Thomas Ryan Ph.D.

Thomas Ryan Ph.D.
Associate Professor

Associate Professor (P), Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Program Director, Biochemistry & Molecular Genetics , Academic Joint Departments 2003 -
Associate Scientist (C), Civitan International Research Center , Academic Joint Departments 2008 -
Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine 2019 -

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Mapping the chromosomal insertion site of the GFP transgene of UBC-GFP mice to the MHC locus. Journal of Immunology. 204:1982-1987. 2020
2017	Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major. Blood Advances. 1:2421-2432. 2017
2017	Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia. Scientific Reports. 7. 2017
2016	The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function 2016
2013	Erythropoiesis in the absence of adult hemoglobin. Molecular and Cellular Biology. 33:2241-2251. 2013
2011	Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. Molecular and Cellular Biology. 31:876-883. 2011
2010	Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology. Annals of the New York Academy of Sciences. 1202:45-51. 2010
2009	Preclinical transfusion-dependent humanized mouse model of β thalassemia major. Blood. 113:4763-4770. 2009
2009	Humanized mouse model of Cooley's anemia. Journal of Biological Chemistry. 284:4889-4896. 2009
2007	JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells. Journal of Biological Chemistry. 282:6875-6886. 2007
2006	Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 108:1183-1188. 2006
2004	A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. Journal of Biological Chemistry. 279:27518-27524. 2004
2004	Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.. Nucleic Acids Research. 32. 2004
2003	Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood. 102:4312-4319. 2003
2003	Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization. Journal of Biological Chemistry. 278:4194-4204. 2003
2002	Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen. Biology of Blood and Marrow Transplantation. 8:453-461. 2002
2001	Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease 2001
2001	Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene 2001
2000	Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention. Blood. 96. 2000
2000	Human β-globin gene promoter element regulates human β-globin gene developmental specificity. Nucleic Acids Research. 28:2736-2740. 2000
1998	Knockout-transgenic mouse models of human hemoglobinopathies. Experimental Hematology. 26:807. 1998
1998	Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Research. 26:2849-2858. 1998
1997	Knockout-transgenic mouse model of sickle cell disease. Science. 278:873-876. 1997
1995	Mouse model of human β⁰ thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells 1995
1994	Preparation of recombinant hemoglobin in transgenic mice. Methods in Enzymology. 231:403-434. 1994
1991	Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice 1991
1990	A Transgenic Mouse Model for Human Sickle Cell Disease. Proceedings of The Japanese Association of Animal Models for Human Diseases. 6:6-12. 1990
1990	Human sickle hemoglobin in transgenic mice. Science. 247:566-568. 1990
1990	Human γ- To β-globin gene switching in transgenic mice. Genes and Development. 4:380-389. 1990
1990	Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody. Journal of Immunology. 145:202-208. 1990
1989	A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.. Genes and Development. 3:314-323. 1989
1989	DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.. Progress in clinical and biological research. 316 A:47-61. 1989
1989	High-level erythroid expression of human α-globin genes in transgenic mice 1989
1989	Synthesis of functional human hemoglobin in transgenic mice. Science. 245:971-973. 1989