Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 A novel strain-specific neutralizing epitope on glycoprotein H of human cytomegalovirusJournal of Virology.  95. 2021
2021 Predictors of Nonseroconversion after SARS-CoV-2 InfectionEmerging Infectious Diseases.  27:2454-2458. 2021
2021 Murine models of central nervous system disease following congenital human cytomegalovirus infectionsPathogens.  10. 2021
2021 Cytomegalovirus infection and inflammation in developing brainViruses.  13. 2021
2021 Virological characteristics of hospitalized children with SARS-CoV-2 infectionPediatrics.  147. 2021
2021 Comparing Nasopharyngeal and Midturbinate Nasal Swab Testing for the Identification of Severe Acute Respiratory Syndrome Coronavirus 2Clinical Infectious Diseases.  72:1253-1255. 2021
2021 Localization of the WD repeat-containing protein 5 to the virion assembly compartment facilitates human cytomegalovirus assemblyJournal of Virology.  95. 2021
2021 Comprehensive evaluation of risk factors for neonatal hearing loss in a large Brazilian cohortJournal of Perinatology.  41:315-323. 2021
2021 NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infectionJournal of Experimental Medicine.  218. 2021
2021 Recent Approaches and Strategies in the Generation of Anti-human Cytomegalovirus VaccinesMethods in Molecular Biology.  2244:403-463. 2021
2020 Cell fusion induced by a fusion-active form of human cytomegalovirus glycoprotein B (gB) is inhibited by antibodies directed at antigenic domain 5 in the ectodomain of gBJournal of Virology.  94. 2020
2020 Human cytomegalovirus envelope protein gpul132 regulates infectious virus production through formation of the viral assembly compartmentmBio.  11:1-16. 2020
2020 Phosphorylation of tegument protein pp28 contributes to trafficking to the assembly compartment in human cytomegalovirus infection 2020
2020 Contribution of congenital cytomegalovirus infection to permanent hearing loss in a highly seropositive population: The brazilian cytomegalovirus hearing and maternal secondary infection studyClinical Infectious Diseases.  70:1379-1384. 2020
2020 Human Cytomegalovirus Infection in Women with Preexisting Immunity: Sources of Infection and Mechanisms of Infection in the Presence of Antiviral ImmunityJournal of Infectious Diseases.  221:S1-S8. 2020
2020 Erratum: Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection (BMC Infectious Diseases (2019) 19 (1046) DOI: 10.1186/s12879-019-4681-0)BMC Infectious Diseases.  20. 2020
2019 Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infectionBMC Infectious Diseases.  19. 2019
2019 Correction to: International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): Study protocol (BMC Pregnancy and Childbirth (2019) 19 (282) DOI: 10.1186/s12884-019-2430-4)BMC Pregnancy and Childbirth.  19. 2019
2019 Virus-induced cochlear inflammation in newborn mice alters auditory functionJCI insight.  4. 2019
2019 International prospective observational cohort study of Zika in infants and pregnancy (ZIP study): Study protocolBMC Pregnancy and Childbirth.  19. 2019
2019 CD4 T cells are required for maintenance of CD8 TRM cells and virus control in the brain of MCMV-infected newborn miceMedical Microbiology and Immunology.  208:487-494. 2019
2019 Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades’ résuméMedical Microbiology and Immunology.  208:415-429. 2019
2019 HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission 2019
2018 Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7Mucosal Immunology.  11:1694-1704. 2018
2018 Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteinsVirology.  524:97-105. 2018
2018 New therapies for human cytomegalovirus infectionsAntiviral Research.  159:153-174. 2018
2018 Immune responses to congenital cytomegalovirus infection 2018
2018 Seroconversion for Cytomegalovirus Infection during Pregnancy and Fetal Infection in a Highly Seropositive Population: "the BraCHS Study"Journal of Infectious Diseases.  218:1200-1204. 2018
2018 Human cytomegalovirus immediate early 1 protein causes loss of SOX2 from neural progenitor cells by trapping unphosphorylated STAT3 in the nucleusJournal of Virology.  92. 2018
2018 Cytomegalovirus Shedding in Seropositive Pregnant Women from a High-Seroprevalence Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection StudyClinical Infectious Diseases.  67:743-750. 2018
2018 Maternal immunity and the natural history of congenital human cytomegalovirus infectionViruses.  10. 2018
2018 Brain-resident memory CD8+ T cells induced by congenital CMV infection prevent brain pathology and virus reactivationEuropean Journal of Immunology.  48:950-964. 2018
2018 WDR5 facilitates human cytomegalovirus replication by promoting capsid nuclear egressJournal of Virology.  92. 2018
2018 Adverse outcomes of pregnancy-associated Zika virus infectionSeminars in Perinatology.  42:155-167. 2018
2018 Human cytomegalovirus nuclear capsids associate with the core nuclear egress complex and the viral protein kinase pUL97Viruses.  10. 2018
2018 Herpesviridae Infection: Prevention, Screening, and ManagementClinical Obstetrics and Gynecology.  61:157-176. 2018
