Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 TBCRC 002: A phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer 2020
2020 Hallmarks and Determinants of Oncogenic Translation Revealed by Ribosome Profiling in Models of Breast Cancer 2020
2020 Therapeutically actionable PAK4 is amplified, overexpressed, and involved in bladder cancer progression 2020
2019 Inclusiveness and ethical considerations for observational, translational, and clinical cancer health disparity research 2019
2019 Issues in the use of human tissues to support precision medicine 2019
2019 Self-Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsy 2019
2019 Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023)) 2019
2019 Biobank: What's in a Name? 2019
2019 Biological, medical, and other tissue variables affecting biospecimen utilization 2019
2019 Biospecimen utilization: A critical challenge in global bioresource/biobanking operations 2019
2019 Commentary on improving biospecimen utilization by classic biobanks: Identifying past and minimizing future mistakes 2019
2019 The importance of human tissue bioresources in advancing biomedical research 2019
2019 The utilization of biospecimens: Impact of the choice of biobanking model 2019
2018 Lessons Learned During Three Decades of Operations of Two Prospective Bioresources 2018
2018 Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle 2018
2018 Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer 2018
2018 A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily 2018
2018 A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression 2018
2018 Nitrocellulose tissue prints: An innovative approach to preparing high quality DNA and RNA from prostate biopsies without compromising the cores for pathology diagnosis 2018
2018 Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c 2018
2018 Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients 2018
2018 Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060)) 2018
2018 Factors that drive the increasing use of FFPE tissue in basic and translational cancer research 2018
2018 Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075)) 2018
2018 AR negative triple negative or “Quadruple Negative” breast cancers in African American women have an enriched basal and immune signature 2018
2018 Reply to "phase II prospective randomized trial of weight loss prior to radical prostatectomy 2018
2018 Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition 2018
2018 The Immune Landscape of Cancer 2018
2018 A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers 2018
2018 Genomic and Functional Approaches to Understanding Cancer Aneuploidy 2018
2018 lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer 2018
2018 A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples 2018
2018 An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics 2018
2018 Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer 2018
2018 Comprehensive Characterization of Cancer Driver Genes and Mutations 2018
2018 Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation 2018
2018 Oncogenic Signaling Pathways in The Cancer Genome Atlas 2018
2018 Pathogenic Germline Variants in 10,389 Adult Cancers 2018
2018 Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics 2018
2018 Driver Fusions and Their Implications in the Development and Treatment of Human Cancers 2018
2018 Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas 2018
2018 Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas 2018
2018 Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types 2018
2018 Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas 2018
2018 Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers 2018
2018 Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context 2018
2018 Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types 2018
2018 Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images 2018
2018 Systematic Analysis of Splice-Site-Creating Mutations in Cancer 2018
2018 The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma 2018
2018 Shifting sands: the complexities and uncertainties of the evolving US regulatory, policy, and scientific landscape for biospecimen research 2018
2018 Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas 2018
2018 Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines 2018
2018 Standard PREanalytical Code Version 3.0 2018
2017 Epigenetic risk score improves prostate cancer risk assessment 2017
2017 Translational dysregulation in cancer: Molecular insights and potential clinical applications in biomarker development 2017
2017 Noninvasive imaging of colitis using multispectral optoacoustic tomography 2017
2017 Erratum: Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer. [BMC Cancer, 16 (2016) (61)] 2017
2017 Genomic regulation of invasion by STAT3 in triple negative breast cancer 2017
2017 Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling 2017
2017 Presurgical weight loss affects tumour traits and circulating biomarkers in men with prostate cancer 2017
2016 Effects of Cold Ischemia on Gene Expression: A Review and Commentary 2016
2016 Construction and validation of a multi-institutional tissue microarray of invasive ductal carcinoma from racially and ethnically diverse populations 2016
2016 IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells 2016
2016 RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4 2016
2016 Exploring effects of presurgical weight loss among women with stage 0-II breast cancer: Protocol for a randomised controlled feasibility trial 2016
2016 Occult Metastases in Pelvic Lymphadenectomy Specimens From Patients With Urothelial Carcinoma of the Bladder 2016
2016 Current and emerging clinical applications of multispectral optoacoustic tomography (MSOT) in oncology 2016
2016 Acidic pH-Targeted Chitosan-Capped Mesoporous Silica Coated Gold Nanorods Facilitate Detection of Pancreatic Tumors via Multispectral Optoacoustic Tomography 2016
2016 A standard tissue as a control for histochemical and immunohistochemical staining 2016
2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype 2016
2016 Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy 2016
2016 Expression of the MHC Class II Pathway in Triple-Negative Breast Cancer Tumor Cells Is Associated with a Good Prognosis and Infiltrating Lymphocytes. 2016
2016 Preservation of Biospecimens at Ambient Temperature: Special Focus on Nucleic Acids and Opportunities for the Biobanking Community 2016
2016 SPARC-independent delivery of nab-paclitaxel without depleting tumor stroma in patient-derived pancreatic Cancer xenografts 2016
2016 Feasibility outcomes of a presurgical randomized controlled trial exploring the impact of caloric restriction and increased physical activity versus a wait-list control on tumor characteristics and circulating biomarkers in men electing prostatectomy for prostate cancer 2016
2016 Surveying the serologic proteome in a tissue-specific kras(G12D) knockin mouse model of pancreatic cancer 2016
2016 Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974 2016
2016 A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines 2016
2016 Factors affecting the use of human tissues in biomedical research: Implications in the design and operation of a biorepository 2016
2016 The other face of miR-17-92a cluster, exhibiting tumor suppressor effects in prostate cancer 2016
2016 The rank pathway in advanced breast cancer: Does Src play a role? 2016
2015 Missed Opportunities and Lost Lives: Consequences of Some Proposed Changes to Regulations on Research with Human Tissues-Letter 2015
2015 Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography 2015
2015 Targeting acidity in pancreatic Adenocarcinoma: Multispectral Optoacoustic tomography detects ph-low insertion peptide probes in vivo 2015
2015 Small molecule inhibitors of IRES-mediated translation 2015
2015 High throughput kinomic profiling of human clear cell renal cell carcinoma identifies kinase activity dependent molecular subtypes 2015
2015 TBCRC 019: A phase II trial of nanoparticle albumin-bound paclitaxel with or without the anti-death receptor 5 monoclonal antibody tigatuzumab in patients with triple-negative breast cancer 2015
