Thomas Ryan Ph.D.

Thomas Ryan Ph.D.
Associate Professor

Scientist, Cancer Cell Biology , O'Neal Comprehensive Cancer Center
Associate Professor (P), Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Program Director, Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments 2008 -
Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine 2019 -

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Mapping the chromosomal insertion site of the GFP transgene of UBC-GFP mice to the MHC locus 2020
2017	Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major 2017
2017	Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia 2017
2016	The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2013	Erythropoiesis in the absence of adult hemoglobin 2013
2011	Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development 2011
2010	Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology 2010
2009	Preclinical transfusion-dependent humanized mouse model of β thalassemia major 2009
2009	Humanized mouse model of Cooley's anemia 2009
2007	JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells 2007
2006	Correction of sickle cell disease by homologous recombination in embryonic stem cells 2006
2004	A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin 2004
2004	Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. 2004
2003	Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells 2003
2003	Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization 2003
2002	Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen 2002
2001	Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
2001	Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene 2001
2000	Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention 2000
2000	Human β-globin gene promoter element regulates human β-globin gene developmental specificity 2000
1998	Knockout-transgenic mouse models of human hemoglobinopathies 1998
1998	Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene 1998
1997	Knockout-transgenic mouse model of sickle cell disease 1997
1995	Mouse model of human β⁰ thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells 1995
1994	Preparation of recombinant hemoglobin in transgenic mice 1994
1991	Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice 1991
1990	A Transgenic Mouse Model for Human Sickle Cell Disease 1990
1990	Human sickle hemoglobin in transgenic mice 1990
1990	Human γ- To β-globin gene switching in transgenic mice 1990
1990	Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody 1990
1989	A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. 1989
1989	DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice. 1989
1989	High-level erythroid expression of human α-globin genes in transgenic mice 1989
1989	Synthesis of functional human hemoglobin in transgenic mice 1989