Positions

Overview

  • The overall theme of Dr. Mitchell’s research has been to study disorders that affect the kidney and to identify potential ways to improve the health and quality of life of individuals with kidney disease. She has a broad background as well as specific training and expertise in mitochondrial function and oxidative stress. Dr. Mitchell’s current research investigates the role of diet on immune cell mitochondria and oxidative stress in kidney stone disease using human dietary feeding studies, animal models, and cell culture models. In addition, she also studies the role of immune cells in interstitial cystitis/painful bladder syndrome. It is Dr. Mitchell’s hope that her research will provide relevant scientific information to help understand, prevent, and/or treat renal diseases and urological disorders.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Dietary oxalate and kidney stone formation 2019
    2018 Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line 2018
    2016 Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils 2016
    2016 The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes 2016
    2016 Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers 2016
    2015 Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients 2015
    2014 Bioenergetics and the oxidative burst: protocols for the isolation and evaluation of human leukocytes and platelets. 2014
    2013 Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells 2013
    2013 Mitochondrially targeted compounds and their impact on cellular bioenergetics 2013
    2012 Controlling radicals in the powerhouse: Development of mitoSOD 2012
    2012 Correction to "The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys" (J Pharmacol Exp Ther (2011) 336, (682-692)) 2012
    2012 Metabolic syndrome and mitochondrial dysfunction: Insights from preclinical studies with a mitochondrially targeted antioxidant 2012
    2011 Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse 2011
    2011 The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys 2011
    2010 Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury 2010
    2009 Alteration of renal respiratory Complex-III during experimental type-1 diabetes 2009
    2007 Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion 2007

    Research Overview

  • Kidney Stones, Immunology, Mitochondria, Oxidative Stress, Metabolism, Urological Disorders, Diet, Oxalate
  • Full Name

  • Tanecia Mitchell