2015 Clinical implications of rabphillin-3A-like gene alterations in breast cancer 2015
2015 Quality management of biorepositories 2015
2015 PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers 2015
2015 Phosphodiesterase 10A: A novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity 2015
2015 S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase 2015
2015 The protective effect of p16 INK4a in oral cavity carcinomas: p16 Ink4A dampens tumor invasion-integrated analysis of expression and kinomics pathways 2015
2014 A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression 2014
2014 Pazopanib combined with radiation: In vivo model of interaction 2014
2014 IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt 2014
2014 Erythropoietin upregulation in pulmonary arterial hypertension 2014
2014 Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling 2014
2014 Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthood 2014
2014 Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study 2014
2014 Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model 2014
2014 Anterior gradient protein-2 is a regulator of cellular adhesion in prostate cancer 2014
2014 A framework for biobank sustainability 2014
2014 A functional anatomic defect of the cystic fibrosis airway 2014
2014 An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load 2014
2014 Effect of niclosamide on basal-like breast cancers 2014
2014 Exosomes: A novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions 2014
2014 L-Methionine inhibits growth of human pancreatic cancer cells 2014
2014 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1 2014
2014 NSAIDs inhibit tumorigenesis, but how? 2014
2014 Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas 2014
2014 Recurrent read-through fusion transcripts in breast cancer 2014
2014 The effects of frozen tissue storage conditions on the integrity of RNA and protein 2014
2013 COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs 2013
2013 The effect of antigen retrieval on cells fixed in 10% neutral buffered formalin followed by transfer to 70% ethanol 2013
2013 Retargeting of gene expression using endothelium specific hexon modified adenoviral vector 2013
2013 It is primarily the control of transcription and post-transcriptional processing that are critical to the development and progression of sporadic neoplasias 2013
2013 Post-transcriptional processing of genetic information and its relation to cancer 2013
2013 Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer 2013
2013 Lung resistance-related protein (LRP) expression in malignant ascitic cells as a prognostic marker for advanced ovarian serous carcinoma 2013
2013 Significant variation of immunohistochemical marker expression in paired primary and metastatic clear cell renal cell carcinomas 2013
2013 Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress wnt/β-catenin signaling 2013
2013 Use of human specimens in research: The evolving United States regulatory, policy, and scientific landscape 2013
2013 An undesired effect of chemotherapy: Gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factorκb- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4 2013
2013 The prognostic value of MicroRNAs varies with patient race/ethnicity and stage of colorectal cancer 2013
2013 Frequencies of mtDNA mutations in primary tissue of colorectal adenopolyps 2013
2013 Mouse model findings and the future of human tissue in disease research 2013
2013 An Extensive Targeted Proteomic Analysis of Disease-Related Protein Biomarkers in Urine from Healthy Donors 2013
2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to Sepsis 2013
2013 A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy 2013
2013 Preservation of immunorecognition by transferring cells from 10% neutral buffered formalin to 70% ethanol 2013
2013 Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells 2013
2013 Exosomes are endogenous nanoparticles that can deliver biological information between cells 2013
2013 Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis 2013
2013 Return of research results from genomic biobanks: A call for data 2013
2013 Return of research results from genomic biobanks: Cost matters 2013
2013 Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography 2013
2013 Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53 2013
2012 CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: Implications for bidirectional tumor-stromal interactions 2012
2012 Alcohol and tobacco lower the age of presentation in sporadic pancreatic cancer in a dose-dependent manner: A multicenter study 2012
2012 Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: Potential role in castration resistance 2012
2012 Nuclear kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells 2012
2012 Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human 2012
2012 A critical need for increased understanding of the use of human tissues in biomedical research 2012
2012 Modern age pathology of pulmonary arterial hypertension 2012
2012 A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease 2012
2012 A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity 2012
2012 Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer 2012
2012 18F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts 2012
2012 Exosomes and immune surveillance of neoplastic lesions: A review 2012
2012 Practical implementation issues and challenges for biobanks in the return of individual research results 2012
2012 Clinical and biological significance of KISS1 expression in prostate cancer 2012
2012 Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73 2012
2012 Predictors of long-term outcome from intraperitoneal radioimmunotherapy for ovarian cancer 2012
2012 BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9. 2012
2012 Corrigendum: Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain 2012
2012 MiRNAs are stable in colorectal cancer archival tissue blocks 2012
2012 Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression 2012
2011 Biomarkers and the genetics of early neoplastic lesions 2011
2011 Development and progression of colorectal neoplasia 2011
2011 Issues in collecting, processing and storing human tissues and associated information to support biomedical research 2011
2011 The biology of incipient, pre-invasive or intraepithelial neoplasia 2011
2011 Translational pathology of early cancer 2011
2011 Translational pathology of neoplasia 2011
2011 MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells 2011
2011 Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins 2011
2011 What are the most oppressing legal and ethical issues facing biorepositories and what are some strategies to address them 2011
2011 Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy 2011
2011 The human face of biobank networks for translational research 2011
2011 MiR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT 2011
2011 Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer 2011
2011 Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathway 2011
2011 Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells 2011
2011 Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice 2011
2011 PCCR: Pancreatic cancer collaborative registry 2011
2011 Early therapy evaluation of combined cetuximab and irinotecan in orthotopic pancreatic tumor xenografts by dynamic contrast-enhanced magnetic resonance imaging 2011
2011 Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer 2011
2011 Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages 2011
2011 CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion 2011
2011 CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion 2011
2011 LL-37 as a therapeutic target for late stage prostate cancer 2011
2011 Self-calibrated warping for mass spectra alignment 2011
2011 Author's reply 2011
2011 Exosomes and cancer: A newly described pathway of immune suppression 2011
2011 L-methionine-induced alterations in molecular signatures in MCF-7 and LNCaP cancer cells 2011
2011 Serum biomarker panels for the detection of pancreatic cancer 2011
