Dr.Hauptfeld-Dolejsek over four decades has been interested in defining the structure and function of the histocompatibility gene products which are fundamental in immunologic mechanisms. When she arrived to US, she joined Dr. Jan Klein in Michigan, where her research focused on the murine major histocompatibility system. In his laboratory, they discovered Ia antigens, later renamed as class II antigens. After 30 years in defining the structure and function of the MHC gene products in mice, she transferred her interest to a human MHC, because of its remarkable genetic and functional homology and feasibility to apply that knowledge to human.
Keywords: HLA, crossmatching, Histocompatibility; Solid organ transplantation, deceased and living donors; bone marrow /HSC transplantation, related and unrelated