Positions

Overview

  • My lab focusses on identifying the heritable component of a wide range of cardiovascular diseases including atherosclerosis and peripheral artery disease. To this end, we utilize publicly available genome-wide genetic and bioinformatics resources in conjunction with in vitro and in vivo approaches to discover the implicated gene and the associated signaling pathway.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report. 2020
    2020 Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade 2020
    2020 Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced AtherosclerosisCirculation.  141:1274-1276. 2020
    2020 Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.Nature Nanotechnology.  15:154-161. 2020
    2019 Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease. 2019
    2018 Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locusPLoS Genetics.  14. 2018
    2018 Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation.Circulation.  137:750-753. 2018
    2017 The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.JACC: Basic to Translational Science.  2:209-211. 2017
    2017 Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 2017
    2016 CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.Nature.  536:86-90. 2016
    2016 De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.PLoS Genetics.  12:e1005963. 2016
    2016 CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.Circulation Research.  118:230-240. 2016
    2015 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.PLoS Genetics.  11:e1005155. 2015
    2014 Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. 2014
    2012 Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.Journal of Biological Chemistry.  287:2459-2467. 2012
    2010 Expression and functional activity of four myocardin isoforms.Gene.  464:1-10. 2010

    Research Overview

  • Cardiovascular disease, vascular biology, atherosclerosis, peripheral artery disease, signal transduction, angiogenesis, genetics, smooth muscle biology, gene transcription, translational research
  • Education And Training

  • Stanford University School of Medicine Surgery, Postdoctoral Research
  • Doctor of Philosophy in Pharmacology, University of Rochester 2014
  • Master of Sciences or Mathematics in Pharmacology, University of Rochester 2011
  • Bachelor of Science or Mathematics in Medical Basic Sciences/Other, Rochester Institute of Technology 2006
  • Full Name

  • Vivek Nanda