2011 DCE-MRI detects early vascular response in breast tumor xenografts following anti-DR5 Therapy 2011
2011 A migration signature and plasma biomarker panel for pancreatic adenocarcinoma 2011
2011 Erratum: Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples (Journal of Biomedical Optics (2010) 15 (067005)) 2011
2011 The national lung screening trial: Overview and study design 2011
2011 Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain 2011
2010 Bax expression is a candidate prognostic and predictive marker of colorectal cancer. 2010
2010 KISS1 over-expression suppresses metastasis of pancreatic adenocarcinoma in a xenograft mouse model 2010
2010 A phase I study of a tropism-modified conditionally replicative adenovirus for recurrent malignant gynecologic diseases 2010
2010 CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide 2010
2010 Development of combination tapered fiber-optic biosensor dip probe for quantitative estimation of interleukin-6 in serum samples 2010
2010 Standards for immunohistochemical imaging: A protein reference device for biomarker quantitation 2010
2010 Analysis of mtDNA sequence variants in colorectal adenomatous polyps 2010
2010 CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion 2010
2010 Gli1 promotes cell survival and is predictive of a poor outcome in ERα-negative breast cancer 2010
2010 Prognostic value of mucin 4 expression in colorectal adenocarcinomas 2010
2010 NSAIDs: Old drugs reveal new anticancer targets 2010
2010 CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion 2010
2010 The deployment of a tissue request tracking system for the CHTN: A case study in managing change in informatics for biobanking operations 2010
2010 Comparison of the predictive qualities of three prognostic models of colorectal cancer 2010
2010 Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES 2010
2010 Suppression by L-methionine of cell cycle progression in LNCaP and MCF-7 cells but not benign cells 2010
2010 A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes 2010
2010 Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells 2010
2010 Organizational issues in providing high-quality human tissues and clinical information for the support of biomedical research. 2010
2010 TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes 2010
2009 Immature myeloid cells induced by a high-fat diet contribute to liver inflammation 2009
2009 Mandatory fortification with folic acid in the United States appears to have adverse effects on histone methylation in women with pre-cancer but not in women free of pre-cancer 2009
2009 Dual effects of TGF-β On ERα-mediated estrogenic transcriptional activity in breast cancer 2009
2009 Combined effects of formalin fixation and tissue processing on immunorecognition Fixation effects on immunostaining 2009
2009 Anosmin-1 involved in neuronal cell migration is hypoxia inducible and cancer regulated 2009
2009 Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines 2009
2009 Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance 2009
2009 Experimental cancer therapy using restoration of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression 2009
2009 CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma 2009
2009 Combined effects of formalin fixation and tissue processing on immunorecognition. 2009
2009 Special symposium: fixation and tissue processing models. 2009
2009 Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion 2009
2009 Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis 2009
2009 Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model 2009
2009 Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1 2009
2009 How to efficiently obtain human tissues to support specific biomedical research projects 2009
2009 Induction of myeloid-derived suppressor cells by tumor exosomes 2009
2009 Regulation of p53 by TopBP1: A potential mechanism for p53 inactivation in cancer 2009
2009 Prognostic significance of p53 Codon 72 polymorphism differs with race in colorectal adenocarcinoma 2009
2009 Immunohistochemical expression of rabphilin -3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas 2009
2009 CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth 2009
2009 Pulmonary Angiogenesis in a Rat Model of Hepatopulmonary Syndrome 2009
2009 Standard operating procedures for serum and plasma collection: Early detection research network consensus statement standard operating procedure integration working group 2009
2009 Timing of consent for the research use of surgically removed tissue is postoperative consenting acceptable? 2009
2008 Erratum: The efficient operation of the surgical pathology gross room (Biotechnic and Histochemistry vol. 82(3) (71-82)) 2008
2008 Immunohistochemistry in the evaluation of neovascularization in tumor xenografts 2008
2008 Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer 2008
2008 Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenograftsby diffusion-weighted magnetic resonance imaging 2008
2008 Applying proteomic-based biomarker tools for the accurate diagnosis of pancreatic cancer 2008
2008 Breast tumor xenografts: Diffusion-weighted MR imaging to assess early therapy with novel apoptosis-inducing anti-DR5 antibody 2008
2008 A standards based ontological approach to information handling for use by organizations providing human tissue for research 2008
2008 mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference 2008
2008 Vascular endothelial growth factor reduces tamoxifen efficacy and promotes metastatic colonization and desmoplasia in breast tumors 2008
2008 Quality Assurance in Tissue Resources Supporting Biomedical Research. 2008
2008 Quality assurance in tissue resources supporting biomedical research 2008
2008 Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma 2008
2008 Effect of exercise and calorie restriction on biomarkers of aging in mice 2008
2008 Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change 2008
2008 Antibody responses of variable lymphocyte receptors in the lamprey 2008
2008 The efficient operation of the surgical pathology gross room 2008
2008 p53 nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior 2008
2008 Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: Sources of sample bias 2008
2008 Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model 2008
2008 Immunohistochemical detection of EGFR, p185erbB-2, Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women 2008
2008 Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix 2008
2008 SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer 2008
2008 Thymus exosomes-like particles induce regulatory T cells 2008
2007 Comparison of predicted probabilities of proportional hazards regression and linear discriminant analysis methods using a colorectal cancer molecular biomarker database 2007
2007 Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: Implications for the molecular analysis of clinically available biopsies 2007
2007 Phosphorylated LIM kinases colocalize with γ-tubulin in centrosomes during early stages of mitosis 2007
2007 Role of microvascular density in nonlocalizing parathyroid sestamibi scans 2007
2007 TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth 2007
2007 Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice 2007
2007 Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70 2007
2007 Combination treatment with TRA-8 anti-death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancer 2007
2007 Assessment of biomarker expression in predicting pathologic response to neoadjuvant chemotherapy in patients with locally advanced breast cancer [1] 2007
2007 Erratum: SIRT1 is significantly elevated in mouse and human prostate cancer (Cancer Research (2007) 67, (6612-6618)) 2007
2007 Inactivation of Smad4 accelerates KrasG12D-mediated pancreatic neoplasia 2007
2007 SIRT1 is significantly elevated in mouse and human prostate cancer 2007
2007 Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity 2007
2007 Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer 2007
2007 Tumor exosomes inhibit differentiation of bone marrow dendritic cells 2007
