Veena Antony M.D.

Veena Antony M.D.
Professor

Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Senior Scientist (C), Cystic Fibrosis Research Center , School of Medicine
Senior Scientist, Experimental Therapeutics , O'Neal Comprehensive Cancer Center
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine
Program Director, Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine
Professor (S), Environmental Health Sciences , School of Public Health
Professor (S), Mechanical Engineering , School of Engineering

Overview

Dr. Antony is Professor of Medicine at the University of Alabama at Birmingham (UAB). Dr. Antony's medical training began at Christian Medical College in Ludhiana, India. Following medical school, Dr. Antony progressed to an internship and residency at New York's Kingsbrook Jewish Medical Center. Following her Pulmonary and Critical Care Medicine Fellowship training in the University of Colorado's School of Medicine, Dr. Antony worked in Pulmonary Medicine at the University of Colorado Health Sciences Center, the Indiana University School of Medicine, and the University of Florida before beginning her work at UAB in 2010.

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. American Journal of Pathology. 191:1227-1239. 2021
2021	NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. JCI insight. 6. 2021
2021	Citrullinated vimentin mediates development and progression of lung fibrosis. Science Translational Medicine. 13. 2021
2021	Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death and Differentiation. 2021
2020	Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals. Annals of the New York Academy of Sciences. 1480:155-169. 2020
2020	Cutaneous lewisite exposure causes acute lung injury. Annals of the New York Academy of Sciences. 1479:210-222. 2020
2020	PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 62:319-330. 2020
2019	Increased flux through the mevalonate pathway mediates fibrotic repair without injury. Journal of Clinical Investigation. 129:4962-4978. 2019
2019	Erratum: Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis (Cell Reports (2018) 25(7) (1938–1952.e5), (S2211124718316772), (10.1016/j.celrep.2018.10.073)). Cell Reports. 28:3286. 2019
2019	Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI insight. 4. 2019
2018	Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics. Scientific Reports. 8. 2018
2018	Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumonia. American Journal of Respiratory and Critical Care Medicine. 198:1288-1301. 2018
2018	Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Reports. 25:1938-1952.e5. 2018
2018	Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells. Redox Biology. 18:54-64. 2018
2018	Cellular senescence in chronic obstructive pulmonary disease: Multifaceted and multifunctional. American Journal of Respiratory Cell and Molecular Biology. 59:135-136. 2018
2018	Is personalized medicine a realistic goal in idiopathic pulmonary fibrosis?. Expert Review of Respiratory Medicine. 12:441-443. 2018
2018	Cutaneous exposure to lewisite causes acute kidney injury by invoking dna damage and autophagic response 2018
2018	Implementation of a successful eradication protocol for Burkholderia Cepacia complex in cystic fibrosis patients. BMC Pulmonary Medicine. 18. 2018
2017	Home monitoring of patients with cystic fibrosis to identify and treat acute pulmonary exacerbations eICE study results. American Journal of Respiratory and Critical Care Medicine. 196:1144-1151. 2017
2017	Autoimmunity to vimentin is associated with outcomes of patients with idiopathic pulmonary fibrosis. Journal of Immunology. 199:1596-1605. 2017
2017	3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. JCI insight. 2. 2017
2017	MIR-34a inhibits lung fibrosis by inducing lung fibroblast senescence. American Journal of Respiratory Cell and Molecular Biology. 56:168-178. 2017
2017	3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.. JCI insight. 2:e91377. 2017
2017	Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin 2017
2016	National institute of environmental health sciences: 50 years of advancing science and improving lung health. American Journal of Respiratory and Critical Care Medicine. 194:1190-1195. 2016
2016	Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis. Nature Communications. 7. 2016
2016	Matrix remodeling in pulmonary fibrosis and emphysema. American Journal of Respiratory Cell and Molecular Biology. 54:751-760. 2016
2016	Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections 2016
2016	Novel mechanisms for the antifibrotic action of nintedanib. American Journal of Respiratory Cell and Molecular Biology. 54:51-59. 2016
2015	Noninvasive imaging of experimental lung fibrosis. American Journal of Respiratory Cell and Molecular Biology. 53:8-13. 2015
