Mark Bevensee

Mark Bevensee
Prof/Asst Dean

Scientist (C), Comprehensive Diabetes Center , School of Medicine
Scientist (C), Cystic Fibrosis Research Center , School of Medicine
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Senior Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Senior Scientist (C), Nephrology Research & Training Center , General Clinical Research Center
Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry
Professor (S), Biomedical & Health Sciences MS Program , Cytotechnology Program
Co-Director, Biomedical & Health Sciences MS Program , Cytotechnology Program
Scientist (C), Civitan International Research Center , Academic Joint Departments
Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments
Professor (S), Neurobiology , Academic Joint Departments
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Science Advances. 6. 2020
2019	A new coupling of an acid-base transporter to PKD and cyst formation 2019
2018	Delivering baking soda to the brain 2018
2017	Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. JCI insight. 2. 2017
2015	Phosphatidylinositol 4,5-bisphosphate degradation inhibits the Na⁺/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus oocytes 2015
2015	Regulators of Slc4 bicarbonate transporter activity. Frontiers in Physiology. 6. 2015
2014	Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. PLoS ONE. 9. 2014
2012	Preface. Current Topics in Membranes. 70. 2012
2012	PIP2 hydrolysis stimulates the electrogenic Na⁺-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes 2012
2012	Increased Na⁺/H⁺ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease 2012
2010	Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: Function, localization, and relevance to neurologic function. Neuroscience. 171:951-972. 2010
2010	Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Experimental Physiology. 95:926-937. 2010
2010	ATP-independent CFTR channel gating and allosteric modulation by phosphorylation 2010
2009	Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopusoocytes 2009
2008	Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain. Neuroscience. 155:818-832. 2008
2008	Effects of acute hypoxia on intracellular-pH regulation in astrocytes cultured from rat hippocampus. Brain Research. 1193:143-152. 2008
2007	Erratum: A cysteine-scanning mutagenesis study of transmembrane domain 8 of the electrogenic sodium/bicarbonate cotransporter NBCe1 (Journal of Biological Chemistry (2006) 281 (32417-32427)). Journal of Biological Chemistry. 282:15940. 2007
2007	Altered pHi regulation and Na⁺/HCO^-3 transporter activity in choroid plexus of cilia-defective Tg737^orpk mutant mouse 2007
2007	Inhibition of the Na/bicarbonate cotransporter NBCe1-A by diBAC oxonol dyes relative to niflumic acid and a stilbene 2007
2006	Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardiovascular Research. 72:262-270. 2006
2006	A cysteine-scanning mutagenesis study of transmembrane domain 8 of the electrogenic sodium/bicarbonate cotransporter NBCe1. Journal of Biological Chemistry. 281:32417-32427. 2006
2006	Electrogenic Na/HCO³ cotransporter (NBCe1) variants expressed in Xenopus oocytes: Functional comparison and roles of the amino and carboxy termini. Journal of General Physiology. 127:639-658. 2006
2006	Heightened epithelial Na⁺ channel-mediated Na⁺ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia 2006
2001	Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury. Cardiovascular Research. 52:387-396. 2001
2001	Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: Ontogeny of protein expression in the rat brain. Neuroscience. 102:217-228. 2001
2000	Na/HCO3 cotransporters in rat brain: Expression in glia, neurons, and choroid plexus 2000
2000	An electrogenic Na⁺-HCO3^- cotransporter (NBC) with a novel cooh- terminus, cloned from rat brain 2000
1999	Effect of trace levels of nigericin on intracellular pH and acid-base transport in rat renal mesangial cells 1999
1999	Shrinkage-induced activation of Na⁺/H⁺ exchange in rat renal mesangial cells 1999
1997	Intracellular pH regulation in cultured astrocytes from rat hippocampus. I. Role of HCO3/^-. Journal of General Physiology. 110:453-465. 1997
1997	Intracellular pH regulation in cultured astrocytes from rat hippocampus. II. Electrogenic Na/HCO3 cotransport. Journal of General Physiology. 110:467-483. 1997
1996	pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats 1996
1996	Functional expression of the cDNA encoded by the human ATP1AL1 gene. American Journal of Physiology. 271. 1996
1995	Out-of-equilibrium CO2/HCO3^- solutions and their use in characterizing a new K/HCO3 cotransporter. Nature. 374:636-639. 1995
1995	Use of BCECF and propidium iodide to assess membrane integrity of acutely isolated CA1 neurons from rat hippocampus. Journal of Neuroscience Methods. 58:61-75. 1995

Book

Year	Title	Altmetric
2014	Preface. Ed. 73. 2014
2003	pH regulation in non-neuronal brain cells and interstitial fluid. Ed. 31. 2003

Chapter

Year	Title	Altmetric
2013	Control of Intracellular pH. 1773-1835. 2013
2008	Control of Intracellular pH. 1429-1480. 2008
2004	pH regulation in non-neuronal brain cells and interstitial fluid. 707-745. 2004
2000	Control of intracellular pH.. 391-442. 2000
1998	Fluorescence Indicators. 129-151. 1998
1995	Manipulation and regulation ofcytosolic pH. 252-273. 1995

Research Overview

My laboratory is interested in the cellular and molecular physiology of intracellular pH (pHi) regulation and acid-base transport, particularly related to brain and kidney function. We are interested in the role of pH changes and sodium-coupled bicarbonate transport activity in modulating neuronal excitability and synaptic transmission. We are also exploring how acid-base transporters, as well as ion channels of the degenerins family contribute to Na+ hyperabsorption and phenotypic changes in models of polycystic kidney disease. Finally, we are performing structure-function studies on sodium-coupled bicarbonate transporters to understand critical residues and regions involved in protein function, ion translocation, and regulation.