Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 The efficacy and safety of citrate mixture vs sodium bicarbonate on urine alkalization in Chinese primary gout patients with benzbromarone: A prospective, randomized controlled studyRheumatology.  60:2661-2671. 2021
2021 Assessing the Causal Relationships between Insulin Resistance and Hyperuricemia and Gout Using Bidirectional Mendelian Randomization.Arthritis and Rheumatology2021
2021 Gout, Rheumatoid Arthritis, and the Risk of Death Related to Coronavirus Disease 2019: An Analysis of the UK Biobank.Acr Open Rheumatology.  3:333-340. 2021
2021 Serum metabolomics identifies dysregulated pathways and potential metabolic biomarkers for hyperuricemia and gout.Arthritis and Rheumatology2021
2021 Effects of Fenofibrate Therapy on Renal Function in Primary Gout Patients.Rheumatology2021
2021 Elevated urate does not alter bone turnover markers. Randomized controlled trial of inosine supplementation in post-menopausal women.Arthritis and Rheumatology2021
2021 Common variants of EDA are associated with non-syndromic hypodontia 2021
2021 Correction to: Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects (Journal of Human Genetics, (2021), 66, 2, (161-169), 10.1038/s10038-020-0821-z)Journal of Human Genetics.  66:225. 2021
2021 Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effectsJournal of Human Genetics.  66:161-169. 2021
2021 Assessing the Relationship Between Serum Urate and Urolithiasis Using Mendelian Randomization: An Analysis of the UK BiobankAmerican Journal of Kidney Diseases2021
2021 Correspondence on 'Variants in urate transporters, ADH1B, GCKR and MEPE genes associated with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank'Annals of the Rheumatic Diseases2021
2021 Genetic correlations between traits associated with hyperuricemia, gout, and comorbiditiesEuropean Journal of Human Genetics2021
2021 Mapping pleiotropic loci using a fast-sequential testing algorithmEuropean Journal of Human Genetics2021
2021 Potential PINK1 Founder Effect in Polynesia Causing Early-Onset Parkinson's DiseaseMovement Disorders2021
2020 Genetic Polymorphisms on OPRM1, DRD2, DRD4, and COMT in Young Adults: Lack of Association With Alcohol ConsumptionFrontiers in Psychiatry.  11. 2020
2020 Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers 2020
2020 The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretionNature Communications.  11. 2020
2020 Urate in fingernail represents the deposition of urate burden in gout patientsScientific Reports.  10. 2020
2020 Gout, rheumatoid arthritis and the risk of death from COVID-19: an analysis of the UK Biobank 2020
2020 Do serum urate-associated genetic variants influence gout risk in people taking diuretics? Analysis of the UK biobankJournal of Rheumatology.  47:1704-1711. 2020
2020 The Shared Genetic Basis of Hyperuricemia, Gout, and Kidney FunctionSeminars in Nephrology.  40:586-599. 2020
2020 Advances in our understanding of gout as an auto-inflammatory diseaseSeminars in Arthritis and Rheumatism.  50:1089-1100. 2020
2020 The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesityDiabetologia.  63:2169-2176. 2020
2020 Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: Predicting Which One is Right Here (WORTH) study protocolBMJ Open.  10. 2020
2020 Systematic genetic analysis of early-onset gout: ABCG2 is the only associated locusRheumatology.  59:2544-2549. 2020
2020 Genetic testing in Polynesian long QT syndrome probands reveals a lower diagnostic yield and an increased prevalence of rare variantsHeart Rhythm.  17:1304-1311. 2020
2020 Do Serum Urate–Associated Genetic Variants Differentially Contribute to Gout Risk According to Body Mass Index? Analysis of the UK BiobankArthritis and Rheumatology.  72:1184-1191. 2020
2020 Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in GoutArthritis and Rheumatology.  72:802-814. 2020
2020 Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patientsAnnals of the Rheumatic Diseases.  79:657-665. 2020
2020 Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate controlHuman Molecular Genetics.  29:923-943. 2020
2020 Pleiotropic effect of the ABCG2 gene in gout: Involvement in serum urate levels and progression from hyperuricemia to gout 2020
