• Dr. Buford is a Professor in the UAB Department of Medicine, Division of Gerontology, Geriatrics & Palliative Care. He also serves as Director for the UAB Center for Exercise Medicine and Co-Director of the NIH-funded Nathan Shock Center for the Basic Biology of Aging. Dr. Buford’s research utilizes clinical and pre-clinical models focused on preserving the health and independence of older adults, including leading multiple recent clinical trials related to exercise and mobility. He current has extensive NIH funding including two active R01 awards and has served on numerous grant peer-review committees including serving as a standing member of the NIH's Aging Systems and Geriatrics panel. Among his prior research projects, he served as a co-investigator on the Phase 3 Lifestyle Interventions and Independence for Elders study and also serves as a clinical center Site PI for the NIH's Molecular Transducers of Physical Activity in Humans consortium funded by the NIH Common Fund.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience. 2022
    2021 Fatigue is independently associated with functional status limitations in older adults with gastrointestinal malignancies—results from the CARE registrySupportive Care in Cancer.  29:6793-6800. 2021
    2021 Bridging the gap: A geroscience primer for neuroscientists with potential collaborative applications. 2021
    2021 A Neuroscience Primer for Integrating Geroscience with the Neurobiology of Aging. 2021
    2021 University of Alabama at Birmingham Nathan Shock Center: comparative energetics of agingGeroscience.  43:2149-2160. 2021
    2021 Mechanisms of exercise as a preventative measure to muscle wasting 2021
    2021 Lipopolysaccharide binding protein is associated with CVD risk in older adultsAging Clinical and Experimental Research.  33:1651-1658. 2021
    2021 Exercise: primus inter pares of Life’s Simple 7Aging.  13:12297-12298. 2021
    2021 A Role for Exercise to Counter Skeletal Muscle Clock DisruptionExercise and Sport Sciences Reviews.  49:35-41. 2021
    2021 Pre-treatment neutrophil to lymphocyte ratio as a biomarker of frailty and predictor of survival among older adults with multiple myelomaJournal of Geriatric Oncology2021
    2021 Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trialExperimental Gerontology.  143. 2021
    2021 Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease 2021
    2020 Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older AdultsCells.  9. 2020
    2020 Angiotensin (1–7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older ratsGeroscience.  42:1307-1321. 2020
    2020 Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to ExerciseCell.  181:1464-1474. 2020
    2020 The PROSPER-HIV Study: A Research Protocol to Examine Relationships Among Physical Activity, Diet Intake, and Symptoms in Adults Living With HIVJournal of the Association of Nurses in AIDS Care.  31:346-352. 2020
    2020 Comparative Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Response to a Physical Activity Intervention in Older Adults: Results from the Lifestyle Interventions and Independence for Elders Study 2020
    2020 Prevalence of Hospital-Associated Disability in Older Adults: A Meta-analysis 2020
    2020 Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive FrailtyFrontiers in Nutrition.  7. 2020
    2020 Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults – A pilot studyExperimental Gerontology.  131. 2020
    2020 Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility DisabilityJournal of the American Geriatrics Society.  68:619-624. 2020
    2020 Physical activity trends and metabolic health outcomes in people living with HIV in the US, 2008–2015Progress in Cardiovascular Diseases.  63:170-177. 2020
    2020 The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertensionGeroscience.  42:141-158. 2020
    2020 Angiotensin Converting Enzyme Inhibitors Combined with Exercise for Hypertensive Seniors (The ACES Trial): Study Protocol of a Randomized Controlled TrialFrontiers in Medicine.  6. 2020
    2020 Age-related differences in the gut microbiome of rhesus macaques 2020
    2020 The gut microbiome and aging 2020
    2020 The gut microbiome as a therapeutic target for cognitive impairment 2020
    2020 Therapeutic delivery of ang(1-7) via genetically modified probiotic: A dosing study 2020
