Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic VirulenceScientific Reports.  7. 2017
2017 Phenotype and function of myeloidderived suppressor cells induced by Porphyromonas gingivalis infectionInfection and Immunity.  85. 2017
2017 Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral MicrobiomeJournal of Dental Research.  96:807-814. 2017
2016 Effects of diadenylate cyclase deficiency on synthesis of extracellular polysaccharide matrix of Streptococcus mutans revisitEnvironmental Microbiology.  18:3612-3619. 2016
2016 Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing TrisaccharideJournal of Organic Chemistry.  81:9560-9566. 2016
2016 8-Hydroxyquinolines are boosting agents of copper-related toxicity in Mycobacterium tuberculosisAntimicrobial Agents and Chemotherapy.  60:5765-5776. 2016
2016 Adaptation of the ToxRTool to Assess the Reliability of Toxicology Studies Conducted with Genetically Modified Crops and Implications for Future Safety TestingCRC critical reviews in food science and nutrition.  56:512-526. 2016
2016 TLR4 regulates Pulmonary vascular homeostasis and remodeling via redox signalingFrontiers in Bioscience.  21:397-409. 2016
2015 IL-1R/TLR2 through MyD88 divergently modulates osteoclastogenesis through regulation of nuclear factor of activated T cells c1 (NFATc1) and B lymphocyte-induced maturation protein-1 (Blimp1)Journal of Biological Chemistry.  290:30163-30174. 2015
2014 Novel catanionic surfactant vesicle vaccines protect against Francisella tularensis LVS and confer significant partial protection against F. tularensis Schu S4 strainClinical and Diagnostic Laboratory Immunology.  21:212-226. 2014
2013 Role of mTOR downstream effector signaling molecules in Francisella tularensis internalization by murine macrophagesPLoS ONE.  8. 2013
2013 Synthesis of QS-21-based immunoadjuvantsJournal of Organic Chemistry.  78:11525-11534. 2013
2013 Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3Journal of Immunology.  190:5000-5011. 2013
2013 Copper-boosting compounds: A novel concept for antimycobacterial drug discoveryAntimicrobial Agents and Chemotherapy.  57:1089-1091. 2013
2013 Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to porphyromonas gingivalisJournal of Leukocyte Biology.  93:21-31. 2013
2012 A Mucosal Subunit Vaccine Protects against Lethal Respiratory Infection with Francisella tularensis LVSPLoS ONE.  7. 2012
2012 YidC1 and YidC2 are functionally distinct proteins involved in protein secretion, biofilm formation and cariogenicity of Streptococcus mutansMicrobiology.  158:1702-1712. 2012
2012 Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesisJournal of Biological Chemistry.  287:15728-15738. 2012
2011 Differentiation of banding patterns between streptococcus mutans and Streptococcus sobrinus isolates in rep-PCR using ERIC primerJournal of Oral Microbiology.  3. 2011
2011 Contribution of a Streptococcus mutans antigen expressed by a Salmonella vector vaccine in dendritic cell activationInfection and Immunity.  79:3792-3800. 2011
2011 TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-κBJournal of Biological Chemistry.  286:24159-24169. 2011
2011 TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin BJournal of Immunology.  186:5772-5783. 2011
2011 Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cellsJournal of Immunology.  186:1391-1398. 2011
2010 Role of Toll-like receptors in host responses to a virulence antigen of Streptococcus mutans expressed by a recombinant, attenuated Salmonella vector vaccineVaccine.  28:4928-4936. 2010
2010 Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of α- and PPII-helicesProceedings of the National Academy of Sciences.  107:5983-5988. 2010
2010 Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cellsAmerican Journal of Pathology.  176:2490-2499. 2010
2010 Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)Immunology Today.  31:24-31. 2010
2010 TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomesAmerican Journal of Pathology.  177:1606-1610. 2010
2009 Immature myeloid cells induced by a high-fat diet contribute to liver inflammationHepatology.  50:1412-1420. 2009
2009 Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistanceDiabetes.  58:2498-2505. 2009
2009 Requirement of TLR4 and CD14 in dendritic cell activation by Hemagglutinin B from Porphyromonas gingivalisMolecular Immunology.  46:2493-2504. 2009
2009 Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis.Journal of Biological Chemistry.  284:12512-12523. 2009
2009 Glycogen synthase kinase-3β (GSK3β) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in miceMolecular Immunology.  46:677-687. 2009
2008 TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensisJournal of Leukocyte Biology.  84:1434-1446. 2008
2008 Phospholipase Cγ2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesisJournal of Biological Chemistry.  283:29593-29601. 2008
2008 Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responsesJournal of Experimental Medicine.  205:79-90. 2008