2017 Congenital human cytomegalovirus infection and the enigma of maternal immunityJournal of Virology.  91. 2017
2017 Cytomegalovirus vector expressing RAE-1γ induces enhanced anti-tumor capacity of murine CD8+ T cellsEuropean Journal of Immunology.  47:1354-1367. 2017
2017 Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirusPLoS Pathogens.  13. 2017
2017 Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligasePLoS Pathogens.  13. 2017
2017 Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspectiveMolecular Ecology.  26:1980-1990. 2017
2017 Tumor necrosis factor alpha-induced recruitment of inflammatory mononuclear cells leads to inflammation and altered brain development in murine cytomegalovirusinfected newborn miceJournal of Virology.  91. 2017
2017 Human cytomegalovirus phosphoproteins are hypophosphorylated and intrinsically disorderedJournal of General Virology.  98:471-485. 2017
2017 Pathogenesis of Non-Zika Congenital Viral InfectionsJournal of Infectious Diseases.  216:S912-S918. 2017
2016 Distinct functional domains within the acidic cluster of tegument protein pp28 required for trafficking and cytoplasmic envelopment of human cytomegalovirusJournal of General Virology.  97:2677-2683. 2016
2016 Phosphorylation of Golgi peripheral membrane protein Grasp65 is an integral step in the formation of the human cytomegalovirus cytoplasmic assembly compartmentmBio.  7. 2016
2016 Microbial Cryptotopes are Prominent Targets of B-cell ImmunityScientific Reports.  6. 2016
2016 Clinical predictors of sensorineural hearing loss and cognitive outcome in infants with symptomatic congenital cytomegalovirus infection 2016
2016 Correction: Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection [Journal of Virology, 87, 20, (2013) (10968-10979)] doi: 10.1128/JVI.01120-13Journal of Virology.  90:10431-10433. 2016
2015 Limits and patterns of cytomegalovirus genomic diversity in humans 2015
2015 Controversies in the natural history of congenital human cytomegalovirus infection: the paradox of infection and disease in offspring of women with immunity prior to pregnancyMedical Microbiology and Immunology.  204:263-271. 2015
2015 A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism 2015
2015 Human cytomegalovirus infection dysregulates the localization and stability of NICD1 and Jag1 in neural progenitor cellsJournal of Virology.  89:6792-6804. 2015
2015 Identification of a neutralizing epitope within Antigenic domain 5 of glycoprotein B of human cytomegalovirusJournal of Virology.  89:361-372. 2015
2015 Immunobiology of congenital cytomegalovirus infection of the central nervous system - The murine cytomegalovirus modelCellular and Molecular Immunology.  12:180-191. 2015
2015 MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25aJournal of Virology.  89:1070-1082. 2015
2015 Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia NeuronsPLoS Pathogens.  11. 2015
2015 Vaccine-derived neutralizing antibodies to the human cytomegalovirus gH/gL pentamer potently block primary cytotrophoblast infectionJournal of Virology.  89:11884-11898. 2015
2014 Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responsesJournal of Immunology.  193:5604-5612. 2014
2014 Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretionCell Host and Microbe.  15:363-373. 2014
2014 Cytomegalovirus microRNAsCurrent Opinion in Virology.  7:40-46. 2014
2014 Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfectionVirology.  462-463:295-298. 2014
2014 Recent approaches and strategies in the generation of antihuman cytomegalovirus vaccinesMethods in Molecular Biology.  1119:311-348. 2014
2014 Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  164:855-859. 2014
2013 CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T CellsPLoS ONE.  8. 2013
2013 The Smallest Capsid Protein Mediates Binding of the Essential Tegument Protein pp150 to Stabilize DNA-Containing Capsids in Human CytomegalovirusPLoS Pathogens.  9. 2013
2013 Glucocortiocoid Treatment of MCMV Infected Newborn Mice Attenuates CNS Inflammation and Limits Deficits in Cerebellar DevelopmentPLoS Pathogens.  9. 2013
2013 Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies 2013
2013 Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damageTransplantation.  95:48-53. 2013
2013 Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infectionJournal of Virology.  87:10968-10979. 2013
2012 Glycoprotein N of Human Cytomegalovirus Protects the Virus from Neutralizing AntibodiesPLoS Pathogens.  8. 2012
2012 Strain-specific neutralizing antibody responses against human cytomegalovirus envelope glycoprotein N 2012
2011 Congenital cytomegalovirus infection as a cause of sensorineural hearing loss in a highly immune population 2011
2011 Ganciclovir transiently attenuates murine cytomegalovirus-associated renal allograft inflammationTransplantation.  92:759-766. 2011
2011 Mixed infection and strain diversity in congenital cytomegalovirus infectionJournal of Infectious Diseases.  204:1003-1007. 2011
2011 Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newbornsNew England Journal of Medicine.  364:2111-2118. 2011
