Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans.  Cell Reports.  39. 2022
2021 Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis.  Trends in Immunology.  42:1077-1087. 2021
2021 Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy.  Journal of Autoimmunity.  118. 2021
2021 Genome regulation in innate and adaptive immune cells.  Immunological Reviews.  300:5-8. 2021
2020 A Future Outlook on Molecular Mechanisms of Immunity.  Trends in Immunology.  41:549-555. 2020
2020 Are You There? Genetic Variation Impacts Long-Distance Connections in Diabetes.  Trends in Immunology.  41:269-271. 2020
2019 Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells.  Science Immunology.  4. 2019
2019 Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.  Immunity.  51:155-168.e5. 2019
2019 T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-γ on B Cells.  Immunity.  50:1172-1187.e7. 2019
2019 Defining Barriers that Impede Choices.  Immunity.  50:542-544. 2019
2019 Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production.  JCI insight.  4. 2019
2018 Connections between Metabolism and Epigenetics in Programming Cellular Differentiation.  Annual Review of Immunology.  36:221-246. 2018
2018 Metabolites, genome organization, and cellular differentiation gene programs.  Current Opinion in Immunology.  51:62-67. 2018
2017 Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.  Nature Immunology.  18:1249-1260. 2017
2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs.  Immunity.  47:251-267.e7. 2017
2017 Protein kinase CK2 controls the fate between Th17 cell and regulatory T cell differentiation.  Journal of Immunology.  198:4244-4254. 2017
2017 Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.  Kidney International Reports.  2:1194-1207. 2017
2015 Transcriptional regulation of T cell metabolism.  Molecular Immunology.  68:520-526. 2015
2015 TCR-signaling events in cellular metabolism and specialization.  Frontiers in Immunology.  6. 2015
2014 Bcl-6 directly represses the gene program of the glycolysis pathway.  Nature Immunology.  15:957-964. 2014
2014 Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility.  Immunology and Cell Biology.  92:34-39. 2014
2014 Roles for helper T cell lineage-specifying transcription factors in cellular specialization.  Advances in Immunology.  124:171-206. 2014
2013 Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats.  Mammalian Genome.  24:400-408. 2013
2013 Toward an understanding of the gene-specific and global logic of inducible gene transcription.  Cold Spring Harbor Laboratory: Symposia on Quantitative Biology.  78:61-68. 2013
2012 Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors.  Nature Reviews Immunology.  12:799-804. 2012
2012 Molecular mechanisms that control the expression and activity of Bcl-6 in T H1 cells to regulate flexibility with a T FH-like gene profile.  Nature Immunology.  13:405-411. 2012
2012 Transcriptional mechanisms that regulate T helper 1 cell differentiation.  Current Opinion in Immunology.  24:191-195. 2012
2012 Encoding stability versus flexibility: Lessons learned from examining epigenetics in T helper cell differentiation.  Current Topics in Microbiology and Immunology.  356:145-164. 2012
2012 T-bet employs diverse regulatory mechanisms to repress transcription.  Trends in Immunology.  33:78-83. 2012
2012 Ikaros changes the face of NuRD remodeling.  Nature Immunology.  13:16-18. 2012
2011 The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns.  Journal of Experimental Medicine.  208:1001-1013. 2011
2011 Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.  Nature Immunology.  12:663-671. 2011
2010 Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate t-box family member-dependent gene expression.  Molecular Cell.  40:594-605. 2010
2010 Molecular mechanisms by which T-bet regulates T-helper cell commitment.  Immunological Reviews.  238:233-246. 2010
2009 T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.  Journal of Experimental Medicine.  206:2469-2481. 2009
2009 CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus.  Immunity.  31:551-564. 2009
2009 Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families.  Immunology.  126:306-315. 2009
2009 An essential interaction between T-box proteins and histone-modifying enzymes.  Epigenetics.  4:85-88. 2009
2008 Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression.  Genes and Development.  22:2980-2993. 2008
2007 T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain.  Molecular and Cellular Biology.  27:8510-8521. 2007
2006 T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects.  Journal of Biological Chemistry.  281:11992-12000. 2006
2005 NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.  Proceedings of the National Academy of Sciences of USA.  102:2016-2021. 2005
2004 T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells.  Immunity.  20:477-494. 2004
2004 Novel ChIP-based strategies to uncover transcription factor target genes in the immune system.  Nature Reviews Immunology.  4:381-386. 2004
2002 Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation.  Methods.  26:37-47. 2002
2002 Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.  Genes and Development.  16:235-244. 2002
2001 Use of chromatin immunoprecipitation to clone novel E2F target promoters.  Molecular and Cellular Biology.  21:6820-6832. 2001
2001 Down-regulation of TDT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activator.  Genes and Development.  15:1817-1832. 2001
2001 Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event.  Nature Immunology.  2:51-57. 2001
1999 Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription.  Immunity.  11:665-675. 1999

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Microbiology, University of California System : Los Angeles 2000
  • Bachelor of Arts in Biology, University of Minnesota System : Morris 1995

    • Full Name

  • Amy Weinmann