2007 Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host 2007
2007 Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model 2007
2007 Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies 2007
2007 Plasma protein profiles differ between women diagnosed with cervical intraepithelial neoplasia (cin) 1 and 3. 2007
2007 Discrimination between benign and malignant prostate tissue using chromatin texture analysis in 3-D by confocal laser scanning microscopy 2007
2007 Methionine inhibits cellular growth dependent on the p53 status of cells 2007
2007 Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1 2007
2007 African-American and Caucasian disparities in colorectal cancer mortality and survival by data source: An epidemiologic review 2007
2006 Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM) 2006
2006 Plasma protein profiles differ between women diagnosed with cervical intraepithelial neoplasia (CIN) 1 and 3 2006
2006 Oncolytic HSV-1 for the treatment of brain tumours 2006
2006 Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates. 2006
2006 Mucinous expression in benign and neoplastic glandular lesions of the uterine cervix 2006
2006 Celecoxib Inhibits Cellular Growth, Decreases Ki-67 Expression and Modifies Apoptosis in Ovarian Cancer Cell Lines 2006
2006 Erratum: A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death (Journal of Immunology (2006) 176 (7385-7393)) 2006
2006 Ovarian expression of markers associated with proliferation or apoptosis in women with diminished ovarian reserve 2006
2006 Phenotypic expression of Bax is a predictive marker of 5-fluorouracil treatment in colorectal cancer. 2006
2006 A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death 2006
2006 Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model 2006
2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function 2006
2006 19 Role of Immunohistochemical Expression of Lewis Y Antigen in Ovarian Carcinoma 2006
2006 Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates: A translational research application 2006
2006 Cell density influences the effect of celecoxib in two carcinoma cell lines 2006
2006 JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α 2006
2006 Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis 2006
2006 Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array. Application to Hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma 2006
2006 Ovarian biopsy in infertile patients with ovarian dysfunction 2006
2005 Development of 3D chromatin texture analysis using confocal laser scanning microscopy 2005
2005 Implementation of accurate and fast DNA cytometry by confocal microscopy in 3D 2005
2005 Novel approaches to smoothing and comparing SELDI TOF spectra 2005
2005 Pattern of nonspecific (or global) DNA methylation in oral carcinogenesis 2005
2005 Selective cyclooxygenase-2 inhibition produces heterogeneous erythema response to ultraviolet irradiation [3] 2005
2005 The need for review and understanding of SELDI/MALDI mass spectroscopy data prior to analysis 2005
2005 Phase I study of90Y-CC49 monoclonal antibody therapy in patients with advanced non-small cell lung cancer: Effect of chelating agents and paclitaxel co-administration 2005
2005 Feasibility of performing chemoprevention trials in women at elevated risk of ovarian carcinoma: Initial examination of celecoxib as a chemopreventive agent 2005
2005 Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors 2005
2005 Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-α-positive breast cancer cells 2005
2005 Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors 2005
2005 High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas 2005
2005 Best practices for repositories I: Collection, storage, and retrieval of human biological materials for research 2005
2005 Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice 2005
2005 Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer 2005
2005 Antiangiogenic cancer gene therapy by adeno-associated virus 2-mediated stable expression of the soluble FMS-like tyrosine kinase-1 receptor 2005
2005 Cholangiocyte endothelin 1 and transforming growth factor β1 production in rat experimental hepatopulmonary syndrome 2005
2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts 2005
2005 Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer 2005
2005 Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer. 2005
2005 Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility 2005
2005 Patterns of global DNA and histone methylation appear to be similar in normal, dysplastic and neoplastic oral epithelium of humans 2005
2005 Recurrence and survival predictive value of phenotypic expression of Bcl-2 varies with tumor stage of colorectal adenocarcinoma 2005
2004 Expression and functional role of CCR9 in prostate cancer cell migration and invasion 2004
2004 Adenovirus-mediated FLT1-targeted proapoptotic gene therapy of human prostate cancer 2004
2004 CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion 2004
2004 Spontaneous pregnancy in a woman with premature ovarian failure: A case report 2004
2004 Confocal 3D DNA cytometry: Assessment of required coefficient of variation by computer simulation 2004
2004 Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator 2004
2004 Clarification in the point/counterpoint discussion related to surface-enhanced laser desorption/ionisation time-of-flight mass spectrometric identification of patients with adenocarcinomas of the prostate [3] (multiple letters) 2004
2004 Promoter hypermethylation profile of kidney cancer 2004
2004 Postsurgical disparity in survival between African Americans and Caucasians with colonic adenocarcinoma 2004
2004 The role of endothelin-1 and the endothelin B receptor in the pathogenesis of hepatopulmonary syndrome in the rat 2004
2004 Nuclear Localization of KLF4 Is Associated with An Aggressive Phenotype in Early-Stage Breast Cancer 2004
2004 Establishing a tumour bank: Banking, informatics and ethics 2004
2004 Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy: Long-Term Efficacy of a Vector Encoding Angiostatin and Endostatin over Vectors Encoding a Single Factor 2004
2004 Expression of sperm protein 17 (Sp17) in ovarian cancer 2004
2004 IL-12 Inhibits Thymic Involution by Enhancing IL-7- and IL-2-Induced Thymocyte Proliferation 2004
2004 Prognostic Significance of p27kip-1 Expression in Colorectal Adenocarcinomas Is Associated with Tumor Stage 2004
2004 Intratumor heterogeneity of biomarker expression in breast carcinomas 2004
2004 Adenoviral vector-mediated augmentation of epidermal growth factor receptor (EGFr) enhances the radiosensitization properties of anti-EGFr treatment in prostate cancer cells 2004
2004 p53 and erbB-2 are not associated in matched cases of primary and metastatic ovarian carcinomas 2004
2003 MUC1 and MUC2 Expression in Pancreatic Ductal Carcinoma Obtained by Fine-Needle Aspiration 2003
2003 Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model 2003
2003 LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: Implications in prostate cancer 2003
2003 Antitumor efficacy of TRA-8 anti-DR5 monoclonal antibody alone or in combination with chemotherapy and/or radiation therapy in a human breast cancer model. 2003
2003 Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma 2003
2003 Inhibition of tumorigenicity by the 5′-untranslated RNA of the human c-myc P0 transcript 2003
2003 Erratum: Cellular mechanism of thymic involution (Scandinavian Journal of Immunology (2003) 57 (410-422)) 2003
2003 Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity 2003
2003 Cellular mechanism of thymic involution 2003
2003 Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: A potential mechanism in experimental hepatopulmonary syndrome 2003
2003 Smad4 as a transcription corepressor for estrogen receptor α 2003
2003 Cancer incidence among triazine herbicide manufacturing workers [1] (multiple letters) 2003
2003 Aging, immunity, and tumor susceptibility 2003
2003 Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States) 2003
2003 The efficacy of 9-Cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: Results of a randomized double-blind clinical trial 2003
