Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 A new coupling of an acid-base transporter to PKD and cyst formation 2019
2018 Delivering baking soda to the brain 2018
2017 Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.JCI insight.  2. 2017
2015 Phosphatidylinositol 4,5-bisphosphate degradation inhibits the Na+/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus oocytes 2015
2015 Regulators of Slc4 bicarbonate transporter activityFrontiers in Physiology.  6. 2015
2014 Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearancePLoS ONE.  9. 2014
2012 PrefaceCurrent Topics in Membranes.  70. 2012
2012 PIP2 hydrolysis stimulates the electrogenic Na+-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes 2012
2012 Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease 2012
2010 Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: Function, localization, and relevance to neurologic functionNeuroscience.  171:951-972. 2010
2010 Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transportExperimental Physiology.  95:926-937. 2010
2010 ATP-independent CFTR channel gating and allosteric modulation by phosphorylation 2010
2009 Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopusoocytes 2009
2008 Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brainNeuroscience.  155:818-832. 2008
2007 Altered pHi regulation and Na+/HCO-3 transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse 2007
2007 Inhibition of the Na/bicarbonate cotransporter NBCe1-A by diBAC oxonol dyes relative to niflumic acid and a stilbene 2007
2006 Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failureCardiovascular Research.  72:262-270. 2006
2006 A cysteine-scanning mutagenesis study of transmembrane domain 8 of the electrogenic sodium/bicarbonate cotransporter NBCe1Journal of Biological Chemistry.  281:32417-32427. 2006
2006 Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: Functional comparison and roles of the amino and carboxy terminiJournal of General Physiology.  127:639-658. 2006
2006 Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia 2006

Book

Year Title Altmetric
2014 Preface.  Ed. 73.  2014
2003 pH regulation in non-neuronal brain cells and interstitial fluid.  Ed. 31.  2003

Chapter

Year Title Altmetric
2013 Control of Intracellular pH.  1773-1835. 2013
2008 Control of Intracellular pH.  1429-1480. 2008
1998 Fluorescence Indicators.  129-151. 1998

Research Overview

  • My laboratory is interested in the cellular and molecular physiology of intracellular pH (pHi) regulation and acid-base transport, particularly related to brain and kidney function. We are interested in the role of pH changes and sodium-coupled bicarbonate transport activity in modulating neuronal excitability and synaptic transmission. We are also exploring how acid-base transporters, as well as ion channels of the degenerins family contribute to Na+ hyperabsorption and phenotypic changes in models of polycystic kidney disease. Finally, we are performing structure-function studies on sodium-coupled bicarbonate transporters to understand critical residues and regions involved in protein function, ion translocation, and regulation.
  • Teaching Activities

  • BHS560 - Integ Systs III: Genitourinary (Fall Term 2020) 2020
  • BHS502 - Molecules and Cells (Summer Term 2020) 2020
  • PCL1170 - RENAL (Spring Term 2020) 2020
  • BHS602 - Seminar III (Spring Term 2020) 2020
  • BHS675 - Spec Topics in BHS (Spring Term 2020) 2020
  • BHS560 - Integ Systs III: Genitourinary (Fall Term 2019) 2019
  • BHS502 - Molecules and Cells (Summer Term 2019) 2019
  • PCL1170 - RENAL (Spring Term 2019) 2019
  • BHS560 - Integ Systs III: Genitourinary (Fall Term 2018) 2018
  • PCL1170 - RENAL (Spring Term 2018) 2018
  • PCL1170 - RENAL (Spring Term 2018) 2018
  • PCL1170 - RENAL (Spring Term 2018) 2018
  • BHS560 - Integ Systs III: Genitourinary (Fall Term 2017) 2017
  • PCL1170R - RENAL REMEDIAL (Fall Term 2017) 2017
  • PCL1170 - RENAL (Spring Term 2017) 2017
  • BHS550 - Integrated Systs I:Neuroendoc (Fall Term 2016) 2016
  • BHS555 - Integrated Systs II: Cardiopul (Fall Term 2016) 2016
  • BHS560 - Integ Systs III: Genitourinary (Fall Term 2016) 2016
  • BHS601 - Seminar II (Fall Term 2016) 2016
  • STP2999EH - Real-Time Laboratory Research Experience for Medical Students (Fall Term 2016) 2016
  • BHS501 - Seminar I (Summer Term 2016) 2016
  • BHS502 - Molecules and Cells (Summer Term 2016) 2016
  • BHS503 - Microbiology and Immunology (Summer Term 2016) 2016
  • PCL1170 - RENAL (Spring Term 2016) 2016
  • PCL1170R - RENAL REMEDIAL (Fall Term 2015) 2015
  • PCL1170 - RENAL (Spring Term 2015) 2015
  • PCL1170 - RENAL (Spring Term 2015) 2015
  • PCL1170 - RENAL (Spring Term 2014) 2014
  • PCL1170 - RENAL (Spring Term 2014) 2014
  • PCL1170 - RENAL (Spring Term 2013) 2013
  • PCL1170 - RENAL (Spring Term 2012) 2012
  • PCL1170 - RENAL (Spring Term 2012) 2012
  • PCL1170 - RENAL (Spring Term 2011) 2011
  • PCL1170 - RENAL (Spring Term 2010) 2010
  • PCL1170 - RENAL (Spring Term 2009) 2009
  • PCL1170 - RENAL (Spring Term 2008) 2008
  • Education And Training

  • Doctor of Philosophy in Physiology, Yale University 1996
  • Awards And Honors

  • Nominated for the 2019 Outstanding Reviewer Award, 2019
  • Star Reviewer, 2019
  • Argus Award (to Renal) for Best MS1 Organ Module, 2018
  • Nominated for the Argus Award for Best Educator, 2017
  • Nominated for the Argus Award for Best MS1 Module, 2017
  • Argus Award (to Renal) for Best MS1 Organ Module, 2016
  • Argus Award for Best Educator in Renal, 2016
  • SOM Dean’s Research Award, 2015
  • Nominated for the Argus Award for Best MS1 Organ Module, 2015
  • Nominated for the Argus Award for Best Educator (Renal Module), 2015
  • Argus Award for Best MS1 Organ Module Director(s), 2014
  • Nominated for the Argus Award for Best MS1 Organ Module, 2014
  • President’s Award for Excellence in Teaching for the Joint Health Science Departments, 2012
  • Member of The Honor Society of Phi Kappa Phi, 2012
  • Nominated for the Argus Award for Best MS1 Organ Module Director, 2012
  • Nominated for the Argus Award for Best Lecturer for MS-1 Renal Module, 2012
  • Nominated for the Argus Award for Best Lecturer in the Renal Module, 2011
  • Argus Award for Best Lecturer for the Renal Module, 2010
  • Nominated for the Argus Award for Best MS1 Organ Module Director, 2010
  • Nominated for the Argus Award for Best Module Director, 2009
  • Speaker, Distinguished Seminar Series, 2008
  • Argus Award for Best Small Group Leader, 2007
  • Nominated for the Argus Award for Best Small Group Leader, 2006
  • Nominated for the Argus Award for Best Small Group Leader, 2005
  • Howard Hughes Medical Institute Junior Faculty Development Award, 2000
  • Honors Research Program, 1989
  • Full Name

  • Mark Bevensee