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Amy Weinmann Ph.D.
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E-mail
weinmann@uab.edu
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Amy Weinmann Ph.D.
Professor
Positions
Senior Scientist (C)
,
O'Neal Comprehensive Cancer Center
,
School of Medicine
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
Senior Scientist
,
Inflammation, Immunology and Immunotherapeutics
,
O'Neal Comprehensive Cancer Center
Senior Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
Professor (P)
,
Microbiology
,
Academic Joint Departments
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2023
Tipping the balance in CD4
+
T cells
.
Nature Immunology
. 24:8-9.
2023
2022
One degree of separation: urgent questions surrounding new USA laws in women's healthcare
.
Trends in Immunology
. 43:851-854.
2022
2022
Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans
.
Cell Reports
. 39.
2022
2021
Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis
.
Trends in Immunology
. 42:1077-1087.
2021
2021
Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy
.
Journal of Autoimmunity
. 118.
2021
2021
Genome regulation in innate and adaptive immune cells
.
Immunological Reviews
. 300:5-8.
2021
2020
A Future Outlook on Molecular Mechanisms of Immunity
.
Trends in Immunology
. 41:549-555.
2020
2020
Are You There? Genetic Variation Impacts Long-Distance Connections in Diabetes
.
Trends in Immunology
. 41:269-271.
2020
2019
Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T
FH
cells
.
Science Immunology
. 4.
2019
2019
Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses
.
Immunity
. 51:155-168.e5.
2019
2019
T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells
.
Immunity
. 50:1172-1187.e7.
2019
2019
Defining Barriers that Impede Choices
.
Immunity
. 50:542-544.
2019
2019
Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production
.
JCI Insight
. 4.
2019
2018
Connections between Metabolism and Epigenetics in Programming Cellular Differentiation
.
Annual Review of Immunology
. 36:221-246.
2018
2018
Metabolites, genome organization, and cellular differentiation gene programs
.
Current Opinion in Immunology
. 51:62-67.
2018
2017
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection
.
Nature Immunology
. 18:1249-1260.
2017
2017
CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs
.
Immunity
. 47:251-267.e7.
2017
2017
Protein kinase CK2 controls the fate between Th17 cell and regulatory T cell differentiation
.
Journal of Immunology
. 198:4244-4254.
2017
2017
Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy
.
Kidney International Reports
. 2:1194-1207.
2017
2015
Transcriptional regulation of T cell metabolism
.
Molecular Immunology
. 68:520-526.
2015
2015
TCR-signaling events in cellular metabolism and specialization
.
Frontiers in Immunology
. 6.
2015
2014
Bcl-6 directly represses the gene program of the glycolysis pathway
.
Nature Immunology
. 15:957-964.
2014
2014
Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility
.
Immunology and Cell Biology
. 92:34-39.
2014
2014
Roles for helper T cell lineage-specifying transcription factors in cellular specialization
.
Advances in Immunology
. 124:171-206.
2014
2013
Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats
.
Mammalian Genome
. 24:400-408.
2013
2013
Toward an understanding of the gene-specific and global logic of inducible gene transcription
2013
2012
Master regulators or lineage-specifying? Changing views on CD4
+
T cell transcription factors
.
Nature Reviews Immunology
. 12:799-804.
2012
2012
Molecular mechanisms that control the expression and activity of Bcl-6 in T
H
1 cells to regulate flexibility with a T
FH
-like gene profile
.
Nature Immunology
. 13:405-411.
2012
2012
Transcriptional mechanisms that regulate T helper 1 cell differentiation
.
Current Opinion in Immunology
. 24:191-195.
2012
2012
Encoding stability versus flexibility: Lessons learned from examining epigenetics in T helper cell differentiation
.
Current Topics in Microbiology and Immunology
. 356:145-164.
2012
2012
T-bet employs diverse regulatory mechanisms to repress transcription
.
Trends in Immunology
. 33:78-83.
2012
2012
Ikaros changes the face of NuRD remodeling
.
Nature Immunology
. 13:16-18.
2012
2011
The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
.
Journal of Experimental Medicine
. 208:1001-1013.
2011
2011
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8
+
T cell responses during chronic infection
.
Nature Immunology
. 12:663-671.
2011
2010
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate t-box family member-dependent gene expression
.
Molecular Cell
. 40:594-605.
2010
2010
Molecular mechanisms by which T-bet regulates T-helper cell commitment
.
Immunological Reviews
. 238:233-246.
2010
2009
T-bet-dependent S1P
5
expression in NK cells promotes egress from lymph nodes and bone marrow
.
Journal of Experimental Medicine
. 206:2469-2481.
2009
2009
CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus
.
Immunity
. 31:551-564.
2009
2009
Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families
.
Immunology
. 126:306-315.
2009
2009
An essential interaction between T-box proteins and histone-modifying enzymes
.
Epigenetics
. 4:85-88.
2009
2008
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression
.
Genes and Development
. 22:2980-2993.
2008
2007
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain
.
Molecular and Cellular Biology
. 27:8510-8521.
2007
2006
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects
.
Journal of Biological Chemistry
. 281:11992-12000.
2006
2005
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
2005
2004
T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells
.
Immunity
. 20:477-494.
2004
2004
Novel ChIP-based strategies to uncover transcription factor target genes in the immune system
.
Nature Reviews Immunology
. 4:381-386.
2004
2002
Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation
.
ImmunoMethods
. 26:37-47.
2002
2002
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis
.
Genes and Development
. 16:235-244.
2002
2001
Use of chromatin immunoprecipitation to clone novel E2F target promoters
.
Molecular and Cellular Biology
. 21:6820-6832.
2001
2001
Down-regulation of TDT transcription in CD4
+
CD8
+
thymocytes by Ikaros proteins in direct competition with an Ets activator
.
Genes and Development
. 15:1817-1832.
2001
2001
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
.
Nature Immunology
. 2:51-57.
2001
1999
Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription
.
Immunity
. 11:665-675.
1999
Research
Principal Investigator On
HSF/GEF Scholar Award for Amy Weinmann
awarded by
UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
Molecular Characterization of T-beta's Role in Immunity
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Molecular Characterization of the Role for Metabolites in Immune Cell Differentiation
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Molecular Characterization of the Role for Metabolites in Immune Cell Differentiation
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Molecular Characterization of the Role for T-bet and Bcl-6 in Immune Cell Metabolism and Differentiation
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Tet1 Activity and Function in Helper T Cells
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Investigator On
Functional Implications of Tfh Cell Heterogeneity After Infection
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Functional Implications of Tfh Cell Heterogeneity After Infection
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Origin and Function of Double Negative T Cells in Lupus
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Origin and Function of Double Negative T Cells in Lupus
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Plasma Cells in Health and Disease-Project 2
awarded by
Emory University
Regulation of T Cell Responses to Allergens and Environmental Microbes
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Regulation of T-Cell Dependent B Cell Responses to Influenza
awarded by
National Institute of Allergy and Infectious Diseases/NIH/DHHS
Teaching
Teaching Activities
GBS747 - Special Topics (Spring Term 2016)
Background
Education And Training
Doctor of Philosophy in Microbiology,
University of California System : Los Angeles
2000
Bachelor of Arts in Biology,
University of Minnesota System : Morris
1995
Contact
Full Name
Amy
Weinmann