2008 Lipoteichoic acid is important in innate immune responses to gram-positive bacteriaInfection and Immunity.  76:206-213. 2008
2007 Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid AVaccine.  25:6201-6210. 2007
2007 Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophagesInfection and Immunity.  75:4127-4137. 2007
2007 Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutationApplied and Environmental Microbiology.  73:357-361. 2007
2006 Immune response in humans to a nasal boost with Streptococcus mutans antigensOral Microbiology and Immunology.  21:309-313. 2006
2006 Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter systemVaccine.  24:5003-5015. 2006
2006 Immunologic consequences of Francisella tularensis live vaccine strain infection: Role of the innate immune response in infection and immunityJournal of Immunology.  176:6888-6899. 2006
2006 Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVSInfection and Immunity.  74:2809-2816. 2006
2006 Erratum: Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2 (Journal of Immunology (2006) 176 (573-579))Journal of Immunology.  176:2671. 2006
2006 Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2Journal of Immunology.  176:573-579. 2006
2005 Cellular mechanisms of the adjuvant activity of the flagellin component FljB of Salmonella enterica serovar typhimurium to potentiate mucosal and systemic responsesInfection and Immunity.  73:6763-6770. 2005
2005 Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalisVaccine.  23:4734-4744. 2005
2005 Toll-like receptor - Mediated cytokine production is differentially regulated by glycogen synthase kinase 3Nature Immunology.  6:777-784. 2005
2005 Role of mitogen-activated protein kinases and NF-κB in the regulation of proinflammatory and anti-inflammatory cytokines by Porphyromonas gingivalis hemagglutinin BInfection and Immunity.  73:3990-3998. 2005
2005 Comparative analysis of the antibacterial effects of combined mouthrinses on Streptococcus mutansOral Microbiology and Immunology.  20:31-34. 2005
2004 Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to attenuated Salmonella enterica serovar typhimurium and its cloned antigenInfection and Immunity.  72:5824-5831. 2004
2004 A caries vaccine? The state of the science of immunization against dental cariesCaries Research.  38:230-235. 2004
2004 Effectiveness of sodium hypochlorite in preventing inoculation of periapical tissues with contaminated patency files.Journal of Endodontics.  30:92-94. 2004
2004 Role of B7 Costimulatory Molecules in Immune Responses and T-Helper Cell Differentiation in Response to Recombinant HagB from Porphyromonas gingivalisInfection and Immunity.  72:637-644. 2004
2004 Effect of a separated instrument on bacterial penetration of obturated root canalsJournal of Endodontics.  30:177-179. 2004
2004 pH required to kill Enterococcus faecalis in vitroJournal of Endodontics.  30:218-219. 2004
2003 Effect of age on immunoglobulin: A subclass distribution in human parotid salivaOral Microbiology and Immunology.  18:298-301. 2003
2003 Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalisVaccine.  21:4459-4471. 2003
2003 Intranasal immunization of humans with Streptococcus mutans antigensOral Microbiology and Immunology.  18:271-277. 2003
2003 Pneumococcal lipoteichoic acid (LTA) is not as potent as staphylococcal LTA in stimulating Toll-like receptor 2Infection and Immunity.  71:5541-5548. 2003
2003 Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharideJournal of Immunology.  171:717-725. 2003
2003 Role of innate immune factors in the adjuvant activity of monophosphoryl lipid AInfection and Immunity.  71:2498-2507. 2003
2003 Intranasal Immunization with Streptococcus Mutans Antigens: Low dose differentiates responses to soluble versus liposomal antigensOral Microbiology and Immunology.  18:1-7. 2003
2002 Enhanced immunogenicity of a genetic chimeric protein consisting of two virulence antigens of Streptococcus mutans and protection against infectionInfection and Immunity.  70:6779-6787. 2002
2002 Microbial/host interactions: Mechanisms involved in host responses to microbial antigensImmunologic Research.  26:223-234. 2002
2002 Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.Journal of Immunology.  169:1744-1752. 2002
2002 Mechanisms of monophosphoryl lipid A augmentation of host responses to recombinant HagB from Porphyromonas gingivalisInfection and Immunity.  70:3557-3565. 2002
2002 Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipainsInfection and Immunity.  70:2512-2518. 2002
2002 Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferase.Infection and Immunity.  70:1136-1142. 2002
2002 Humans immunized with Streptococcus mutans antigens by mucosal routesJournal of Dental Research.  81:48-52. 2002
2001 Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coliJournal of Immunology.  167:5278-5285. 2001
2001 Effect of attenuated Salmonella enterica serovar Typhimurium expressing a Streptococcus mutans antigen on secondary responses to the cloned protein.Infection and Immunity.  69:6604-6611. 2001
