• My lab focusses on identifying the heritable component of a wide range of cardiovascular diseases including atherosclerosis and peripheral artery disease. To this end, we utilize publicly available genome-wide genetic and bioinformatics resources in conjunction with in vitro and in vivo approaches to discover the implicated gene and the associated signaling pathway.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stabilityCardiovascular Research.  117:2767-2780. 2021
    2020 18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.Arteriosclerosis, Thrombosis and Vascular Biology.  40:2821-2828. 2020
    2020 Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascadeProceedings of the National Academy of Sciences of USA.  117:15818-15826. 2020
    2020 Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to Smooth Muscle Cell Proliferation, Vascular Calcification, and Advanced AtherosclerosisCirculation.  141:1274-1276. 2020
    2020 Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.Nature Nanotechnology.  15:154-161. 2020
    2019 Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease.Arteriosclerosis, Thrombosis and Vascular Biology.  39:982-983. 2019
    2018 Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locusPLoS Genetics.  14. 2018
    2018 Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation.Circulation.  137:750-753. 2018
    2017 The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.JACC: Basic to Translational Science.  2:209-211. 2017
    2017 Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.Proceedings of the National Academy of Sciences of USA.  114:E2739-E2747. 2017
    2016 CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.Nature.  536:86-90. 2016
    2016 De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.PLoS Genetics.  12:e1005963. 2016
    2016 CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.Circulation Research.  118:230-240. 2016
    2015 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.PLoS Genetics.  11:e1005155. 2015
    2014 Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.Arteriosclerosis, Thrombosis and Vascular Biology.  34:1249-1259. 2014
    2012 Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.Journal of Biological Chemistry.  287:2459-2467. 2012
    2010 Expression and functional activity of four myocardin isoforms.Gene.  464:1-10. 2010

    Research Overview

  • Cardiovascular disease, vascular biology, atherosclerosis, peripheral artery disease, signal transduction, angiogenesis, genetics, smooth muscle biology, gene transcription, translational research
  • Education And Training

  • Stanford University School of Medicine Surgery, Postdoctoral Research
  • Doctor of Philosophy in Pharmacology, University of Rochester 2014
  • Master of Sciences or Mathematics in Pharmacology, University of Rochester 2011
  • Bachelor of Science or Mathematics in Medical Basic Sciences/Other, Rochester Institute of Technology 2006
  • Full Name

  • Vivek Nanda