2011 Biochemical and structural characterization of the capsid-bound tegument proteins of human cytomegalovirus 2011
2011 A role for the small GTPase Rab6 in assembly of human cytomegalovirusJournal of Virology.  85:5213-5219. 2011
2010 Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine propertiesJournal of Clinical Investigation.  120:4532-4545. 2010
2010 Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to- mesenchymal transitionPLoS Pathogens.  6. 2010
2010 G-CSF and CD34+ progenitor cells in hematopoietic grafts: Too fertile for human cytomegalovirusCell Host and Microbe.  8:223-224. 2010
2010 Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infectionObstetrical and Gynecological Survey.  65:484-485. 2010
2010 Human cytomegalovirus: Propagation, quantification, and storageCurrent Protocols in Microbiology2010
2010 Optimal replication of human cytomegalovirus correlates with endocytosis of glycoprotein gpUL132Journal of Virology.  84:7039-7052. 2010
2010 Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection 2010
2010 Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cellsJournal of Virology.  84:3162-3177. 2010
2010 Modified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccinesVaccine.  28:1547-1557. 2010
2010 Cytomegalovirus reinfections in healthy seroimmune womenJournal of Infectious Diseases.  201:386-389. 2010
2010 Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal populationAmerican Journal of Obstetrics and Gynecology.  202:297.e1-297.e8. 2010
2009 Glycoprotein N subtypes of human cytomegalovirus induce a strain-specific antibody response during natural infectionJournal of General Virology.  90:1951-1961. 2009
2009 HCMV-encoded glycoprotein M (UL100) interacts with rab11 effector protein FIP4Traffic.  10:1439-1457. 2009
2009 Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune populationClinical Infectious Diseases.  49:522-528. 2009
2009 Enzyme-linked immunosorbent assay method for detection of cytomegalovirus strain-specific antibody responses 2009
2009 Cytomegalovirus blood viral load and hearing loss in young children with congenital infection 2009
2009 Cytomegalovirus shedding and delayed sensorineural hearing loss: Results from longitudinal follow-up of children with congenital infection 2009
2008 Manifestations of human cytomegalovirus infection: Proposed mechanisms of acute and chronic diseaseCurrent Topics in Microbiology and Immunology.  325:417-470. 2008
2008 Passive immunization reduces murine cytomegalovirus-induced brain pathology in newborn miceJournal of Virology.  82:12172-12180. 2008
2008 A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vectorVirology.  377:379-390. 2008
2008 CD8+ T lymphocytes control murine cytomegalovirus replication in the central nervous system of newborn animalsJournal of Immunology.  181:2111-2123. 2008
2008 Longitudinal metabolic and cognitive changes in mild cognitive impairment patientsAlzheimer Disease and Associated Disorders.  22:269-277. 2008
2008 Multimerization of tegument protein pp28 within the assembly compartment is required for cytoplasmic envelopment of human cytomegalovirusJournal of Virology.  82:6272-6287. 2008
2008 Altered development of the brain after focal herpesvirus infection of the central nervous systemJournal of Experimental Medicine.  205:423-435. 2008
2008 Congenital cytomegalovirus infection in a highly seropositive semi-urban population in India 2008
2007 Human cytomegalovirus induces cellular tyrosine kinase signaling and promotes glioma cell invasivenessJournal of Neuro-Oncology.  85:271-280. 2007
2007 The cytoplasmic tail of glycoprotein M (gpUL100) expresses trafficking signals required for human cytomegalovirus assembly and replicationJournal of Virology.  81:10316-10328. 2007
2007 Cytoplasmic envelopment of human cytomegalovirus requires the postlocalization function of tegument protein pp28 within the assembly compartmentJournal of Virology.  81:6536-6547. 2007
2007 The carboxy-terminal domain of glycoprotein N of human cytomegalovirus is required for virion morphogenesisJournal of Virology.  81:5212-5224. 2007
2007 DNA vaccines expressing glycoprotein complex II antigens gM and gN elicited neutralizing antibodies against multiple human cytomegalovirus (HCMV) isolatesVaccine.  25:3319-3327. 2007
2007 Vaccine properties of a novel marker gene-free recombinant modified vaccinia Ankara expressing immunodominant CMV antigens pp65 and IE1Vaccine.  25:1132-1141. 2007
2006 Cytomegalovirus blocks intestinal stroma-induced down-regulation of macrophage HIV-1 infectionJournal of Leukocyte Biology.  80:1111-1117. 2006
2006 Human cytomegalovirus attenuates interleukin-1β and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-κB activationJournal of Virology.  80:5588-5598. 2006
2006 Sequence requirements for localization of human cytomegalovirus tegument protein pp28 to the virus assembly compartment and for assembly of infectious virusJournal of Virology.  80:5611-5626. 2006
2006 Human cytomegalovirus infection elicits a glycoprotein M (gM)/gN-specific virus-neutralizing antibody responseJournal of Virology.  80:4591-4600. 2006