2020 Comorbidities in gout and hyperuricemia: Causality or epiphenomena?Current Opinion in Rheumatology.  32:126-133. 2020
2020 The Māori and Pacific specific CREBRF variant and adult heightInternational Journal of Obesity.  44:748-752. 2020
2020 Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) allelesJournal of Lipid Research.  61:432-444. 2020
2020 Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of goutAnnals of the Rheumatic Diseases2020
2020 Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate-Lowering Response—In Search of a Minimum Effective Oxypurinol ConcentrationClinical and Translational Science.  13:110-115. 2020
2020 Trends in the manifestations of 9754 gout patients in a Chinese clinical center: A 10-year observational study 2020
2019 What predicts regression from pre-diabetes to normal glucose regulation following a primary care nurse-delivered dietary intervention? A study protocol for a prospective cohort studyBMJ Open.  9. 2019
2019 Associations of autozygosity with a broad range of human phenotypesNature Communications.  10. 2019
2019 Population-specific factors associated with fractional excretion of uric acid 2019
2019 Risk factors for acute rheumatic fever: Literature review and protocol for a case-control study in New ZealandInternational Journal of Environmental Research and Public Health.  16. 2019
2019 Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of goutAnnals of the Rheumatic Diseases.  78:1592-1600. 2019
2019 Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into goutAnnals of the Rheumatic Diseases.  78:1430-1437. 2019
2019 Mouse models for human hyperuricaemia: a critical reviewNature Reviews Rheumatology.  15:413-426. 2019
2019 Are Liquid Sugars Different from Solid Sugar in Their Ability to Cause Metabolic Syndrome? 2019
2019 MTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: A prelude to a new add-on therapy?Annals of the Rheumatic Diseases.  78:663-671. 2019
2019 Response to: The reference levels of serum urate for clinically evident incident gout by Chen and DingAnnals of the Rheumatic Diseases.  78. 2019
2019 Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis 2019
2019 Genetic advances in gout: Potential applications in clinical practiceCurrent Opinion in Rheumatology.  31:144-151. 2019
2019 Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in GoutArthritis Care and Research.  71:427-434. 2019
2019 No association between ATP-binding cassette transporter G2 rs2231142 (Q141K) and urate-lowering response to febuxostatRheumatology.  58:547-548. 2019
2019 Greater insulin response to acute fructose ingestion among Māori and Pacific people compared to European people living in Aotearoa New ZealandInternal Medicine Journal.  49:196-202. 2019
2019 Interactions between serum urate-associated genetic variants and sex on gout risk: Analysis of the UK Biobank 06 Biological Sciences 0604 Genetics 2019
2019 Erratum: Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRr (Frontiers in Genetics (2019) 9 (733) DOI: 10.3389/fgene.2018.00733)Frontiers in Genetics.  10. 2019
2019 Functional urate-associated genetic variants influence expression of lincRNAs LINC01229 and MAFTRRFrontiers in Genetics.  10. 2019
2019 No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization studyPLoS Medicine.  16. 2019
2018 The oxytocin receptor gene (OXTR) variant rs53576 is not related to emotional traits or states in young adultsFrontiers in Psychology.  9. 2018
2018 ABCG2 rs2231142 (Q141K) and oxypurinol concentrations in people with gout receiving allopurinolDrug Metabolism and Pharmacokinetics.  33:241-242. 2018
2018 Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathyScientific Reports.  8. 2018
2018 A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expressionHuman Molecular Genetics.  27:3964-3973. 2018
2018 Pharmaceutical interventions for weight-loss maintenance: no effect from cabergolineInternational Journal of Obesity.  42:1871-1879. 2018
2018 Association of solute carrier family 2, member 9 (SLC2A9) genetic variant rs3733591 with gout in a Malay sample set 2018
2018 Genomic medicine must reduce, not compound, health inequities: The case for hauora-enhancing genomic resources for New ZealandNew Zealand Medical Journal.  131:81-89. 2018
