• The overall theme of Dr. Mitchell’s research has been to study disorders that affect the kidney and to identify potential ways to improve the health and quality of life of individuals with kidney disease. She has a broad background as well as specific training and expertise in mitochondrial function and oxidative stress. Dr. Mitchell’s current research investigates the role of diet on immune cell mitochondria and oxidative stress in kidney stone disease using human dietary feeding studies, animal models, and cell culture models. In addition, she also studies the role of immune cells in interstitial cystitis/painful bladder syndrome. It is Dr. Mitchell’s hope that her research will provide relevant scientific information to help understand, prevent, and/or treat renal diseases and urological disorders.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat kidney stone model 2022
    2022 Oxalate Induced Mitochondrial and Lysosomal Dysfunction in Myeloid Cells is Mediated by IL-10 Signaling 2022
    2022 Acclimation to a High-Salt Diet Is Sex DependentJournal of the American Heart Association.  11. 2022
    2021 The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancerJCI Insight.  6. 2021
    2021 Oxalate Alters Cellular Bioenergetics, Redox Homeostasis, Antibacterial Response, and Immune Response in MacrophagesFrontiers in Immunology.  12. 2021
    2021 Dietary Oxalate Loading Impacts Monocyte Metabolism and Inflammatory Signaling in HumansFrontiers in Immunology.  12. 2021
    2021 TGF-β signaling suppresses TCA cycle metabolism in renal cancer 2021
    2021 Contribution of dietary oxalate and oxalate precursors to urinary oxalate excretionNutrients.  13:1-13. 2021
    2021 Estimation of urinary nanocrystals in humans using calcium fluorophore labeling and nanoparticle tracking analysisJournal of Visualized Experiments.  2021:1-14. 2021
    2020 Dietary Oxalate Induces Urinary Nanocrystals in HumansKidney International Reports.  5:1040-1051. 2020
    2020 PRDM16 suppresses HIF-targeted gene expression in kidney cancerJournal of Experimental Medicine.  217. 2020
    2020 Sex differences in redox homeostasis in renal disease: Sex-differences in renal redox signalingRedox Biology.  31. 2020
    2019 Dietary oxalate and kidney stone formation 2019
    2018 Stay in the Loop: New Insights about Randall's Plaques and Stone Disease. 2018
    2018 Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell lineRedox Biology.  15:207-215. 2018
    2016 Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophilsRedox Biology.  9:57-66. 2016
    2016 The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytesRedox Biology.  8:43-50. 2016
    2016 Monocyte Mitochondrial Function in Calcium Oxalate Stone FormersUrology.  93:224.e1-224.e6. 2016
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patientsLaboratory Investigation.  95:132-141. 2015
    2014 Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets.Journal of Visualized Experiments2014
    2014 Mitochondria in monocytes and macrophages-implications for translational and basic research 2014
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells 2013
    2013 Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeuticsBiochemical Society Transactions.  41:127-133. 2013
    2013 Mitochondrially targeted compounds and their impact on cellular bioenergeticsRedox Biology.  1:86-93. 2013
    2012 Controlling radicals in the powerhouse: Development of mitoSODCell chemical biology.  19:1217-1218. 2012
    2012 Correction to "The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys" (J Pharmacol Exp Ther (2011) 336, (682-692))Journal of Pharmacology and Experimental Therapeutics.  342:596. 2012
    2012 Metabolic syndrome and mitochondrial dysfunction: Insights from preclinical studies with a mitochondrially targeted antioxidantFree Radical Biology and Medicine.  52:838-840. 2012
    2011 Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouseFree Radical Biology and Medicine.  51:406-416. 2011
    2011 The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneysJournal of Pharmacology and Experimental Therapeutics.  336:682-692. 2011
    2010 Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injuryFree Radical Biology and Medicine.  49:1273-1282. 2010
    2009 Alteration of renal respiratory Complex-III during experimental type-1 diabetesBMC Endocrine Disorders.  9. 2009
    2007 Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusionFree Radical Biology and Medicine.  42:1571-1578. 2007

    Research Overview

  • Kidney Stones, Immunology, Mitochondria, Oxidative Stress, Metabolism, Urological Disorders, Diet, Oxalate
  • Education And Training

  • Doctor of Philosophy, University of Arkansas 2011
  • Bachelor of Science or Mathematics, Alcorn State University 2005
  • Full Name

  • Tanecia Mitchell