• Dr. Wei obtained his M.D. from China Medical University (Shenyang, China) and received his Ph.D. from Okayama University in Japan. He completed a post-doctoral fellowship at Washington University School of Medicine (St. Louis, Missouri) prior to coming to UAB, where he finished his pathology residency followed by a surgical pathology fellowship. He obtained additional clinical subspecialty training at Emory, Mt. Sinai and Harvard Universities. Dr. Wei is board certified in Anatomic and Clinical Pathology. He joined the faculty at UAB in July, 2008 and is currently a Tenured Professor. Dr. Wei heads the Surgical Pathology Section at the Division of Anatomic Pathology, Department of Pathology, and directs the Surgical Pathology Fellowship Program.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 A CD24-p53 axis contributes to African American prostate cancer disparities 2020
    2020 Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor 2020
    2020 PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression 2020
    2020 RANKLed by the Complexity of Signaling in Breast Cancer Metastasis to the Brain 2020
    2019 Synchronous and metachronous bilateral breast cancer: clinicopathologic characteristics and prognostic outcomes 2019
    2019 Autophagy-related 7 modulates tumor progression in triple-negative breast cancer 2019
    2019 Bone Pathology for Hematopathologists 2019
    2019 Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification 2019
    2019 PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall 2019
    2019 Inhibition of heme oxygenase-1 enhances hyperthermia-induced autophagy and antiviral effect 2019
    2019 Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c-Myc 2019
    2018 Comparison of AJCC Anatomic and Clinical Prognostic Stage Groups in Breast Cancer: Analysis of 3322 Cases From a Single Institution 2018
    2018 The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome 2018
    2018 Clinicopathologic Features and Clinical Outcome Differences in De Novo Versus Secondary Histiocytic Sarcomas: A Multi-institutional Experience and Review of the Literature 2018
    2018 Chondroblastoma-like tumor of the skull in a patient with cardio-facio-cutaneous syndrome 2018
    2018 Gene Expression Profiling of Advanced Penile Squamous Cell Carcinoma Receiving Cisplatin-based Chemotherapy Improves Prognostication and Identifies Potential Therapeutic Targets 2018
    2018 Phosphorylation of SMC1A promotes hepatocellular carcinoma cell proliferation and migration 2018
    2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors 2018
    2018 Surviving at a distant site: The organotropism of metastatic breast cancer 2018
    2017 Prognostic outcomes in advanced breast cancer: the metastasis-free interval is important 2017
    2017 Clinical and pathological factors related to brain relapse-free survival in breast cancer patients—reply 2017
    2017 Corrigendum to “Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone” (Human Pathology (2017) 65 (239–246) (S0046817717301727) (10.1016/j.humpath.2017.05.015)) 2017
    2017 Extraskeletal aneurysmal bone cyst: Report of a case and review of the literature 2017
    2017 The CD4/CD8 ratio of tumor-infiltrating lymphocytes at the tumor-host interface has prognostic value in triple-negative breast cancer 2017
    2017 Not Your Typical Renal Cyst 2017
    2017 Carcinoma in situ involving sclerosing adenosis: Seeking the salient histological characteristics to prevent overdiagnosis 2017
    2017 Soft tissue tumor immunohistochemistry update illustrative examples of diagnostic pearls to avoid pitfalls 2017
    2017 Diagnostic utility of IDH1/2 mutations to distinguish dedifferentiated chondrosarcoma from undifferentiated pleomorphic sarcoma of bone 2017
    2017 GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall 2017
    2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer 2017
    2017 Clinicopathological factors associated with survival in patients with breast cancer brain metastasis 2017
    2017 Reacquisition of E-cadherin expression in metastatic deposits of signet-ring cell carcinoma of the upper gastrointestinal system: A potential anchor for metastatic deposition 2017
    2017 Well-Differentiated Laryngeal/Hypopharyngeal Liposarcoma in the MDM2 Era Report of Three Cases and Literature Review 2017
    2017 Let-7 status is crucial for PARP1 expression in HER2-overexpressing breast tumors 2017
    2017 DNA-PkCS expression in oropharyngeal squamous cell carcinoma: Correlations with human papillomavirus status and recurrence after transoral robotic surgery 2017
    2017 Differential gene expression in ductal carcinoma in situ of the breast based on ERBB2 status 2017
    2017 Metastatic organotropism: An intrinsic property of breast cancer molecular subtypes 2017
    2017 Primary Renal Ewing Sarcoma in an Adult 2017
    2017 Reduced E-Cadherin and Aberrant β-Catenin Expression are Associated with Advanced Disease in Signet-Ring Cell Carcinomas 2017
    2016 Clinicopathologic factors associated with de novo metastatic breast cancer 2016
    2016 Notch signaling activation is associated with patient mortality and increased FGF1-mediated invasion in squamous cell carcinoma of the oral cavity 2016
    2016 Kinase gene expression profiling of metastatic clear cell renal cell carcinoma tissue identifies potential new therapeutic targets 2016
    2016 Papillary lesions of the breast an update 2016
    2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cells 2016
    2016 Gorham-stout disease successfully treated with sirolimus and zoledronic acid therapy 2016
    2016 Prognostic factors in advanced breast cancer: Race and receptor status are significant after development of metastasis 2016
    2016 Prognostic value of E-cadherin and β-catenin in triple-negative breast cancer 2016