2018 The relationship between ferritin and urate levels and risk of gout 2018
2018 Testicular Cancer in New Zealand (TCNZ) study: Protocol for a national case-control studyBMJ Open.  8. 2018
2018 Mediation analysis to understand genetic relationships between habitual coffee intake and gout 2018
2018 Expert opinion on emerging urate-lowering therapiesExpert Opinion on Emerging Drugs.  23:201-209. 2018
2018 Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New ZealandDiabetologia.  61:1603-1613. 2018
2018 Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood”International Journal of Obesity.  42:1389-1391. 2018
2018 Relationship between serum urate concentration and clinically evident incident gout: An individual participant data analysisAnnals of the Rheumatic Diseases.  77:1048-1052. 2018
2018 An association of smoking with serum urate and gout: A health paradoxSeminars in Arthritis and Rheumatism.  47:825-842. 2018
2018 An update on the genetics of hyperuricaemia and goutNature Reviews Rheumatology.  14:351-353. 2018
2018 Ecological momentary assessment of pain in adolescents undergoing orthodontic treatment using a smartphone appSeminars in Orthodontics.  24:209-216. 2018
2018 Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney FoundationAmerican Journal of Kidney Diseases.  71:851-865. 2018
2018 Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities 2018
2018 Application of Genetic Epidemiology to CETP (Cholesteryl Ester Transfer Protein) Concentration and Risk of Cardiovascular DiseaseCirculation: Genomic and Precision Medicine.  11:e002138. 2018
2018 Elevated serum uric acid levels are associated with endothelial dysfunction in HIV patients receiving highly-active antiretroviral therapyAtherosclerosis.  272:101-107. 2018
2018 The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing toolBritish Journal of Clinical Pharmacology.  84:937-943. 2018
2018 Multiplexed Nanopore Sequencing of HLA-B Locus in Māori and Pacific Island SamplesFrontiers in Genetics.  9. 2018
2018 Cardio-metabolic disease genetic risk factors among Māori and Pacific Island people in Aotearoa New Zealand: current state of knowledge and future directionsAnnals of Human Biology.  45:202-214. 2018
2018 Association between ABCG2 rs2231142 and poor response to allopurinol: Replication and meta-analysisRheumatology.  57:656-660. 2018
2018 Mitochondrial genetic variation and gout in Maori and Pacific people living in Aotearoa New ZealandAnnals of the Rheumatic Diseases.  77:571-578. 2018
2018 Plasma oxypurinol as a measure of adherence in clinical trialsAnnals of the Rheumatic Diseases.  77:313-314. 2018
2018 Association of Crohn's disease-related chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and faecal calprotectinPeerJ.  2018. 2018
2018 Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohortsBMJ.  363. 2018
2017 Dietary sodium modifies serum uric acid concentrations in humansAmerican Journal of Hypertension.  30:1196-1202. 2017
2017 Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritisScientific Reports.  7. 2017
2017 Functional non-synonymous variants of ABCG2 and gout riskRheumatology.  56:1982-1992. 2017
2017 Risk factors for cryptorchidism 2017
2017 Performance of gout definitions for genetic epidemiological studies: Analysis of UK Biobank 2017
2017 Genomic Influences on Hyperuricemia and GoutRheumatic Disease Clinics of North America.  43:389-399. 2017
2017 Maternal Smoking during Pregnancy Is Associated with Offspring HypodontiaJournal of Dental Research.  96:1014-1019. 2017
2017 Multiplexed nanopore sequencing of HLA-B locus in Māori and Polynesian samples 2017
2017 Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout 2017
2017 Patients with gout have short telomeres compared with healthy participants: Association of telomere length with flare frequency and cardiovascular disease in goutAnnals of the Rheumatic Diseases.  76:1309-1315. 2017
2017 Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific MenArthritis and Rheumatology.  69:1461-1469. 2017
2017 Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy 2017
2017 The genetics of gout: Towards personalised medicine?BMC Medicine.  15. 2017