    2019 Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal MuscleCells.  8. 2019
    2019 Exercise and the Gut Microbiome: A Review of the Evidence, Potential Mechanisms, and Implications for Human HealthExercise and Sport Sciences Reviews.  47:75-85. 2019
    2019 Blood-flow restriction resistance exercise for older adults with knee osteoarthritis: A pilot randomized clinical trialJournal of Clinical Medicine.  8. 2019
    2019 Exercise is Medicine as a Vital Sign: Challenges and Opportunities.Translational Journal of the American College of Sports Medicine.  4:1-7. 2019
    2019 Mitochondrial DNA variants and pulmonary function in older personsExperimental Gerontology.  115:96-103. 2019
    2019 Multimodal intervention to improve functional status in hypertensive older adults: A pilot randomized controlled trialJournal of Clinical Medicine.  8. 2019
    2019 The impact of multisite pain on functional outcomes in older adults: Biopsychosocial considerationsJournal of Pain Research.  12:1115-1125. 2019
    2019 Wearable technology to reduce sedentary behavior and cvd risk in older adults: A pilot randomized clinical trialClinical Interventions in Aging.  14:1817-1828. 2019
    2018 Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speedGeroscience.  40:497-511. 2018
    2018 Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older AdultsFrontiers in Aging Neuroscience.  10. 2018
    2018 Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults 2018
    2018 Circadian rhythms, exercise, and cardiovascular healthJournal of Circadian Rhythms.  16. 2018
    2018 A 3-minute test of cardiorespiratory fitness for use in primary care clinicsPLoS ONE.  13. 2018
    2018 Composition and richness of the serum microbiome differ by age and link to systemic inflammationGeroscience.  40:257-268. 2018
    2018 Effect of physical activity on frailty: Secondary analysis of a randomized controlled trialAnnals of Internal Medicine.  168:309-316. 2018
    2018 Nutrition and exercise in sarcopeniaCurrent Protein and Peptide Science.  19:649-667. 2018
    2018 Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE StudyThe Journals of Gerontology: Series B.  73:1501-1513. 2018
    2017 Association of accelerometry-measured physical activity and cardiovascular events in mobility-limited older adults: The LIFE (Lifestyle Interventions and Independence for Elders) study 2017
    2017 Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older AdultsJournal of the American Geriatrics Society.  65:2251-2256. 2017
    2017 Sarcopenia: Relocating the Forest among the TreesToxicologic Pathology.  45:957-960. 2017
    2017 Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging 2017
    2017 Metabolic costs of daily activity in older adults (Chores XL) study: Design and methodsContemporary Clinical Trials Communications.  6:1-8. 2017
    2017 Mobile device accuracy for step counting across age groupsJMIR mHealth and uHealth.  5. 2017
    2017 Resveratrol and exercise to treat functional limitations in late life: Design of a randomized controlled trialContemporary Clinical Trials Communications.  6:58-63. 2017
    2017 Wearable technology to reduce sedentary behavior and CVD risk in older adults: Design of a randomized controlled trialContemporary Clinical Trials Communications.  6:122-126. 2017
    2017 Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study 2017
    2017 Systemic inflammation, body composition, and physical performance in old community-dwellersJournal of Cachexia, Sarcopenia and Muscle.  8:69-77. 2017
    2017 (Dis)trust your gut: The gut microbiome in age-related inflammation, health, and diseaseMicrobiome.  5:1-11. 2017
    2017 Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE StudyArchives of Physical Medicine and Rehabilitation.  98:11-24.e3. 2017
    2016 Effects of different doses of high-speed resistance training on physical performance and quality of life in older women: A randomized controlled trialClinical Interventions in Aging.  11:1797-1804. 2016
    2016 Effect of a Long-Term Physical Activity Intervention on Resting Pulse Rate in Older Persons: Results from the Lifestyle Interventions and Independence for Elders StudyJournal of the American Geriatrics Society.  64:2511-2516. 2016
    2016 Effect of Statin Use on Mobility Disability and its Prevention in At-risk Older Adults: The LIFE Study 2016
