchives of Pathology and Laboratory Medicine.  113:727-728. 1989
1989 Dietary fish oil inhibits bleomycin-induced pulmonary fibrosis in the ratExperimental Lung Research.  15:315-329. 1989
1989 Functional and morphological studies of long-term islet allografts in the renal subcapsular space of the BB/W ratTransplantation.  47:580-582. 1989
1989 Gastrointestinal autonomic nerve tumors. 'Plexosarcomas'Archives of Pathology and Laboratory Medicine.  113:846-853. 1989
1989 Special communication. The cooperative human tissue networkCancer.  63:1452-1455. 1989
1988 Guidelines to avoid personnel contamination by infective agents in research laboratories that use human tissues 1988
1988 Distribution of receptors for insulin and insulin-like growth factor I (somatomedin C) in the adrenal glandBiochemical and Biophysical Research Communications.  154:138-145. 1988
1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats.American Journal of Physiology.  254:E749-E755. 1988
1988 Tachybrady-arrhythmias and "spells" in a 47-year-old man.The Alabama journal of medical sciences.  25:151-158. 1988
1988 Modulation of the development of bleomycin-induced fibrosis by deferoxamineToxicology and Applied Pharmacology.  92:358-367. 1988
1988 Methods of measuring thyroid hormone levels.American Journal of Psychiatry.  145:266. 1988
1988 Demonstration of the adenosine reservoirs with nitrobenzylthioinosine in liver and diaphragm by high-performance liquid chromatographyJournal of Chromatography - Biomedical Applications.  426:249-258. 1988
1988 Effect of haemolysis on radioimmunoassay for insulinDiabetologia.  31:403-404. 1988
1988 Effect of iron deficiency on bleomycin-induced lung fibrosis in the hamsterThe American review of respiratory disease.  137:85-89. 1988
1988 Lactate dehydrogenase isolated from human liver mitochondria: Its purification and partial biochemical characterizationClinical Biochemistry.  21:231-237. 1988
1988 Neuroendocrine differentiation in prostatic carcinomas. A retrospective autospy studyArchives of Pathology and Laboratory Medicine.  112:1100-1105. 1988
1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult ratsAmerican Journal of Physiology.  254. 1988
1988 Pathology of the adrenal glandSeminars in Roentgenology.  23:323-331. 1988
1988 Stability and electrophoretic characteristics of creatine kinase BB extracted from human brain and intestine 1988
1987 A 35-year-old black woman with hypokalemia and accelerated hypertension.The Alabama journal of medical sciences.  24:31-40. 1987
1987 Availability of human tissues for research in cancer [4]Science.  237:10-11. 1987
1987 Detection of high incidence of K-ras oncogenes during human colon tumorigenesisNature.  327:298-303. 1987
1987 Effect of temperature on argyrophil impregnation: Development of a high temperature rapid argyrophil procedure 1987
1987 Effects of dietary fats on bleomycin-induced pulmonary fibrosisExperimental Lung Research.  12:149-161. 1987
1987 High incidence of c-K-ras oncogenes in human colon cancer detected by the RNAse A mismatch cleavage methodJournal of Tumor Marker Oncology.  2:113-123. 1987
1987 New developments in understanding phenytoin-induced gingival hyperplasia.Journal of the American Dental Association.  114:814-816. 1987
1986 Elevated Atypical Creatine Kinases 1986