2001 Human salivary immunoglobulin and antigen-specific antibody activity after tonsillectomyOral Microbiology and Immunology.  16:265-269. 2001
2001 Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40 ligand on CD4 + T cellsInfection and Immunity.  69:4486-4492. 2001
2001 Induction of protective immunity against Streptococcus mutans colonization after mucosal immunization with attenuated Salmonella enterica serovar typhimurium expressing an S. mutans adhesin under the control of in vivo-inducible nirB promoterInfection and Immunity.  69:2154-2161. 2001
2001 Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4 + T cellsInfection and Immunity.  69:252-261. 2001
2001 A vaccine against dental caries: An overviewClinical immunotherapeutics.  15:501-508. 2001
2000 Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigen.Infection and Immunity.  68:5509-5516. 2000
2000 Genetic characterization of a Streptococcus mutans LraI family operon and role in virulenceInfection and Immunity.  68:4441-4451. 2000
2000 Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexesInfection and Immunity.  68:1441-1449. 2000
2000 Construction and characterization of a Salmonella enterica serovar typhimurium clone expressing a salivary adhesin of Streptococcus mutans under control of the anaerobically inducible nirB promoterInfection and Immunity.  68:1549-1556. 2000
2000 Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental cariesInfection and Immunity.  68:543-549. 2000
2000 Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigenInfection and Immunity.  68:5509-5516. 2000
2000 Comparative analysis of the mucosal adjuvanticity of the type II heat- labile enterotoxins LT-IIa and LT-IIbInfection and Immunity.  68:281-287. 2000
1999 Protective immunity against Streptococcus mutans infection in mice after intranasal immunization with the glucan-binding region of S. mutans glucosyltransferaseInfection and Immunity.  67:6543-6549. 1999
1999 Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat modelInfection and Immunity.  67:4352-4359. 1999
1999 Interleukin (IL)-1 and Porphyromonas gingivalis lipopolysaccharide stimulation of IL-6 production by fibroblasts derived from healthy or periodontally diseased human gingival tissueJournal of Periodontology.  70:274-282. 1999
1999 Virulence of a spaP mutant of Streptococcus mutans in a gnotobiotic rat modelInfection and Immunity.  67:1201-1206. 1999
1999 A controlled clinical study of the effect of nasal immunization with a Streptococcus mutans antigen alone or incorporated into liposomes on induction of immune responsesInfection and Immunity.  67:618-623. 1999
1999 Current status of a mucosal vaccine against dental cariesOral Microbiology and Immunology.  14:1-20. 1999
1999 Cholera toxin B subunit as an immunomodulator for mucosal vaccine deliveryAdvances in Veterinary Medicine -San Diego-.  41:105-114. 1999
1999 Functional and immunogenic characterization of two cloned regions of Streptococcus mutans glucosyltransferase IInfection and Immunity.  67:810-816. 1999
1999 Secretory Immunity in Defense against Cariogenic Mutans StreptococciCaries Research.  33:4-15. 1999
1998 Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: Evidence for compartmentalization within the common mucosal immune system in humansInfection and Immunity.  66:5630-5635. 1998
1998 Effectiveness of liposomes possessing surface-linked recombinant B subunit of cholera toxin as an oral antigen delivery systemInfection and Immunity.  66:4299-4304. 1998
1998 Induction of protective immune responses against venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccineVaccine.  16:1314-1323. 1998
1998 Inactivation of the gbpA gene of Streptococcus mutans increases virulence and promotes in vivo accumulation of recombinations between the glucosyltransferase B and C genesInfection and Immunity.  66:2180-2185. 1998
1998 Effect of lipopolysaccharide and inflammatory cytokines on interleukin- 6 production by healthy human gingival fibroblastsInfection and Immunity.  66:608-614. 1998
1998 Repetitive adenovirus administration to the parotid gland: Role of immunological barriers and induction of oral toleranceHuman Gene Therapy.  9:305-313. 1998
1998 Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization.Infection and Immunity.  66:1740-1743. 1998
1998 Effect of immune T cells derived from mucosal or systemic tissue on host responses to Porphyromonas gingivalisOral Microbiology and Immunology.  13:73-80. 1998
1997 Current options for vaccine delivery systems by mucosal routesJournal of Controlled Release.  48:243-257. 1997
1997 Effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mononuclear phagocytesInfection and Immunity.  65:3248-3254. 1997
1997 Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H miceInfection and Immunity.  65:2278-2282. 1997
1997 Mucosal immunogenicity of a recombinant Salmonella typhimurium-cloned heterologous antigen in the absence or presence of coexpressed cholera toxin A2 and B subunitsInfection and Immunity.  65:1445-1454. 1997
