Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Discovery and evaluation of nNav1.5 sodium channel blockers with potent cell invasion inhibitory activity in breast cancer cellsBioorganic and Medicinal Chemistry.  26:2428-2436. 2018
2016 Translation of a tissue-selective rexinoid, UAB30, to the clinic for breast cancer preventionCurrent Topics in Medicinal Chemistry.  16. 2016
2015 Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary CancersJournal of Medicinal Chemistry.  58:7763-7774. 2015
2014 Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicityJournal of Medicinal Chemistry.  57:5370-5380. 2014
2014 A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: Design of potent new ligandsBioorganic and Medicinal Chemistry.  22:95-104. 2014
2014 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and preventionBioorganic and Medicinal Chemistry.  22:178-185. 2014
2012 Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6BMC Structural Biology.  12. 2012
2012 Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: The hydrophobic side chain influences type A subtype selectivityBioorganic and Medicinal Chemistry.  20:4582-4589. 2012
2010 A pilot, first-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteersCancer Prevention Research.  3:1565-1570. 2010
2009 SAR studies for a new class of antibacterial NAD biosynthesis inhibitorsJournal of Combinatorial Chemistry.  11:617-625. 2009
2009 Synthesis of biotin-tagged chemical cross-linkers and their applications for mass spectrometryRapid Communications in Mass Spectrometry.  23:1719-1726. 2009
2009 Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs)Bioorganic and Medicinal Chemistry Letters.  19:2001-2005. 2009
2009 Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoidCancer Biology and Therapy.  8:285-294. 2009
2009 Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoidCancer Biology and Therapy.  8:285-294. 2009
2008 Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracisActa Crystallographica Section F: Structural Biology and Crystallization Communications.  64:893-898. 2008
2008 The novel retinoid, 9cUAB30, inhibits telomerase and induces apoptosis in HL60 cellsTranslational Oncology.  1:148-152. 2008
2007 Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracisActa Crystallographica Section D: Biological Crystallography.  63:891-905. 2007
2007 In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoidDrug Metabolism and Disposition.  35:1157-1164. 2007
2007 Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groupsJournal of Medicinal Chemistry.  50:2612-2621. 2007
2006 Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkersCarcinogenesis.  27:1232-1239. 2006
2005 Tethered dimer inhibitors of NAD synthetase: Parallel synthesis of an aryl-substituted SAR libraryJournal of Combinatorial Chemistry.  7:898-904. 2005
2004 Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligandsJournal of Medicinal Chemistry.  47:6519-6528. 2004
2004 A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidaseActa Crystallographica Section D: Biological Crystallography.  60:1017-1023. 2004
2004 Syntheses and Neuraminidase Inhibitory Activity of Multisubstituted Cyclopentane Amide DerivativesJournal of Medicinal Chemistry.  47:1919-1929. 2004
2004 Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetaseProtein Science.  13:830-841. 2004
2003 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancersCancer Letters.  201:17-24. 2003
2003 Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3′,4′-dihydro-1′(2′H) -naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30)Journal of Medicinal Chemistry.  46:3766-3769. 2003
2003 Tethered dimers as NAD synthetase inhibitors with antibacterial activityJournal of Medicinal Chemistry.  46:3371-3381. 2003
2003 Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: Modifications of essential pyrrolidinone ring substituentsBioorganic and Medicinal Chemistry.  11:2739-2749. 2003
