Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Neutralization of rhesus cytomegalovirus IL-10 reduces horizontal transmission and alters long-term immunity. 2019
2019 Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. 2019
2018 Human interferon- and interferon- exhibit low potency and low affinity for cell-surface IFNAR and the poxvirus antagonist B18R 2018
2017 Cutting Edge: Endogenous IFN-β regulates survival and development of transitional B cells 2017
2017 A panel of synthetic antibodies that selectively recognize and antagonize members of the interferon alpha family 2017
2017 Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys 2017
2017 Plasmablast response to primary rhesus cytomegalovirus (CMV) infection in a monkey model of congenital CMV transmission 2017
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions 2016
2016 Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions. 2016
2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites. 2016
2016 The susceptibility of primary cultured rhesus macaque kidney epithelial cells to rhesus cytomegalovirus strains 2016
2016 A heterozygous RAB27A mutation associated with delayed cytolytic granule polarization and hemophagocytic lymphohistiocytosis 2016
2016 Cytokine activation by antibody fragments targeted to cytokine-receptor signaling complexes 2016
2016 Exploitation of interleukin-10 (IL-10) signaling pathways: Alternate roles of viral and cellular IL-10 in rhesus cytomegalovirus infection 2016
2016 VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites 2016
2015 Elucidating new drug targets in psoriasis by gene profiling: An opportunity to be seized 2015
2014 Production and characterization of thirteen human type-I interferon-α subtypes 2014
2014 The molecular basis of IL-10 function: From receptor structure to the onset of signaling 2014
2014 The old but new IgM Fc receptor (Fc;R) 2014
2014 Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation 2014
2013 Vaccination against a virus-encoded cytokine significantly restricts viral challenge 2013
2013 Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers 2013
2012 Epstein-barr virus IL-10 engages IL-10R1 by a two-step mechanism leading to altered signaling properties 2012
2012 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines 2012
2012 Host immune responses to a viral immune modulating protein: Immunogenicity of viral interleukin-10 in Rhesus cytomegalovirus-infected rhesus macaques 2012
2012 Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex 2012
2011 Design and analysis of rhesus cytomegalovirus IL-10 mutants as a model for novel vaccines against human cytomegalovirus 2011
2010 Interleukin-26: An IL-10-related cytokine produced by Th17 cells 2010
2010 Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy 2010
2010 Cytokine-receptor interactions as drug targets 2010
2010 Structure and mechanism of receptor sharing by the IL-10R2 common chain 2010
2010 A docking model based on mass spectrometric and biochemical data describes phage packaging motor incorporation 2010
2008 Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain 2008
2008 Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to the extracellular IL-22R1 chain 2008
2008 Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein 2008
2007 Isolation of flagellated bacteria implicated in Crohn's disease 2007
2007 Identification and characterization of a +1 frameshift observed during the expression of Epstein-Barr virus IL-10 in Escherichia coli 2007
2007 Protein crystallization. 2007
2006 Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex 2006
2006 The unique C termini of orthopoxvirus gamma interferon binding proteins are essential for ligand binding 2006
2006 BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis 2006
2006 Characterization of monocyte-derived dendritic cells maturated with IFN-α 2006
2005 Unique aspects of mda-7/IL-24 antitumor bystander activity: Establishing a role for secretion of MDA-7/IL-24 protein by normal cells 2005
2005 Structure of insect-cell-derived IL-22 2005
2005 Phenotypic and functional characterization of clinical grade dendritic cells generated from patients with advanced breast cancer for therapeutic vaccination 2005
2005 Same structure, different function: Crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10r1 chain 2005
2004 Interferons, interferon-like cytokines, and their receptors 2004
2004 The IL-10R2 binding hot spot on IL-22 is located on the N-terminal helix and is dependent on N-linked glycosylation 2004
2004 Crystallization and X-ray diffraction analysis of insect-cell-derived IL-22 2004
2004 Interleukin-10 and related cytokines and receptors 2004
2004 An Early Stage of Mason-Pfizer Monkey Virus Budding Is Regulated by the Hydrophobicity of the Gag Matrix Domain Core 2004
2004 Induction of regulatory dendritic cells by dexamethasone and 1α,25-Dihydroxyvitamin D3 2004
2004 Crystallization of cytokine-receptor complexes. 2004
2004 Structural analysis of IL-10 and type I interferon family members and their complexes with receptor 2004
2002 Type I interferon structures: Possible scaffolds for the interferon-alpha receptor complex 2002
2002 Structure of interleukin-10/interleukin-10R1 complex: A paradigm for class 2 cytokine activation 2002
2002 Crystal structures of α-helical cytokine-receptor complexes: We've only scratched the surface 2002
2002 Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and X-ray crystallography 2002
2002 Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1 2002
2002 Comparison of interleukin-22 and interleukin-10 soluble receptor complexes 2002
2001 Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1 2001
2001 Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. 2001
2001 Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site 2001
2000 The COOH-terminal nuclear localization sequence of interferon γ regulates STAT1α nuclear translocation at an intracellular site 2000
2000 Erratum: Design and analysis of an engineered human interleukin-10 monomer (Journal of Biological Chemistry (2000) 275 (13552-13557)) 2000
2000 Design, characterization, and structure of a biologically active single-chain mutant of human IFN-γ 2000
2000 Design and analysis of an engineered human interleukin-10 monomer 2000
1999 Crystal structure of ovine interferon-τ at 2.1 Å resolution 1999
1998 Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase 1998
1998 Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon 1998
1997 Structural biology of cytokines, their receptors, and signaling complexes: Implications for the immune and neuroendocrine circuit 1997
1997 Three-dimensional models of interferon-alpha subtypes IFN-con1, IFN-alpha8, andIFN-alpha1 derived from the crystal structure of IFN-alpha2b. 1997
1997 Three-dimensional models of interferon-α subtypes IFN-con1, IFN-α8, and IFN-α1 derived from the crystal structure of IFN-α(2b) 1997
1996 Zinc mediated dimer of human interferon-α(2b) revealed by X-ray crystallography 1996
1995 Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor 1995
1995 Crystal Structure of Interleukin 10 Reveals an Interferon γ-like Fold 1995
1995 Crystallization and preliminary X‐ray investigation of recombinant human interleukin 10 1995
1994 Drug Binding by Calmodulin: Crystal Structure of a Calmodulin-Trifluoperazine Complex 1994
1994 Comparison of four independently determined structures of human recombinant interleukin-4 1994
1992 Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor 1992
1992 Crystal structure of recombinant human interleukin-4 1992
1990 Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 Å resolution 1990

Book

Year Title Altmetric
2014 The molecular basis of IL-10 function: From receptor structure to the onset of signaling.  Ed. 380.  2014
2014 The old but new IgM Fc receptor (FcμR).  Ed. 382.  2014

Chapter

Year Title Altmetric
2016 Structural Biology of JAK/STAT Cytokines and Their Receptors.  124-133. 2016
2010 Structure of ifnγ and its receptors.  261-263. 2010
2003 Structure of IFNγ and Its Receptors.  271-273. 2003

Principal Investigator On

Investigator On

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Alabama at Birmingham 1989

    • Full Name

  • Mark Walter