2006 Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infectionJournal of Clinical Virology.  35:324-331. 2006
2006 Hearing loss in children with congenital cytomegalovirus infection born to mothers with preexisting immunityJournal of Pediatrics.  148:332-336. 2006
2006 Congenital cytomegalovirus infection following first trimester maternal infection: Symptoms at birth and outcomeJournal of Clinical Virology.  35:216-220. 2006
2006 Nonhuman primate models of intrauterine cytomegalovirus infection 2006
2005 Human cytomegalovirus UL97 kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesisJournal of Virology.  79:15494-15502. 2005
2005 Association between genital tract cytomegalovirus infection and bacterial vaginosisJournal of Infectious Diseases.  192:1727-1730. 2005
2005 Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblastsJournal of Virology.  79:11837-11847. 2005
2005 Congenital cytomegalovirus infection: Association between virus burden in infancy and hearing lossJournal of Pediatrics.  146:817-823. 2005
2005 Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein BJournal of Virology.  79:4066-4079. 2005
2005 Complex formation by glycoproteins M and N of human cytomegalovirus: Structural and functional aspectsJournal of Virology.  79:2160-2170. 2005
2005 Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous systemJournal of Infectious Diseases.  191:227-233. 2005
2005 Three-dimensional localization of the smallest capsid protein in the human cytomegalovirus capsidJournal of Virology.  79:1327-1332. 2005
2004 Erratum: Identification of proteins in human cytomegalovirus (HCMV) particles: The HCMV proteome (Journal of Virology (2004) 78:20 (10960-10966))Journal of Virology.  78:13395. 2004
2004 Identification of proteins in human cytomegalovirus (HCMV) particles: The HCMV proteomeJournal of Virology.  78:10960-10966. 2004
2004 Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cellsBlood.  104:847-856. 2004
2004 Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirusJournal of Virology.  78:6688-6691. 2004
2004 Recombinant Modified Vaccinia Virus Ankara Expressing A Soluble Form of Glycoprotein B Causes Durable Immunity and Neutralizing Antibodies against Multiple Strains of Human CytomegalovirusJournal of Virology.  78:3965-3976. 2004
2004 Human cytomegalovirus virion proteinsHuman Immunology.  65:395-402. 2004
2004 Phosphorylation of Human Cytomegalovirus Glycoprotein B (gB) at the Acidic Cluster Casein Kinase 2 Site (Ser900) Is Required for Localization of gB to the trans-Golgi Network and Efficient Virus ReplicationJournal of Virology.  78:285-293. 2004
2004 Rapid Genetic Engineering of Human Cytomegalovirus by Using a Lambda Phage Linear Recombination System: Demonstration that pp28 (UL99) Is Essential for Production of Infectious VirusJournal of Virology.  78:539-543. 2004
2003 High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma 2003
2003 Erratum: Envelopment of human cytomegalovirus occurs by budding into golgi-derived vacuole compartments positive for gB, Rab 3, trans-golgi network 46, and mannosidase II (Journal of Virology (2003) 77:5 (3191-3203))Journal of Virology.  77:8179. 2003
2003 Envelopment of human cytomegalovirus occurs by budding into Golgi-derived vacuole compartments positive for gB, Rab 3, trans-Golgi network 46, and mannosidase IIJournal of Virology.  77:3191-3203. 2003
2003 Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: Identification of a novel subgroup, geographical distribution and evidence of positive selective pressureJournal of General Virology.  84:647-655. 2003
2003 Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-β releaseJournal of Infectious Diseases.  187:534-541. 2003
2003 The interaction between the major capsid protein and the smallest capsid protein of human cytomegalovirus is dependent on two linear sequences in the smallest capsid proteinJournal of Virology.  77:2730-2735. 2003
2002 Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer 2002
2002 Rapid reconstitution of humoral immunity against cytomegalovirus but not HIV following highly active antiretroviral therapyAIDS.  16:2129-2135. 2002
2002 Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infectionPediatrics.  110:762-767. 2002
2002 Experimental coinfection of rhesus macaques with rhesus cytomegalovirus and simian immunodeficiency virus: PathogenesisJournal of Virology.  76:7661-7671. 2002
2002 Human cytomegalovirus infection and expression in human malignant gliomaCancer Research.  62:3347-3350. 2002
2002 Human cytomegalovirus enhances chemokine production by lipopolysaccharide-stimulated lamina propria macrophagesJournal of Infectious Diseases.  185:584-590. 2002
2002 Identification of glycoprotein gpTRL10 as a structural component of human cytomegalovirusJournal of Virology.  76:1450-1460. 2002
2001 Modification of maternal and congenital cytomegalovirus infection by anti-glycoprotein B antibody transfer in guinea pigsJournal of Infectious Diseases.  183:1547-1553. 2001
2001 Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunityNew England Journal of Medicine.  344:1366-1371. 2001