2001 Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilisActa Crystallographica Section D: Biological Crystallography.  57:806-812. 2001
1999 Erratum: Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping (Bioorg. Med. Chem. Lett. (1999) 9 (1901) PII: S0960894X99003182)Bioorganic and Medicinal Chemistry Letters.  9:3259. 1999
1999 Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active siteJournal of Molecular Biology.  293:1107-1119. 1999
1999 Hydrophobic benzoic acids as inhibitors of influenza neuraminidaseBioorganic and Medicinal Chemistry.  7:2487-2497. 1999
1999 Stereoselective synthesis of a conformationally defined cyclohexyl carnitine analogue that binds CPT-1 with high affinityBioorganic and Medicinal Chemistry.  7:1505-1511. 1999
1999 Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl groupingBioorganic and Medicinal Chemistry Letters.  9:1901-1906. 1999
1999 Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituentJournal of Medicinal Chemistry.  42:2332-2343. 1999
1999 Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channelJournal of Medicinal Chemistry.  42:1537-1545. 1999
1999 1H and 13C NMR assignments of conformationally defined 6-s-cis-retinoidsMagnetic Resonance in Chemistry.  37:82-85. 1999
1999 Bioactivity of peptide analogs of the neutrophil chemoattractant, N- acetyl-proline-glycine-prolineInvestigative Ophthalmology & Visual Science.  40:2427-2429. 1999
1998 Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitorBioorganic and Medicinal Chemistry.  6:2133-2138. 1998
1998 Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemiasJournal of Medicinal Chemistry.  41:1679-1687. 1998
1997 Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoidsArchives of Biochemistry and Biophysics.  344:220-227. 1997
1997 Guanidinobenzoic acid inhibitors of influenza virus neuraminidaseJournal of Molecular Biology.  267:584-594. 1997
1997 Effects of log P and phenyl ring conformation on the binding of 5- phenylhydantoins to the voltage-dependent sodium channelJournal of Medicinal Chemistry.  40:602-607. 1997
1997 A structural model for a new class of conformationally constrained retinoid: (2Z,4E)-4-[3',4'-dihydro-1'(2'H)-naphthalene-1'-ylidene]-2-butenoic acidJournal of Chemical Crystallography.  27:231-235. 1997
1996 Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure- activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activityJournal of Medicinal Chemistry.  39:3625-3635. 1996
1996 Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acidToxicology and Applied Pharmacology.  139:310-316. 1996
1995 Structure-Based Inhibitors of Inñuenza Virus Sialidase. A Benzoic Acid Lead with Novel InteractionJournal of Medicinal Chemistry.  38:3217-3225. 1995
1995 Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 2. Selective Agonists for Nuclear Receptor Binding and Transcriptional ActivityJournal of Medicinal Chemistry.  38:2302-2310. 1995
1995 Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configurationBioorganic and Medicinal Chemistry Letters.  5:953-958. 1995
1995 4-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid.Acta Crystallographica Section C: Crystal Structure Communications.  51 ( Pt 9):1910-1912. 1995
1995 13C NMR assignments of conforma‐tionally defined 6‐s‐trans‐retinoidsMagnetic Resonance in Chemistry.  33:497-499. 1995
1995 A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidaseProteins.  23:264-277. 1995
1995 Conformationally defined cyclohexyl carnitine analogs.Acta Crystallographica Section C: Crystal Structure Communications.  51 ( Pt 6):1160-1164. 1995
1995 Structures of Aromatic Inhibitors of Influenza Virus NeuraminidaseBiochemistry.  34:3144-3151. 1995
1994 A Conformationally Defined 6-s-trans-Retinoic Acid Isomer: Synthesis, Chemopreventive Activity, and ToxicityJournal of Medicinal Chemistry.  37:4499-4507. 1994