1986 A small adrenocortical carcinoma with aggressive behavior. An evaluation of criteria for malignancyArchives of Pathology and Laboratory Medicine.  110:1076-1079. 1986
1986 Cytogenetics of medullary carcinoma of the thyroidCancer Genetics.  20:247-253. 1986
1986 A methyl green nuclear stain for argyrophil proceduresLaboratory Medicine.  17:532-534. 1986
1986 Histologic variation in the skin lesions of the glucagonoma syndromeAmerican Journal of Surgical Pathology.  10:445-453. 1986
1985 Cushing's syndrome. Screening methods in hospitalized patientsArchives of Pathology and Laboratory Medicine.  109:222-229. 1985
1985 Nonresolving cushing's syndrome due to depot methylprednisolone verified by high-performance liquid chromatographySouthern Medical Journal.  78:1143-1144. 1985
1985 Plasmacytoid-T-cell lymphoma associated with chronic myeloproliferative disorderAmerican Journal of Surgical Pathology.  9:380-387. 1985
1984 Corticotropin production by tumors of the autonomic nervous systemArchives of Pathology and Laboratory Medicine.  108:545-550. 1984
1984 Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma) - Light and electron microscopic study confirming the origin of the neoplasmDigestive Diseases and Sciences.  29:275-284. 1984
1984 Abnormal Lactate Dehydrogenase Isoenzyme Pattern in a Critically 111 PatientSouthern Medical Journal.  77:921-923. 1984
1984 Aldosterone blocks adrenal compensatory hypertrophy in the rat 1984
1984 Aldosterone blocks adrenal compensatory hypertrophy in the rat 1984
1984 Clinical significance and partial biochemical characterization of lactate dehydrogenase isoenzyme 6 1984
1984 Golden syrian hamsters: A new experimental model for adrenal compensatory hypertrophyEndocrinology.  114:1490-1495. 1984
1984 LD-6 isoenzyme and lactate-independent dehydrogenase differ. 1984
1982 Radiology rounds: fever of unknown origin in a 48-year-old man seven years after mesocaval shunt.The Alabama journal of medical sciences.  19:289-295. 1982
1982 An extra-adrenal pheochromocytoma mimicking lymph node metastasis from a cervical cancerGynecologic Oncology.  13:416-422. 1982
1982 Functional carotid paragangliomas. Biochemical, ultrastructural, and histochemical correlation with clinical symptomsArchives of Pathology and Laboratory Medicine.  106:599-603. 1982
1982 Squamous cell carcinoma metastatic to placenta and ovaryObstetrics and Gynecology.  59:81S-83S. 1982
1981 Membranous nephropathy in a renal allograft. Its occurrence in a patient with previous anti-glomerular basement membrane diseaseArchives of Pathology and Laboratory Medicine.  105:71-75. 1981
1978 Organization of the medial hypothalamus for control of adrenocorticotropin in the catEndocrinology.  103:957-970. 1978
1976 Inhibitory and facilitatory areas of the rostral pons mediating acth release in the catEndocrinology.  99:1220-1228. 1976
1975 Hypothalamic cells in an area mediating ACTH release respond to right atrial stretchAmerican Journal of Physiology.  228:1039-1045. 1975
1974 Inhibitory and facilitatory hypothalamic areas mediating ACTH release in the catEndocrinology.  95:1450-1461. 1974
1973 Localized hypothalamic area related to neural control of ACTHThe FASEB Journal.  32:448. 1973
1966 Wide-line NMR study of molecular motion in [Me3SiNSiMe 2]2Journal of Chemical Physics.  45:1954-1960. 1966