2003 The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP 2003
2003 The use of dimethylsulfoxide as a vehicle in cell culture experiments using ovarian carcinoma cell lines 2003
2003 Analysis of Pulmonary Heme Oxygenase-1 and Nitric Oxide Synthase Alterations in Experimental Hepatopulmonary Syndrome 2003
2003 Expression of CEA, Tag-72, and Lewis-Y Antigen in Primary and Metastatic Lesions of Ovarian Carcinoma 2003
2003 Nuclear accumulation of p53 is a potential marker for the development of squamous cell lung cancer in smokers 2003
2003 Receiver operating characteristic (ROC) to determine cut-off points of biomarkers in lung cancer patients 2003
2003 Risk biomarker assessment for breast cancer progression: Replication precision of nuclear morphometry 2003
2003 Serum protein expression profiling for cancer detection: Validation of a SELDI-based approach for prostate cancer 2003
2002 Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation 2002
2002 Analysis of the molecular quality of human tissues: An experience from the Cooperative Human Tissue Network 2002
2002 Cancer incidence among triazine herbicide manufacturing workers 2002
2002 A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumors 2002
2002 A phase II breast cancer chemoprevention trial of oral α-difluoromethylornithine: Breast tissue, imaging, and serum and urine biomarkers 2002
2002 BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model 2002
2002 The pattern of expression of Mn and Cu-Zn superoxide dismutase varies among squamous cell cancers of the lung, larynx, and oral cavity 2002
2002 Transforming growth factor-α: A surrogate endpoint biomarker? 2002
2002 Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung 2002
2002 Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer 2002
2002 Review of the 2002 annual meeting of the biological stain commission 2002
2002 Hormone receptors and proliferation in breast carcinomas of equivalent histologic grades in pre- and postmenopausal women 2002
2002 Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: A sensitive method for assessing 5-fluorocytosine toxicity in Vitro 2002
2002 Molecular staging of colorectal cancer in African-American and caucasian patients using phenotypic expression of p53, Bcl-2, MUC-1 and p27kip-1 2002
2002 10 Role of global methylation of dma in lung carcinoma 2002
2002 A phase I study of combined modality90Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer 2002
2002 A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesis 2002
2002 Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology 2002
2002 Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: Preclinical evaluation of NSAIDs as chemopreventive agents 2002
2002 Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice 2002
2002 Paradigms for primary prevention of ovarian carcinoma 2002
2001 Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer 2001
2001 Altered subcellular localization of Suppressin, a novel inhibitor of cell-cycle entry, is an independent prognostic factor in colorectal adenocarcinomas 2001
2001 Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo 2001
2001 Intraperitoneal radioimmunochemotherapy of ovarian cancer: A phase I study 2001
2001 Genetic dissection of age-related changes of immune function in mice 2001
2001 Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2 and p53 2001
2001 Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer. 2001
2001 Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention. 2001
2001 Molecular characterization of colorectal neoplasia in translational research 2001
2001 Advanced concepts in fixation: 1. Effects of fixation on immunohistochemistry, reversibility of fixation and recovery of proteins, nucleic acids, and other molecules from fixed and processed tissues. 2. Developmental methods of fixation 2001
2001 Altered global methylation of DNA: An epigenetic difference in susceptibility for lung cancer is associated with its progression 2001
2001 Avoiding biohazards in medical, veterinary and research laboratories 2001
2001 Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers 2001
2001 Effects of time and temperature during attachment of sections to microscope slides on immunohistochemical detection of antigens 2001
2001 Fatty acid synthase: An early molecular marker of progression of prostatic adenocarcinoma to androgen independence 2001
2001 Immunohistochemical expression of molecular markers in an avian model: A potential model for preclinical evaluation of agents for ovarian cancer chemoprevention 2001
2001 Introduction to the theory and practice of fixation of tissues 2001
2001 Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands 2001
2001 Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation 2001
2001 The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen 2001
2001 The effects of tissue processing variables other than fixation on histochemical staining and immunohistochemical detection of antigens 2001
2001 The use of fixatives in diagnostic pathology 2001
2000 Increase of GKLF messenger RNA and protein expression during progression of breast cancer 2000
2000 Racial differences in the prognostic usefulness of MUC1 and MUC2 in colorectal adenocarcinomas 2000
2000 BC1-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas 2000
2000 Bcl-2 expression is associated with improved prognosis in patients with distal colorectal adenocarcinomas. 2000
2000 Methods of antigen recovery vary in their usefulness in unmasking specific antigens in immunohistochemistry 2000
2000 Longitudinal analysis of mammary cancer multiplicity in chemoprevention studies 2000
2000 Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors 2000
2000 The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx is associated with global methylation of DNA 2000
2000 Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high-affinity peptide radiolabeled with 99mTc or 188Re 2000
2000 The p44(S10) locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma 2000
2000 A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo 2000
2000 Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models 2000
2000 Immunohistochemical evaluation of global DNA methylation: Comparison with in vitro radiolabeled methyl incorporation assay 2000
2000 Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation 2000
2000 The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung 2000
2000 The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung 2000
1999 Phase II study of interferon-enhanced 131I-labeled high affinity CC49 monoclonal antibody therapy in patients with metastatic prostate cancer. 1999
1999 Transforming growth factor α (TGF-α) expression in dysplastic oral leukoplakia: Modulation by 13-cis retinoic acid 1999
1999 Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinoma 1999
1999 Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue 1999
1999 Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF 1999
1999 Evaluation of biomarker modulation by fenretinide in prostate cancer patients 1999
1999 Recommended policies for uses of human tissue in research, education, and quality control 1999
1999 Changes in cyclin dependent kinase inhibitors p21 and p27 during the castration induced regression of the CWR22 model of prostatic adenocarcinoma 1999
1999 Combined modality therapy of A431 human epidermoid cancer using anti- EGFR antibody C225 and radiation 1999
1999 Ep-CAM levels in prostatic adenocarcinoma and prostatic intraepithelial neoplasia 1999
1999 Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors 1999
1998 Nuclear accumulation of p53 in colorectal adenocarcinoma prognostic importance differs with race and location of the tumor 1998
1998 Genetic induction of antigens and receptors as targets for cancer radiotherapy 1998
1998 Providing human tissues for research: How to establish a program 1998
1998 Radiosensitization mediated by a transfected anti-ERBB-2 single-chain antibody in vitro and in vivo 1998
1998 Chimeric antibodies with specificity for tumor antigens: Demonstration of in situ localization to tumors after antibody therapy 1998
