Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cellsPulmonary Pharmacology and Therapeutics.  55:5-16. 2019
2019 α 1G T-type calcium channel determines the angiogenic potential of pulmonary microvascular endothelial cellsAmerican Journal of Physiology - Cell Physiology.  316:C353-C364. 2019
2019 NLRX1 regulation following acute mitochondrial injuryFrontiers in Immunology.  10. 2019
2014 A unique pulmonary microvascular endothelial cell niche revealed by weibel-palade bodies and Griffonia simplicifoliaPulmonary Circulation.  4:111-115. 2014
2014 The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entryPulmonary Circulation.  4:116-127. 2014
2014 Transcriptional regulation of α1H T-type calcium channel under hypoxiaAmerican Journal of Physiology - Cell Physiology.  307:C648-C656. 2014
2013 Regulation of store-operated calcium entry by FK506-binding immunophilinsCell Calcium.  53:275-285. 2013
2013 TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cellsPhysiological Reports.  1. 2013
2012 Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conductionJournal of Clinical Investigation.  122:4218-4230. 2012
2012 KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research.  1823:1666-1675. 2012
2012 Orai1 determines calcium selectivity of an endogenous trpc heterotetramer channelCirculation Research.  110:1435-1444. 2012
2012 Lung endothelial Ca 2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6American Journal of Respiratory and Critical Care Medicine.  185:160-170. 2012
2010 Effect of hypernatremia on injury caused by energy deficiency: Role of T-type Ca2+ channelAmerican Journal of Physiology - Cell Physiology.  299. 2010
2010 α1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endotheliumAJP - Lung Cellular and Molecular Physiology.  299. 2010
2010 New developments in lung endothelial heterogeneity: Von willebrand factor, P-selectin, and the weibel-palade bodySeminars in Thrombosis and Hemostasis.  36:301-308. 2010
2009 A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferationOncology Reports.  22:1229-1235. 2009
2009 Ca2+ entry via α1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endotheliumAJP - Lung Cellular and Molecular Physiology.  297. 2009
2008 Quantum dots - Utilization in TEMMicroscopy and Microanalysis.  14:702-703. 2008
2008 Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4Circulation Research.  102:966-974. 2008
2008 T-type Ca2+ channel expression in human esophageal carcinomas: A functional role in proliferationCell Calcium.  43:49-58. 2008
2007 Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeabilityJournal of Biological Chemistry.  282:34801-34808. 2007
2007 Cav3.1 (α1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cellsAJP - Lung Cellular and Molecular Physiology.  292. 2007
2006 T-type calcium channels in pulmonary vascular endotheliumMicrocirculation.  13:645-656. 2006
2005 Activation of the endothelial store-operated ISOC Ca 2+ channel requires interaction of protein 4.1 with TRPC4Circulation Research.  97:1164-1172. 2005
2005 Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability determinants of the vascular leak siteCirculation Research.  96:856-863. 2005
2005 Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytesCirculation Research.  96:864-872. 2005
2005 Reversal of hyperglycemic preconditioning by angiotensin II: Role of calcium transportAJP - Heart and Circulatory Physiology.  288. 2005
2005 Is there a role for T-type Ca2+ channel in glioma cell proliferation? (multiple letter)Cell Calcium.  38:593-595. 2005
2005 The low-voltage-activated calcium channel CAV3.1 controls proliferation of human pulmonary artery myocytesChest.  128:581S-582S. 2005
2004 Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypesMicrovascular Research.  67:139-151. 2004
2003 CaV3.1 (α1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculationCirculation Research.  93:346-353. 2003
2003 On the endothelial cell ISOCCell Calcium.  33:323-336. 2003
2001 Essential control of an endothelial cell ISOC by the spectrin membrane skeletonJournal of Cell Biology.  154:1225-1233. 2001
2001 Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathwayFederation proceedings.  15:1727-1738. 2001
2000 Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cellsJournal of Biological Chemistry.  275:18887-18896. 2000
2000 A mibefradil metabolite is a potent intracellular blocker of L-type Ca2+ currents in pancreatic β-cellsJournal of Pharmacology and Experimental Therapeutics.  292:939-943. 2000
2000 Cloning of a T-type Ca2+ channel isoform in insulin-secreting cellsDiabetes.  49:59-64. 2000

Chapter

Year Title Altmetric
2015 Regulation of t-type ca2+ channels by intercellular and intracellular signals.  19-35. 2015
2009 Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels.  129-142. 2009
2005 Receptor-operated Ca2+ channels.  99-124. 2005
2005 Transient receptor potential cation channels and store-operated Ca2+ channels.  125-146. 2005

Research Overview

  • Lung endothelial cell calcium channels
    Lung endothelial cell barrier integrity
    Lung endothelial cell activation and pro-inflammatory phenotype
    Lung endothelial cell angioproliferative phenotype and idiopathic pulmonary arterial hypertension
    Lung endothelial cell and hypoxic pulmonary vasoconstriction
  • Principal Investigator On

    Education And Training

  • Master of Science in Health Professions and Related Clinical Sciences, Zhengzhou University 1992
  • Doctor of Medicine, Zhengzhou University 1986
  • Medical College of Georgia, Georgia Regents University Department of Anesthesiology and Perioperstive Medicine, Internship 2013
  • Medical College of Geogia at Augusta University Department of Anesthesiology and Perioperstive Medicine, Residency 2017
  • Department of Internal Medicine, The Second Affiliated Hospital of Henan Medical University Internal Medicine, Residency 1989
  • University of South Alabama College of Medicine Department of Pharmacology, Postdoctoral Fellowship 2001
  • Full Name

  • Songwei Wu