Selected Publications

Academic Article

Year Title Altmetric
2022 Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusMicrobiology Spectrum.  10. 2022
2022 Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodyPLoS Pathogens.  18. 2022
2022 Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmission. 2022
2022 Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody. 2022
2022 Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membraneCell Reports: Methods.  2. 2022
2021 A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivoJournal of Virology.  95. 2021
2021 Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses 2021
2021 Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of ConcernFrontiers in Immunology.  12. 2021
2021 Generation and characterization of recombinant SARS-CoV-2 expressing reporter genesJournal of Virology.  95. 2021
2021 Selection, identification, and characterization of SARS-CoV-2 monoclonal antibody resistant mutantsJournal of Virological Methods.  290. 2021
2021 Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamstersCell Reports Medicine.  2. 2021
2021 Editorial: Structures, Signaling Mechanisms, and Functions of Types I and III InterferonsFrontiers in Immunology.  12. 2021
2021 Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2Journal of Virological Methods.  287. 2021
2020 The Role of Structure in the Biology of Interferon SignalingFrontiers in Immunology.  11. 2020
2020 Engineered il-10 variants elicit potent immunomodulatory effects at low ligand dosesScience Signaling.  13. 2020
2020 Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urineLupus.  29:1095-1105. 2020
2020 Cytomegalovirus-vectored vaccines for HIV and other pathogensAIDS.  34:335-349. 2020
2019 Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion cultureMolecular Vision.  25:266-282. 2019
2019 Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity 2019
2018 Human interferon- and interferon- exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18RJournal of Biological Chemistry.  293:16057-16068. 2018
2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cellsJournal of Immunology.  199:2618-2623. 2017
2017 A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family 2017
2017 Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeysJCI Insight.  2. 2017
2017 Plasmablast response to primary rhesus cytomegalovirus (CMV) infection in a monkey model of congenital CMV transmissionClinical and Vaccine Immunology.  24. 2017
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions 2016
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. 2016
2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.Science Immunology.  1:aaf6628. 2016
2016 The susceptibility of primary cultured rhesus macaque kidney epithelial cells to rhesus cytomegalovirus strainsJournal of General Virology.  97:1426-1438. 2016
2016 A heterozygous RAB27A mutation associated with delayed cytolytic granule polarization and hemophagocytic lymphohistiocytosisJournal of Immunology.  196:2492-2503. 2016
2016 Cytokine activation by antibody fragments targeted to cytokine-receptor signaling complexesJournal of Biological Chemistry.  291:447-461. 2016
2016 Exploitation of interleukin-10 (IL-10) signaling pathways: Alternate roles of viral and cellular IL-10 in rhesus cytomegalovirus infectionJournal of Virology.  90:9920-9930. 2016
2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sitesScience Immunology.  1. 2016
2015 Elucidating new drug targets in psoriasis by gene profiling: An opportunity to be seizedAnnals of translational medicine.  3. 2015
2014 Production and characterization of thirteen human type-I interferon-α subtypesProtein Expression and Purification.  103:75-83. 2014
2014 The molecular basis of IL-10 function: From receptor structure to the onset of signalingCurrent Topics in Microbiology and Immunology.  380:191-212. 2014
2014 The old but new IgM Fc receptor (Fc;R)Current Topics in Microbiology and Immunology.  382:3-28. 2014
2014 Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantationJournal of Clinical Immunology.  34:331-339. 2014
2013 Vaccination against a virus-encoded cytokine significantly restricts viral challengeJournal of Virology.  87:11323-11331. 2013
2013 Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimersProtein Science.  22:1100-1108. 2013
2012 Epstein-barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling propertiesJournal of Biological Chemistry.  287:26586-26595. 2012
2012 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines 2012
2012 Host immune responses to a viral immune modulating protein: Immunogenicity of viral interleukin-10 in Rhesus cytomegalovirus-infected rhesus macaquesPLoS One.  7. 2012
2012 Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complexActa Crystallographica Section F: Structural Biology Communications.  68:89-92. 2012
2011 Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirusPLoS One.  6. 2011
2010 Interleukin-26: An IL-10-related cytokine produced by Th17 cellsCytokine and Growth Factor Reviews.  21:393-401. 2010
2010 Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacyMolecular Cancer Therapeutics.  9:2536-2544. 2010
2010 Cytokine-receptor interactions as drug targetsCurrent Opinion in Chemical Biology.  14:511-519. 2010
2010 Structure and mechanism of receptor sharing by the IL-10R2 common chainFolding & design.  18:638-648. 2010
2010 A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporationMolecular and Cellular Proteomics.  9:1764-1773. 2010
2008 Structure of IL-22 Bound to Its High-Affinity IL-22R1 ChainFolding & design.  16:1333-1344. 2008
2008 Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chainActa Crystallographica Section F: Structural Biology Communications.  64:266-269. 2008
2008 Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein 2008
2007 Isolation of flagellated bacteria implicated in Crohn's diseaseInflammatory Bowel Diseases.  13:1191-1201. 2007
2007 Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coliProtein Expression and Purification.  53:132-137. 2007
2007 Protein crystallization.Methods in Molecular Biology.  383:337-349. 2007
2006 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complexJournal of Biological Chemistry.  281:35088-35096. 2006