    2016 Effects of blood-flow restriction on biomarkers of myogenesis in response to resistance exercise 2016
    2016 Cardiovascular events in a physical activity intervention compared with a successful aging intervention: The LIFE study randomized trialJAMA Cardiology.  1:568-574. 2016
    2016 Antihypertensive use and the effect of a physical activity intervention in the prevention of major mobility disability among older adults: The LIFE study 2016
    2016 Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical TrialJournal of the American Geriatrics Society.  64:933-943. 2016
    2016 Hypertension and agingAgeing Research Reviews.  26:96-111. 2016
    2016 Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: Randomized clinical trial (LIFE study)BMJ.  352. 2016
    2016 Exercise Interventions for Preserving Physical Function Among Cancer Survivors in Middle to Late Life 2016
    2015 Successful aging: Advancing the science of physical independence in older adultsAgeing Research Reviews.  24:304-327. 2015
    2015 Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations - The LIFE StudyExperimental Gerontology.  70:32-36. 2015
    2015 Dietary Antioxidants as Modifiers of Physiologic Adaptations to ExerciseMedicine and Science in Sports and Exercise.  47:1857-1868. 2015
    2015 Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: The LIFE randomized trial 2015
    2015 Associations Between Ankle-Brachial Index and Cognitive Function: Results From the Lifestyle Interventions and Independence for Elders Trial 2015
    2015 Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjectsBMC Immunology.  16. 2015
    2015 Kaatsu training to enhance physical function of older adults with knee osteoarthritis: Design of a randomized controlled trialContemporary Clinical Trials.  43:217-222. 2015
    2015 Multi-modal intervention to reduce cardiovascular risk among hypertensive older adults: Design of a randomized clinical trialContemporary Clinical Trials.  43:237-242. 2015
    2015 Effects of a one-year physical activity program on serum C-terminal Agrin Fragment (CAF) concentrations among mobility-limited older adultsJournal of Nutrition, Health and Aging.  19:922-927. 2015
    2015 The renin–angiotensin system and prevention of age-related functional decline: where are we now?AGE.  37:1-11. 2015
    2015 Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults 2015
    2014 Physical activity and resting pulse rate in older adults: Findings from a randomized controlled trialAmerican Heart Journal.  168:597-604. 2014
    2014 Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults 2014
    2014 Genetic influence on exercise-induced changes in physical function among mobility-limited older adultsPhysiological Genomics.  46:149-158. 2014
    2014 Resveratrol as a supplement to exercise training: Friend or foe? 2014
    2014 Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged malesEuropean Journal of Applied Physiology.  114:1321-1332. 2014
    2014 Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: A pilot study 2014
    2014 Optimizing the benefits of exercise on physical function in older adults 2014
    2014 Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: A partial least squares-discriminant analysis approachFrontiers in Medicine.  1. 2014
    2013 Atenolol Induced HDL-C Change in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) StudyPLoS ONE.  8. 2013
    2013 Obesity and diabetes as accelerators of functional decline: Can lifestyle interventions maintain functional status in high risk older adults?Experimental Gerontology.  48:888-897. 2013
    2013 Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscleAGE.  35:1061-1075. 2013
    2013 Toward exercise as personalized medicineSports Medicine.  43:157-165. 2013
    2013 Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. 2013
    2013 Erratum to "Making preventive medicine more personalized: Implications for exercise-related research" [Prev. Med. 55 (2012) 34-36]Preventive Medicine.  56:94. 2013
    2013 Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials 2013
    2012 Blood flow restriction enhances post-resistance exercise angiogenic gene expressionMedicine and Science in Sports and Exercise.  44:2077-2083. 2012
    2012 Growth hormone responses to acute resistance exercise with vascular restriction in young and old menGrowth Hormone and IGF Research.  22:167-172. 2012