2001 Lymphotoxins and cytomegalovirus cooperatively induce interferon-β, establishing host-virus DétenteImmunity.  15:617-626. 2001
2000 Complex formation by human cytomegalovirus glycoproteins M (gpUL100) and N (gpUL73)Journal of Virology.  74:11881-11892. 2000
2000 B lymphoblastoid cell lines as efficient APC to elicit CD8+ T cell responses against a cytomegalovirus antigenJournal of Immunology.  165:4105-4111. 2000
2000 Longitudinal investigation of hearing disorders in children with congenital cytomegalovirusJournal of the American Academy of Audiology.  11:283-290. 2000
2000 Infectious clones of herpesviruses: A new approach for understanding viral gene functionTrends in Microbiology.  8:262-265. 2000
2000 Human cytomegalovirus pp28 (UL99) localizes to a cytoplasmic compartment which overlaps the endoplasmic reticulum-Golgi-intermediate compartmentJournal of Virology.  74:3842-3851. 2000
2000 A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolatesAntimicrobial Agents and Chemotherapy.  44:688-692. 2000
2000 Accumulation of virion tegument and envelope proteins in a stable cytoplasmic compartment during human cytomegalovirus replication: Characterization of a potential site of virus assemblyJournal of Virology.  74:975-986. 2000
1999 A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvantJournal of Infectious Diseases.  180:970-975. 1999
1999 Simultaneous ex vivo expansion of cytomegalovirus and Epstein-Barr virus-specific cytotoxic T lymphocytes using B-lymphoblastoid cell lines expressing cytomegalovirus pp65Blood.  94:3242-3250. 1999
1999 Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirusPediatrics.  104:55-60. 1999
1999 Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus.Pediatrics.  104:55-60. 1999
1999 Human cytomegalovirus infection of Caco-2 cells occurs at the basolateral membrane and is differentiation state dependentJournal of Virology.  73:4552-4560. 1999
1998 Localization of human cytomegalovirus structural proteins to the nuclear matrix of infected human fibroblastsJournal of Virology.  72:3321-3329. 1998
1998 Neuropathogenesis induced by rhesus cytomegalovirus in fetal rhesus monkeys (Macaca mulatta)Journal of Infectious Diseases.  177:446-450. 1998
1997 Expression, purification, and characterization of a soluble form of human cytomegalovirus glycoprotein BVirology.  239:198-205. 1997
1997 Effects of primary maternal cmv infection on early pregnancy and the immature placenta in guinea pigsClinical Infectious Diseases.  25:375. 1997
1997 Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group.Journal of Infectious Diseases.  175:1080-1086. 1997
1997 Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infectionPediatrics.  99:409-414. 1997
1997 Detection of antibodies to respiratory syncytial virus attachment and nucleocapsid proteins with recombinant baculovirus-expressed antigensJournal of Clinical Microbiology.  35:354-357. 1997
1997 Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: Results of a phase II studyJournal of Infectious Diseases.  175:1080-1086. 1997
1997 Glycoprotein H-related complexes of human cytomegalovirus: Identification of a third protein in the gCIII complexJournal of Virology.  71:3090-3097. 1997
1997 Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  130:624-630. 1997
1996 Recognition of human cytomegalovirus gene products by HCMV-specific cytotoxic T cellsVirology.  222:293-296. 1996
1996 Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructuresVirology.  216:133-145. 1996
1996 A novel mechanism for persistence of human cytomegalovirus in macrophagesJournal of Virology.  70:1855-1862. 1996
1996 Antigenic and immunogenic analysis of group A and group B respiratory syncytial virus G proteins expressed from recombinant baculovirusesJournal of General Virology.  77:641-648. 1996
1996 Glycoprotein H of human cytomegalovirus is a major antigen for the neutralizing humoral immune responseJournal of General Virology.  77:1537-1547. 1996
1996 Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49Journal of Virology.  70:5680-5683. 1996
1996 Human cytomegalovirus glycoproteins 1996
1996 Human cytomegalovirus infections during pregnancyBaillieres Clinical Infectious Diseases.  3:327-343. 1996
1996 Human cytomegalovirus overview: The virus and its pathogenic mechanismsBaillieres Clinical Infectious Diseases.  3:307-325. 1996
1996 Immunodetection of cytomegalovirus (cmvo immediate early (ie-1) protein in tissue culture at 16 hours incubation: Validation and comparison to conventional culture, and evaluation of normal and immunodepressed polPediatric Research.  39:371. 1996
1996 Transplacentally acquired antiviral antibodies and outcome in congenital human cytomegalovirus infectionViral Immunology.  9:211-218. 1996
1996 Vaccines against human cytomegalovirus: Time to testTrends in Microbiology.  4:34-38. 1996
1995 Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediatedby the human endoprotease furinVirology.  206:746-749. 1995
1995 Antiviral antibody responses and intrauterine transmission after primary maternal cytomegalovirus infectionJournal of Infectious Diseases.  171:1115-1121. 1995