2015	Heme oxygenase-1 protects Corexit 9500ainduced respiratory epithelial injury across species. PLoS ONE. 10. 2015
2015	Long-term treatment with oral N-acetylcysteine: Affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial. Journal of Cystic Fibrosis. 14:219-227. 2015
2015	SMAD-independent down-regulation of caveolin-1 by TGF-β: Effects on proliferation and survival of myofibroblasts. PLoS ONE. 10. 2015
2015	Blue Journal Conference: Aging and susceptibility to lung disease. American Journal of Respiratory and Critical Care Medicine. 191:261-269. 2015
2015	Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice 2015
2015	Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Experimental Gerontology. 61:62-75. 2015
2015	Pleural mesothelial cells in pleural and lung diseases. Journal of thoracic disease. 7:964-980. 2015
2014	Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics. 351:87-95. 2014
2014	The effect of biomass fuel exposure on the prevalence of asthma in adults in India - Review of current evidence 2014
2014	The pleural mesothelium in development and disease. Frontiers in Physiology. 5 JUL. 2014
2014	Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. The FASEB Journal. 28:1122-1131. 2014
2013	MiR-145 regulates myofibroblast differentiation and lung fibrosis. The FASEB Journal. 27:2382-2391. 2013
2013	Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury. American Journal of Pathology. 182:1239-1247. 2013
2012	Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. Laboratory Investigation. 92:1541-1552. 2012
2012	Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis. European Respiratory Journal. 39:133-140. 2012
2011	A Trojan horse strategy to deliver amikacin to mycobacterial granulomas [1]. American Journal of Respiratory and Critical Care Medicine. 184:860. 2011
2011	New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs. 71:981-1001. 2011
2010	Targeted delivery of amikacin into granuloma. American Journal of Respiratory and Critical Care Medicine. 182:1546-1553. 2010
2009	Pleural mesothelial cell transformation into myofibroblasts and haptotactic migration in response to TGF-β1 in vitro 2009
2009	Erythromycin improves gastric emptying half-time in adult cystic fibrosis patients with gastroparesis. Journal of Cystic Fibrosis. 8:193-197. 2009
2008	Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of β-defensin-2 by staphylococcal peptidoglycan 2008
2008	Thioredoxin as a biomarker for graft rejection in lung transplant recipients. Biomarkers. 13:486-495. 2008
2008	Pathophysiology of the pleura. Respiration: international journal of thoracic medicine. 75:121-133. 2008
2007	Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM). Cancer Letters. 258:215-222. 2007
2007	Bacterial induction of early response genes and activation of proapoptotic factors in pleural mesothelial cells 2007
2007	Pleural effusions: How to confirm the cause - And manage effectively. Consultant. 47:969-977. 2007
2007	Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells 2007
2007	Advances in pleural disease. Drug Discovery Today: Disease Mechanisms. 4:103-108. 2007
2007	Erratum: "Talc mediates angiostasis in malignant pleural effusions via endostatin induction" (European Respiratory Journal (2007) vol. 29 (761-769)). European Respiratory Journal. 29:1286. 2007
2007	Talc mediates angiostasis in malignant pleural effusions via endostatin induction. European Respiratory Journal. 29:761-769. 2007
2007	Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release 2007
2006	Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. Cancer. 107:2425-2435. 2006
2006	Pleural Fibrosis. Clinics in Chest Medicine. 27:181-191. 2006
2005	Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase. American Journal of Respiratory Cell and Molecular Biology. 33:513-520. 2005
2005	Respiratory system responsiveness in rabbits in vivo is reduced by prolonged continuous positive airway pressure 2005
2005	The mysterious pulmonary brush cell: A cell in search of a function. American Journal of Respiratory and Critical Care Medicine. 172:136-139. 2005
2004	Primum non nocere and malignant pleural effusions. Respiration: international journal of thoracic medicine. 71:549-550. 2004
2004	RSV causes HIF-1α stabilization via NO release in primary bronchial epithelial cells. Inflammation. 28:245-251. 2004
2004	Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells. Journal of Clinical Immunology. 24:426-434. 2004
2004	Pathogenesis of pleural infection. Respirology. 9:12-15. 2004
2004	Respiratory syncytial virus causes increased bronchial epithelial permeability. Chest. 126:186-191. 2004
2004	Talc pleurodesis: Basic fibroblast growth factor mediates pleural fibrosis. Chest. 126:1522-1528. 2004
