Positions

Overview

  • Dr. Hauptfeld-Dolejsek attended the Charles University in Prague, where she obtained a Masters Degree, in Experimental Zoology; PhD in Embryology and Candidate of Science in Molecular Biology.

    She became Board certified for Human Histocompatibility and Immunogenetics D(ABHI) in US by American Society for Histocompatibility and Immunogenetics.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19.  Transplant International.  35. 2022
    2022 First clinical-grade porcine kidney xenotransplant using a human decedent model.  American Journal of Transplantation.  22:1037-1053. 2022
    2021 Aspects of histocompatibility testing in xenotransplantation.  Transplant Immunology.  67. 2021
    2021 Eplet mismatch scores and de novo donor-specific antibody development in simultaneous pancreas-kidney transplantation.  Human Immunology.  82:139-146. 2021
    2021 Impact of Subclinical Borderline Inflammation on Kidney Transplant Outcomes.  Transplantation Direct.  2021
    2019 Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens.  Immunogenetics.  71:479-487. 2019
    2019 CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients.  Pediatric Transplantation.  23. 2019
    2018 Impact of high-dose steroid premedication on the outcome of myeloablative T-cell replete haploidentical peripheral blood stem cell transplant.  Bone Marrow Transplantation.  53:1345-1348. 2018
    2018 Subclinical inflammation phenotypes and long-term outcomes after pediatric kidney transplantation.  American Journal of Transplantation.  18:2189-2199. 2018
    2018 Examining the biosynthesis and xenoantigenicity of Class II swine leukocyte antigen proteins.  Journal of Immunology.  200:2957-2964. 2018
    2016 Deceased-donor apolipoprotein L1 renal-risk variants have minimal effects on liver transplant outcomes.  PLoS One.  11. 2016
    2016 APOL1 genotype and kidney transplantation outcomes from deceased african American donors.  Transplantation.  100:194-202. 2016
    2016 Outcomes in Simultaneous Liver Kidney Transplants in the Setting of a Positive Crossmatch: A Single Center Experience.  Clinical transplants.  32:119-125. 2016
    2015 Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.  Kidney International.  88:584-592. 2015
    2015 Apolipoprotein L1 gene variants in deceased organ donors are associated with renal allograft failure.  American Journal of Transplantation.  15:1615-1622. 2015
    1997 The Association of HLA-DR Alleles and T Cell Activation with Allergic Bronchopulmonary Aspergillosis.  Journal of Immunology.  159:4072-4076. 1997
    1995 Class I and class II antigens in the rejection of murine islet cell transplants.  Transplantation Proceedings.  27:3234-3235. 1995
    1994 Continued mapping of chromosome 2 genes.  Immunogenetics.  40:21-26. 1994
    1992 The evolutionary origin of the HLA-DR3 haplotype.  Immunogenetics.  35:263-271. 1992
    1991 Production of marked prolongation of islet xenograft survival (rat to mouse) by local release of mouse and rat antilymphocyte sera at transplant site.  Diabetes.  40:482-485. 1991
    1989 Antigenic properties of 36 new H-2 congenic strains and 4 independently derived strains, W10LT, DDD, BZH, and FM.  Immunogenetics.  30:132-136. 1989
    1989 Immune response gene control of the mouse antibody responses to human creatine kinase-MM and the lactate dehydrogenase-1 enzymes.  Immunogenetics.  30:128-131. 1989
    1989 Production of H-2 class II (Ia. 7) antibody is under Ir gene control.  Immunogenetics.  30:126-127. 1989
    1989 Induction of Ia antigen expression on murine islet parenchymal cells does not diminish islet allograft survival.  American Journal of Pathology.  134:237-242. 1989
    1988 Studies on recombination within the mouse H-2 complex: IV. Characterization of new recombinant haplotypes H-2t7, H-2t8, H-2as2, and H-2as3..  The Journal of molecular and cellular immunology : JMCI.  4:1-8. 1988
    1988 Tumor necrosis factor enhances interferon-induced Ia antigen expression on murine islet parenchymal cells.  American Journal of Pathology.  130:427-430. 1988
    1987 Induction of class II MHC antigens on human and rodent islet parenchymal cells in vitro..  Diabetologia.  30:441. 1987
    1987 Effect of low-temperature culture and site of transplantation on hamster islet xenograft survival (Hamster to mouse).  Transplantation.  44:465-468. 1987
    1986 Interferon-mediated induction of Ia antigen expression on isolated murine whole islets and dispersed islet cells.  Diabetes.  35:1174-1177. 1986
    1986 The effect of cyclosporin-A, low-temperature culture, and anti-Ia antibodies on prevention of rejection of rat islet allografts.  Diabetes.  35:83-88. 1986
    1985 Monoclonal antibodies to mouse antigens - II. Characterization of thirty-one anti-14 reagents.  Immunogenetics.  21:193-197. 1985
    1985 Prolonged survival of donor skin grafts on mice bearing established islet of langerhans transplants.  Transplantation.  40:216-218. 1985
    1984 Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody..  Proceedings of the National Academy of Sciences of USA.  81:3864-3868. 1984
    1984 Monoclonal antibodies to mouse MHC antigens - I. Serologic characterization of ten anti-H-2 and anti-Ia reagents.  Immunogenetics.  19:169-173. 1984
    1984 Characterization of monoclonal anti-I-J reagents.  The FASEB Journal.  43. 1984
