Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cellsPulmonary Pharmacology and Therapeutics.  55:5-16. 2019
2019 α 1G T-type calcium channel determines the angiogenic potential of pulmonary microvascular endothelial cells 2019
2019 NLRX1 regulation following acute mitochondrial injuryFrontiers in Immunology.  10. 2019
2014 Transcriptional regulation of α1H T-type calcium channel under hypoxia 2014
2014 A unique pulmonary microvascular endothelial cell niche revealed by weibel-palade bodies and Griffonia simplicifoliaPulmonary Circulation.  4:111-115. 2014
2014 The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entryPulmonary Circulation.  4:116-127. 2014
2013 TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cellsPhysiological Reports.  1. 2013
2013 Regulation of store-operated calcium entry by FK506-binding immunophilinsCell Calcium.  53:275-285. 2013
2012 Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conductionJournal of Clinical Investigation.  122:4218-4230. 2012
2012 KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells 2012
2012 Orai1 determines calcium selectivity of an endogenous trpc heterotetramer channelCirculation Research.  110:1435-1444. 2012
2012 Lung endothelial Ca 2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6American Journal of Respiratory and Critical Care Medicine.  185:160-170. 2012
2010 Effect of hypernatremia on injury caused by energy deficiency: Role of T-type Ca2+ channel 2010
2010 α1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium 2010
2010 New developments in lung endothelial heterogeneity: Von willebrand factor, P-selectin, and the weibel-palade bodySeminars in Thrombosis and Hemostasis.  36:301-308. 2010
2009 A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation 2009
2009 Ca2+ entry via α1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium 2009
2008 Quantum dots - Utilization in TEMMicroscopy and Microanalysis.  14:702-703. 2008
2008 Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4Circulation Research.  102:966-974. 2008
2008 T-type Ca2+ channel expression in human esophageal carcinomas: A functional role in proliferationCell Calcium.  43:49-58. 2008
2007 Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeabilityJournal of Biological Chemistry.  282:34801-34808. 2007
2007 Cav3.1 (α1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells 2007
2006 T-type calcium channels in pulmonary vascular endotheliumMicrocirculation.  13:645-656. 2006
2005 Activation of the endothelial store-operated ISOC Ca 2+ channel requires interaction of protein 4.1 with TRPC4Circulation Research.  97:1164-1172. 2005
2005 Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability determinants of the vascular leak siteCirculation Research.  96:856-863. 2005
2005 Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytesCirculation Research.  96:864-872. 2005
2005 Reversal of hyperglycemic preconditioning by angiotensin II: Role of calcium transport 2005
2005 Is there a role for T-type Ca2+ channel in glioma cell proliferation? (multiple letter)Cell Calcium.  38:593-595. 2005
2005 The low-voltage-activated calcium channel CAV3.1 controls proliferation of human pulmonary artery myocytesChest.  128:581S-582S. 2005
2004 Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypesMicrovascular Research.  67:139-151. 2004
2003 CaV3.1 (α1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculationCirculation Research.  93:346-353. 2003
2003 On the endothelial cell ISOCCell Calcium.  33:323-336. 2003
2001 Essential control of an endothelial cell ISOC by the spectrin membrane skeleton 2001
2001 Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathwayThe FASEB Journal.  15:1727-1738. 2001
2000 Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cellsJournal of Biological Chemistry.  275:18887-18896. 2000
2000 A mibefradil metabolite is a potent intracellular blocker of L-type Ca2+ currents in pancreatic β-cellsJournal of Pharmacology and Experimental Therapeutics.  292:939-943. 2000
2000 Cloning of a T-type Ca2+ channel isoform in insulin-secreting cellsDiabetes.  49:59-64. 2000

Chapter

Year Title Altmetric
2015 Regulation of t-type ca2+ channels by intercellular and intracellular signals.  19-35. 2015
2009 Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels.  129-142. 2009
2005 Receptor-operated Ca2+ channels.  99-124. 2005
2005 Transient receptor potential cation channels and store-operated Ca2+ channels.  125-146. 2005

Research Overview

  • Lung endothelial cell calcium channels
    Lung endothelial cell barrier integrity
    Lung endothelial cell activation and pro-inflammatory phenotype
    Lung endothelial cell angioproliferative phenotype and idiopathic pulmonary arterial hypertension
    Lung endothelial cell and hypoxic pulmonary vasoconstriction
  • Education And Training

  • Medical College of Georgia, Georgia Regents University Department of Anesthesiology and Perioperstive Medicine, Internship
  • Department of Internal Medicine, The Second Affiliated Hospital of Henan Medical University Internal Medicine, Residency
  • Medical College of Geogia at Augusta University Department of Anesthesiology and Perioperstive Medicine, Residency
  • University of South Alabama College of Medicine Department of Pharmacology, Postdoctoral Fellowship
  • Master of Science in Health Professions and Related Clinical Sciences, Zhengzhou University 1992
  • Doctor of Medicine, Zhengzhou University 1986
  • Full Name

  • Songwei Wu