2003	Mycobacteria induces pleural mesothelial permeability by down-regulating β-catenin expression 2003
2003	Defensive role of pleural mesothelial cell sialomucins in tumor metastasis. Chest. 124:682-687. 2003
2003	Immunological mechanisms in pleural disease. European Respiratory Journal. 21:539-544. 2003
2003	Pleural Mesothelial Cell (PMC) Defense Mechanisms Against Malignancy 2003
2003	Pleural mesothelial cells modulate polymorphonuclear leukocyte apoptosis in empyema. Journal of Clinical Immunology. 23:1-10. 2003
2002	Adherence of Ovarian Cancer Cells Induces Pleural Mesothelial Cell (PMC) Permeability 2002
2002	Low Molecular Weight Hyaluronan Induces Malignant Mesothelioma Cell (MMC) Proliferation and Haptotaxis: Role of CD44 Receptor in MMC Proliferation and Haptotaxis 2002
2002	Fibrinolysis in the pleural space. Breaking the bonds that bind. American Journal of Respiratory and Critical Care Medicine. 166:909-910. 2002
2002	Drawing the line: Differentiating transudates from exudates. Respiration: international journal of thoracic medicine. 69:198. 2002
2002	Induction of MCP-1 expression in airway epithelial cells: Role of CCR2 receptor in airway epithelial injury. Journal of Clinical Immunology. 22:144-152. 2002
2002	Inflammatory cytokines mediate C-C (monocyte chemotactic protein 1) and C-X-C (interleukin 8) chemokine expression in human pleural fibroblasts. Inflammation. 26:73-82. 2002
2002	When should decortication be done in patients with pleural disease?. Clinical Pulmonary Medicine. 9:97-104. 2002
2001	Management of malignant pleural effusions. European Respiratory Journal. 18:402-419. 2001
2001	Bacterial induction of pleural mesothelial monolayer barrier dysfunction. 2001
2001	Polar production of interleukin-8 by mesothelial cells promotes the transmesothelial migration of neutrophils: Role of intercellular adhesion molecule-1. Journal of Infectious Diseases. 183:1638-1645. 2001
2001	Bacterial induction of pleural mesothelial monolayer barrier dysfunction 2001
2001	Pleural effusions: The workup and treatment 2001
2000	Pleural effusions: How to interpret the signs 2000
2000	Induction of acute pleural inflammation by Staphylococcus aureus. I. Cd4⁺ T cells play a critical role in experimental empyema. Journal of Infectious Diseases. 181:1693-1699. 2000
2000	MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. 2000
2000	Talc induces apoptosis in human malignant mesothelioma cells in vitro.. American Journal of Respiratory and Critical Care Medicine. 161:595-600. 2000
2000	MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells 2000
2000	Management of malignant pleural effusions. American Journal of Respiratory and Critical Care Medicine. 162:1987-2001. 2000
2000	Talc induces apoptosis in human malignant mesothelioma cells in vitro. American Journal of Respiratory and Critical Care Medicine. 161:595-600. 2000
1999	Inhibition of interleukin-8 reduces human malignant pleural mesothelioma propagation in nude mouse model 1999
1999	Mycobacterium-induced transmesothelial migration of monocytes into pleural space: Role of intercellular adhesion molecule-1 in tuberculous pleurisy. Journal of Infectious Diseases. 180:1616-1623. 1999
1999	Helper T cell type 1 and 2 cytokines regulate C-C chemokine expression in mouse pleural mesothelial cells.. American Journal of Respiratory and Critical Care Medicine. 159:1653-1659. 1999
1999	Pathophysiology of pleural space infections. Seminars in Respiratory Infections. 14:9-17. 1999
1999	Interleukin 8: An autocrine growth factor for malignant mesothelioma. Cancer Research. 59:367-371. 1999
1999	Helper T cell type 1 and 2 cytokines regulate C-C chemokine expression in mouse pleural mesothelial cells. American Journal of Respiratory and Critical Care Medicine. 159:1653-1659. 1999
1999	Pathogenesis of malignant pleural effusions and talc pleurodesis. Pneumologie. 53:493-498. 1999
1998	Mycobacterium-mediated chemokine expression in pleural mesothelial cells: role of C-C chemokines in tuberculous pleurisy.. Journal of Infectious Diseases. 178:1450-1456. 1998
1998	Drug-induced pleural disease. Clinics in Chest Medicine. 19:331-340. 1998
1998	Macrophage inflammatory protein-1α C-C chemokine in parapneumonic pleural effusions 1998
1998	Preface. Clinics in Chest Medicine. 19:13a. 1998
1998	Talc-induced expression of C-C and C-X-C chemokines and intercellular adhesion molecule-1 in mesothelial cells. American Journal of Respiratory and Critical Care Medicine. 158:971-978. 1998
1997	Pleurodesis: State of the art. Pneumologie. 51:986. 1997
1997	Immunobiology of pleural inflammation: Potential implications for pathogenesis, diagnosis and therapy. European Respiratory Journal. 10:2411-2418. 1997