1995 Formulation of an immunogenic human cytomegalovirus vaccine: responses in miceJournal of Infectious Diseases.  171:18-25. 1995
1995 Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophagesJournal of Virology.  69:3737-3743. 1995
1995 Human cytomegalovirus neutralizing antibody-resistant phenotype is associated with reduced expression of glycoprotein HJournal of Virology.  69:6047-6053. 1995
1995 Postoligomerization folding of human cytomegalovirus glycoprotein B: Identification of folding intermediates and importance of disulfide bondingJournal of Virology.  69:7015-7022. 1995
1995 Reduced congenital cytomegalovirus (CMV) infection after maternal immunization with a guinea pig CMV glycoprotein before gestational primary cmv infection in the guinea pig modelJournal of Infectious Diseases.  172:1212-1220. 1995
1995 Virus-specific antibody responses to human cytomegalovirus (hcmv) in human immunodeficiency virus type 1-infected persons with hcmv retinitisJournal of Infectious Diseases.  171:182-185. 1995
1994 Sequence analysis and expression of the murine cytomegalovirus phosphoprotein pp50, a homolog of the human cytomegalovirus UL44 gene productVirology.  200:413-427. 1994
1994 Epitope-specific distribution of igg subclasses against antigenic domains on glycoproteins of human cytomegalovirusJournal of Infectious Diseases.  169:83-90. 1994
1994 Human neural xenografts: Progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infectionAdvances in neuroimmunology.  4:257-260. 1994
1994 Identification of an abundant disulfide-linked complex of glycoproteins in the envelope of guinea pig cytomegalovirusVirology.  201:294-302. 1994
1994 Late onset and reactivation of chorioretinitis in children with congenital cytomegalovirus infection 1994
1994 Methods in laboratory investigation. Cytomegalovirus infection of human retinal tissue: An in vivo modelLaboratory Investigation.  71:141-148. 1994
1993 Analysis of Proteins Encoded by IE Regions 1 and 2 of Human Cytomegalovirus Using Monoclonal Antibodies Generated against Recombinant AntigensVirology.  193:642-652. 1993
1993 Antibodies Induced by a Primary Cytomegalovirus Infection React with Human Herpesvirus 6 ProteinsJournal of Infectious Diseases.  168:1119-1126. 1993
1993 Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sitesJournal of Virology.  67:489-496. 1993
1993 Virus-specific antibody responses in mothers and their newborn infants with asymptomatic congenital cytomegalovirus infectionsJournal of Infectious Diseases.  167:72-77. 1993
1992 The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusNew England Journal of Medicine.  326:663-667. 1992
1992 Recognition of compartmentalized intracellular analogs of glycoprotein H of human cytomegalovirusArchives of Virology.  126:67-80. 1992
1992 A continuous sequence of more than 70 amino acids is essential for antibody binding to the dominant antigenic site of glycoprotein gp58 of human cytomegalovirusJournal of Virology.  66:5290-5297. 1992
1992 Evaluation of a microtiter plate fluorescent-antibody assay for rapid detection of human cytomegalovirus infectionJournal of Clinical Microbiology.  30:721-723. 1992
1992 Oligomerization of the human cytomegalovirus major envelope glycoprotein complex gB (gp55-116)Journal of Virology.  66:6747-6754. 1992
1992 Symptomatic congenital cytomegalovirus infection: Neonatal morbidity and mortality 1992
1992 The dominant linear neutralizing antibody-binding site of glycoprotein gp86 of human cytomegalovirus is strain specificJournal of Virology.  66:1303-1311. 1992
1992 The outcome of congenital cytomegalovirus infection in relation to maternal antibody statusObstetrical and Gynecological Survey.  47:544-546. 1992
1991 Characterization of a membrane-associated phosphoprotein of murine cytomegalovirus (pp50) and its immunological cross-reactivity with a human cytomegalovirus proteinVirology.  183:181-194. 1991
1991 Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expressionJournal of Immunology.  146:2795-2804. 1991
1991 Distribution of linear antigenic sites on glycoprotein gp55 of human cytomegalovirusJournal of Virology.  65:138-146. 1991
1991 Recent advances in the identification of significant human cytomegalovirus-encoded proteinsTransplantation Proceedings.  23:64-69. 1991
1990 A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia virusesJournal of Virology.  64:6176-6183. 1990
1990 Antiviral antibody responses in mothers and their newborn infants with clinical and subclinical congenital cytomegalovirus infectionsJournal of Infectious Diseases.  161:214-219. 1990
1990 Cell surface expression of human cytomegalovirus (HCMV) gp55-116 (gB): Use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody responseJournal of Virology.  64:1079-1085. 1990
1990 Congenital and perinatal cytomegalovirus infectionsReviews of infectious diseases.  12:S745-S753. 1990
1990 Host genetic control of spontaneous and induced immunity to friend murine retrovirus infectionAnnual Review of Immunology.  8:477-499. 1990
1990 Nuclear compartmentation of glycoprotein B of human cytomegalovirusVirology.  177:515-522. 1990
