Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Human cytomegalovirus nuclear capsids associate with the core nuclear egress complex and the viral protein kinase pUL97Viruses.  10. 2018
2017 Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cellsEuropean Journal of Immunology.  47:1354-1367. 2017
2017 Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus.PLoS Pathogens.  13:e1006601. 2017
2017 Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligasePLoS Pathogens.  13. 2017
2017 Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity.Journal of Virology.  91. 2017
2017 Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspectiveMolecular Ecology.  26:1980-1990. 2017
2017 Tumor necrosis factor alpha-induced recruitment of inflammatory mononuclear cells leads to inflammation and altered brain development in murine cytomegalovirusinfected newborn miceJournal of Virology.  91. 2017
2017 Human cytomegalovirus phosphoproteins are hypophosphorylated and intrinsically disorderedJournal of General Virology.  98:471-485. 2017
2016 Phosphorylation of Golgi peripheral membrane protein Grasp65 is an integral step in the formation of the human cytomegalovirus cytoplasmic assembly compartmentmBio.  7. 2016
2016 Clinical predictors of sensorineural hearing loss and cognitive outcome in infants with symptomatic congenital cytomegalovirus infectionPediatric Infectious Disease Journal.  35:924-926. 2016
2016 Correction: Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection [Journal of Virology, 87, 20, (2013) (10968-10979)] doi: 10.1128/JVI.01120-13Journal of Virology.  90:10431-10433. 2016
2015 Identification of a neutralizing epitope within Antigenic domain 5 of glycoprotein B of human cytomegalovirusJournal of Virology.  89:361-372. 2015
2014 Cytomegalovirus microRNAs.Journal of Environmental Management.  7:40-46. 2014
2014 Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion.Heart Surgery Forum.  15:363-373. 2014
2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responsesJournal of Immunology.  193:5604-5612. 2014
2014 Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfectionVirology.  462-463:295-298. 2014
2014 Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccinesMethods in Molecular Biology.  1119:311-348. 2014
2014 Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  164:855-859. 2014
2013 The Smallest Capsid Protein Mediates Binding of the Essential Tegument Protein pp150 to Stabilize DNA-Containing Capsids in Human CytomegalovirusPLoS Pathogens.  9. 2013
2013 Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infectionJournal of Virology.  87:10968-10979. 2013
2011 Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newbornsNew England Journal of Medicine.  364:2111-2118. 2011
2011 Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirusJournal of ultrastructure research.  174:451-460. 2011
2011 A role for the small GTPase Rab6 in assembly of human cytomegalovirusJournal of Virology.  85:5213-5219. 2011
2010 Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine propertiesJournal of Clinical Investigation.  120:4532-4545. 2010
2010 G-CSF and CD34+ progenitor cells in hematopoietic grafts: Too fertile for human cytomegalovirusHeart Surgery Forum.  8:223-224. 2010
2010 Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionObstetrical and Gynecological Survey.  65:484-485. 2010
2010 Human cytomegalovirus: Propagation, quantification, and storageHealth IT Advisory Report2010
2010 Optimal replication of human cytomegalovirus correlates with endocytosis of glycoprotein gpUL132Journal of Virology.  84:7039-7052. 2010
2010 Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionJournal of the American Medical Association.  303:1375-1382. 2010
2010 Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cellsJournal of Virology.  84:3162-3177. 2010
2008 Passive immunization reduces murine cytomegalovirus-induced brain pathology in newborn miceJournal of Virology.  82:12172-12180. 2008
2008 CD8+ T lymphocytes control murine cytomegalovirus replication in the central nervous system of newborn animalsJournal of Immunology.  181:2111-2123. 2008
2008 Multimerization of tegument protein pp28 within the assembly compartment is required for cytoplasmic envelopment of human cytomegalovirusJournal of Virology.  82:6272-6287. 2008
2008 Altered development of the brain after focal herpesvirus infection of the central nervous systemJournal of Experimental Medicine.  205:423-435. 2008
2008 Congenital cytomegalovirus infection in a highly seropositive semi-urban population in IndiaPediatric Infectious Disease Journal.  27:841-843. 2008
2008 Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease.Philological Questions.  325:417-470. 2008
2007 Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasivenessJournal of Neuro-Oncology.  85:271-280. 2007
2007 The cytoplasmic tail of glycoprotein M (gpUL100) expresses trafficking signals required for human cytomegalovirus assembly and replicationJournal of Virology.  81:10316-10328. 2007
2007 Cytoplasmic envelopment of human cytomegalovirus requires the postlocalization function of tegument protein pp28 within the assembly compartmentJournal of Virology.  81:6536-6547. 2007
2007 The carboxy-terminal domain of glycoprotein N of human cytomegalovirus is required for virion morphogenesisJournal of Virology.  81:5212-5224. 2007
2005 Human cytomegalovirus UL97 kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesisJournal of Virology.  79:15494-15502. 2005
2005 Association between genital tract cytomegalovirus infection and bacterial vaginosisJournal of Infectious Diseases.  192:1727-1730. 2005
2005 Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts.Journal of Virology.  79:11837-11847. 2005
2005 Congenital cytomegalovirus infection: Association between virus burden in infancy and hearing lossJournal of Pediatrics.  146:817-823. 2005
2005 Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein BJournal of Virology.  79:4066-4079. 2005
2005 Complex formation by glycoproteins M and N of human cytomegalovirus: Structural and functional aspectsJournal of Virology.  79:2160-2170. 2005
2005 Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous systemJournal of Infectious Diseases.  191:227-233. 2005