Year Title Altmetric
2013 New NSAID targets and derivatives for colorectal cancer chemoprevention.  Ed. 191.  2013


Year Title Altmetric
2017 Biobank and expertise networks.  111-135. 2017
2017 Safety issues in biorepositories.  65-83. 2017
2017 Safety and the Biorepository.  479-492. 2017
2016 Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository..  1-38. 2016
2014 The effects of exosomes and related vesicles on cancer development, progression, and dissemination.  107-129. 2014
2013 Human tissue biorepository.  483-497. 2013
2012 Biomarkers and the genetics of early neoplastic lesions.  41-64. 2012
2012 Development and progression of colorectal neoplasia.  235-265. 2012
2009 General Considerations Concerning Safety in Biomedical Research Laboratories.  563-572. 2009
2006 Biology of breast cancer: Molecular and pathologic features of ductal neoplasia of the breast: Racial considerations.  39-70. 2006

Research Overview

  • Our laboratory is focused on understanding the molecular features of epithelial cancers such as prostate, pancreas, mammary, colorectal and ovarian adenocarcinomas as well as squamous cell lesions of oral cavity, esophagus, lung, cervix and skin in order to identify biomarkers associated either with early pre-invasive neoplastic lesions or with advanced stage malignant lesions. Of special interest are biomarkers that can be used to aid in determining prognosis or risk assessment or in predicting therapy. For example, the earliest putative pre-invasive lesion of the prostate is prostatic intraepithelial neoplasia (PIN); we have demonstrated the phenotypic expression of molecular markers in PIN is similar to the phenotypic expression of these same molecular markers in prostatic adenocarcinomas. We study the escape of PCa from the requirement for androgens, i.e., development of androgen resistance. We use the human xenograft tumor models CWR22, LNCaP, DU145 and PC-3 in nude mice to investigate androgen effects on prostate tumors and the development of androgen resistance in these tumors. These data are supplemented by in vitro studies. In colorectal adenocarcinoma (CRCs), we have identified six molecular markers that aid in identifying aggressive subgroups of CRCs. These are p53, Bcl-2, p27kip-1, Suppressin, MUC-1 and MUC-2. We have identified differences in prognostic usefulness of biomarkers based on the anatomic location of CRCs. Our studies also have focused on the racial differences in the expression of these molecular markers as well as racial differences in the clinical importance of the expression of these biomarkers. Our studies of breast neoplasia also have emphasized racial differences in molecular features of ductal carcinoma. Besides our interests in epithelial neoplasia, we have a broad interest in diffuse pulmonary diseases including pulmonary arterial hypertension as well as tissue reparative processes leading to granulation tissues and neovascularity. In general our laboratory utilizes proteomic techniques but also has capabilities in molecular biology. In addition to quantitative immunohistochemistry (fluorescent or bright field), Western blotting, high throughput ELISA, multiplex immunoassays (Luminex and MESO), we have a SELDI-TOF-MS system for identification of unique proteomic patterns and we collaborate using other mass spectrometry systems in the early detection of cancers by determining the proteins of specific cancers in biological fluids such as serum. We also have automated cytomorphometric instrumentation and tissue arrays that can be used in multi-tissue analyses. Similarly, we can use gene chip (affymetrix) and spotted array analysis in gene discovery. Of great interest are collaborative efforts to improve the biomathematic/statistical approaches to evaluating biomarkers and multiplex methods of analysis and how bias in collecting and processing tissue samples may affect multiplex assays. Also, for the last two decades we have provided human tissues to support the research of biomedical investigators throughout North America. In this effort, sponsored primarily by the Cooperative Human Tissue Network (CHTN), we have introduced to tissue resources the utilization of quality control of tissues provided for research and we have been involved in database development for tissue resources. We also have great expertise in how fixation of tissues interacts with the stages of tissue processing to affect immunorecognition and other molecular assays.

    Grant Support (P.I.)

    Biomarker Reference Laboratory – Early Detection Research Network (EDRN)
    Tissue Resource and Molecular Pathology Core of the Breast SPORE
    Tissue Research and Molecular Pathology Core of the Pancreatic SPORE
    Cooperative Human Tissue Network (CHTN)
    Pulmonary Hypertension Breakthrough Initiative (PHBI)

    Goals – Multiplex Assays in Early Detection, Risk Assessment and Prognosis.
  • Principal Investigator On

