My laboratory is interested in the cellular and molecular physiology of intracellular pH (pHi) regulation and acid-base transport, particularly related to brain and kidney function. We are interested in the role of pH changes and sodium-coupled bicarbonate transport activity in modulating neuronal excitability and synaptic transmission. We are also exploring how acid-base transporters, as well as ion channels of the degenerins family contribute to Na+ hyperabsorption and phenotypic changes in models of polycystic kidney disease. Finally, we are performing structure-function studies on sodium-coupled bicarbonate transporters to understand critical residues and regions involved in protein function, ion translocation, and regulation.