2017 GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genesAnnals of the Rheumatic Diseases.  76:869-877. 2017
2017 Impact of skeletal divergence on oral health-related quality of life and self-reported jaw function 2017
2017 ABCG2 polymorphisms in gout: Insights into disease susceptibility and treatment approachesPharmacogenomics and Personalized Medicine.  10:129-142. 2017
2017 Influence of genetic variants on renal uric acid handling in response to frusemide: An acute intervention studyRMD Open.  3. 2017
2017 Population-specific association between ABCG2 variants and tophaceous disease in people with gout 2017
2017 ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout 2017
2017 PPARGC1B: Insight into the expression of the gouty inflammation phenotypeRheumatology.  56:323. 2017
2017 Uric acid and bone mineral density in postmenopausal osteoporotic women: the link lies within the fatOsteoporosis International.  28:973-981. 2017
2017 Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk LociCirculation Research.  120:341-353. 2017
2017 Hypodontia: An Update on Its Etiology, Classification, and Clinical ManagementBioMed Research International.  2017. 2017
2017 Multiple common and rare variants of ABCG2 cause goutRMD Open.  3. 2017
2017 Self-reported oral behaviour habits in hyperdivergent and normodivergent facial typesJournal of Oral Rehabilitation.  44:16-21. 2017
2017 Testing the validity of taxonic schizotypy using genetic and environmental risk variablesSchizophrenia Bulletin.  43:633-643. 2017
2016 Lack of direct evidence for natural selection at the candidate thrifty gene locus, PPARGC1ABMC Medical Genetics.  17. 2016
2016 Gout 2016
2016 SRBreak: A read-depth and split-read framework to identify breakpoints of different events inside simple copy-number variable regionsFrontiers in Genetics.  7. 2016
2016 Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestryCytokine.  85:201-206. 2016
2016 Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association StudiesArthritis and Rheumatology.  68:2338-2344. 2016
2016 Insight into rheumatological cause and effect through the use of Mendelian randomizationNature Reviews Rheumatology.  12:486-493. 2016
2016 Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of goutRheumatology.  55:1421-1430. 2016
2016 Clinical and genetic features of diuretic-associated gout: A case-control studyRheumatology.  55:1172-1176. 2016
2016 Hyperuricaemia: Contributions of urate transporter ABCG2 and the fractional renal clearance of urateAnnals of the Rheumatic Diseases.  75:1363-1366. 2016
2016 Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout 2016
2016 Predicting allopurinol response in patients with goutBritish Journal of Clinical Pharmacology.  81:277-289. 2016
2016 PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritisRMD Open.  2. 2016
2016 The toll-like receptor 4 (TLR4) variant rs2149356 and risk of gout in European and polynesian sample setsPLoS ONE.  11. 2016
2016 Twenty-eight loci that influence serum urate levels: Analysis of association with goutAnnals of the Rheumatic Diseases.  75:124-130. 2016
2015 Gout is a chronic inflammatory disease in which high levels of interleukin-8 (CXCL8), myeloid-related protein 8/myeloid-related protein 14 complex, and an altered proteome are associated with diabetes mellitus and cardiovascular diseaseArthritis and Rheumatology.  67:3303-3313. 2015
2015 Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in OceaniaAnnals of Human Genetics.  79:470-480. 2015
2015 The distribution and impact of common copy-number variation in the genome of the domesticated apple, Malus x domestica BorkhBMC Genomics.  16. 2015
2015 Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout 2015
2015 Body mass index modulates the relationship of sugar-sweetened beverage intake with serum urate concentrations and gout 2015
2015 Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients 2015
2015 Positive association of tomato consumption with serum urate: Support for tomato consumption as an anecdotal trigger of gout flaresBMC Musculoskeletal Disorders.  16. 2015
2015 Causal or noncausal relationship of uric acid with diabetesDiabetes.  64:2720-2722. 2015