    2016 Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury 2016
    2016 The rank pathway in advanced breast cancer: Does Src play a role? 2016
    2015 Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancer 2015
    2015 Sinonasal renal cell-like adenocarcinomas: Robust carbonic anhydrase expression 2015
    2015 Effect of African-American Race on Tumor Recurrence after Radical Cystectomy for Urothelial Carcinoma of the Bladder 2015
    2015 Solitary, adult-onset, intraosseous myofibroma of the finger: report of a case and review of literature 2015
    2015 The IVVY motif and tumor necrosis factor receptor-associated factor (TRAF) sites in the cytoplasmic domain of the receptor activator of nuclear factor κB (RANK) cooperate to induce osteoclastogenesis 2015
    2015 Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: A comparative study 2015
    2015 FOXP3-MIR-146-NF-κB axis and therapy for precancerous lesions in prostate 2015
    2015 PARP1 and phospho-p65 protein expression is increased in human HER2-positive breast cancers 2015
    2015 Composite encapsulated papillary carcinoma and solid papillary carcinoma 2015
    2015 Breast cancer subtypes predispose the site of distant metastases 2015
    2015 Florid reactive periostitis ossificans of the humerus: Case report and differential diagnosis of periosteal lesions of long bones 2015
    2015 GATA3 expression in advanced breast cancer: Prognostic value and organ-specific relapse 2015
    2015 The utility of phosphohistone H3 in breast cancer grading 2015
    2014 An extremely rare primary gallbladder myxoid liposarcoma associated with amplification of DDIT3 gene 2014
    2014 Envisioning the Next WHO Head and Neck Classification 2014
    2014 Breast implant-associated anaplastic large cell lymphoma: Review of a distinct clinicopathologic entity 2014
    2014 Changing prognostic factors in osteosarcoma: Analysis of 381 cases from two institutions 2014
    2014 Characteristics of breast carcinoma cases with false-negative sentinel lymph nodes 2014
    2014 L-2-hydroxyglutarate: An epigenetic modifier and putative oncometabolite in renal cancer 2014
    2014 Optimal handling of bone tumor specimens 2014
    2014 Prognostic factors in patients with metastatic breast cancer at the time of diagnosis 2014
    2014 Round cell tumors of bone: An update on recent molecular genetic advances 2014
    2013 Syndecan-1 overexpression is associated with nonluminal subtypes and poor prognosis in advanced breast cancer 2013
    2013 Immunohistochemical studies of metastatic germ-cell tumors in retroperitoneal dissection specimens: A sensitive and specific panel 2013
    2013 Expression of SALL4 and SF-1 in gonadoblastoma: Useful markers in the identification of the invasive germ cell component 2013
    2013 Microsatellite instability and TARBP2 mutation study in upper urinary tract urothelial carcinoma 2013
    2013 Sclerosing epithelioid fibrosarcoma of the pancreas 2013
    2013 AIRP best cases in radiologic-pathologic correlation: Gallbladder carcinoma with direct invasion of the liver 2013
    2013 SALL4 and SF-1 are sensitive and specific markers for distinguishing granulosa cell tumors from yolk sac tumors 2013
    2012 Factors associated with residual disease after initial breast-conserving surgery for ductal carcinoma in situ 2012
    2012 A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst) 2012
    2012 Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis 2012
    2012 CD138 (syndecan-1) expression in bone-forming tumors 2012
    2012 Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts 2012
    2012 Molecular mechanisms of the biphasic effects of interferon-γ on osteoclastogenesis 2012
    2011 A 23-year-old woman with a right femoral neck fracture 2011
    2011 Composite cutaneous atypical vascular lesion and Langerhans cell histiocytosis after radiation for breast carcinoma: Can radiation induce Langerhans cell histiocytosis? 2011
    2011 Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6: A novel mechanism mediating its blockade of osteoclastogenesis 2011
    2011 Renal cell carcinoma metastasizing to solitary fibrous tumor of the pleura: A case report 2011
    2011 Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs 2011
    2010 Juxtatumoral stromal reactions in uterine endometrioid adenocarcinoma and their prognostic significance 2010
    2009 Estrogen and progesterone receptor expression is not always specific for mammary and gynecologic carcinomas: A tissue microarray and pooled literature review study 2009
    2008 Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome 2008
    2008 Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets 2008
    2008 Targeting p38 MAPK for the treatment of inflammatory arthritis 2008
    2007 p38 MAPK as a potential therapeutic target for inflammatory osteolysis 2007
    2005 Receptor activator of NF-κB (RANK) cytoplasmic motif, 369PFQEP373, plays a predominant role in osteoclast survival in part by activating Akt/PKB and its downstream effector AFX/FOXO4 2005
    2005 IL-1 mediates TNF-induced osteoclastogenesis 2005
    2004 Marrow stromal cells and osteoclast precursors differentially contribute to TNF-α-induced osteoclastogenesis in vivo 2004
    2004 The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling 2004
    2002 Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and function 2002
    2002 Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-κB and mitogen-activated protein kinase signaling 2002
    2001 Receptor activator of nuclear factor-κB ligand activates nuclear factor-κB in osteoclast precursors 2001
    2000 Tumor necrosis factor α regulates αvβ5 integrin expression by osteoclast precursors in vitro and in vivo 2000


