Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase4/6 degradation and inhibits melanoma proliferationJournal of Biological Chemistry.  102013-102013. 2022
2022 FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradationCardiovascular Research.  118:1150-1163. 2022
2022 LED Light-Induced ROS Differentially Regulates Focal Adhesion Kinase Activity in HaCaT Cell ViabilityCurrent Issues in Molecular Biology.  44:1235-1246. 2022
2022 Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathyJournal of Biological Chemistry.  298. 2022
2021 Fak activation promotes smc dedifferentiation via increased dna methylation in contractile genesCirculation Research.  129:E215-E233. 2021
2021 SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activityNature Communications.  12. 2021
2021 EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition 2021
2021 SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemiaCancer Gene Therapy.  28:1000-1015. 2021
2021 Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB ActivationInflammation.  44:1130-1144. 2021
2020 Targeting focal adhesion kinase in cancer cells and the tumor microenvironment 2020
2020 FAK Family Kinases in Vascular Diseases.International Journal of Molecular Sciences.  21. 2020
2019 FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammationScientific Reports.  9. 2019
2019 Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cellsJournal of Biological Chemistry.  294:11213-11224. 2019
2019 SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypesKidney International.  95:1494-1504. 2019
2019 FAK inhibition reduces metastasis of α4 integrin-expressing melanoma to lymph nodes by targeting lymphatic VCAM-1 expressionBiochemical and Biophysical Research Communications.  509:1034-1040. 2019
2019 A quantitative method to measure low levels of ros in nonphagocytic cells by using a chemiluminescent imaging systemOxidative Medicine and Cellular Longevity.  2019. 2019
2019 Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcriptionCirculation Research.  125:152-166. 2019
2016 De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability SyndromeAmerican Journal of Human Genetics.  99:711-719. 2016
2016 Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation 2016
2016 SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated GenesMolecular Cell.  61:859-873. 2016
2016 FAK and Pyk2 in diseaseFrontiers in Biology.  11. 2016
2015 Understanding the Roles of FAK in Cancer: Inhibitors, Genetic Models, and New Insights 2015
2013 Nuclear FAK: A new mode of gene regulation from cellular adhesionsMolecules and Cells.  36:1-6. 2013
2012 Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cellsJournal of Cell Science.  125:5960-5973. 2012
2012 Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression 2012
2012 Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrinsPLoS ONE.  7. 2012
2012 EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1PLoS ONE.  7. 2012
2012 FAK promotes recruitment of talin to nascent adhesions to control cell motility 2012
2012 VEGF-Induced Vascular Permeability Is Mediated by FAKDevelopmental Cell.  22:146-157. 2012
2012 FAK promotes recruitment of talin to nascent adhesions to control cell motility 2012
2011 P190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinaseCancer Research.  71:360-370. 2011
2010 Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferationJournal of Biological Chemistry.  285:21526-21536. 2010
2010 PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environmentsCancer Biology and Therapy.  9:762-775. 2010
2010 Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survivalJournal of Biological Chemistry.  285:1743-1753. 2010
2010 Erratum to "A novel strong promoter of the groEx operon of symbiotic bacteria in Amoeba proteus" [Gene 148 (1994) 43-49] (DOI:10.1016/0378-1119(94)90231-3)Gene.  449:118. 2010
2009 Erratum: A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells (Journal of Cell Science vol. 122 (1852-1862))Journal of Cell Science.  122:3005. 2009
2009 A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cellsJournal of Cell Science.  122:1852-1862. 2009
2008 FERM control of FAK function: Implications for cancer therapyCell Cycle.  7:2306-2314. 2008
2008 FAK nuclear export signal sequencesFEBS Letters.  582:2402-2406. 2008
2008 Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK 2008
2008 Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motilityOncogene.  27:1439-1448. 2008
2008 Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 DegradationMolecular Cell.  29:9-22. 2008
2008 PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility 2008
2007 Tumor necrosis factor-α stimulates focal adhesion kinase activity required for mitogen-activated kinase-associated interleukin 6 expressionJournal of Biological Chemistry.  282:17450-17459. 2007
2007 Focal adhesion kinase controls ph-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localizationAmerican Journal of Pathology.  170:2055-2067. 2007
2006 Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumorsOncogene.  25:5969-5984. 2006
2006 Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor modelOncogene.  25:4429-4440. 2006
2006 Analyzing FAK and Pyk2 in early integrin signaling events. 2006
2005 Integrin α4β1 promotes focal adhesion kinase-independent cell motility via α4 cytoplasmic domain-specific activation of c-SrcMolecular and Cellular Biology.  25:9700-9712. 2005
2004 Calmodulin binding to the Fas death domain: Regulation by Fas activationJournal of Biological Chemistry.  279:5661-5666. 2004
2003 Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase Cα (PKCα) increases focal adhesion localization of PKCαJournal of Biological Chemistry.  278:13795-13802. 2003
2002 Regulation of inositol phospholipid binding and signaling through syndecan-4Journal of Biological Chemistry.  277:49296-49303. 2002
2001 Heat Shock Complementation and Thermotolerance Increase in E. coli by groEx of Symbiotic Bacteria in Amoeba proteus 2001
1998 Syndecan-4 proteoglycan cytoplasmic domain and phosphatidylinositol 4,5- bisphosphate coordinately regulate protein kinase C activityJournal of Biological Chemistry.  273:10624-10629. 1998
1996 Characterization of promoter sequences for strong expression of groEx in Escherichia coli 1996
1994 A novel strong promoter of the groEx operon of symbiotic bacteria in Amoeba proteusGene.  148:43-49. 1994

Full Name

  • Ssang-Taek Lim