1998 Models for early chemoprevention trials in breast cancer 1998
1997 Ductal distribution of annexin III 1997
1997 Hormone levels and mammary epithelial cell proliferation in rats treated with a regimen of estradiol and progesterone that mimics the preventive effect of pregnancy against mammary cancer 1997
1997 Hormone levels and mammary epithelial cell proliferation in rats treated with a regimen of estradiol and progesterone that mimics the preventive effect of pregnancy against mammary cancer. 1997
1997 Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma 1997
1997 A novel gene therapy strategy for elimination of prostate carcinoma cells from human bone marrow 1997
1997 Aging alters zonation in the adrenal cortex of men 1997
1997 Assessment of genomic damage in colorectal cancer by DNA fingerprinting: Prognostic applications 1997
1997 Expression of nitric oxide synthase III in human thyroid follicular cells: Evidence for increased expression in hyperthyroidism 1997
1997 Intraperitoneal radioimmunotherapy of ovarian cancer with 177Lu- CC49: A phase I/II study 1997
1997 Re: loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. 1997
1997 The use of biomarker expression to characterize neoplastic processes 1997
1996 The effects of dihydrotestosterone on the expression of p185(erbB-2) and c-erbB-2 mRNA in the prostatic cell line LNCaP 1996
1996 Elevated serum levels of p105(erbB-2) in patients with advanced-stage prostatic adenocarcinoma 1996
1996 Phase II study of dual 131I-labeled monoclonal antibody therapy with interferon in patients with metastatic colorectal cancer 1996
1996 The pathologist's role in the use of human tissues in research - Legal, ethical, and other issues 1996
1996 CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagus 1996
1996 Biomarker expression in prostatic intraepithelial neoplasia 1996
1996 Intraperitoneal radioimmunotherapy of ovarian cancer with lutetium-177- CC49 1996
1996 CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagus. 1996
1996 Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene 1996
1996 Effects of mutation and growth rates on patterns of microsatellite instability 1996
1996 Dissociation of cyclic inositol phosphohydrolase activity from annexin III 1996
1996 Lymphoplasmacytic aortitis and acute aortic dissection: An uncommon association 1996
1996 Effects of fixation and tissue processing on immunohistochemical demonstration of specific antigens 1996
1996 Expression of nm23-H1 in prostatic intraepithelial neoplasia and adenocarcinoma 1996
1996 Silver staining methods to identify cells of the dispersed neuroendocrine system 1996
1996 Theory and practice of silver staining in histopathology 1996
1995 Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells. 1995
1995 Decreased cyclic inositol phosphohydrolase activity in hamster renal tumors and human renal cell carcinomas 1995
1995 Erratum: Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells (Journal of Clinical Endocrinology and Metabolism (1995) 80 (1027-1031)) 1995
1995 Expression of tumor-associated glycoprotein 72 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma 1995
1995 Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice 1995
1995 Immunocytochemical analyses of dehydroepiandrosterone sulfotransferase in cultured human fetal adrenal cells 1995
1995 Immunohistochemical evaluation of the cellular localization and ontogeny of 3βhydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal Gland 1995
1995 Lewis Y Antigen as Detected by the Monoclonal Antibody BR96 is Expressed Strongly in Prostatic Adenocarcinoma 1995
1995 Nesidioblastosis causing reversal of insulin-dependent diabetes and development of hyperinsulinemic hypoglycemia 1995
1995 Prognostic Biomarkers in Breast Cancer: Factors Affecting Immunohistochemical Evaluation 1995
1994 Expression of p160erbb-3 and p185erbb-2 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma 1994
1994 Evaluation of thyroid nodules: Clinical considerations 1994
1994 Interactions between TGF-beta and adrenocorticotropin in growth regulation of human adrenal fetal zone cells. 1994
1994 Accumulation of the p53 protein occurs more frequently in metastatic than in localized prostatic adenocarcinomas 1994
1994 Counter-regulatory hormone responses to insulin-induced acute hypoglycemia in hypopituitary patients 1994
1994 Evaluation of biomarkers in breast and prostate cancer 1994
1994 FDA regulation of immunochemicals used in immunohistochemistry: Our view 1994
1994 Immunohistochemical localization of dehydroepiandrosterone sulfotransferase in human fetal tissues 1994
1994 Interactions between TGF-β and adrenocorticotropin in growth regulation of human adrenal fetal zone cells 1994
1994 Interactions between TGF-β and adrenocorticotropin in growth regulation of human adrenal fetal zone cells 1994
1994 Retinoid modulation of biomarkers in oral leukoplakia/dysplasia 1994
1994 The effects of coumarin and suramin on the growth of malignant renal and prostatic cell lines 1994
1994 The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary 1994
1994 Thyroid dysfunction in nonpregnant women 1994
1994 Thyroid function screening in newly admitted psychiatric inpatients 1994
1994 Treatment of metastatic prostate carcinoma with radiolabeled antibody CC49 1994
1993 Expression of transforming growth factor-alpha, epidermal growth factor and the epidermal growth factor receptor in adenocarcinoma of the prostate and benign prostatic hyperplasia 1993
1993 A Phase I Clinical Trial of Murine Monoclonal Antibody D612 in Patients with Metastatic Gastrointestinal Cancer 1993
1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells. 1993
1993 Direct localization comparison of murine and chimeric B72.3 antibodies in patients with colon cancer 1993
1993 Expression of IGF-II/Man-6-P receptors on rat, rabbit, and human colon epithelial cells 1993
1993 The cooperative human tissue network. An update 1993
1993 The success of a clinical librarian program in an academic autopsy pathology service 1993
1992 Phase I trial of the chimeric anti-GD2 monoclonal antibody ch14.18 in patients with malignant melanoma 1992
1991 Identification of bile acid-CoA:amino acid N-acyltransferase in rat kidney 1991
1991 Systemic absorption of insulin delivered topically to the rat eye 1991
1990 Alterations in dietary sodium affect isoproterenol-induced cardiac hypertrophy 1990
1990 Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma 1990
1989 Compensatory ovarian hypertrophy occurs by a mechanism distinct from compensatory growth in the regenerating liver. 1989
1989 Receptors for insulin and insulin-like growth factor-I in the human adrenal gland 1989
1989 Unsuspected Cushing's disease in a patient with fatal staphylococcal bacteremia and multiple pituitary adenomas. 1989
1989 Colonic absorption of insulin: An in vitro and in vivo evaluation 1989
1989 Compensatory ovarian hypertrophy occurs by a mechanism distinct from compensatory growth in the regenerating liver 1989
1989 Cushing's syndrome. Diagnosis of the atypical patient 1989
1989 Dietary fish oil inhibits bleomycin-induced pulmonary fibrosis in the rat 1989
1989 Functional and morphological studies of long-term islet allografts in the renal subcapsular space of the BB/W rat 1989
1989 Gastrointestinal autonomic nerve tumors. 'Plexosarcomas' 1989
1989 Special communication. The cooperative human tissue network 1989
1989 Unsuspected cushing's disease in a patient with fatal staphylococcal bacteremia and multiple pituitary adenomas 1989
1988 Guidelines to avoid personnel contamination by infective agents in research laboratories that use human tissues 1988
1988 Distribution of receptors for insulin and insulin-like growth factor I (somatomedin C) in the adrenal gland 1988
1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats. 1988
1988 Tachybrady-arrhythmias and "spells" in a 47-year-old man. 1988
1988 Modulation of the development of bleomycin-induced fibrosis by deferoxamine 1988
1988 Methods of measuring thyroid hormone levels. 1988
1988 Demonstration of the adenosine reservoirs with nitrobenzylthioinosine in liver and diaphragm by high-performance liquid chromatography 1988