1990 Procaryotic expression of phosphorylated tegument protein pp65 of human cytomegalovirus and application of recombinant peptides for immunoblot analysesJournal of Clinical Microbiology.  28:1229-1235. 1990
1990 Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain TowneJournal of Virology.  64:2922-2931. 1990
1990 Structural and immunological characterization of human cytomegalovirus gp55-116 (gB) expressed in insect cellsJournal of General Virology.  71:873-880. 1990
1989 NON-SPECIFIC MESANGIAL STAINING WITH ANTIBODIES AGAINST CYTOMEGALOVIRUS IN IMMUNOGLOBULIN-A NEPHROPATHY 1989
1989 A rapid microneutralization assay for the measurement of neutralizing antibody reactive with human cytomegalovirusJournal of Virological Methods.  23:157-167. 1989
1989 Identification of a neutralizing epitope on glycoprotein gp58 of human cytomegalovirusJournal of Virology.  63:1995-2001. 1989
1989 Non-specific mesangial staining with antibodies against cytomegalovirus in immunoglobulin-A nephropathy 1989
1989 Processing of the gp55-116 envelope glycoprotein complex (gB) of human cytomegalovirusJournal of Virology.  63:403-410. 1989
1988 Induction of complement-dependent and -independent neutralizing antibodies by recombinant-derived human cytomegalovirus gp55-116 (gB)Journal of Virology.  62:3309-3318. 1988
1988 Primary cytomegalovirus infection in pregnancy: Comparison of antibody responses to virus-encoded proteins between women with and without intrauterine infectionJournal of Infectious Diseases.  158:917-924. 1988
1987 Young Children as a Probable Source of Maternal and Congenital Cytomegalovirus InfectionNew England Journal of Medicine.  317:1539-1540. 1987
1987 Young Children as a Probable Source of Maternal and Congenital Cytomegalovirus InfectionNew England Journal of Medicine.  316:1366-1370. 1987
1987 Antibody response to virus-encoded proteins after cytomegalovirus mononucleosisJournal of Infectious Diseases.  156:615-621. 1987
1987 Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infectionJournal of Pediatrics.  111:343-348. 1987
1987 Structural and immunological characterization of the intracellular forms of an abundant 68000 M(r) human cytomegalovirus proteinJournal of General Virology.  68:1897-1907. 1987
1986 Primary cytomegalovirus infection in pregnancy 1986
1986 Primary Cytomegalovirus Infection in Pregnancy: Incidence, Transmission to Fetus, and Clinical Outcome 1986
1986 Intellectual development in school-aged children with asymptomatic congenital cytomegalovirus infectionPediatrics.  77:801-806. 1986
1986 Congenital Cytomegalovirus Infection: Prospects for PreventionAnnals of the New York Academy of Sciences.  477:123-127. 1986
1986 Human cytomegalovirus virion-associated protein with kinase activityJournal of Virology.  59:185-188. 1986
1986 Synthesis and processing of the envelope gp55-116 complex of human cytomegalovirusJournal of Virology.  58:185-191. 1986
1985 Serological heterogeneity of cmv isolates with a monoclonal antibodyJournal of Infectious Diseases.  152:648. 1985
1985 Detection of cytomegalovirus antibody with latex agglutinationJournal of Clinical Microbiology.  22:68-70. 1985
1985 Identification of a 65000 dalton virion envelope protein of human cytomegalovirusVirus Research.  4:31-36. 1985
1984 Congenital and perinatal cytomegalovirus infections: Clinical characteristics and pathogenic factorsBirth defects original article series.  20:65-85. 1984
1984 Identification of a unique erythroleukemia- associated retroviral gp70 expressed during early stages of normal erythroid differentiationJournal of Experimental Medicine.  159:1591-1603. 1984
1984 Factors associated with primary cytomegalovirus infection during pregnancyJournal of Medical Virology.  13:347-353. 1984
1984 Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirusVirology.  135:369-378. 1984
1983 H-2d control of recovery from friend virus leukemia: H-2d region influences the kinetics of the t lymphocyte response to friend virusJournal of Experimental Medicine.  157:1736-1745. 1983
1983 An immunological focus assay for murine leukemia viruses on viable attached cell linesVirology.  129:212-217. 1983
1983 Characterization of monoclonal antibodies reactive with murine leukemia viruses: Use in analysis of strains of friend MCF and friend ecotropic murine leukemia virusVirology.  127:134-148. 1983
1983 Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirusJournal of Infectious Diseases.  148:953-961. 1983
1983 Use of monoclonal anti-gp70 antibodies to mimic the effects of the Rfv-3 gene in mice with Friend virus-induced leukemiaJournal of Immunology.  130:2363-2367. 1983
1981 New cell surface gp70 related to friend mink cell focus-inducing virus is expressed on friend virus-induced erythroleukemic spleen cells after elimination of ecotropic friend virus gp70 in Rfv-3 r/s miceJournal of Experimental Medicine.  154:868-882. 1981
1981 Characterization of mouse monoclonal antibodies specific for friend murine leukemia virus-induced erythroleukemia cells: Friend-specific and FMR-specific antigensVirology.  112:131-144. 1981
1980 H-2D (Rfv-1) gene influence on recovery from friend virus leukemia is mediated by nonleukemic cells of the spleen and bone marrowJournal of Experimental Medicine.  152:1795-1804. 1980