2005 Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsidJournal of Virology.  79:1327-1332. 2005
2004 Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirusJournal of Virology.  78:6688-6691. 2004
2004 Human cytomegalovirus virion proteinsHuman Immunology.  65:395-402. 2004
2001 Modification of maternal and congenital cytomegalovirus infection by anti-glycoprotein b antibody transfer in guinea pigs.Journal of Infectious Diseases.  183:1547-1553. 2001
2001 Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunityNew England Journal of Medicine.  344:1366-1371. 2001
2000 B lymphoblastoid cell lines as efficient APC to elicit CD8+ T cell responses against a cytomegalovirus antigenJournal of Immunology.  165:4105-4111. 2000
2000 Longitudinal investigation of hearing disorders in children with congenital cytomegalovirusJournal of the American Academy of Audiology.  11:283-290. 2000
2000 Infectious clones of herpesviruses: A new approach for understanding viral gene functionTrends in Microbiology.  8:262-265. 2000
2000 Human cytomegalovirus pp28 (UL99) localizes to a cytoplasmic compartment which overlaps the endoplasmic reticulum-Golgi-intermediate compartmentJournal of Virology.  74:3842-3851. 2000
2000 Accumulation of virion tegument and envelope proteins in a stable cytoplasmic compartment during human cytomegalovirus replication: Characterization of a potential site of virus assemblyJournal of Virology.  74:975-986. 2000
1999 A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvantJournal of Infectious Diseases.  180:970-975. 1999
1999 Simultaneous ex vivo expansion of cytomegalovirus and Epstein-Barr virus-specific cytotoxic T lymphocytes using B-lymphoblastoid cell lines expressing cytomegalovirus pp65Journal of Health Psychology.  94:3242-3250. 1999
1999 Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus.Pediatrics.  104:55-60. 1999
1996 Recognition of human cytomegalovirus gene products by HCMV-specific cytotoxic T cellsVirology.  222:293-296. 1996
1996 Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructuresVirology.  216:133-145. 1996
1996 Antigenic and immunogenic analysis of group A and group B respiratory syncytial virus G proteins expressed from recombinant baculovirusesJournal of General Virology.  77:641-648. 1996
1996 Glycoprotein H of human cytomegalovirus is a major antigen for the neutralizing humoral immune responseJournal of General Virology.  77:1537-1547. 1996
1996 Human cytomegalovirus glycoproteinsIntervirology.  39:401-412. 1996
1996 Human cytomegalovirus infections during pregnancyTranslational gastrointestinal cancer.  3:327-343. 1996
1996 Human cytomegalovirus overview: The virus and its pathogenic mechanismsTranslational gastrointestinal cancer.  3:307-325. 1996
1996 Transplacentally acquired antiviral antibodies and outcome in congenital human cytomegalovirus infectionViral Immunology.  9:211-218. 1996
1996 Vaccines against human cytomegalovirus: Time to testTrends in Microbiology.  4:34-38. 1996
1995 Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary cmv infection in the guinea pig modelJournal of Infectious Diseases.  172:1212-1220. 1995
1993 Antibodies Induced by a Primary Cytomegalovirus Infection React with Human Herpesvirus 6 ProteinsJournal of Infectious Diseases.  168:1119-1126. 1993
1993 Virus-specific antibody responses in mothers and their newborn infants with asymptomatic congenital cytomegalovirus infectionsJournal of Infectious Diseases.  167:72-77. 1993
1992 The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusNew England Journal of Medicine.  326:663-667. 1992
1992 Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infectionJournal of Clinical Microbiology.  30:721-723. 1992
1992 Oligomerization of the human cytomegalovirus major envelope glycoprotein complex gB (gp55-116)Journal of Virology.  66:6747-6754. 1992
1992 Symptomatic congenital cytomegalovirus infection: Neonatal morbidity and mortalityPediatric Infectious Disease Journal.  11:93-99. 1992
1992 The dominant linear neutralizing antibody-binding site of glycoprotein gp86 of human cytomegalovirus is strain specificJournal of Virology.  66:1303-1311. 1992
1992 The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusObstetrical and Gynecological Survey.  47:544-546. 1992
1991 Recent advances in the identification of significant human cytomegalovirus-encoded proteins.Transplantation Proceedings.  23:64-69. 1991
1991 Characterization of a membrane-associated phosphoprotein of murine cytomegalovirus (pp50) and its immunological cross-reactivity with a human cytomegalovirus proteinVirology.  183:181-194. 1991
1989 NON-SPECIFIC MESANGIAL STAINING WITH ANTIBODIES AGAINST CYTOMEGALOVIRUS IN IMMUNOGLOBULIN-A NEPHROPATHYLancet.  333:129-131. 1989
1989 Processing of the gp55-116 envelope glycoprotein complex (gB) of human cytomegalovirusJournal of Virology.  63:403-410. 1989
1988 Primary cytomegalovirus infection in pregnancy: comparison of antibody responses to virus-encoded proteins between women with and without intrauterine infection.Journal of Infectious Diseases.  158:917-924. 1988
1988 Induction of complement-dependent and -independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB)Journal of Virology.  62:3309-3318. 1988
1987 Young Children as a Probable Source of Maternal and Congenital Cytomegalovirus InfectionNew England Journal of Medicine.  317:1539-1540. 1987
1987 Young Children as a Probable Source of Maternal and Congenital Cytomegalovirus InfectionNew England Journal of Medicine.  316:1366-1370. 1987
1987 Antibody response to virus-encoded proteins after cytomegalovirus mononucleosisJournal of Infectious Diseases.  156:615-621. 1987
1987 Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  111:343-348. 1987
1987 Structural and immunological characterization of the intracellular forms of an abundant 68000 M(r) human cytomegalovirus proteinJournal of General Virology.  68:1897-1907. 1987
1986 Primary cytomegalovirus infection in pregnancyJournal of the American Medical Association.  256:1904-1908. 1986
1983 Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirusJournal of Infectious Diseases.  148:953-961. 1983