1994 3-Amino-5,5-dimethylhexanoic Acid. Synthesis, Resolution, and Effects on Carnitine AcyltransferasesJournal of Medicinal Chemistry.  37:3247-3251. 1994
1994 Bicyclic Hydantoins with a Bridgehead Nitrogen. Comparison of Anticonvulsant Activities with Binding to the Neuronal Voltage-Dependent Sodium ChannelJournal of Medicinal Chemistry.  37:3289-3293. 1994
1994 Synthesis and Enzymtic Evaluation of Conformationally Defined Carnitine AnalogsJournal of Organic Chemistry.  59:4297-4303. 1994
1993 Effects of C-methylated carnitine analogs on rates of mitochondrial fatty acid oxidationBiochemical Pharmacology.  46:1671-1673. 1993
1993 Carnitine Acyltransferase Enzymatic Catalysis Requires a Positive Charge on the Carnitine CofactorArchives of Biochemistry and Biophysics.  305:307-312. 1993
1993 Preparation of the racemate and enantiomers of 3-hydroxy-5,5-dimethylhexanoic acidOrganic Preparations and Procedures International: The New Journal for Organic Synthesis.  25:243-246. 1993
1990 Bicyclic Imides with Bridgehead Nitrogen. Synthesis of an Anti-Bredt Bicyclic HydantoinJournal of Organic Chemistry.  55:5222-5225. 1990
1990 Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5‐phenyl substituentsJournal of Pharmaceutical Sciences.  79:871-874. 1990
1989 Sodium Channel Binding and Anticonvulsant Activities for the Enantiomers of t Bicyclic 2,4-Oxazolidinedione and Monocyclic ModelsJournal of Medicinal Chemistry.  32:1577-1580. 1989
1989 Reactions of Vinylogous Phosphonate Carbanions and Reformatsky Reagents with a Sterically Hindered Ketone and EnoneJournal of Organic Chemistry.  54:1992-1997. 1989
1988 Anticonvulsant Activities of Phenyl-Substituted Bicyclic 2,4-Oxazolidinediones and Monocyclic Models. Comparison with Binding to the Neuronal Voltage-Dependent Sodium ChannelJournal of Medicinal Chemistry.  31:2218-2221. 1988
1988 Assignment of Absolute Configurations for 4-Methylcarnitine Stereoisomers by Proton Nuclear Magnetic ResonanceJournal of Organic Chemistry.  53:1121-1122. 1988
1987 Syntheses of the Enantiomers of Carnitine and 4-Methylcarnitine via the Chromatographic Resolution of γ-(Dimethylamino)-β-hydroxy Ester PrecursorsJournal of Organic Chemistry.  52:2311-2314. 1987
1987 13C NMR assignments of the isoprenoid chain carbons of retinoids from empirical chemical shift differencesMagnetic Resonance in Chemistry.  25:1040-1045. 1987
1987 Preparation of the 9-cis, 13-cis-, and all trans-isomers of α- and β2-retinalOrganic Preparations and Procedures International: The New Journal for Organic Synthesis.  19:187-195. 1987
1985 An efficient synthesis of d, l-carnitine hydrochloride via the acylation of an α-aminoketoneOrganic Preparations and Procedures International: The New Journal for Organic Synthesis.  17:175-181. 1985
1985 Syntheses of α-, β-, and γ-Substituted Carnitines via β-Keto EstersJournal of Organic Chemistry.  50:3627-3631. 1985
1984 Bicyclic imides with bridgehead nitrogen. synthesis and x-ray crystal structure of a bicyclic 2,4-oxazolidinedione1Journal of Organic Chemistry.  49:5113-5116. 1984
1984 Synthesis and Anticonvulsant Activity of Some Substituted Lactams and AmidesJournal of Medicinal Chemistry.  27:202-206. 1984
1984 Synthesis and carbon-13 nmr of an unusual tricyclic barbituric acid derivativetJournal of Organic Chemistry.  49:3227-3230. 1984
1980 Synthesis of α-hydroxyamides via the cyanosilylation of aromatic ketonesTetrahedron Letters.  21:1219-1220. 1980
1979 N-Acylcarbamates as Intermediates in Synthetic Approaches to a Bicyclic Trimethylene-Bridged 2, 4-Oxazolidinedione and Hydantoin 1Journal of Organic Chemistry.  44:839-843. 1979
1978 An Ethoxycarbonyl Migration from an Amide Nitrogen to OxygenJournal of Organic Chemistry.  43:1839-1841. 1978

Education And Training

  • Doctor of Philosophy in Medicinal/Pharmaceutical Chemistry, University of Kansas 1977
  • Full Name

  • Wayne Brouillette