My lab aims to understand the structure-function relationships involved in the processes of viral replication, virus-host interactions, capsid structure, polynucleotide synthesis and antibody-antigen complex formation. Toward this goal, we have used structural techniques (cryo-electron microscopy, x-ray crystallography and small angle x-ray scattering) and biochemistry to study: viral proteins from negative strand RNA viruses (NSV: influenza A, mumps, rabies virus, VSV), retroviruses (HIV), coronaviruses (SARS-CoV-2), human antibodies (associated with IgA nephropathy), and bacteria (IgA1 proteases). This dual approach has been successful in producing near atomic-level snapshots of many complex protein assemblies as well as enabling a fast-track to novel biological discovery and new experimental design. Professionally, my expertise in structural biology has led to my collaboration with investigators locally, nationally and internationally on viral, bacterial, human and murine targets.