    1984 Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.  Proceedings of the National Academy of Sciences of USA.  81:3864-3868. 1984
    1984 Three subpopulations of Ia+ cells within murine islets of Langerhans.  The FASEB Journal.  43. 1984
    1982 Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.  Proceedings of the National Academy of Sciences of USA.  79:4153-4155. 1982
    1982 Differences in expression of MHC products between several H-2-restricted CTL clones.  Journal of Immunology.  128:2026-2031. 1982
    1982 Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.  Science.  217:157-158. 1982
    1982 Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibody.  Immunogenetics.  15:41-52. 1982
    1981 Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants..  Proceedings of the National Academy of Sciences of USA.  78:5156-5159. 1981
    1981 Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.  Proceedings of the National Academy of Sciences of USA.  78:5156-5159. 1981
    1980 Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens..  Journal of Experimental Medicine.  151:1563-1568. 1980
    1979 Evidence for partial defect in stem cell function induced in mice by neonatal thymectomy.  Immunology Letters.  1:133-136. 1979
    1977 Histocompatibility antigens controlled by the I region of the murine H-2 complex: II. KID Region compatibility is not required for I-region cell-mediated lymphocytotoxicity*.  Journal of Experimental Medicine.  145:450-454. 1977
    1977 A new histogenetic method for minor histocompatibility antigen typing.  Journal of Immunology.  118:423-426. 1977
    1976 Histocompatibility-2 system in wild mice - III. mixed lymphocyte reaction and cell-mediated lymphocytotoxicity with t-bearing mice.  Immunogenetics.  3:489-497. 1976
    1976 Histocompatibility antigens controlled by the I region of the murine H-2 complex*: I. Mapping of H-2A and H-2C loci.  Journal of Experimental Medicine.  143:1439-1452. 1976
    1976 Ia Antigens: Their Serology, Molecular Relationships, and their role in Allograft Reactions.  Immunological Reviews.  30:83-100. 1976
    1976 Ia antigens: their serology, molecular relationships, and their role in allograft reactions..  Transplantation Reviews.  30:83-100. 1976
    1976 Immunogenetic Analysis of H‐2 Mutations: IV. Mapping of and Immune Reactions to the H‐2fa Mutation.  Scandinavian Journal of Immunology.  5:521-528. 1976
    1975 A method for detection of Ia antigens in the absence of appropriate H2 recombinants.  Journal of Immunology.  115:351-355. 1975
    1975 Evidence for a fifth (G) region in the H-2 complex of the mouse.  Immunogenetics.  2:141-150. 1975
    1975 Immunogenetic analysis of H-2 mutations. III. Genetic mapping and involvement in immune reactions of the H-2(ka) mutation.  Journal of Immunology.  115:716-718. 1975
    1975 Ia and H-2 antigens on blast cells.  Transplantation.  19:528-530. 1975
    1975 Induction of resistance to antibody mediated cytotoxicity. H-2, Ia and Ig antigens are independent entities in the membrane of mouse lymphocytes.  Journal of Experimental Medicine.  141:1047-1056. 1975
    1975 Molecular relationship between private and public H 2 antigens as determined by antigen redistribution method.  Journal of Experimental Medicine.  142:288-298. 1975
    1975 Splitting of Antigen H‐2.9 and Mapping of its Genetic Determinants.  Tissue Antigens: immune response genetics.  6:46-49. 1975
    1974 Evidence for a third, Ir-associated histocompatibility region in the H-2 complex of the mouse.  Immunogenetics.  1:45-56. 1974
    1974 Tissue distribution of I region associated antigens in the mouse.  Journal of Immunology.  113:181-188. 1974
    1974 Serological distinction of mutants B6.C-H(z1) ans B6.M505 from strain C57BL/6.  Journal of Experimental Medicine.  140:1127-1132. 1974
    1974 Production of anti‐H‐2 antibodies in thymectomized mice.  European Journal of Immunology.  4:41-44. 1974
    1973 Serologic detection of antigens controlled by the Ir region of the H-2 complex in the mouse..  Transplantation Proceedings.  5:1811-1813. 1973
    1973 Serological identification of an Ir-region product.  Science.  181:167-168. 1973

    Research Overview

  • Dr.Hauptfeld-Dolejsek over four decades has been interested in defining the structure and function of the histocompatibility gene products which are fundamental in immunologic mechanisms. When she arrived to US, she joined Dr. Jan Klein in Michigan, where her research focused on the murine major histocompatibility system. In his laboratory, they discovered Ia antigens, later renamed as class II antigens. After 30 years in defining the structure and function of the MHC gene products in mice, she transferred her interest to a human MHC, because of its remarkable genetic and functional homology and feasibility to apply that knowledge to human.


    Keywords: HLA, crossmatching, Histocompatibility; Solid organ transplantation, deceased and living donors; bone marrow /HSC transplantation, related and unrelated

    • Principal Investigator On

    Investigator On

    Education And Training

  • Doctor of Philosophy in Molecular Genetics, 1996
  • Master of Science in Biology, Charles University in Prague 1968
  • Bachelor of Science or Mathematics in Zoology / Animal Biology, Charles University in Prague 1966

    • Full Name

  • Vera Hauptfeld-Dolejsek