  • A Metabolomics Approach to Define a Novel Chemopreventive Pathway  awarded by University of South Alabama
  • Active - Tissue Procurement - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Biomarkers in the Detection of Prostate Cancer in African Americans  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • COMPLETED - Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 2: Molecular Regulation of Kaiso in Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Center for Tissue Processing to Support Research in Pulmonary Arterial Hypertension  awarded by CARDIOVASCULAR MEDICAL RESEARCH AND EDUCATION FUND
  • Collaborative Human Tissue Network  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS
  • Cooperative Human Tissue Network  awarded by National Cancer Institute/NIH/DHHS
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Bioethics Shared Resource  awarded by National Cancer Institute/NIH/DHHS
  • Multicenter Genetic Epigenetic & Expression Analysis of DCIS Outcome Predictors  awarded by Johns Hopkins University
  • Novel Sulindac Derivatives for Colon Cancer Chemoprevention  awarded by University of South Alabama
  • PHBI Transition  awarded by Indiana University
  • Phosphodiesterase 5: A Novel Target and Inhibitor for Breast Cancer Chemoprevention  awarded by University of South Alabama
  • Private Grant  awarded by ROCKLAND IMMUNOCHEMICALS
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC.
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC.
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC.
  • Pulmonary Hypertension Breakthrough Initiative  awarded by University of Colorado
  • Pulmonary Hypertension Breakthrough Initiative  awarded by Indiana University
  • SPORE in Breast Cancer - Tissue Core  awarded by National Cancer Institute/NIH/DHHS
  • The Importance of ENT in Breast Cancer in African American Women  awarded by George Washington University
  • Theranostic Nanoparticles For Detection and Treatment of Pancreatic Cancer  awarded by BOARD OF TRUSTEES OF THE UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER
  • Theranostic Nanoparticles for Detection and Treatment of Pancreatic Cancer  awarded by WAKE FOREST UNIVERSITY
  • Tissue Resource Site (TSS) in Support of the The Cancer Genome Atlas (TCGA) Program - Admin Core  awarded by SAIC - FREDERICK
  • Tissue Resource Site (TSS) in Support of the The Cancer Genome Atlas (TCGA) Program - Task Order 1  awarded by SAIC - FREDERICK
  • Tissue Source Site (TSS) in Support of the NCI Clinical Assay Development Program - Admin Core  awarded by SAIC - FREDERICK
  • Transcriptional Repressor Kaiso Promotes Metastasis through Epithelial to Mesenchymal Transition  awarded by TUSKEGEE UNIVERSITY
  • UAB / UMN SPORE in Pancreatic Cancer - Core B  awarded by National Cancer Institute/NIH/DHHS
  • UAB Skin Disease Research Center - Tissue Resources and Molecular Pathology Core - Core C  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Investigator On

  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS
  • A Specific Screening Strategy to Reduce Prostate Cancer Mortality  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Breast Tumor Tissue-Derived Hedgehog Morphogens Immunoedit the Polarization of Breast Cancer Associated Macrophages  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS
  • Exploring Effects of Weight Loss on Ductal Carcinoma In Situ  awarded by National Cancer Institute/NIH/DHHS
  • Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Glycosylation-Dependent Mechanisms Regulating Ovarian Tumor Cell Survival  awarded by National Institute of General Medical Sciences/NIH/DHHS
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Mechanisms of Resistance to Cancer Therapeutics  awarded by National Cancer Institute/NIH/DHHS
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS
  • Networks of Tissue Source Site (TSS) in Support of the Cancer Genome Atlas (TCGA) Program  awarded by Washington University
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC.
  • SPORE in Breast Cancer  awarded by National Cancer Institute/NIH/DHHS
  • Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression  awarded by National Cancer Institute/NIH/DHHS
  • TGFBR1 Signaling in Colorectal Cancer  awarded by National Cancer Institute/NIH/DHHS
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • UAB / UMN SPORE in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS
  • UAB / UMN SPORE in Pancreatic Cancer - Project 1  awarded by National Cancer Institute/NIH/DHHS
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Education And Training

  • Vanderbilt University Medical Center, Internship
  • UAB Hospital, Residency
  • Doctor of Medicine, Johns Hopkins University 1977
  • Doctor of Philosophy in Biophysics, Johns Hopkins University 1975
  • Full Name

  • William Grizzle