1997 Nasal immunization of humans with dehydrated liposomes containing Streptococcus mutans antigenOral Microbiology and Immunology.  12:329-335. 1997
1997 Passive Immunization against Dental Plaque Formation in Humans: Effect of a Mouth Rinse Containing Egg Yolk Antibodies (IgY) Specific to Streptococcus mutansCaries Research.  31:268-274. 1997
1997 Profile of cytokine mRNA expression in chronic adult periodontitisJournal of Dental Research.  76:1833-1839. 1997
1997 Quantitative assessment of inflammatory cytokine gene expression in chronic adult periodontitisOral Microbiology and Immunology.  12:336-344. 1997
1997 Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.Behring Institute Mitteilungen.  33-43. 1997
1996 Construction and oral immunogenicity of a Salmonella typhimurium strain expressing a streptococcal adhesin linked to the A2/B subunits of cholera toxinVaccine.  14:1545-1548. 1996
1996 Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunitInfection and Immunity.  64:1272-1283. 1996
1996 Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxinInfection and Immunity.  64:665-667. 1996
1996 Effect of host responses on the pathogenicity of strains of Porphyromonas gingivalisOral Microbiology and Immunology.  11:309-318. 1996
1996 Effect of in vitro passage of healthy human gingival fibroblasts on cellular morphology and cytokine expressionArchives of Oral Biology.  41:263-270. 1996
1996 Host responses induced by co-infection with Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in a murine modelOral Microbiology and Immunology.  11:274-281. 1996
1996 Oral immunization with recombinant Salmonella typhimurium expressing surface protein antigen A (SpaA) of Streptococcus sobrinus: Effects of the Salmonella virulence plasmid on the induction of protective and sustained humoral responses in ratsVaccine.  14:868-878. 1996
1996 Properties of practical oral liposome-Streptococcus mutans glucosyltransferase vaccines for effective induction of caries protectionOral Microbiology and Immunology.  11:172-180. 1996
1995 Conjugation of cholera toxin or its B subunit to liposomes for targeted delivery of antigensJournal of Immunological Methods.  185:31-42. 1995
1995 Sucrose-derived exopolymers have site-dependent roles in Streptococcus mutans-promoted dental decayFEMS Microbiology Letters.  128:327-332. 1995
1995 Oral immunization with recombinant Salmonella typhimurium expressing surface protein antigen A of Streptococcus sobrinus: dose response and induction of protective humoral responses in rats.Infection and Immunity.  63:2004-2011. 1995
1995 Enhancement of protective immune responses to Venezuelan equine encephalitis (VEE) virus with microencapsulated vaccineVaccine.  13:1411-1420. 1995
1995 Generation of monoclonal antibodies to Macaca mulatta (rhesus) IgAJournal of Medical Primatology.  24:74-80. 1995
1995 Induction of salivary IgA responses to Streptococcus mutans antigen I/II after intranasal immunizationAdvances in Experimental Medicine and Biology.  371:1153-1156. 1995
1995 Oral immunization studies with streptococcus mutans and influenza vaccines in rhesus macaque monkeysAdvances in Experimental Medicine and Biology.  371:1423-1429. 1995
1994 Effectiveness of sealed dental prophylaxis angles inoculated with Bacillus stearothermophilus in preventing leakage.Journal of Clinical Dentistry.  5:35-37. 1994
1994 Oral immunization with recombinant Salmonella typhimurium expressing surface protein antigen A of Streptococcus sobrinus: persistence and induction of humoral responses in rats.Infection and Immunity.  62:3162-3171. 1994
1994 Oral immunization of humans with dehydrated liposomes containing Streptococcus mutans glucosyltransferase induces salivary immunoglobulin A2 antibody responsesOral Microbiology and Immunology.  9:146-153. 1994
1993 Role of M protein in pharyngeal colonization by group A streptococci in rats.Infection and Immunity.  61:2277-2283. 1993
1993 Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunitInfection and Immunity.  61:2162-2171. 1993
1993 Protective salivary immunoglobulin A responses against Streptococcus mutans infection after intranasal immunization with S. mutans antigen I/II coupled to the B subunit of cholera toxinInfection and Immunity.  61:1964-1971. 1993
1992 Liposomes and conjugate vaccines for antigen delivery and induction of mucosal immune responsesAdvances in Experimental Medicine and Biology.  327:191-198. 1992
1992 Humoral response to Porphyromonas (Bacteroides) gingivalis in rats: Time course and T-cell dependenceInfection and Immunity.  60:3579-3585. 1992
1991 A method for generating antigen-specific rat T helper cell clonesJournal of Immunological Methods.  138:77-86. 1991
1991 Effect of immune bovine milk on Streptococcus mutans in human dental plaqueArchives of Oral Biology.  36:41-47. 1991
1990 Mucosal and systemic responses to an oral liposome-Streptococcus mutans carbohydrate vaccine in humansRegional immunology.  3:289-296. 1990