2015 Lack of gene - Diuretic interactions on the risk of incident gout: The Nurses' Health Study and Health Professionals Follow-up StudyAnnals of the Rheumatic Diseases.  74:1394-1398. 2015
2015 Mendelian randomization analysis to examine for a causal effect of urate on bone mineral densityJournal of Bone and Mineral Research.  30:985-991. 2015
2015 Sugar sweetened beverage consumption among adults with gout or type 2 diabetesPLoS ONE.  10. 2015
2015 Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancersNature Genetics.  47:381-386. 2015
2015 An update on the genetic architecture of hyperuricemia and gout 2015
2015 Modulation of genetic associations with serum urate levels by body-mass-index in humansPLoS ONE.  10. 2015
2015 A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptidesAnnals of the Rheumatic Diseases.  74. 2015
2015 A human leukocyte antigen locus haplotype confers risk for allopurinol-related adverse effects in Caucasian patients with gout 2015
2015 Association of SLC2A9 genotype with phenotypic variability of serum urate in pre-menopausal womenFrontiers in Genetics.  6. 2015
2015 Does midlife obesity really lower dementia risk?Lancet Diabetes and Endocrinology.  3:501. 2015
2015 Smoking behaviour modifies IL23r-associated disease risk in patients with Crohn's diseaseJournal of Gastroenterology and Hepatology.  30:299-307. 2015
2014 Sugar-sweetened beverage consumption: A risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of goutAnnals of the Rheumatic Diseases.  73:2101-2106. 2014
2014 The relationship of apolipoprotein B and very low density lipoprotein triglyceride with hyperuricemia and gout 2014
2014 Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acidHuman Molecular Genetics.  23:5061-5068. 2014
2014 Impaired response or insufficient dosage?-Examining the potential causes of "inadequate response" to allopurinol in the treatment of goutSeminars in Arthritis and Rheumatism.  44:170-174. 2014
2014 Gout in Māori: Modern affliction or ancestral trait?Rheumatology.  53:773-774. 2014
2014 Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European CohortsPLoS ONE.  9. 2014
2014 An 'end-game' for sugar sweetened beverages? 2014
2014 Fat storage syndrome in Pacific peoples: a combination of environment and genetics? 2014
2014 Sugar-sweetened beverages, urate, gout and genetic interaction 2014
2014 Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge 2014
2014 A bioinformatics workflow for detecting signatures of selection in genomic dataFrontiers in Genetics.  5. 2014
2014 FIZZ sugary drink free pacific by 2030—Symposium declarationNew Zealand Medical Journal.  127:98-101. 2014
2014 Frequency of CYP2C9 polymorphisms in Polynesians and potential relevance for the treatment of gout by benzbromaroneRevue du Rhumatisme.  81:159-163. 2014
2014 Frequency of CYP2C9 polymorphisms in polynesian people and potential relevance to management of gout with benzbromarone 2014
2014 Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013 2014
2014 Hyperuricaemia in the pacific: Why the elevated serum urate levels? 2014
2014 Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal functionKidney International.  85:344-351. 2014
2014 Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levelsCirculation: Cardiovascular Genetics.  7:830-837. 2014
2014 Mutations in the zinc finger protein gene, Znf469, Contribute to the pathogenesis of keratoconusInvestigative Ophthalmology and Visual Science.  55:5629-5635. 2014
2014 Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in goutArthritis and Rheumatology.  66:1327-1339. 2014
2014 Population-specific effects of SLC17A1 genotype on serum urate concentrations and renal excretion of uric acid during a fructose loadAnnals of the Rheumatic Diseases.  73:313-314. 2014
2014 The CNVrd2 package: Measurement of copy number at complex loci using high-throughput sequencing dataFrontiers in Genetics.  5. 2014
2014 The genetic basis of goutRheumatic Disease Clinics of North America.  40:279-290. 2014
2014 The global burden of gout: Estimates from the Global Burden of Disease 2010 studyAnnals of the Rheumatic Diseases.  73:1470-1476. 2014
2013 Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case-control sample sets reveals multiple ancestral-specific effects 2013