    Year Title Altmetric
    2015 Advances in surgical pathology: Breast cancer 2015


    Year Title Altmetric
    2015 Molecular pathology of osteosarcoma.  213-222. 2015
    2014 Benign Tumors and Tumor-Like Conditions of Bone.  838-855. 2014
    2014 MaLignant Tumors of Bone.  856-873. 2014

    Research Overview

  • Dr. Wei is actively engaged in the diagnostic surgical pathology service and has special interests in breast, muskuloskeletal and genitourinary pathology. His major research interests include discovery and evaluation of biomarkers in breast cancer and other malignancies, evaluation of prognostic factors in breast cancer and malignant bone tumors, and tumor bone metastasis. He has published more than a hundred manuscripts in these areas in some of the leading peer-reviewed journals, of which he first- or senior-authored approximately two-thirds. Dr. Wei is a Senior Scientist at UAB Comprehensive Cancer Center, Experimental Therapeutics Program. He co-directs the Pathology Research Core Laboratory.

    Keywords: Breast Pathology; Muskuloskeletal Pathology; Genitourinary Pathology
  • Investigator On

  • Synergistic Targeted Therapy of Antibody-Drug Conjugates for Triple-Negative Breast Cancer  awarded by National Cancer Institute/NIH/DHHS 2020 - 2024
  • 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • Morehouse School of Medicine/Tuskegee University/University of Alabama Cancer Center Partnership: Project 1: CD24-Dependent Inactivation of Mutant p53 in Metastatic Castration-Resistant Prostate Cancer  awarded by National Cancer Institute/NIH/DHHS 2016 - 2021
  • UAB 1174: Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis 2  awarded by QUANTUM LEAP HEALTH CARE 2018 - 2020
  • Effects of CD24-RCC2 Signaling on Prostate Cancer Metastasis  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2015 - 2020
  • Utilizing microRNA-146a to Block Triple-Negative Breast Cancer Cell Colonization  awarded by National Cancer Institute/NIH/DHHS 2019 - 2020
  • UAB 1174: Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis 2  awarded by QUANTUM LEAP HEALTH CARE 2012 - 2019
  • Prospective Study of MRI and Multi-Parameter Gene Expression Assay in Ductal Carcinoma in Situ (DCIS) (R15-037)  awarded by American College of Radiology Imaging Network 2015 - 2017
  • Whole Exome and Comprehensive Kinomics Analysis of Penile Squamous Cell Carcinoma  awarded by Conquer Cancer Foundation of ASCO 2014 - 2015
  • Whole Exome Sequencing of Penile Squamous Cell Carcinoma to Improve Prognostication and Uncover Potentially Actionable Therapeutic Targets  awarded by FONDAZIONE IRCCS INSITUTO NAZIONLE DEI TUMORI 2014 - 2015
  • Elevated NF-kB Signaling in Breast Cancers of African American Women  awarded by H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE 2013
  • Education And Training

  • Doctor of Medicine, China Medical University 1989
  • UAB Hospital, Residency 2008
  • Full Name

  • Shi Wei