Ryan Ph.D., Thomas

Ryan Ph.D., Thomas
Associate Professor

Scientist, Cancer Cell Biology , O'Neal Comprehensive Cancer Center
Associate Professor (P), Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Program Director, Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments 2008 -
Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine 2019 -

Selected Publications

Academic Article

Year	Title	Altmetric
2017	Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major.. Blood Advances. 1:2421-2432. 2017
2017	Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia. Scientific Reports. 7. 2017
2016	The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function. Proceedings of the National Academy of Sciences. 113:E51-E60. 2016
2013	Erythropoiesis in the absence of adult hemoglobin. Molecular and Cellular Biology. 33:2241-2251. 2013
2011	Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. Molecular and Cellular Biology. 31:876-883. 2011
2010	Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology. Annals of the New York Academy of Sciences. 1202:45-51. 2010
2009	Preclinical transfusion-dependent humanized mouse model of β thalassemia major. Blood. 113:4763-4770. 2009
2009	Humanized mouse model of Cooley's anemia. Journal of Biological Chemistry. 284:4889-4896. 2009
2007	JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. Journal of Biological Chemistry. 282:6875-6886. 2007
2006	Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 108:1183-1188. 2006
2004	A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. Journal of Biological Chemistry. 279:27518-27524. 2004
2004	Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.. Nucleic Acids Research. 32. 2004
2003	Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood. 102:4312-4319. 2003
2003	Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization. Journal of Biological Chemistry. 278:4194-4204. 2003
2002	Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen. Biology of Blood and Marrow Transplantation. 8:453-461. 2002
2001	Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proceedings of the National Academy of Sciences. 98:15215-15220. 2001
2001	Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Proceedings of the National Academy of Sciences. 98:986-991. 2001
2000	Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention. Blood. 96. 2000
2000	Human β-globin gene promoter element regulates human β-globin gene developmental specificity. Nucleic Acids Research. 28:2736-2740. 2000
1998	Knockout-transgenic mouse models of human hemoglobinopathies. Experimental Hematology. 26:807. 1998
1998	Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Research. 26:2849-2858. 1998
1997	Knockout-transgenic mouse model of sickle cell disease. Science. 278:873-876. 1997
1995	Mouse model of human β⁰ thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells. Proceedings of the National Academy of Sciences. 92:9259-9263. 1995
1994	Preparation of recombinant hemoglobin in transgenic mice. Methods in Enzymology. 231:403-434. 1994
1991	Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice. Proceedings of the National Academy of Sciences. 88:1626-1630. 1991
1990	A Transgenic Mouse Model for Human Sickle Cell Disease. Proceedings of The Japanese Association of Animal Models for Human Diseases. 6:6-12. 1990
1990	Human sickle hemoglobin in transgenic mice. Science. 247:566-568. 1990
1990	Human γ- To β-globin gene switching in transgenic mice. Genes and Development. 4:380-389. 1990
1990	Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody. Journal of Immunology. 145:202-208. 1990
1989	A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.. Genes and Development. 3:314-323. 1989
1989	DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.. Progress in clinical and biological research. 316 A:47-61. 1989
1989	High-level erythroid expression of human α-globin genes in transgenic mice. Proceedings of the National Academy of Sciences. 86:37-41. 1989
1989	Synthesis of functional human hemoglobin in transgenic mice. Science. 245:971-973. 1989