1988 Effect of haemolysis on radioimmunoassay for insulin 1988
1988 Effect of iron deficiency on bleomycin-induced lung fibrosis in the hamster 1988
1988 Lactate dehydrogenase isolated from human liver mitochondria: Its purification and partial biochemical characterization 1988
1988 Neuroendocrine differentiation in prostatic carcinomas. A retrospective autospy study 1988
1988 Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats 1988
1988 Pathology of the adrenal gland 1988
1988 Stability and electrophoretic characteristics of creatine kinase BB extracted from human brain and intestine 1988
1987 Availability of human tissues for research in cancer [4] 1987
1987 A 35-year-old black woman with hypokalemia and accelerated hypertension. 1987
1987 Detection of high incidence of K-ras oncogenes during human colon tumorigenesis 1987
1987 Effect of temperature on argyrophil impregnation: Development of a high temperature rapid argyrophil procedure 1987
1987 Effects of dietary fats on bleomycin-induced pulmonary fibrosis 1987
1987 High incidence of c-K-ras oncogenes in human colon cancer detected by the RNAse A mismatch cleavage method 1987
1987 New developments in understanding phenytoin-induced gingival hyperplasia. 1987
1986 Elevated Atypical Creatine Kinases 1986
1986 A small adrenocortical carcinoma with aggressive behavior. An evaluation of criteria for malignancy 1986
1986 Cytogenetics of medullary carcinoma of the thyroid 1986
1986 A methyl green nuclear stain for argyrophil procedures 1986
1986 Histologic variation in the skin lesions of the glucagonoma syndrome 1986
1985 Cushing's syndrome. Screening methods in hospitalized patients 1985
1985 Nonresolving cushing's syndrome due to depot methylprednisolone verified by high-performance liquid chromatography 1985
1985 Plasmacytoid-T-cell lymphoma associated with chronic myeloproliferative disorder 1985
1984 Corticotropin production by tumors of the autonomic nervous system 1984
1984 LD-6 isoenzyme and lactate-independent dehydrogenase differ. 1984
1984 Clinical significance and partial biochemical characterization of lactate dehydrogenase isoenzyme 6 1984
1984 Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma) - Light and electron microscopic study confirming the origin of the neoplasm 1984
1984 Abnormal Lactate Dehydrogenase Isoenzyme Pattern in a Critically 111 Patient 1984
1984 Aldosterone blocks adrenal compensatory hypertrophy in the rat 1984
1984 Aldosterone blocks adrenal compensatory hypertrophy in the rat 1984
1984 Golden syrian hamsters: A new experimental model for adrenal compensatory hypertrophy 1984
1982 Radiology rounds: fever of unknown origin in a 48-year-old man seven years after mesocaval shunt. 1982
1982 An extra-adrenal pheochromocytoma mimicking lymph node metastasis from a cervical cancer 1982
1982 Functional carotid paragangliomas. Biochemical, ultrastructural, and histochemical correlation with clinical symptoms 1982
1982 Squamous cell carcinoma metastatic to placenta and ovary 1982
1981 Membranous nephropathy in a renal allograft. Its occurrence in a patient with previous anti-glomerular basement membrane disease 1981
1978 Organization of the medial hypothalamus for control of adrenocorticotropin in the cat 1978
1976 Inhibitory and facilitatory areas of the rostral pons mediating acth release in the cat 1976
1975 Hypothalamic cells in an area mediating ACTH release respond to right atrial stretch 1975
1974 Inhibitory and facilitatory hypothalamic areas mediating ACTH release in the cat 1974
1973 Localized hypothalamic area related to neural control of ACTH 1973
1966 Wide-line NMR study of molecular motion in [Me3SiNSiMe 2]2 1966

Book

Year Title Altmetric
2013 New NSAID targets and derivatives for colorectal cancer chemoprevention.  Ed. 191.  2013

Chapter

Year Title Altmetric
2017 Biobank and expertise networks.  111-135. 2017
2017 Safety issues in biorepositories.  65-83. 2017
2017 Safety and the Biorepository.  479-492. 2017
2016 Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository..  1-38. 2016
2014 The effects of exosomes and related vesicles on cancer development, progression, and dissemination.  107-129. 2014
2013 Human tissue biorepository.  483-497. 2013
2012 Biomarkers and the genetics of early neoplastic lesions.  41-64. 2012
2012 Development and progression of colorectal neoplasia.  235-265. 2012
2009 General Considerations Concerning Safety in Biomedical Research Laboratories.  563-572. 2009
2006 Biology of breast cancer: Molecular and pathologic features of ductal neoplasia of the breast: Racial considerations.  39-70. 2006

Research Overview

  • Our laboratory is focused on understanding the molecular features of epithelial cancers such as prostate, pancreas, mammary, colorectal and ovarian adenocarcinomas as well as squamous cell lesions of oral cavity, esophagus, lung, cervix and skin in order to identify biomarkers associated either with early pre-invasive neoplastic lesions or with advanced stage malignant lesions. Of special interest are biomarkers that can be used to aid in determining prognosis or risk assessment or in predicting therapy. For example, the earliest putative pre-invasive lesion of the prostate is prostatic intraepithelial neoplasia (PIN); we have demonstrated the phenotypic expression of molecular markers in PIN is similar to the phenotypic expression of these same molecular markers in prostatic adenocarcinomas. We study the escape of PCa from the requirement for androgens, i.e., development of androgen resistance. We use the human xenograft tumor models CWR22, LNCaP, DU145 and PC-3 in nude mice to investigate androgen effects on prostate tumors and the development of androgen resistance in these tumors. These data are supplemented by in vitro studies. In colorectal adenocarcinoma (CRCs), we have identified six molecular markers that aid in identifying aggressive subgroups of CRCs. These are p53, Bcl-2, p27kip-1, Suppressin, MUC-1 and MUC-2. We have identified differences in prognostic usefulness of biomarkers based on the anatomic location of CRCs. Our studies also have focused on the racial differences in the expression of these molecular markers as well as racial differences in the clinical importance of the expression of these biomarkers. Our studies of breast neoplasia also have emphasized racial differences in molecular features of ductal carcinoma. Besides our interests in epithelial neoplasia, we have a broad interest in diffuse pulmonary diseases including pulmonary arterial hypertension as well as tissue reparative processes leading to granulation tissues and neovascularity. In general our laboratory utilizes proteomic techniques but also has capabilities in molecular biology. In addition to quantitative immunohistochemistry (fluorescent or bright field), Western blotting, high throughput ELISA, multiplex immunoassays (Luminex and MESO), we have a SELDI-TOF-MS system for identification of unique proteomic patterns and we collaborate using other mass spectrometry systems in the early detection of cancers by determining the proteins of specific cancers in biological fluids such as serum. We also have automated cytomorphometric instrumentation and tissue arrays that can be used in multi-tissue analyses. Similarly, we can use gene chip (affymetrix) and spotted array analysis in gene discovery. Of great interest are collaborative efforts to improve the biomathematic/statistical approaches to evaluating biomarkers and multiplex methods of analysis and how bias in collecting and processing tissue samples may affect multiplex assays. Also, for the last two decades we have provided human tissues to support the research of biomedical investigators throughout North America. In this effort, sponsored primarily by the Cooperative Human Tissue Network (CHTN), we have introduced to tissue resources the utilization of quality control of tissues provided for research and we have been involved in database development for tissue resources. We also have great expertise in how fixation of tissues interacts with the stages of tissue processing to affect immunorecognition and other molecular assays.