1990 Ultrastructural study of liposome uptake by M cells of rat Peyer's patch: An oral vaccine system for delivery of purified antigenRegional immunology.  3:8-16. 1990
1990 Characterization of rat T helper cell clones specific for Bacteroides gingivalis antigenInfection and Immunity.  58:2785-2791. 1990
1990 Development and outlook for a caries vaccineJournal of Dental Research.  1:37-54. 1990
1990 Liposomes containing anti-idiotypic antibodies: An oral vaccine to induce protective secretory immune response specific for pathogens of mucosal surfacesInfection and Immunity.  58:1932-1936. 1990
1990 Low-cariogenicity of the tetrasaccharide nystoseGeneral Pharmacology.  21:175-179. 1990
1989 Characterization of liposome suspensions by flow cytometryJournal of Immunological Methods.  119:135-143. 1989
1989 Liposomes as oral adjuvants.Current Topics in Microbiology and Immunology.  146:51-58. 1989
1988 Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model systemInfection and Immunity.  56:322-330. 1988
1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigensAnnals of allergy.  59:54-59. 1987
1987 Protection of gnotobiotic rats against dental caries by passive immunization with bovine milk antibodies to Streptocococcus mutansInfection and Immunity.  55:2341-2347. 1987
1987 Enteric immunization reveals a T cell network for IgA responses and suggests that humans possess a common mucosal immune systemAntonie van Leeuwenhoek.  53:537-543. 1987
1987 Induction and molecular properties of secretory and serum IgA antibodies specific for environmental antigens.Annals of allergy.  59:54-59. 1987
1987 Streptococcal serotype carbohydrate represents a novel class of type 2 antigen which is T-independentJournal of Immunology.  138:4387-4394. 1987
1987 Structure of the serotype f polysaccharide antigen of Streptococcus mutansCarbohydrate Research.  166:123-131. 1987
1987 IgA antibody-producing cells in peripheral blood after antigen ingestion: Evidence for a common mucosal immune system in humansProceedings of the National Academy of Sciences.  84:2449-2453. 1987
1987 Characterization of liposomes for oral vaccines.Advances in Experimental Medicine and Biology.  216 B:1771-1780. 1987
1987 Haptenated streptococcal antigens elicit either T cell dependent type 1 or T cell-independent type 2 immune responsesImmunobiology.  174:146-161. 1987
1987 IgA subclass responses to lipopolysaccharide in humans.Advances in Experimental Medicine and Biology.  216 B:1199-1205. 1987
1987 Induction of secretory immunity to type 3 Streptococcus pneumoniae by oral immunization.Advances in Experimental Medicine and Biology.  216 B:1765-1770. 1987
1987 Novel oral vaccines: the effectiveness of cloned gene products on inducing secretory immune responses.Advances in Experimental Medicine and Biology.  216 B:1741-1747. 1987
1987 Oral immunization with bacterial antigen induces IgA-secreting cells in peripheral blood in humans.Advances in Experimental Medicine and Biology.  216 B:1709-1719. 1987
1987 Oral vaccines and the secretory immune systemClinical Immunology Newsletter.  8:158-159. 1987
1987 Regulatory T cell networks in the secretory immune system.Advances in Experimental Medicine and Biology.  216 A:45-55. 1987
1987 Type-specific antibodies against group B streptococci in human serum, saliva and vaginal secretions.Advances in Experimental Medicine and Biology.  216 B:995-1003. 1987
1986 Characterization of immune response to oral administration of Streptococcus sobrinus ribosomal preparations in liposomesInfection and Immunity.  54:780-786. 1986
1986 Characterization of the serotype e polysaccharide antigen of Streptococcus mutansMolecular Immunology.  23:141-145. 1986
1986 Independence of macrophage activation and expression of the alleles of the Ity (immunity to typhimurium) locusMicrobial Pathogenesis.  1:33-41. 1986
1986 Salivary immunoglobulin A and serum antibodies to Streptococcus mutans ribosomal preparations in dental caries-free and caries-susceptible human subjectsInfection and Immunity.  51:348-351. 1986
1985 An enzyme-linked immunosorbent assay (ELISA) for detection of Fcα receptors on isotype-specific T cellsJournal of Immunological Methods.  85:269-277. 1985
1985 Relationship between immune system and gram-negative bacteria. III. Functional analysis of human peripheral blood lymphocyte subpopulations separated by cytoadherence with Salmonella minnesota RbClinical and Experimental Immunology.  62:248-255. 1985
1985 Immunoregulation in the rat: Ontogeny of B cell responses to types 1, 2, and T-dependent antigensJournal of Immunology.  134:2839-2846. 1985
1985 Inhibition of plaque and caries formation by a glucan produced by Streptococcus mutans mutant UAB108Infection and Immunity.  50:833-843. 1985
1985 Relationship between immune system and gram-negative bacteria. IV. T lymphocytes from Lps(d) mice possess binding site(s) for Rb SalmonellaJournal of Immunology.  135:3473-3478. 1985
1985 Immunoregulation in the rat: Cellular and molecular requirements for B cell responses to types 1, 2, and T-dependent antigensJournal of Immunology.  134:2236-2246. 1985
