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Thomas Ryan Ph.D.
Associate Professor
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E-mail
tryan@uab.edu
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Thomas Ryan Ph.D.
Associate Professor
Positions
Scientist
,
Cancer Cell Biology
,
O'Neal Comprehensive Cancer Center
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2020
Mapping the chromosomal insertion site of the GFP transgene of UBC-GFP mice to the MHC locus
.
Journal of Immunology
. 204:1982-1987.
2020
2017
Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia major
.
Blood Advances
. 1:2421-2432.
2017
2017
Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia
.
Scientific Reports
. 7.
2017
2016
The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function
2016
2013
Erythropoiesis in the absence of adult hemoglobin
.
Molecular and Cellular Biology
. 33:2241-2251.
2013
2011
Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development
.
Molecular and Cellular Biology
. 31:876-883.
2011
2010
Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology
.
Annals of the New York Academy of Sciences
. 1202:45-51.
2010
2009
Preclinical transfusion-dependent humanized mouse model of β thalassemia major
.
Blood
. 113:4763-4770.
2009
2009
Humanized mouse model of Cooley's anemia
.
Journal of Biological Chemistry
. 284:4889-4896.
2009
2007
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cells
.
Journal of Biological Chemistry
. 282:6875-6886.
2007
2006
Correction of sickle cell disease by homologous recombination in embryonic stem cells
.
Blood
. 108:1183-1188.
2006
2004
A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin
.
Journal of Biological Chemistry
. 279:27518-27524.
2004
2004
Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.
.
Nucleic Acids Research
. 32.
2004
2003
Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells
.
Blood
. 102:4312-4319.
2003
2003
Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerization
.
Journal of Biological Chemistry
. 278:4194-4204.
2003
2002
Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen
.
Biology of Blood and Marrow Transplantation
. 8:453-461.
2002
2001
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
2001
2001
Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene
2001
2000
Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention
.
Blood
. 96.
2000
2000
Human β-globin gene promoter element regulates human β-globin gene developmental specificity
.
Nucleic Acids Research
. 28:2736-2740.
2000
1998
Knockout-transgenic mouse models of human hemoglobinopathies
.
Experimental Hematology
. 26:807.
1998
1998
Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene
.
Nucleic Acids Research
. 26:2849-2858.
1998
1997
Knockout-transgenic mouse model of sickle cell disease
.
Science
. 278:873-876.
1997
1995
Mouse model of human β
0
thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cells
1995
1994
Preparation of recombinant hemoglobin in transgenic mice
.
Methods in Enzymology
. 231:403-434.
1994
1991
Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice
1991
1990
A Transgenic Mouse Model for Human Sickle Cell Disease
.
Proceedings of The Japanese Association of Animal Models for Human Diseases
. 6:6-12.
1990
1990
Human sickle hemoglobin in transgenic mice
.
Science
. 247:566-568.
1990
1990
Human γ- To β-globin gene switching in transgenic mice
.
Genes and Development
. 4:380-389.
1990
1990
Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody
.
Journal of Immunology
. 145:202-208.
1990
1989
A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.
.
Genes and Development
. 3:314-323.
1989
1989
DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.
.
Progress in clinical and biological research
. 316 A:47-61.
1989
1989
High-level erythroid expression of human α-globin genes in transgenic mice
1989
1989
Synthesis of functional human hemoglobin in transgenic mice
.
Science
. 245:971-973.
1989
Research
Principal Investigator On
Adult Stem Cell Therapy in Humanized Mouse Models of Anemia
awarded by
ALABAMA INSTITUTE OF MEDICINE
2014 - 2018
Bone Marrow Transplant Without Cytoreductive Conditioning to Cure Cooley's Anemia
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2015 - 2018
Cell Therapies for Cooley's Anemia
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2014 - 2016
Correction of Humanized Cooley's Anemia Mice by Gene Editing Hematopoietic Stem Cells
awarded by
Cooley's Anemia Foundation, Inc.
2015 - 2016
Correction of Humanized Cooley's Anemia Mice by Gene Editing Hematopoietic Stem Cells
awarded by
Cooley's Anemia Foundation, Inc.
