Selected Publications

Academic Article

Year Title Altmetric
2019 Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared FunctionsCell.  177:478-491.e20. 2019
2017 Kctd13 deletion reduces synaptic transmission via increased RhoANature.  551:227-231. 2017
2016 CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineeringNucleic Acids Research.  44:W272-W276. 2016
2016 Internal guide RNA interactions interfere with Cas9-mediated cleavageNature Communications.  7. 2016
2016 Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish DevelopmentCell Reports.  15:707-714. 2016
2014 Massively parallel determination and modeling of endonuclease substrate specificityNucleic Acids Research.  42:13839-13852. 2014
2014 Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAsPLoS ONE.  9. 2014
2014 Reprogramming homing endonuclease specificity through computational design and directed evolutionNucleic Acids Research.  42:2564-2576. 2014
2014 Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locusNucleic Acids Research.  42:6463-6475. 2014
2012 Improved modeling of side-chain-base interactions and plasticity in protein-dna interface designJournal of Molecular Biology.  419:255-274. 2012
2011 Mining endonuclease cleavage determinants in genomic sequence dataJournal of Biological Chemistry.  286:32617-32627. 2011
2011 A synthetic homing endonuclease-based gene drive system in the human malaria mosquitoNature.  473:212-215. 2011
2009 Exploitation of binding energy for catalysis and designNature.  461:1300-1304. 2009
2007 Mechanistic study of competitive sp3-sp3 and sp 2-sp3 carbon-carbon reductive elimination from a platinum (IV) center and the isolation of a C-C agostic complexJournal of the American Chemical Society.  129:9538-9539. 2007


Year Title Altmetric
2016 Computational design of DNA-binding proteins.  265-283. 2016
2014 Redesigning the specificity of protein-DNA interactions with rosetta.  265-282. 2014

Full Name

  • Summer Thyme