1985 Isotype-specific immunoregulation: IgA-binding factors produced by Fcα receptor-positive T cell hybridomas regulate IgA responsesJournal of Experimental Medicine.  161:731-747. 1985
1985 Cell Wall Preparation Consisting of Group A Carbohydrate and Peptidoglycan Moieties from Streptococcus pyogenes Activates Murine B LymphocytesImmunobiology.  170:293-304. 1985
1985 Characterization of monoclonal antibodies to rough Salmonella lipopolysaccharideFederation proceedings.  44. 1985
1985 Chemical properties and immunobiological activities of streptococcal lipoteichoic acidsZentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology.  259:228-243. 1985
1985 Prevention of Streptococcus mutans colonization by salivary IgA antibodiesJournal of Clinical Immunology.  5:55-62. 1985
1985 The possible role of Fcα receptors in T-cell regulation of IgA antibody production in mucosal immune responsesAnnales de l'Institut Pasteur. Immunology.  136:407-411. 1985
1984 LPS regulation of the immune response: Separate mechanisms for murine B cell activation by lipid A (direct) and polysaccharide (macrophage-dependent) derived from Bacteroides LPSJournal of Immunology.  133:2294-2300. 1984
1984 Lack of cross-reactivity of antibodies to ribosomal preparations from Streptococcus mutans with human heart and kidney antigensInfection and Immunity.  46:42-47. 1984
1984 Isotype-specificity of helper T cell clones: Fcα receptors regulate T and B cell collaboration for IgA responsesJournal of Immunology.  133:1087-1089. 1984
1984 Monoclonal antibodies to Salmonella lipopolysaccharide: Anti-O-polysaccharide antibodies protect C3H mice against challenge with virulent Salmonella typhimuriumJournal of Immunology.  133:950-957. 1984
1984 LPS regulation of the immune response: Bacteroides endotoxin induces mitogenic, polyclonal, and antibody responses in classical LPS responsive but not C3H/HeJ miceJournal of Immunology.  133:299-305. 1984
1984 Isotype specificity of helper T cell clones peyer’s patch Th cells preferentially collaborate with mature IgA B cells for IgA responsesJournal of Experimental Medicine.  159:798-811. 1984
1984 Function of anti-Streptococcus mutans antibodies: Anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activityInfection and Immunity.  45:286-289. 1984
1984 Immunoglobulin a in saliva of protein-calorie malnourished hospitalized adultsNutrition Research.  4:33-41. 1984
1984 Lps(d) mice respond to Bacteroides fragilis LPS polysaccharide but not lipid AFederation proceedings.  43. 1984
1984 Mucosal ImmunoregulationMicrobiology and Immunology.  28:261-280. 1984
1984 Mucosal Immunoregulation: Environmental Lipopolysaccharide and GALT T Lymphocytes Regulate the IgA ResponseMicrobiology and Immunology.  28:261-280. 1984
1984 Murine immune responses to Salmonella lipopolysaccharide: Oral administration of whole bacteria to C3H/HeJ mice induces secondary anti-LPS responses, especially to the IgAisotypeJournal of Immunology.  132:1702-1711. 1984
1984 Oral antigen enhances functional Fc receptor+ cells in C3H/HeJ miceFederation proceedings.  43. 1984
1984 Oral immunization with killed salmonella protects mice against intragastric challenge with virulent S. typhimuriumFederation proceedings.  43. 1984
1983 IgA responses in xid mice: Oral antigen primes Peyer's patch cells for in vitro immune responses and secretory antibody productionJournal of Immunology.  131:2616-2622. 1983
1983 In vitro and in vivo complementation of Streptococcus mutans mutants defective in adherenceInfection and Immunity.  42:558-566. 1983
1983 Immunoregulation in the rat: Requirements for in vitro B cell responses to classical TI-1 and TI-2 antigensJournal of Immunology.  131:1131-1137. 1983
1983 Effective immunity to dental caries: Enhancement of salivary anti-Streptococcus mutans antibody responses with oral adjuvantsInfection and Immunity.  40:577-591. 1983
1983 A plaque assay for assessment of immune responses to Streptococcus mutans cell wall carbohydrateJournal of Immunological Methods.  59:381-388. 1983
1983 Effective immunity to dental caries: Gastric intubation of Streptococcus mutans whole cells or cell walls induces protective immunity in gnotobiotic ratsInfection and Immunity.  39:645-654. 1983
1983 Evidence for a mature B cell subpopulation in peyer’s patches of young adult xid miceJournal of Experimental Medicine.  157:789-794. 1983
1983 AUGMENTATION OF IgA RESPONSES AND CARIES IMMUNITY BY ORAL ADJUVANTSAnnals of the New York Academy of Sciences.  409:851-852. 1983
1983 An enzyme-linked immunosorbent assay (ELISA) for quantification of antibodies to Streptococcus mutans surface antigensMolecular Immunology.  20:453-464. 1983
1983 Effective Immunity to Dental Caries: Protection of Gnotobiotic Rats by Local, Immunization with a Ribosomal Preparation from Streptococcus mutansMicrobiology and Immunology.  27:787-800. 1983
1983 IMMUNE REGULATION OF SUPPRESSION IN OFFSPRING OF ORALLY TOLERIZED MICEAnnals of the New York Academy of Sciences.  409:888-889. 1983
