Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Initiation and propagation of α-synuclein aggregation in the nervous systemMolecular Neurodegeneration.  15. 2020
2020 Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged miceNature Neuroscience.  23:327-336. 2020
2020 Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusionsNeurobiology of Disease.  134. 2020
2019 Hsp110 mitigates α-synuclein pathology in vivo 2019
2019 Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?Movement Disorders.  34:1406-1422. 2019
2019 Defining α-synuclein species responsible for Parkinson's disease phenotypes in miceJournal of Biological Chemistry.  294:10392-10406. 2019
2019 Generation of alpha-synuclein preformed fibrils from monomers and use in vivoJournal of Visualized Experiments.  2019. 2019
2019 Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondriaNeurobiology of Disease.  124:248-262. 2019
2019 Assays for neuronal defects caused by early formation of α-synuclein inclusions in primary cultured neuronsMethods in Molecular Biology.  1948:1-14. 2019
2018 14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic α-synuclein 2018
2018 Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodiesJournal of Comparative Neurology.  526:1978-1990. 2018
2018 α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neuronsActa Neuropathologica Communications.  6:35. 2018
2018 Best practices for generating and using alpha-synuclein pre-formed fibrils to model Parkinson's disease in rodentsJournal of Parkinson's Disease.  8:303-322. 2018
2018 Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease 2018
2017 LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model.Molecular Therapy : Nucleic Acids.  8:508-519. 2017
2017 Effects of α-synuclein on axonal transportNeurobiology of Disease.  105:321-327. 2017
2017 α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic NeurodegenerationNeurobiology of Disease.  105:84-98. 2017
2017 Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrilsRedox Biology.  11:429-437. 2017
2016 How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?Journal of Neurochemistry.  131-155. 2016
2016 G2019s-LRRK2 expression augments α-synuclein sequestration into inclusions in neurons 2016
2016 MicroRNA-155 regulates alpha-synuclein-induced inflammatory responses in models of Parkinson disease 2016
2016 Invisible KillersMovement Disorders.  31:44-44. 2016
2015 Trophic factors for Parkinson's disease: To live or let dieMovement Disorders.  30:1715-1724. 2015
2015 Transforming growth factor beta (TGF-β) is a muscle biomarker of disease progression in ALS and correlates with smad expressionPLoS ONE.  10. 2015
2015 Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegenerationJournal of Biological Chemistry.  290:19433-19444. 2015
2015 Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models 2015
2014 Unique functional and structural properties of the LRRK2 protein ATP-binding pocketJournal of Biological Chemistry.  289:32937-32951. 2014
2014 Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodentsJournal of Comparative Neurology.  522:2465-2480. 2014
2014 Abrogation of α-synuclein -mediated dopaminergic neurodegeneration in LRRK2-deficient rats 2014
2014 Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregatesNature Protocols.  9:2135-2146. 2014
2014 Formation of α-synuclein lewy neurite-like aggregates in axons impedes the transport of distinct endosomes 2014
2013 Reduction of synaptojanin 1 accelerates aβ clearance and attenuates cognitive deterioration in an alzheimer mouse modelJournal of Biological Chemistry.  288:32050-32063. 2013
2013 Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons 2013
2013 Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagyJournal of Biological Chemistry.  288:15194-15210. 2013
2012 Role of dynamin, synaptojanin, and endophilin in podocyte foot processesJournal of Clinical Investigation.  122:4401-4411. 2012
2012 TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways 2012
2012 Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's DiseaseScience Translational Medicine.  4:141ra90-141ra90. 2012
2011 Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.Neuron.  72:57-71. 2011
2011 Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin 2011
2010 Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brainJournal of Biological Chemistry.  285:28708-28714. 2010
2009 The  - and  -isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cellsJournal of Cell Science.  122:2567-2574. 2009
2008 Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 PhosphorylationScience.  321:1350-1353. 2008
2007 Phosphoinositides' link to neurodegenerationNature Medicine.  13:784-786. 2007
2005 Arf family GTPases: roles in membrane traffic and microtubule dynamicsBiochemical Society Transactions.  33:1269-1272. 2005
2005 Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic 2005
2004 Immunohistochemical localization of proteins in the nervous system.Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].  Chapter 1. 2004
2004 Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus.Progress in Brain Research.  145:59-66. 2004
2003 Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout MiceMolecular Pharmacology.  64:1309-1316. 2003
2003 Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient miceAnnals of Neurology.  53:788-796. 2003
2003 Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathwayJournal of Cell Science.  116:1969-1980. 2003
2003 Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice 2003
2002 Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. 2002
2002 Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. 2002
2001 Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies.Journal of Biological Chemistry.  276:47590-47598. 2001
1999 Sensitization to daily morphine injections in rats with unilateral lesions of the substantia nigra. 1999
1997 Naltrexone and Alcohol DependenceArchives of General Psychiatry.  54:737-737. 1997
1996 Naltrexone in the treatment of alcoholism: A clinical reviewAlcohol.  13:35-39. 1996
MEDICAL MANAGEMENT OF ALCOHOL DEPENDENCE: CLINICAL USE AND LIMITATIONS OF NALTREXONE TREATMENTAlcohol and Alcoholism
Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in DiseaseInternational Journal of Molecular Sciences.  21:8043-8043.