2013 Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption 2013
2013 Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose loadAnnals of the Rheumatic Diseases.  72:1868-1873. 2013
2013 Workshop report: 4th European crystal network meeting 2013
2013 Prevalence of HLA-B27 in the New Zealand population: Effect of age and ethnicity 2013
2013 Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysisWorld Journal of Gastroenterology.  19:6656-6664. 2013
2013 New urate-lowering therapies in Aotearoa New Zealand: A response to Dr Lance Gravatt's letter on benzbromarone hepatotoxicityNew Zealand Medical Journal.  126:120-123. 2013
2013 Association of CD247 Polymorphisms with Rheumatoid Arthritis: A Replication Study and a Meta-AnalysisPLoS ONE.  8. 2013
2013 A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysmHuman Molecular Genetics.  22:2941-2947. 2013
2013 The population pharmacokinetics of allopurinol and oxypurinol in patients with goutEuropean Journal of Clinical Pharmacology.  69:1411-1421. 2013
2013 CNVrd, a Read-Depth Algorithm for Assigning Copy-Number at the FCGR Locus: Population-Specific Tagging of Copy Number Variation at FCGR3BPLoS ONE.  8. 2013
2013 Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand CaucasiansSpringerPlus.  2:1-8. 2013
2013 Author replyInternal Medicine Journal.  43:466. 2013
2013 Hospital admissions associated with gout and their comorbidities in new zealand and england 1999-2009Rheumatology.  52:118-126. 2013
2012 Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 2012
2012 Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010 2012
2012 Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophreniaGenes, Brain and Behavior.  11:859-863. 2012
2012 Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritisRespiratory Medicine.  106:1441-1446. 2012
2012 Evidence that deletion at FCGR3B is a risk factor for systemic sclerosisGenes and Immunity.  13:458-460. 2012
2012 No evidence for association of Chr 9p21 variant rs1333049 with gout in New Zealand case-control sample setsRheumatology.  51:1129-1130. 2012
2012 Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypesHuman Molecular Genetics.  21:2370-2376. 2012
2012 The renal urate transporter SLC17A1 locus: Confirmation of association with gout 2012
2012 Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohortAmerican Journal of Gastroenterology.  107:589-596. 2012
2012 IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritisGenes and Immunity.  13:282-287. 2012
2012 Independent replication of an association of CNVR7113.6 with Crohn's disease in caucasiansInflammatory Bowel Diseases.  18:305-311. 2012
2012 A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 2012
2012 Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample setsAnnals of the Rheumatic Diseases.  71:155-157. 2012
2012 Systematic review of the prevalence of gout and hyperuricaemia in Australia.Internal Medicine Journal.  42:997-1007. 2012
2012 Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010 2012
2011 Smad2: A candidate gene for the murine autoimmune diabetes locus Idd21.1Journal of Clinical Endocrinology and Metabolism.  96. 2011
2011 Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitisInflammatory Bowel Diseases.  17:2287-2294. 2011
2011 Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysmsAtherosclerosis.  218:123-126. 2011
2011 Population Heterogeneity in the Genetic Control of Serum UrateSeminars in Nephrology.  31:420-425. 2011
2011 Analysis of association of DNASE2 promoter variation with rheumatoid arthritis in European CaucasiansAnnals of the Rheumatic Diseases.  70:1512-1514. 2011
2011 Editorial 2011
2011 The SLC2A9 nonsynonymous Arg265His variant and gout: Evidence for a population-specific effect on severity 2011
2011 Vitamin D receptor gene polymorphism associated with inflammatory bowel disease in New Zealand malesAlimentary Pharmacology and Therapeutics.  33:855-856. 2011
2011 Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChipsBMC Bioinformatics.  12. 2011
2011 Association of the protein-tyrosine phosphatase nonreceptor type substrate 1 (PTPNS1) gene with inflammatory bowel diseaseInflammatory Bowel Diseases.  17. 2011