2014 - 2015
Cell Therapies for Cooley's Anemia
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2009 - 2014
Investigator On
Mechanism of Tgfbr2 in Chondroprotection
awarded by
National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
2020 - 2025
Teaching
Teaching Activities
GBS748 - Special Topics (Summer Term 2020)
2020
GBS784 - Stem Cell Biology (Spring Term 2020)
2020
GBSC700 - Journal Clubs (Spring Term 2020)
2020
GBSC742 - Student Theme Meeting Course (Spring Term 2020)
2020
GBS748 - Special Topics (Fall Term 2019)
2019
GBSC700 - Journal Clubs (Fall Term 2019)
2019
GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2019)
2019
GBSC742 - Student Theme Meeting Course (Fall Term 2019)
2019
GBS784 - Stem Cell Biology (Spring Term 2019)
2019
GBSC700 - Journal Clubs (Spring Term 2019)
2019
GBSC742 - Student Theme Meeting Course (Spring Term 2019)
2019
GBSC700 - Journal Clubs (Fall Term 2018)
2018
GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2018)
2018
GBSC742 - Student Theme Meeting Course (Fall Term 2018)
2018
GBS784 - Stem Cell Biology (Spring Term 2018)
2018
GBSC700 - Journal Clubs (Spring Term 2018)
2018
GBSC701 - Seminars (Spring Term 2018)
2018
GBSC701 - Seminars (Spring Term 2018)
2018
GBSC700 - Journal Clubs (Fall Term 2017)
2017
GBSC701 - Seminars (Fall Term 2017)
2017
GBSC701 - Seminars (Fall Term 2017)
2017
GBS784 - Stem Cell Biology (Spring Term 2017)
2017
GBSC700 - Journal Clubs (Spring Term 2017)
2017
GBSC701 - Seminars (Spring Term 2017)
2017
GBSC701 - Seminars (Spring Term 2017)
2017
GBSC700 - Journal Clubs (Fall Term 2016)
2016
GBSC701 - Seminars (Fall Term 2016)
2016
GBSC701 - Seminars (Fall Term 2016)
2016
GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2016)
2016
GBS784 - Stem Cell Biology (Spring Term 2016)
2016
GBSC700 - Journal Clubs (Spring Term 2016)
2016
GBSC700 - Journal Clubs (Fall Term 2015)
2015
GBS784 - STEM CELL BIOLOGY (Spring Term 2015)
2015
GBS784 - Stem Cell Biology (Spring Term 2015)
2015
GBSC700 - Journal Clubs (Spring Term 2015)
2015
GBSC700 - Journal Clubs (Fall Term 2014)
2014
GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2014)
2014
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2014)
2014
GBS784 - Stem Cell Biology (Spring Term 2014)
2014
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2013)
2013
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2013)
2013
GBS784 - Stem Cell Biology (Spring Term 2013)
2013
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2012)
2012
OBHS111 - Fundamentals Dent/Optometry I (Fall Term 2012)
2012
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2012)
2012
GBS784 - Stem Cell Biology (Spring Term 2012)
2012
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2011)
2011
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011)
2011
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2011)
2011
GBS784 - Stem Cell Biology (Spring Term 2011)
2011
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2010)
2010
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010)
2010
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2010)
2010
CMB774 - CMB VII Stem Cell Biology (Spring Term 2010)
2010
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2009)
2009
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009)
2009
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2009)
2009
CMB774 - CMB VII Stem Cell Biology (Spring Term 2009)
2009
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2008)
2008
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008)
2008
BMG773 - Journal Club in Stem Cell Biol (Spring Term 2008)
2008
BMG798 - Non-Dissertation Research (Spring Term 2008)
2008
BMG799 - Dissertation Research (Spring Term 2008)
2008
CMB774 - CMB VII Stem Cell Biology (Spring Term 2008)
2008
BMG773 - Journal Club in Stem Cell Biol (Fall Term 2007)
2007
BMG798 - Non-Dissertation Research (Fall Term 2007)
2007
BMG799 - Dissertation Research (Fall Term 2007)
2007
Background
Education And Training
Doctor of Philosophy in Microbiology,
University of Alabama at Birmingham
1990
Bachelor of Arts in Biology,
California State University System : Humboldt State University
1982
Bachelor of Arts in Chemistry,
California State University System : Humboldt State University
1982
Contact
Full Name
Thomas
Ryan