1997	Pleurodesis: State of the art. European Respiratory Journal. 10:1648-1654. 1997
1996	Thoracoscopy: The pumonologist's role. Pneumologie. 50:418. 1996
1996	Angiogenesis in mesotheliomas. Role of mesothelial cell derived IL-8.. Chest. 109:21S-22S. 1996
1996	Adenosine deaminase isoenzymes and pleural tuberculosis. 1996
1996	Mechanism of talc induced pleurodesis. Journal of Investigative Medicine. 44. 1996
1995	Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin 8) chemokines.. American Journal of Respiratory Cell and Molecular Biology. 12:581-588. 1995
1995	Testing the waters: Differentiating transudates from exudates. Chest. 108:1191-1192. 1995
1995	Thoracoscopy: The pulmonologist's role 1995
1994	The immunopathology of chemotactic cytokines: The role of interleukin-8 and monocyte chemoattractant protein-1 1994
1994	Mesothelial cell modulation of pleural repair: Thrombin stimulated mesothelial cells release prostaglandin E2 1994
1993	Recruitment of inflammatory cells to the pleural space: Chemotactic cytokines, IL-8, and monocyte chemotactic peptide-1 in human pleural fluids. Journal of Immunology. 151:7216-7223. 1993
1992	NHLBI workshop summaries. Pleural cell biology in health and disease.. The American review of respiratory disease. 145:1236-1239. 1992
1992	Mechanism of tetracycline-hydrochloride-induced pleurodesis: Tetracycline- hydrochloride-stimulated mesothelial cells produce a growth-factor-like activity for fibroblasts. The American review of respiratory disease. 146:1009-1013. 1992
1992	Mesothelial cell response to pleural injury: thrombin-induced proliferation and chemotaxis of rat pleural mesothelial cells.. American Journal of Respiratory Cell and Molecular Biology. 6:421-425. 1992
1991	Alveolar cell population in HIV infected patients. European Respiratory Journal. 4:639-642. 1991
1989	Cystic fibrosis tracheobronchial effluent stimulates proliferation of lung fibroblasts in vitro. Chest. 95:234S-236S. 1989
1989	Mechanisms of pleural fibrosis in empyema. Pleural macrophage-mediated inhibition of fibroblast proliferation. Chest. 95. 1989
1989	Pleural mesothelial cells stimulated by asbestos release chemotactic activity for neutrophils in vitro. The American review of respiratory disease. 139:199-206. 1989
1988	Polymorphonuclear leukocyte cytoplasts mediate acute lung injury 1988
1988	Stimulation of cAMP accumulation and superoxide production in human neutrophils and monocytes. American Journal of the Medical Sciences. 295:178-182. 1988
1987	Pleural tuberculosis. Seminars in Respiratory Medicine. 9:54-58. 1987
1987	Pleurodesis--testing the waters.. The American review of respiratory disease. 135:775-776. 1987
1985	Bacillus Calmette-Guerin-stimulated neutrophils release chemotaxis for monocytes in rabbit pleural spaces and in vitro. Journal of Clinical Investigation. 76:1514-1521. 1985
1984	Pathogenesis of pleural plaques. Relationship of early cellular response and pathology. The American review of respiratory disease. 130:884-887. 1984
1983	Dimethyl sulfoxide inhibits phagocyte influx into infected pleural spaces and phagocyte locomotion in vitro. Inflammation. 7:377-385. 1983
1983	The contribution of leukocytes and bacteria to the low pH of empyema fluid. The American review of respiratory disease. 128:811-815. 1983
1983	The pathogenesis of the low pleural fluid pH in esophageal rupture. The American review of respiratory disease. 127:702-704. 1983
1983	Lung repair and granuloma formation. Tubercle bacilli stimulated neutrophils release chemotactic factors for monocytes.. Chest. 83:95S-96S. 1983
1983	EFFECT OF DIMETHYL SULFOXIDE ON CHEMOTAXIS OF PHAGOCYTIC CELLS. Annals of the New York Academy of Sciences. 411:321-323. 1983
1983	Lung repair and granuloma formation. Tubercle bacilli stimulated neutrophils release chemotactic factors for monocytes. Chest. 83:95S-96S. 1983
1983	Lupus pleuritis. Clinical features and pleural fluid characteristics with special reference to pleural fluid antinuclear antibodies. Chest. 84:714-718. 1983
1983	The pleuropulmonary manifestations of the postcardiac injury syndrome. Chest. 84:383-387. 1983
1981	Empyema after internal jugular catheterisation in rheumatoid arthritis. Thorax. 36:958-959. 1981

Chapter

Year	Title	Altmetric
2006	Pleural Effusions: Malignant Pleural Effusions. 372-379. 2006
2003	Chemokines in pleural disorders. 325-339. 2003

Research Overview

Dr. Antony’s research is focused on environmental and translational medicine, cystic fibrosis, pleural disease, and lung injury. Active studies involve work in the development of novel anti-fibrotic therapies, disease-relevant animal models of non-resolving fibrosis, the role of HO-1 in protection against bromine-induced lung injury/fibrosis, and the infrastructure needed to support cystic fibrosis clinical trials.