Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model.  Scientific Reports.  7. 2017
2014 Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.  Journal of Medicinal Chemistry.  57:5370-5380. 2014
2014 Defining the communication between agonist and coactivator binding in the retinoid x receptor α ligand binding domain.  Journal of Biological Chemistry.  289:814-826. 2014
2014 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention.  Bioorganic and Medicinal Chemistry.  22:178-185. 2014
2009 Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.  Cancer Biology and Therapy.  8:1840-1851. 2009
2009 Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.  Cancer Biology and Therapy.  8:285-294. 2009
2009 Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid.  Cancer Biology and Therapy.  8:289-298. 2009
2008 Bad things happen in the basal layer KLF4 and squamous cell carcinoma.  Cancer Biology and Therapy.  7:783-785. 2008
2007 Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β-catenin.  Oncogene.  26:4489-4498. 2007
2006 Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation.  Oncogene.  25:609-621. 2006
2006 Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer.  Cancer Biology and Therapy.  5:674-683. 2006
2005 Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia.  Oncogene.  24:1491-1500. 2005
2005 KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia.  Cancer Biology and Therapy.  4:1401-1408. 2005
2004 Nuclear Localization of KLF4 Is Associated with An Aggressive Phenotype in Early-Stage Breast Cancer.  Clinical Cancer Research.  10:2709-2719. 2004
2001 Transcription of the Schizosaccharomyces pombe U2 gene in vivo and in vitro is directed by two essential promoter elements.  Nucleic Acids Research.  29:2003-2011. 2001
2000 Alternatively spliced hBRF variants function at different RNA polymerase III promoters 2000
1999 Pac1p, an RNAse III homolog, is required for formation of the 3' end of U2 snRNA in Schizosaccharomyces pombe.  RNA.  5:1083-1098. 1999
1999 Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: Transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF 1999
1996 Monoclonal antibodies directed against the amino-terminal domain of human TBP cross-react with TBP from other species.  Hybridoma.  15:55-68. 1996
1993 Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE..  Genes and Development.  7:1535-1548. 1993
1992 A TBP complex essential for transcription from TATA-less but not TATA-containing RNA polymerase III promoters is part of the TFIIB fraction.  Cell.  71:1029-1040. 1992
1991 The cloned RNA polymerase II transcription factor IID selects RNA polymerase III to transcribe the human U6 gene in vitro..  Genes and Development.  5:1477-1489. 1991
1990 U3 snRNPs and nucleolar development during oocyte maturation, fertilization and early embryogenesis in the mouse: U3 snRNA and snRNPs are not regulated coordinate with other snRNAs and snRNPs.  Developmental Biology.  138:247-255. 1990
1990 Cis-acting elements required for RNA polymerase II and III transcription in the human U2 and U6 snRNA promoters.  Nucleic Acids Research.  18:2891-2899. 1990
1990 Transcription of the human U2 and U6 RNA genes 1990
1989 A 7 bp mutation converts a human RNA polymerase II snRNA promoter into an RNA polymerase III promoter.  Cell.  58:55-67. 1989
1988 Localization and expression of U1 RNA in early mouse embryo development.  Developmental Biology.  127:349-361. 1988
1988 Mapping and gene order of U1 small nuclear RNA, endogenous viralenv sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3.  Somatic Cell and Molecular Genetics.  14:133-142. 1988
1987 Synthesis of U1 RNA in isolated mouse cell nuclei: initiation and 3'-end formation.  Molecular and Cellular Biology.  7:4290-4296. 1987
1987 A mouse Ulb-2 gene with extensive sequence similarity to a rat Ula gene for 670 nucleotides 5′ to the gene.  Nucleic Acids Research.  15:3622-3622. 1987
1985 Expression of a mouse U1b gene in mouse L cells.  Gene.  36:311-319. 1985
1983 Isolation and characterization of two linked mouse U1b small nuclear RNA genes.  Nucleic Acids Research.  11:6255-6270. 1983

Education And Training

  • Doctor of Philosophy in Chemistry, Florida State University 1987

    • Full Name

  • Susan Ruppert