1980 Cytotoxic T lymphocyte recognition of gp70 on Friend virus-induced erythroleukemia cell clonesJournal of Immunology.  125:1318-1324. 1980
1977 Detection of errors in methylmalonyl CoA metabolism by using amniotic fluid 1977

Chapter

Year Title Altmetric
2013 Beta-and gammaherpesviruses: Cytomegalovirus and Epstein-Barr virus.  428-437. 2013
2012 Beta- and gammaherpesviruses: Cytomegalovirus and epstein-barr virus.  428-437. 2012
2011 Cytomegalovirus.  706-755. 2011
2007 CMV maturation and egress.  311-323. 2007
2007 HCMV: Pathogenesis and disease consequences.  737-764. 2007
2006 Cytomegalovirus Infections.  739-781. 2006

Principal Investigator On

  • CMV Vaccines: Reinfection and Antigenic Variation  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • CMV Vaccines: Reinfection and Antigenic Variation  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Congenital CMV and CNS Infection Mechanisms of Protective Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Congenital CMV and CNS Infection: Mechanisms of Protective Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Envelope Assembly of Human Cytomegalovirus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Envelope Assembly of Human Cytomegalovirus  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Hearing Loss and Congenital CMV Infections: Exploration of Strategies to Limit Hearing Loss in Infected Infants  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE
  • Identification of Pre-fusion Conformers of HCMV gB  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Inflammation and Hearing Loss Following Congenital CMV Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS
  • Inflammation and Hearing Loss Following Congenital CMV Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS
  • Lipid Trafficking In HCMV Infected Cells  awarded by American Heart Association
  • MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Mechanistic Approaches to Inhibition of Emerging DNA Viruses  awarded by University of Southern California
  • Private Grant  awarded by WESTAT, INC.
  • Private Grant  awarded by MERCK SHARP & DOHME CORP
  • Small Molecule Inhibitors Targeting Adenovirus  awarded by University of Southern California
  • UAB Neuroscience Core Center - Core C  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Neuroscience Core Center - Core C  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Neuroscience Core Center - Core C: Vector and Virus Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Vaccine-Mediated Targeting of Viral IL 10 to Control HCMV Shedding and Reinfection  awarded by University of California, Davis
  • gM/gN and Envelopment of HCMV  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Investigator On

  • A Clinic-Based Behavioral Intervention to Reduce CMV Transmission in Pregnancy  awarded by CDC - Centers for Disease Control and Prevention/DHHS
  • Acquisition of HCMV from Breast Milk-Correlates of Protection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Adaptive Immunity and Persistent SARS-CoV-2 Replication  awarded by National Cancer Institute/NIH/DHHS
  • Blocking CMV Transmission through the Human Milk Metabolome and Microbiome  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Cytomegalovirus Infection Exacerbates Macrophage-driven Inflammation in Inflammatory Bowel Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Innate Immunity and Viral Renal Allograft Injury  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Innate Immunity and Viral Renal Allograft Injury  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Mechanism of Cytomegalovirus-induced Mucosal Inflammation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
  • Pediatric Physician Training in Translational Research  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Prenatal Behavioral Intervention to Prevent Maternal Cytomegalovirus in Pregnancy  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Private Grant  awarded by MERCK SHARP & DOHME CORP
  • Tissue and Organ Specific Human B Cell Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Tissue and Organ Specific Human B Cell Immunity - Project 2: Characterization of Virus-Specific Human B Cell Subsets in Lymphoid and Non-Lymphoid Tissues  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Training Program in the Neurobiology of Cognition and Cognitive Disorders  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • UAB Neuroscience Core Center  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS
  • Viral Adaptation to CD4 T Cell Responses and the Impact on HIV Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS
  • Viral Diversity in Congenital Cytomegalovirus Infection  awarded by National Institute on Deafness & Other Communication Disorders/NIH/DHHS
  • Education And Training

  • McGill University, Internship
  • ALABAMA MEDICAL LICENSURE COMMISSION, Residency
  • NIH, NIAID, Rocky Mountain Laboratories, Postdoctoral Fellowship
  • UAB Hospital, Postdoctoral Fellowship
  • Doctor of Medicine, University of Arizona 1976
  • Full Name

  • William Britt