    Grant Support (P.I.)

    Biomarker Reference Laboratory – Early Detection Research Network (EDRN)
    Tissue Resource and Molecular Pathology Core of the Breast SPORE
    Tissue Research and Molecular Pathology Core of the Pancreatic SPORE
    Cooperative Human Tissue Network (CHTN)
    Pulmonary Hypertension Breakthrough Initiative (PHBI)
    EDRN

    Goals – Multiplex Assays in Early Detection, Risk Assessment and Prognosis.
  • Principal Investigator On

  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Bioethics Shared Resource  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 2: Molecular Regulation of Kaiso in Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Theranostic Nanoparticles for Detection and Treatment of Pancreatic Cancer  awarded by WAKE FOREST UNIVERSITY 2017 - 2019
  • Pulmonary Hypertension Breakthrough Initiative  awarded by Indiana University 2016 - 2019
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Collaborative Human Tissue Network  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Pulmonary Hypertension Breakthrough Initiative  awarded by University of Colorado 2014 - 2018
  • Phosphodiesterase 5: A Novel Target and Inhibitor for Breast Cancer Chemoprevention  awarded by University of South Alabama 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement Shared Facility  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Transcriptional Repressor Kaiso Promotes Metastasis through Epithelial to Mesenchymal Transition  awarded by TUSKEGEE UNIVERSITY 2013 - 2016
  • Novel Sulindac Derivatives for Colon Cancer Chemoprevention  awarded by University of South Alabama 2015 - 2016
  • Biomarkers in the Detection of Prostate Cancer in African Americans  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2010 - 2016
  • UAB / UMN SPORE in Pancreatic Cancer - Core B  awarded by National Cancer Institute/NIH/DHHS 2010 - 2016
  • Active - Tissue Procurement - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • UAB Skin Disease Research Center - Tissue Resources and Molecular Pathology Core - Core C  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • A Metabolomics Approach to Define a Novel Chemopreventive Pathway  awarded by University of South Alabama 2013 - 2015
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC. 2014 - 2015
  • Tissue Source Site (TSS) in Support of the NCI Clinical Assay Development Program - Admin Core  awarded by SAIC - FREDERICK 2014 - 2015
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC. 2014 - 2015
  • Tissue Resource Site (TSS) in Support of the The Cancer Genome Atlas (TCGA) Program - Task Order 1  awarded by SAIC - FREDERICK 2013 - 2014
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC. 2013 - 2014
  • Center for Tissue Processing to Support Research in Pulmonary Arterial Hypertension  awarded by CARDIOVASCULAR MEDICAL RESEARCH AND EDUCATION FUND 2006 - 2014
  • Tissue Resource Site (TSS) in Support of the The Cancer Genome Atlas (TCGA) Program - Admin Core  awarded by SAIC - FREDERICK 2013 - 2014
  • Cooperative Human Tissue Network  awarded by National Cancer Institute/NIH/DHHS 2008 - 2014
  • SPORE in Breast Cancer - Tissue Core  awarded by National Cancer Institute/NIH/DHHS 2007 - 2013
  • Multicenter Genetic Epigenetic & Expression Analysis of DCIS Outcome Predictors  awarded by Johns Hopkins University 2011 - 2013
  • Private Grant  awarded by ROCKLAND IMMUNOCHEMICALS 2011 - 2012
  • The Importance of ENT in Breast Cancer in African American Women  awarded by George Washington University 2010 - 2012
  • Comprehensive Cancer Center Core Support Grant - Tissue Procurement  awarded by National Cancer Institute/NIH/DHHS 2006 - 2011
  • Investigator On

  • Sialylation-dependent Mechanisms Driving Pancreatic Cancer Progression  awarded by National Cancer Institute/NIH/DHHS 2018 - 2023
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Mechanisms of Resistance to Cancer Therapeutics  awarded by National Cancer Institute/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • UAB NRG Oncology Member Institution Purchased Service Agreement  awarded by NRG ONCOLOGY FOUNDATION 2014 - 2019
  • Breast Tumor Tissue-Derived Hedgehog Morphogens Immunoedit the Polarization of Breast Cancer Associated Macrophages  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2014 - 2018
  • Glycosylation-Dependent Mechanisms Regulating Ovarian Tumor Cell Survival  awarded by National Institute of General Medical Sciences/NIH/DHHS 2014 - 2018
  • Glycan Control of Stem Cell-Associated Pathways in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS 2015 - 2017
  • UAB / UMN SPORE in Pancreatic Cancer  awarded by National Cancer Institute/NIH/DHHS 2010 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Exploring Effects of Weight Loss on Ductal Carcinoma In Situ  awarded by National Cancer Institute/NIH/DHHS 2014 - 2017
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • UAB / UMN SPORE in Pancreatic Cancer - Project 1  awarded by National Cancer Institute/NIH/DHHS 2010 - 2016
  • Molecular Pathogenesis and Phenotype of Acquired CFTR Dysfunction in COPD  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • UAB Skin Disease Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2015
  • A Specific Screening Strategy to Reduce Prostate Cancer Mortality  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2012 - 2015
  • Networks of Tissue Source Site (TSS) in Support of the Cancer Genome Atlas (TCGA) Program  awarded by Washington University 2010 - 2015
  • Private Grant  awarded by LEIDOS BIOMEDICAL RESEARCH, INC. 2013 - 2014
  • TGFBR1 Signaling in Colorectal Cancer  awarded by National Cancer Institute/NIH/DHHS 2010 - 2014
  • SPORE in Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2007 - 2013
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2006 - 2012
  • Education And Training

  • Doctor of Medicine, Johns Hopkins University 1977
  • Doctor of Philosophy in Biophysics, Johns Hopkins University 1975
  • Vanderbilt University Medical Center, Internship 1979
  • UAB Hospital, Residency 1980
  • Full Name

  • William Grizzle