1983 IgA HYBRIDOMAS TO CELL‐SURFACE COMPONENTS OF PATHOGENIC BACTERIAAnnals of the New York Academy of Sciences.  409:794-796. 1983
1983 Isolation and Characterization of the Serotype g Carbohydrate Moiety from an Enzyme Lysate of Streptococcus mutans 6715 Cell WallsMicrobiology and Immunology.  27:237-249. 1983
1983 Lymphoid Cell Responses to Bacterial Cell Wall Components: Murine B‐Cell Responses to a Purified Cell Wall Moiety of ActinomycesScandinavian Journal of Immunology.  17:313-322. 1983
1983 MURINE PEYER'S PATCH T‐HELPER CELL CLONES THAT PREFERENTIALLY SUPPORT IgA RESPONSESAnnals of the New York Academy of Sciences.  409:829-830. 1983
1983 Oral adjuvants enhance IgA responses to Streptococcus mutansMolecular Immunology.  20:1009-1018. 1983
1983 THE IgA RESPONSE: INDUCTIVE ASPECTS, REGULATORY CELLS, AND EFFECTOR FUNCTIONSAnnals of the New York Academy of Sciences.  409:48-71. 1983
1982 IgA hybridomas: A method for generation in high numbersJournal of Immunological Methods.  54:259-266. 1982
1982 Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance inductionJournal of Immunology.  129:959-965. 1982
1982 Murine peyer’s patch T cell clones: Characterization of antigen-specific helper T cells for immunoglobulin a responsesJournal of Experimental Medicine.  156:1115-1130. 1982
1982 Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance inductionJournal of Immunology.  128:1992-1998. 1982
1982 An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophagesJournal of Immunological Methods.  48:33-44. 1982
1982 Enhancement of Murine Immune Responses to Orally Administered Haptenated Streptococcus mutansScandinavian Journal of Immunology.  16:455-463. 1982
1982 Enhancement of in Vitro Immune Responses of Murine Peyer's Patch Cultures by Concanavalin A, Muramyl Dipeptide and LipopolysaccharideScandinavian Journal of Immunology.  15:329-339. 1982
1982 In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch.Proceedings of the National Academy of Sciences.  79:596-600. 1982
1982 Lack of oral tolerance in C3H/HeJ miceJournal of Experimental Medicine.  155:605-610. 1982
1982 Novel antigens of oral actinomyces species prepared from a cell wall enzyme lysateJapanese Journal of Medical Science and Biology.  35:171-181. 1982
1981 Lymphoid cell responses to bacterial cell wall components: Polyclonal and immune responses of murine B cells to Streptococcus mutans carbohydrate antigensJournal of Immunology.  127:2106-2112. 1981
1981 Oral ecology and virulence of Lactobacillus casei and Streptococcus mutans in gnotobiotic ratsInfection and Immunity.  33:690-696. 1981
1981 Lymphoid cell responses to bacterial cell wall components: Mitogenic responses of murine B cells to Streptococcus mutans carbohydrate antigensJournal of Immunology.  126:2279-2283. 1981
1981 Virulence of Streptococcus mutans: Characterization of a serotype g antigen-defective mutant and its revertantsInfection and Immunity.  31:151-159. 1981
1981 LPS regulation of the immune response: Suppression of immune responses to orally administered T-independent antigenJournal of Immunology.  127:1052-1057. 1981
1981 Streptococcus mutans serotype g carbohydrate antigen is a B-cell mitogenImmunology Letters.  3:129-131. 1981
1980 Molecular-cellular interactions in the secretory IgA response.Journal of the Reticuloendothelial Society.  28. 1980
1980 Lipopolysaccharide (LPS) regulation of the immune response: T lymphocytes from normal mice suppress mitogenic and immunogenic responses to LPSJournal of Immunology.  124:1603-1611. 1980
1980 Virulence of Streptococcus mutans: Immunochemical characterization of a serotype g-defective mutant (C307)Infection and Immunity.  27:697-699. 1980
1980 Virulence of Streptococcus mutans: In vivo reversion of a low-virulence mutant results in partial displacement and pathogenesisInfection and Immunity.  27:1003-1011. 1980
1980 Virulence of Streptococcus mutans: Restoration of pathogenesis of a glucosyltransferase-defective mutant (C4)Infection and Immunity.  27:915-921. 1980
1980 Cellular basis for elevated IgA responses in C3H/HeJ miceJournal of Immunology.  125:732-737. 1980
1980 Inheritance of LPS nonresponsiveness and elevated splenic IgA immune responses in mice orally immunized with heterologous erythrocytesJournal of Immunology.  125:2220-2224. 1980
1980 Lipopolysaccharide regulation of the immune response: Comparison of responses to LPS in germfree, Escherichia coli-monoassociated and conventional miceJournal of Immunology.  124:36-41. 1980
1980 The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxinJournal of Infectious Diseases.  141:55-63. 1980
1979 The mechanism of lipopolysaccharide induced adjuvanticity: Cellular and molecular basisToxicon.  17:120. 1979
1978 Concept of the local and common mucosal immune response.Advances in Experimental Medicine and Biology.  107:185-192. 1978
1978 Effective immunity to dental caries: selective induction of secretory immunity by oral administration of Streptococcus mutans in rodents.Advances in Experimental Medicine and Biology.  107:261-269. 1978