2011 The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samplesArthritis and Rheumatism.  63:365-372. 2011
2011 The genetic basis of hyperuricaemia and gout 2011
2010 A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample setsHuman Molecular Genetics.  19:4813-4819. 2010
2010 Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populationsInflammatory Bowel Diseases.  16:2080-2089. 2010
2010 The PTPN22 locus and rheumatoid arthritis: No evidence for an effect on risk independent of Arg620TrpPLoS ONE.  5. 2010
2010 KCNN4 gene variant is associated with ileal crohn's disease in the Australian and New Zealand populationAmerican Journal of Gastroenterology.  105:2209-2217. 2010
2010 High frequency of MCM6 lactose intolerance genotype in Polynesian peopleAlimentary Pharmacology and Therapeutics.  32:828-829. 2010
2010 A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: Implications for clinical interpretationPLoS Medicine.  7. 2010
2010 Association of variation in Fcγ receptor 3B gene copy number with rheumatoid arthritis in Caucasian samplesAnnals of the Rheumatic Diseases.  69:1711-1716. 2010
2010 Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in CaucasiansGenes and Immunity.  11:509-514. 2010
2010 The genetic basis of hyperuricaemia and gout 2010
2010 Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance 2010
2010 Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's diseaseGenes and Immunity.  11:351-356. 2010
2010 Consolidation of evidence for association of the kiaa1109-tenr-il2-il21 rs6822844 variant with crohn's diseaseAmerican Journal of Gastroenterology.  105:1204-1206. 2010
2010 Association of Higher DEFB4 Genomic Copy Number with Crohn's DiseaseAmerican Journal of Gastroenterology.  105:354-359. 2010
2009 No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian populationRheumatology.  48:1614-1615. 2009
2009 Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample setsArthritis and Rheumatism.  60:3485-3492. 2009
2009 The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets 2009
2009 Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritisAnnals of the Rheumatic Diseases.  68:1340-1344. 2009
2009 Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20Nature Genetics.  41:824-828. 2009
2009 Genetics of Type 1 Diabetes and Autoimmune Thyroid DiseaseEndocrinology and Metabolism Clinics of North America.  38:289-301. 2009
2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesNature Genetics.  41:703-707. 2009
2009 Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New ZealandRheumatology.  48:367-370. 2009
2009 Crystal ball gazing: New therapeutic targets for hyperuricaemia and goutRheumatology.  48:222-226. 2009
2009 Type 1 diabetes, the A1 milk hypothesis and vitamin D deficiencyDiabetes Research and Clinical Practice.  83:149-156. 2009
2008 Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohortGenes and Immunity.  9:561-565. 2008
2008 Debunking the myths to provide 21st Century management of goutNew Zealand Medical Journal.  121:79-85. 2008
2008 A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian populationBMC Cancer.  8. 2008
2008 Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritisAnnals of the Rheumatic Diseases.  67:409-413. 2008
2008 IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn's disease patients [5] 2008
2007 Erratum: Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21 (Human Molecular Genetics (1997) vol. 6(7) (1003-1010))Human Molecular Genetics.  16:3197. 2007
2007 Erratum: Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11 (Human Molecular Genetics (1997) vol. 6(7) (1011-1016))Human Molecular Genetics.  16:3198. 2007
2007 IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel diseaseAmerican Journal of Gastroenterology.  102:2754-2761. 2007
2007 Colony-stimulating factor-1 receptor gene polymorphisms and Crohn's disease [7] 2007
2007 Maternal psychological reaction to newborn genetic screening for type 1 diabetesPediatrics (Spanish Edition).  120. 2007
2007 Peroxisome proliferator-activated receptor-γ gene polymorphisms and Crohn's disease [1] 2007
2007 The human genome and understanding of common disease: Present and future technologiesCritical Sociology.  64:961-978. 2007