    2012 The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individualsAging Cell.  11:801-809. 2012
    2012 On muscle atrophy, aging, and disease 2012
    2012 Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exerciseJournal of the American Geriatrics Society.  60:1244-1252. 2012
    2012 Making preventive medicine more personalized: Implications for exercise-related researchPreventive Medicine.  55:34-36. 2012
    2012 Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: An exploratory studyPLoS ONE.  7. 2012
    2012 Age-related differences in lower extremity tissue compartments and associations with physical function in older adultsExperimental Gerontology.  47:38-44. 2012
    2011 Protein and amino acid supplementation does not alter proteolytic gene expression following immobilizationJournal of Nutrition and Metabolism.  2011. 2011
    2011 The impact of behavioral intervention on obesity mediated declines in mobility function: Implications for longevityJournal of Aging Research.  2011. 2011
    2011 Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt/mTOR pathway signaling compared to carbohydrateJournal of the International Society of Sports Nutrition.  8. 2011
    2011 Erratum to: Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway rats (Age DOI: 10.1007/s11357-010-9196-y)AGE.  33:185. 2011
    2011 Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 x Brown Norway ratsAGE.  33:167-183. 2011
    2011 Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and functionAging Clinical and Experimental Research.  23:170-174. 2011
    2010 Nutritional strategies and immune functionStrength and Conditioning Journal.  32:65-70. 2010
    2010 Sedentary individuals as "controls" in human studies: The correct approach? 2010
    2010 Effects of age and sedentary lifestyle on skeletal muscle nf-κb signaling in men 2010
    2010 Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophyAgeing Research Reviews.  9:369-383. 2010
    2009 Protease supplementation improves muscle function after eccentric exerciseMedicine and Science in Sports and Exercise.  41:1908-1914. 2009
    2009 Resistance exercise-induced changes of inflammatory gene expression within human skeletal muscleEuropean Journal of Applied Physiology.  107:463-471. 2009
    2009 Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in malesJournal of the International Society of Sports Nutrition.  6. 2009
    2009 Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle 2009
    2008 The acute effects of the thermogenic supplement Meltdown on energy expenditure, fat oxidation, and hemodynamic responses in young, healthy malesJournal of the International Society of Sports Nutrition.  5. 2008
    2008 Impact of DHEA(S) and cortisol on immune function in aging: A brief review 2008
    2008 Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individualsJournal of the International Society of Sports Nutrition.  5. 2008
    2008 Seasonal changes of body mass, body composition, and muscular performance in collegiate wrestlersInternational Journal of Sports Physiology and Performance.  3:176-184. 2008
    2007 A comparison of periodization models during nine weeks with equated volume and intensity for strengthJournal of Strength and Conditioning Research.  21:1245-1250. 2007
    2007 International Society of Sports Nutrition position stand: Creatine supplementation and exerciseJournal of the International Society of Sports Nutrition.  4. 2007
    2007 Bilateral comparison of barbell kinetics and kinematics during a weightlifting competition.International Journal of Sports Physiology and Performance.  2:150-158. 2007
    2006 The effect of a competitive wrestling season on body weight, hydration, and muscular performance in collegiate wrestlersJournal of Strength and Conditioning Research.  20:689-692. 2006


    Year Title Altmetric
    2008 Macronutrient intake for physical activity.  95-119. 2008

    Research Overview

  • Aging, Exercise, Mobility, Skeletal Muscle, Microbiome, Rehabilitation, Cognition
  • Education And Training

  • Doctor of Philosophy in Exercise Physiology, Baylor University 2009
  • Master of Science in Kinesiology and Exercise Science, Oklahoma State University 2006
  • Bachelor of Science or Mathematics in Social Science Teacher Education, Oklahoma Baptist University 2004
  • Full Name

  • Thomas Buford