Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with β-thalassemia majorAmerican Journal of Clinical Nutrition.  1:2421-2432. 2017
2017 Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemiaScientific Reports.  7. 2017
2016 The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell functionProceedings of the National Academy of Sciences.  113:E51-E60. 2016
2013 Erythropoiesis in the absence of adult hemoglobinMolecular and Cellular Biology.  33:2241-2251. 2013
2011 Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal developmentMolecular and Cellular Biology.  31:876-883. 2011
2010 Humanized mouse models of Cooley's anemia: Correct fetal-to-adult hemoglobin switching, disease onset, and disease pathologyOnkologie.  1202:45-51. 2010
2009 Preclinical transfusion-dependent humanized mouse model of β thalassemia majorJournal of Health Psychology.  113:4763-4770. 2009
2009 Humanized mouse model of Cooley's anemiaJournal of Biological Chemistry.  284:4889-4896. 2009
2007 JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cellsJournal of Biological Chemistry.  282:6875-6886. 2007
2006 Correction of sickle cell disease by homologous recombination in embryonic stem cellsJournal of Health Psychology.  108:1183-1188. 2006
2004 A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobinJournal of Biological Chemistry.  279:27518-27524. 2004
2004 Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts.Nucleic Acids Research.  32. 2004
2003 Correction of a mouse model of sickle cell disease: Lentiviral/ antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cellsJournal of Health Psychology.  102:4312-4319. 2003
2003 Nitric oxide-dependent generation of reactive species in sickle cell disease: Actin tyrosine nitration induces defective cytoskeletal polymerizationJournal of Biological Chemistry.  278:4194-4204. 2003
2002 Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimenJournal of applied physiology: respiratory, environmental and exercise physiology.  8:453-461. 2002
2001 Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell diseaseProceedings of the National Academy of Sciences.  98:15215-15220. 2001
2001 Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor geneProceedings of the National Academy of Sciences.  98:986-991. 2001
2000 Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic interventionJournal of Health Psychology.  96. 2000
2000 Human β-globin gene promoter element regulates human β-globin gene developmental specificityNucleic Acids Research.  28:2736-2740. 2000
1998 Knockout-transgenic mouse models of human hemoglobinopathiesExperimental Hematology.  26:807. 1998
1998 Stochastic, stage-specific mechanisms account for the variegation of a human globin transgeneNucleic Acids Research.  26:2849-2858. 1998
1997 Knockout-transgenic mouse model of sickle cell diseaseScience.  278:873-876. 1997
1995 Mouse model of human β0 thalassemia: Targeted deletion of the mouse β(maj)- and β(min)-globin genes in embryonic stem cellsProceedings of the National Academy of Sciences.  92:9259-9263. 1995
1994 Preparation of recombinant hemoglobin in transgenic miceMethods in Enzymology.  231:403-434. 1994
1991 Human β-globin locus control region: Analysis of the 5' DNase I hypersensitive site HS 2 in transgenic miceProceedings of the National Academy of Sciences.  88:1626-1630. 1991
1990 A Transgenic Mouse Model for Human Sickle Cell DiseaseProceedings of The Japanese Association of Animal Models for Human Diseases.  6:6-12. 1990
1990 Human sickle hemoglobin in transgenic miceScience.  247:566-568. 1990
1990 Human γ- To β-globin gene switching in transgenic miceGenes and Development.  4:380-389. 1990
1990 Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibodyJournal of Immunology.  145:202-208. 1990
1989 A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.Genes and Development.  3:314-323. 1989
1989 DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.Progress in clinical and biological research.  316 A:47-61. 1989
1989 High-level erythroid expression of human α-globin genes in transgenic miceProceedings of the National Academy of Sciences.  86:37-41. 1989
1989 Synthesis of functional human hemoglobin in transgenic miceScience.  245:971-973. 1989

Teaching Activities

  • GBS748 - Special Topics (Fall Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2019) 2019
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Fall Term 2019) 2019
  • GBS784 - Stem Cell Biology (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Fall Term 2018) 2018
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • GBS784 - Stem Cell Biology (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC701 - Seminars (Spring Term 2018) 2018
  • GBSC700 - Journal Clubs (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBSC701 - Seminars (Fall Term 2017) 2017
  • GBS784 - Stem Cell Biology (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC701 - Seminars (Spring Term 2017) 2017
  • GBSC700 - Journal Clubs (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC701 - Seminars (Fall Term 2016) 2016
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2016) 2016
  • GBS784 - Stem Cell Biology (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Spring Term 2016) 2016
  • GBSC700 - Journal Clubs (Fall Term 2015) 2015
  • GBS784 - STEM CELL BIOLOGY (Spring Term 2015) 2015
  • GBS784 - Stem Cell Biology (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Spring Term 2015) 2015
  • GBSC700 - Journal Clubs (Fall Term 2014) 2014
  • GBSC709 - Adv Stem Cell/Regen Med (Fall Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2014) 2014
  • GBS784 - Stem Cell Biology (Spring Term 2014) 2014
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2013) 2013
  • GBS784 - Stem Cell Biology (Spring Term 2013) 2013
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2012) 2012
  • OBHS111 - Fundamentals Dent/Optometry I (Fall Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2012) 2012
  • GBS784 - Stem Cell Biology (Spring Term 2012) 2012
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2011) 2011
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2011) 2011
  • GBS784 - Stem Cell Biology (Spring Term 2011) 2011
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2010) 2010
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2010) 2010
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2010) 2010
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2009) 2009
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2009) 2009
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2009) 2009
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2008) 2008
  • OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Spring Term 2008) 2008
  • BMG798 - Non-Dissertation Research (Spring Term 2008) 2008
  • BMG799 - Dissertation Research (Spring Term 2008) 2008
  • CMB774 - CMB VII Stem Cell Biology (Spring Term 2008) 2008
  • BMG773 - Journal Club in Stem Cell Biol (Fall Term 2007) 2007
  • BMG798 - Non-Dissertation Research (Fall Term 2007) 2007
  • BMG799 - Dissertation Research (Fall Term 2007) 2007
  • Education And Training

  • Doctor of Philosophy in Microbiology, University of Alabama at Birmingham 1990
  • Bachelor of Arts in Biology, California State University System : Humboldt State University 1982
  • Bachelor of Arts in Chemistry, California State University System : Humboldt State University 1982
  • Full Name

  • Thomas Ryan