Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Mapping the chromosomal insertion site of the GFP transgene of UBC-GFP mice to the MHC locusJournal of Immunology.  204:1982-1987. 2020
2019 In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI TechniquesScientific Reports.  9. 2019
2019 Publisher Correction: In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques (Scientific Reports, (2019), 9, 1, (11592), 10.1038/s41598-019-48078-4)Scientific Reports.  9. 2019
2017 Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia majorBlood Advances.  1:2421-2432. 2017
2017 Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemiaScientific Reports.  7. 2017
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2013 Erythropoiesis in the absence of adult hemoglobinMolecular and Cellular Biology.  33:2241-2251. 2013
2011 Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal developmentMolecular and Cellular Biology.  31:876-883. 2011
2010 Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathologyAnnals of the New York Academy of Sciences.  1202:45-51. 2010
2009 Preclinical transfusion-dependent humanized mouse model of β thalassemia majorBlood.  113:4763-4770. 2009
2009 Humanized mouse model of Cooley's anemiaJournal of Biological Chemistry.  284:4889-4896. 2009
2007 Active integration: New strategies for transgenesisTransgenic Research.  16:333-339. 2007
2007 JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cellsJournal of Biological Chemistry.  282:6875-6886. 2007
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cellsBlood.  108:1183-1188. 2006
2004 A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobinJournal of Biological Chemistry.  279:27518-27524. 2004
2004 Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.Nucleic Acids Research.  32. 2004
2003 Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cellsBlood.  102:4312-4319. 2003
2003 Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerizationJournal of Biological Chemistry.  278:4194-4204. 2003
2003 Distinguishable live erythroid and myeloid cells in β-globin ECFP x lysozyme EGFP miceBlood.  101:903-906. 2003
2002 Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimenBiology of Blood and Marrow Transplantation.  8:453-461. 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
2001 Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene 2001
2000 Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic interventionBlood.  96. 2000
2000 Human β-globin gene promoter element regulates human β-globin gene developmental specificityNucleic Acids Research.  28:2736-2740. 2000
1998 Knockout-transgenic mouse models of human hemoglobinopathiesExperimental Hematology.  26:807. 1998
1998 double-replacement gene targeting in mouse embryonic stem cells - creation of a mouse model for congenital polycythemiaExperimental Hematology.  26:765. 1998
1998 Stochastic, stage-specific mechanisms account for the variegation of a human globin transgeneNucleic Acids Research.  26:2849-2858. 1998
1997 Knockout-transgenic mouse model of sickle cell diseaseScience.  278:873-876. 1997
1995 Mouse model of human β0 thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells 1995
1994 Preparation of recombinant hemoglobin in transgenic miceMethods in Enzymology.  231:403-434. 1994
1991 Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice 1991
1991 Thymus-dependent network responses to a monoclonal cross-reactive antiidiotypic antibodyJournal of Immunology.  147:1849-1855. 1991
1990 A Transgenic Mouse Model for Human Sickle Cell DiseaseProceedings of The Japanese Association of Animal Models for Human Diseases.  6:6-12. 1990
1990 Human sickle hemoglobin in transgenic miceScience.  247:566-568. 1990
1990 Human γ- To β-globin gene switching in transgenic miceGenes and Development.  4:380-389. 1990
1990 Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibodyJournal of Immunology.  145:202-208. 1990
1989 A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.Genes and Development.  3:314-323. 1989
1989 DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.Progress in clinical and biological research.  316 A:47-61. 1989
1989 High-level erythroid expression of human α-globin genes in transgenic mice 1989
1989 Synthesis of functional human hemoglobin in transgenic miceScience.  245:971-973. 1989

Teaching Activities

  • GBSC746 - Gene Editing (Summer Term 2021) 2021
  • GBS784 - Stem Cell Biology (Spring Term 2021) 2021
  • GBSC700 - Journal Clubs (Spring Term 2021) 2021
  • GBSC742 - Student Theme Meeting Course (Spring Term 2021) 2021
  • GBSC700 - Journal Clubs (Fall Term 2020) 2020
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Fall Term 2020) 2020
  • GBS748 - Special Topics (Summer Term 2020) 2020
  • GBS784 - Stem Cell Biology (Spring Term 2020) 2020
  • GBSC700 - Journal Clubs (Spring Term 2020) 2020
  • GBSC742 - Student Theme Meeting Course (Spring Term 2020) 2020
  • GBS748 - Special Topics (Fall Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2019) 2019
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBS784 - Stem Cell Biology (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2018) 2018
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS784 - Stem Cell Biology (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBS784 - Stem Cell Biology (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2016) 2016
  • GBS784 - Stem Cell Biology (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Fall Term 2015) 2015
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015) 2015
  • GBS784 - Stem Cell Biology (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Fall Term 2014) 2014
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2014) 2014
  • GBS784 - Stem Cell Biology (Spring Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2013) 2013
  • GBS784 - Stem Cell Biology (Spring Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2012) 2012
  • OBHS111 - Fundamentals Dent/Optometry I (Fall Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2012) 2012
  • GBS784 - Stem Cell Biology (Spring Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2011) 2011
  • GBS784 - Stem Cell Biology (Spring Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2010) 2010
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2009) 2009
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2008) 2008
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2008) 2008
  • BMG798 - Non-Dissertation Research (Spring Term 2008) 2008
  • BMG799 - Dissertation Research (Spring Term 2008) 2008
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2007) 2007
  • BMG798 - Non-Dissertation Research (Fall Term 2007) 2007
  • BMG799 - Dissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 1990
  • Bachelor of Arts in Biology, California State University System : Humboldt State University 1982
  • Bachelor of Arts in Chemistry, California State University System : Humboldt State University 1982
  • Full Name

  • Thomas Ryan