2007 Risk-taking: Behind the warrior gene storyNew Zealand Medical Journal.  120. 2007
2007 Analysis of the Fc receptor-like-3 (FCRL3) locus in caucasians with autoimmune disorders suggests a complex pattern of disease associationJournal of Clinical Endocrinology and Metabolism.  92:1106-1111. 2007
2007 Genomic DNA pooling for whole-genome association scans in complex disease: Empirical demonstration of efficacy in rheumatoid arthritisGenes and Immunity.  8:57-68. 2007
2007 Polymorphisms in NFKBIA and ICAM-1 genes in New Zealand Caucasian Crohn's disease patientsJournal of Gastroenterology and Hepatology.  22:1666-1670. 2007
2007 TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohortJournal of Gastroenterology and Hepatology.  22:1760-1766. 2007
2006 Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohortImmunology and Cell Biology.  84:233-236. 2006
2006 Genetic progress towards the molecular basis of autoimmunity 2006
2006 Genetic progress towards the molecular basis of common autoimmunity.Discovery medicine.  6:40-45. 2006
2006 PPAR-γ and Crohn's Disease in New ZealandGastroenterology.  130:2249-2250. 2006
2005 Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patientsImmunology and Cell Biology.  83:498-503. 2005
2005 Colocalization of mouse autoimmune diabetes loci Idd21.1 and Idd21.2 with IDDM6 (human) and Iddm3 (rat)Diabetes.  54:2820-2825. 2005
2005 Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohortArthritis and Rheumatism.  52:2222-2225. 2005
2005 Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritisAnnals of the Rheumatic Diseases.  64:487-490. 2005
2004 Association of thymidylate synthase polymorphisms with gastric cancer susceptibilityInternational Journal of Cancer.  112:1010-1014. 2004
2004 Beta testing: The β-cell and autoimmune diabetes 2004
2003 The deleted in colorectal carcinoma (DCC) gene 201 R→G polymorphism: No evidence for genetic association with autoimmune diseaseEuropean Journal of Human Genetics.  11:840-844. 2003
2003 An autoimmune diabetes locus (Idd21) on mouse Chromosome 18Mammalian Genome.  14:335-339. 2003
2002 Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancerOncogene.  21:8192-8195. 2002
2002 Novel germline CDH1 mutations in hereditary diffuse gastric cancer familiesHuman Mutation.  19:518-525. 2002
2001 Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseasesDiabetes.  50:184-194. 2001
2000 The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genesNature Genetics.  25:320-323. 2000
2000 The genome search for insulin-dependent diabetes mellitus (IDDM) susceptibility 2000
1998 Fine mapping of the diabetes-susceptibility locus, IDDM4, on chromosome 11q13American Journal of Human Genetics.  63:547-556. 1998
1998 Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6)Human Molecular Genetics.  7:517-524. 1998
1997 Evidence by allelic association-dependent methods for a type 1 diabetes polygene (IDDM6) on chromosome 18q21Human Molecular Genetics.  6:1003-1010. 1997
1997 Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11Human Molecular Genetics.  6:1011-1016. 1997
1997 The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibilityHuman Molecular Genetics.  6:1017-1020. 1997
1995 Mutation of the glucagon receptor gene and diabetes mellitus in the UK: Association or founder effect?Human Molecular Genetics.  4:1609-1612. 1995
1995 Cloning and characterization of pvdS, a gene required for pyoverdine synthesis in Pseudomonas aeruginosa: PvdS is probably an alternative sigma factorJournal of Bacteriology.  177:2744-2750. 1995
1995 Genetics of autoimmune diseaseCurrent Opinion in Immunology.  7:786-792. 1995
1995 Nucleotide sequence of pvdD, a pyoverdine biosynthetic gene from Pseudomonas aeruginosa: PvdD has similarity to peptide synthetasesJournal of Bacteriology.  177:252-258. 1995
1993 Construction and use of a self-cloning promoter probe vector for Gram-negative bacteriaGene.  126:17-23. 1993

Chapter

Year Title Altmetric
2017 Genetic influences in gout.  1-22. 2017
2013 An update on the genetic causes of hyperuricemia and gout.  54-69. 2013

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Otago 1993
  • Full Name

  • Tony Merriman