Positions

Overview

  • I am interested in determining the heritable component of a wide range of cardiovascular diseases including atherosclerosis and peripheral artery disease. To this end, I utilize publicly available genome-wide genetic and bioinformatics resources in combination with in vitro and in vivo approaches to identify the implicated gene and associated signaling pathway.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.Nature Nanotechnology.  15:154-161. 2020
    2019 Clonal Smooth Muscle Cell Expansion, Autophagy, and Vascular Integrity in Aortic Aneurysm Disease. 2019
    2018 Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locusPLoS Genetics.  14. 2018
    2018 Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation.Circulation.  137:750-753. 2018
    2017 The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.JACC: Basic to Translational Science.  2:209-211. 2017
    2017 Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. 2017
    2016 CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.Nature.  536:86-90. 2016
    2016 De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.PLoS Genetics.  12:e1005963. 2016
    2016 CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.Circulation Research.  118:230-240. 2016
    2015 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.PLoS Genetics.  11:e1005155. 2015
    2014 Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. 2014
    2012 Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.Journal of Biological Chemistry.  287:2459-2467. 2012
    2010 Expression and functional activity of four myocardin isoforms.Gene.  464:1-10. 2010

    Research Overview

  • Cardiovascular disease, vascular biology, atherosclerosis, peripheral artery disease, signal transduction, angiogenesis, genetics, smooth muscle biology, gene transcription, translational research
  • Education And Training

  • Stanford University School of Medicine Surgery, Postdoctoral Research 2018
  • Doctor of Philosophy in Pharmacology, University of Rochester 2014
  • Master of Sciences or Mathematics in Pharmacology, University of Rochester 2011
  • Bachelor of Science or Mathematics in Medical Basic Sciences/Other, Rochester Institute of Technology 2006
  • Full Name

  • Vivek Nanda