1978 Induction of secretory antibodies in humans following ingestion of Streptococcus mutans.Advances in Experimental Medicine and Biology.  107:177-184. 1978
1978 Use of mutants in the elucidation of virulence of Streptococcus mutans.Advances in Experimental Medicine and Biology.  107:673-683. 1978
1978 Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to ratsInfection and Immunity.  19:217-224. 1978
1978 Selective induction of an immune response in human external secretions by ingestion of bacterial antigen.Journal of Clinical Investigation.  61:731-737. 1978
1977 Effective immunity to dental caries: passive transfer to rats of antibodies to Streptococcus mutans elicits protectionInfection and Immunity.  17:644-650. 1977
1977 A Plastic Intraoral Device for the Collection of Human Parotid SalivaJournal of Dental Research.  56:728-733. 1977
1977 Low sucrose levels promote extensive Streptococcus mutans induced dental cariesInfection and Immunity.  16:712-714. 1977
1977 Virulence of Streptococcus mutans: An Antibiotic-Suppressed Rat Model for Studies of PathogenesisJournal of Dental Research.  56:205-211. 1977
1977 Virulence of Streptococcus mutans: cariogenicity of S. mutans in adult gnotobiotic ratsInfection and Immunity.  15:466-471. 1977
1976 Effective immunity to dental caries: protection of malnourished rats by local injection of Streptococcus mutansInfection and Immunity.  13:782-789. 1976
1976 Effective immunity to dental caries: studies of active and passive immunity to Streptococcus mutans in malnourished ratsJournal of Dental Research.  55. 1976
1976 Caries immunization through ingestion of Streptococcus mutans.Dental Abstracts.  21:522-523. 1976
1976 Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunityScience.  192:1238-1240. 1976
1976 Oral vaccination of rats with Streptococcus mutans: induction of secretory antibodies and reduced cariesJournal of Dental Research.  55. 1976
1975 Virulence of Streptococcus mutans: a sensitive method for evaluating cariogenicity in young gnotobiotic ratsInfection and Immunity.  12:69-75. 1975
1975 Effective immunity to dental caries: protection of gnotobiotic rats by local immunization with Streptococcus mutansJournal of Immunology.  114. 1975
1975 Rat immunoglobulins in serum and secretions: Purification of rat IgM, IgA, and IgG and their quantitation in serum, colostrum, milk and salivaImmunochemistry.  12:817-823. 1975
1974 Complement levels in malnourished animals: measurement of complement in rat milk during the period of lactationJournal of the Reticuloendothelial Society.  16:213-219. 1974
1974 Complement levels in malnourished animals: quantification of serum complement in rat dams and their offspringJournal of the Reticuloendothelial Society.  16:204-212. 1974

Chapter

Year Title Altmetric
2005 Antigen delivery systems i: Nonliving microparticles, liposomes, and immune stimulating complexes (iscoms).  987-1007. 2005

Investigator On

  • Bacterial Second Messenger Mediated Virulence Regulation in Streptococcus Mutans  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2019 - 2024
  • Small Molecule Inhibitors of Carciogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • Glycosylation and Biogenesis of Streptococcal Adhesins  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2023
  • Role of Osteoclast Precursors in Periodontal Bone Loss  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2017 - 2022
  • Development of Structurally Defined Synthetic Vaccine Adjuvants  awarded by National Institute of General Medical Sciences/NIH/DHHS 2017 - 2020
  • Development of Structurally Defined QS-17/18-Based Vaccine Adjuvants  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2019
  • Small Molecule Inhibitors of Cariogenic Biofilms  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2018
  • Glycosylation and Function of an Oral Streptococcal Adhesion  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2018
  • S. Mutans GTF - A Novel Target for Dental Caries Prevention  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2015 - 2017
  • Molecular Mechanisms of the Innate Regulation of Osteoclastogenesis  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2015
  • Biosynthesis and Function of Treponema Denticola Lipooligosaccharide  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2012 - 2015
  • Development of Small Molecules That Inhibit and Disperse Carciogenic Biofilms  awarded by International Association for Dental Research 2011 - 2014
  • Determination of the SAG Binding Motif on AgI/II of Streptococcous Mutans  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2014
  • The Role of PcpA in the Mechanism of Virulence and Protective Immunity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Alabama at Birmingham 1976
  • Master of Sciences or Mathematics in Biology / Biological Sciences, Illinois State University 1968
  • Bachelor of Science or Mathematics in Biology / Biological Sciences, Illinois State University 1967
  • Full Name

  • Suzanne Michalek