My lab aims to understand virus structure and the structure-function relationships involved in the processes of viral replication, including virus-host interactions, capsid structure and polynucleotide synthesis. Toward this goal, we have used structural techniques (cryo-electron microscopy, x-ray crystallography and small angle x-ray scattering) alongside biochemistry and classical virology techniques to study viral proteins from negative strand RNA viruses (NSV: influenza A, mumps, rabies virus, VSV) and retroviruses (HIV). This dual approach has been successful in producing near atomic-level snapshots of many complex protein assemblies as well as enabling a fast-track to novel biological discovery and new experimental design. Professionally, my expertise in structural biology has lead to my collaboration with investigators locally, nationally and internationally on viral, bacterial, human and murine targets.