2006 The unique C termini of orthopoxvirus gamma interferon binding proteins are essential for ligand bindingJournal of Virology.  80:10675-10682. 2006
2006 BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosisCancer Research.  66:8182-8191. 2006
2006 Characterization of monocyte-derived dendritic cells maturated with IFN-αScandinavian Journal of Immunology.  63:217-222. 2006
2005 Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cellsOncogene.  24:7552-7566. 2005
2005 Structure of insect-cell-derived IL-22Acta crystallographica. Section D, Structural biology.  61:942-950. 2005
2005 Phenotypic and functional characterization of clinical grade dendritic cells generated from patients with advanced breast cancer for therapeutic vaccinationScandinavian Journal of Immunology.  61:147-156. 2005
2005 Same structure, different function: Crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10r1 chainFolding & design.  13:551-564. 2005
2004 Interferons, interferon-like cytokines, and their receptorsImmunological Reviews.  202:8-32. 2004
2004 The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylationJournal of Molecular Biology.  342:503-514. 2004
2004 Crystallization and X-ray diffraction analysis of insect-cell-derived IL-22Acta crystallographica. Section D, Structural biology.  60:1295-1298. 2004
2004 Interleukin-10 and related cytokines and receptorsAnnual Review of Immunology.  22:929-979. 2004
2004 An Early Stage of Mason-Pfizer Monkey Virus Budding Is Regulated by the Hydrophobicity of the Gag Matrix Domain CoreJournal of Virology.  78:5023-5031. 2004
2004 Induction of regulatory dendritic cells by dexamethasone and 1α,25-Dihydroxyvitamin D3Immunology Letters.  91:63-69. 2004
2004 Crystallization of cytokine-receptor complexes.Methods in Molecular Biology.  249:81-92. 2004
2004 Structural analysis of IL-10 and type I interferon family members and their complexes with receptorAdvances in protein chemistry and structural biology.  68:171-223. 2004
2002 Type I interferon structures: Possible scaffolds for the interferon-alpha receptor complexCanadian Journal of Chemistry.  80:1166-1173. 2002
2002 Structure of interleukin-10/interleukin-10R1 complex: A paradigm for class 2 cytokine activationImmunologic Research.  26:303-308. 2002
2002 Crystal structures of α-helical cytokine-receptor complexes: We've only scratched the surface 2002
2002 Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and X-ray crystallographyFolding & design.  10:981-987. 2002
2002 Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1 2002
2002 Comparison of interleukin-22 and interleukin-10 soluble receptor complexesJournal of Interferon and Cytokine Research.  22:1099-1112. 2002
2001 Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1Acta Crystallographica Section D: Biological Crystallography.  57:1908-1911. 2001
2001 Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1.Acta crystallographica. Section D, Structural biology.  57:1908-1911. 2001
2001 Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding siteImmunity.  15:35-46. 2001
2000 The COOH-terminal nuclear localization sequence of interferon γ regulates STAT1α nuclear translocation at an intracellular siteJournal of Cell Science.  113:2771-2781. 2000
2000 Erratum: Design and analysis of an engineered human interleukin-10 monomer (Journal of Biological Chemistry (2000) 275 (13552-13557))Journal of Biological Chemistry.  275:25054. 2000
2000 Design, characterization, and structure of a biologically active single-chain mutant of human IFN-γJournal of Molecular Biology.  299:169-179. 2000
2000 Design and analysis of an engineered human interleukin-10 monomerJournal of Biological Chemistry.  275:13552-13557. 2000
1999 Crystal structure of ovine interferon-τ at 2.1 Å resolutionJournal of Molecular Biology.  286:151-162. 1999
1998 Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylaseJournal of Molecular Biology.  281:285-299. 1998
1998 Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferonCancer Biotherapy and Radiopharmaceuticals.  13:143-154. 1998
1997 Three-dimensional models of interferon-alpha subtypes IFN-con1, IFN-alpha8, andIFN-alpha1 derived from the crystal structure of IFN-alpha2b.Seminars in Oncology.  24. 1997
1997 Structural biology of cytokines, their receptors, and signaling complexes: Implications for the immune and neuroendocrine circuitChemical immunology and allergy.  69:76-98. 1997
1997 Three-dimensional models of interferon-α subtypes IFN-con1, IFN-α8, and IFN-α1 derived from the crystal structure of IFN-α(2b)Seminars in Oncology.  24. 1997
1996 Zinc mediated dimer of human interferon-α(2b) revealed by X-ray crystallographyFolding & design.  4:1453-1463. 1996
1995 Crystal structure of a complex between interferon-γ and its soluble high-affinity receptorNature.  376:230-235. 1995
1995 Crystal Structure of Interleukin 10 Reveals an Interferon γ-like FoldBiochemistry.  34:12118-12125. 1995
1995 Crystallization and preliminary X‐ray investigation of recombinant human interleukin 10 1995
1994 Drug Binding by Calmodulin: Crystal Structure of a Calmodulin-Trifluoperazine ComplexBiochemistry.  33:15259-15265. 1994
1994 Comparison of four independently determined structures of human recombinant interleukin-4Nature Structural and Molecular Biology.  1:301-310. 1994
1992 Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factorJournal of Molecular Biology.  224:1075-1085. 1992
1992 Crystal structure of recombinant human interleukin-4Journal of Biological Chemistry.  267:20371-20376. 1992
1990 Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 Å resolutionJournal of Biological Chemistry.  265:14016-14022. 1990


Year Title Altmetric
2014 The molecular basis of IL-10 function: From receptor structure to the onset of signaling.  Ed. 380.  2014
2014 The old but new IgM Fc receptor (FcμR).  Ed. 382.  2014


Year Title Altmetric
2016 Structural Biology of JAK/STAT Cytokines and Their Receptors.  124-133. 2016
2010 Structure of ifnγ and its receptors.  261-263. 2010
2003 Structure of IFNγ and Its Receptors.  271-273. 2003

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 1989
  • Full Name

  • Mark Walter