Principal Investigator On

  • Innate and Adaptive Immunity in Parkinson Disease - Core C: Animal Core  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Role of Presynaptic Targeting of Alpha-Synuclein in the Pathogenesis of Parkinson's Disease and Dementia with Lewy Bodies  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • Private Grant  awarded by OCCAMZRAZOR 2020 - 2022
  • Validate PFF a-syn-induced Inflammatory Phenotype in Mice  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2021 - 2022
  • Rescue of Parkinson’s Disease Related Neuronal Defects by LRRK2 and Rab GTPase Substrates  awarded by Parkinson's Foundation 2019 - 2021
  • Private Grant  awarded by MERCK SHARP & DOHME CORP 2017 - 2021
  • Alpha-Synuclein Aggregate Induced Synapse Loss is a Pathological Event contributing to Lewy Body Dementias  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2020 - 2021
  • Seeking Neuro-Protection Via a Novel Complex-1 Chaperone Supplement  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2021
  • Expansion Microscopy to Visualize Intracellular aSyn Pathology  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2018 - 2020
  • Reducing Tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson's Disease  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2016 - 2019
  • Antisense Oligonucleotide Knockdown of the Transcriptional Repressor RIP140 to Enhance Survival of Dopaminergic Neurons in a Mouse of PD  awarded by SOUTHERN RESEARCH INSTITUTE 2017 - 2018
  • Defining Alpha-Synuclein Conformers Responsible for PD Phenotypes in Mice  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2018
  • Further Validation of SIRT3 as a Disease Modifying Agent in Parkinson's Disease  awarded by University of Toronto 2015 - 2016
  • LRRK2 in Pathological Synuclein Transmission  awarded by American Parkinson Disease Association 2014 - 2015
  • LRRK2 in Pathological Synuclein Transmission  awarded by American Parkinson Disease Association 2013 - 2014
  • Investigator On

  • Contribution of the Interaction Between Synuclein and Tau in the Pathophysiology of Dementia with Lewy Bodies  awarded by National Institute on Aging/NIH/DHHS 2018 - 2023
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • The Nigral Molecular Clock and Vulnerability to Neurodegeneration  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018 - 2023
  • The Edmond J. Safra Fellowship in Movement Disorders 2019 Program  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2019 - 2022
  • Role of Rab27b in Synucleinopathies  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2020 - 2021
  • Lysosomal Enhancement Strategies in Dopaminergic Neurodegeneration  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2017 - 2021
  • Alpha-Galactosidase A: A Novel Target for Reducing Alpha-Synuclein Toxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2019
  • Mechanisms of LRRK2 Mediated Neurotoxicity  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2019
  • Efficacies and Pharmacodynamic Assays for LRRK2 Small-Molecule Inhibitors  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2018
  • Innate and Adaptive Immunity in Parkinson Disease  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Innate and Adaptive Immunity in Parkinson Disease - Project 1: PD-Linked Susceptibilities in Myeloid-Cell CNS Infiltration  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2015 - 2018
  • Identification of Robust and Relevant Pre-Clinical Phenotypes for LRRK2 Therapeutics  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2015 - 2018
  • Efficacies and Pharmacodynamic Assays for LRRK2 Small-Molecule Inhibitors  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2016 - 2017
  • Validation of CCR2-Dependent Monocyte Entry in Alpha-Synuclein-Induced Toxicity  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2016 - 2017
  • Education And Training

  • Emory University Biochemistry, Postdoctoral Fellowship
  • Yale University Cell Biology, Postdoctoral Fellowship
  • Doctor of Philosophy in Neuroscience, Emory University 2003
  • Bachelor of Science or Mathematics, Franklin & Marshall College 1993
  • Full Name

  • Laura Volpicelli-Daley