Mark Bevensee

Mark Bevensee
Professor

Scientist (C), Civitan International Research Center , Academic Joint Departments 2006 -
Scientist (C), Center for Glial Biology in Medicine , Academic Joint Departments 2006 -
Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry 2008 -
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments 2012 -
Scientist (C), Comprehensive Diabetes Center , School of Medicine 2013 -
Scientist (C), Cystic Fibrosis Research Center , School of Medicine 2013 -
Co-Director, Biomedical & Health Sciences MS Program , Cytotechnology Program 2018 -
Senior Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center 2019 -
Senior Scientist (C), Nephrology Research & Training Center , General Clinical Research Center 2019 -
Professor (S), Biomedical & Health Sciences MS Program , Cytotechnology Program 2019 -
Professor (S), Neurobiology , Academic Joint Departments 2019 -

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation. Science Advances. 6. 2020
2019	A new coupling of an acid-base transporter to PKD and cyst formation 2019
2018	Delivering baking soda to the brain 2018
2017	Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo.. JCI insight. 2. 2017
2015	Phosphatidylinositol 4,5-bisphosphate degradation inhibits the Na⁺/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus oocytes 2015
2015	Regulators of Slc4 bicarbonate transporter activity. Frontiers in Physiology. 6. 2015
2014	Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance. PLoS ONE. 9. 2014
2012	Preface. Current Topics in Membranes. 70. 2012
2012	PIP2 hydrolysis stimulates the electrogenic Na⁺-bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus laevis oocytes 2012
2012	Increased Na⁺/H⁺ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease 2012
2010	Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: Function, localization, and relevance to neurologic function. Neuroscience. 171:951-972. 2010
2010	Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Experimental Physiology. 95:926-937. 2010
2010	ATP-independent CFTR channel gating and allosteric modulation by phosphorylation 2010
2009	Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopusoocytes 2009
2008	Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain. Neuroscience. 155:818-832. 2008
2007	Altered pHi regulation and Na⁺/HCO^-3 transporter activity in choroid plexus of cilia-defective Tg737^orpk mutant mouse 2007
2007	Inhibition of the Na/bicarbonate cotransporter NBCe1-A by diBAC oxonol dyes relative to niflumic acid and a stilbene 2007
2006	Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure. Cardiovascular Research. 72:262-270. 2006
2006	A cysteine-scanning mutagenesis study of transmembrane domain 8 of the electrogenic sodium/bicarbonate cotransporter NBCe1. Journal of Biological Chemistry. 281:32417-32427. 2006
2006	Electrogenic Na/HCO³ cotransporter (NBCe1) variants expressed in Xenopus oocytes: Functional comparison and roles of the amino and carboxy termini. Journal of General Physiology. 127:639-658. 2006
2006	Heightened epithelial Na⁺ channel-mediated Na⁺ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia 2006

Book

Year	Title	Altmetric
2014	Preface. Ed. 73. 2014
2003	pH regulation in non-neuronal brain cells and interstitial fluid. Ed. 31. 2003

Chapter

Year	Title	Altmetric
2013	Control of Intracellular pH. 1773-1835. 2013
2008	Control of Intracellular pH. 1429-1480. 2008
1998	Fluorescence Indicators. 129-151. 1998

Research Overview

My laboratory is interested in the cellular and molecular physiology of intracellular pH (pHi) regulation and acid-base transport, particularly related to brain and kidney function. We are interested in the role of pH changes and sodium-coupled bicarbonate transport activity in modulating neuronal excitability and synaptic transmission. We are also exploring how acid-base transporters, as well as ion channels of the degenerins family contribute to Na+ hyperabsorption and phenotypic changes in models of polycystic kidney disease. Finally, we are performing structure-function studies on sodium-coupled bicarbonate transporters to understand critical residues and regions involved in protein function, ion translocation, and regulation.