Chapter

Year Title Altmetric
2013 Beta-and gammaherpesviruses: Cytomegalovirus and Epstein-Barr virus.  428-437. 2013

Principal Investigator On

  • CMV Vaccines: Reinfection and Antigenic Variation  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2019 - 2023
  • Mechanistic Approaches to Inhibition of Emerging DNA Viruses  awarded by University of Southern California 2019 - 2023
  • Congenital CMV and CNS Infection Mechanisms of Protective Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Inflammation and Hearing Loss Following Congenital CMV Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • Lipid Trafficking In HCMV Infected Cells  awarded by American Heart Association 2018 - 2020
  • Identification of Pre-fusion Conformers of HCMV gB  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2020
  • Envelope Assembly of Human Cytomegalovirus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • UAB Neuroscience Core Center - Core C: Vector and Virus Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2020
  • Small Molecule Inhibitors Targeting Adenovirus  awarded by University of Southern California 2019
  • Private Grant  awarded by WESTAT, INC. 2018 - 2019
  • CMV Vaccines: Reinfection and Antigenic Variation  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2011 - 2018
  • Congenital CMV and CNS Infection: Mechanisms of Protective Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2018
  • Vaccine-Mediated Targeting of Viral IL 10 to Control HCMV Shedding and Reinfection  awarded by University of California, Davis 2011 - 2017
  • Inflammation and Hearing Loss Following Congenital CMV Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS 2016 - 2017
  • Hearing Loss and Congenital CMV Infections: Exploration of Strategies to Limit Hearing Loss in Infected Infants  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2015 - 2017
  • MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2010 - 2017
  • UAB Neuroscience Core Center - Core C  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2016
  • gM/gN and Envelopment of HCMV  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2014
  • Envelope Assembly of Human Cytomegalovirus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2007 - 2013
  • UAB Neuroscience Core Center - Core C  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011
  • Investigator On

  • Viral Adaptation to CD4 T Cell Responses and the Impact on HIV Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2019 - 2021
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2020
  • Acquisition of HCMV from Breast Milk-Correlates of Protection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Viral Diversity in Congenital Cytomegalovirus Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS 2012 - 2019
  • Mechanism of Cytomegalovirus-induced Mucosal Inflammation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2019
  • Cytomegalovirus Infection Exacerbates Macrophage-driven Inflammation in Inflammatory Bowel Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2019
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2011 - 2016
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2013 - 2016
  • A Clinic-Based Behavioral Intervention to Reduce CMV Transmission in Pregnancy  awarded by CDC - Centers for Disease Control and Prevention/DHHS 2012 - 2015
  • Innate Immunity and Viral Renal Allograft Injury  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2015
  • Pediatric Physician Training in Translational Research  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2008 - 2013
  • Innate Immunity and Viral Renal Allograft Injury  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2013
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2005 - 2011
  • Education And Training

  • Doctor of Medicine, University of Arizona 1976
  • McGill University, Internship 1977
  • ALABAMA MEDICAL LICENSURE COMMISSION, Residency 1978
  • UAB Hospital, Postdoctoral Fellowship 1984
  • Rocky Mountain Laboratories, Postdoctoral Fellowship 1982
  • Full Name

  • William Britt