Positions

Overview

  • Dr. Prabhu received a BS degree in Science from Penn State University and his MD degree from Jefferson Medical College in Philadelphia. He did internal medicine residency and a basic research fellowship at the University of Pittsburgh and cardiovascular disease fellowship at the University of Texas Health Science Center at San Antonio. He was a cardiology faculty there as well as at the University of Louisville, before his arrival to UAB as Director of the Division of Cardiovascular Disease. At UAB, he is also Director of the Comprehensive Cardiovascular Center. Dr. Prabhu serves on the Editorial Board of several cardiovascular journals. He is a member of the American Society for Clinical Investigation.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Risk of Major Adverse Cardiovascular Events and Major Hemorrhage Among White and Black Patients Undergoing Percutaneous Coronary InterventionJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  8:e012874. 2019
    2019 Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical TrialCirculation Research.  125:957-968. 2019
    2019 Race-based demographic, anthropometric and clinical correlates of N-terminal-pro B-type natriuretic peptideInternational Journal of Cardiology.  286:145-151. 2019
    2019 Response by Bansal et al to Letter Regarding Article, "dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy"Circulation.  139:E1035-E1036. 2019
    2019 Impact of medical therapy for cardiovascular disease on left ventricular diastolic properties and remodelingInternational Journal of Cardiology: Heart and Vasculature.  23. 2019
    2019 Role of left ventricle deformation analysis in stress echocardiography for significant coronary artery disease detection: A diagnostic study meta-analysisEchocardiography.  36:1084-1094. 2019
    2019 Cardiovascular Events and Hospital Deaths Among Patients With Severe SepsisAmerican Journal of Cardiology.  123:1406-1413. 2019
    2019 HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injuryJournal of Molecular and Cellular Cardiology.  130:36-48. 2019
    2019 Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture modelThe Journal of heart transplantation.  38:456-465. 2019
    2019 Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in miceRedox Biology.  21. 2019
    2019 Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic CardiomyopathyCirculation.  139:206-221. 2019
    2019 Convergences of Life Sciences and Engineering in Understanding and Treating Heart FailureCirculation Research.  124:161-169. 2019
    2019 Intracellular metabolism analysis of Clostridium cellulovorans via modeling integrating proteomics, metabolomics and fermentationProcess Biochemistry2019
    2019 Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDSJCI insight.  4. 2019
    2018 Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarctionJournal of Molecular and Cellular Cardiology.  118:70-80. 2018
    2018 CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure OverloadJACC: Basic to Translational Science.  3:230-244. 2018
    2018 Effect of NT-proBNP–Guided Therapy on All-Cause Mortality in Chronic Heart Failure With Reduced Ejection FractionJournal of the American College of Cardiology.  71:951-952. 2018
    2018 Racial differences in plasma levels of n-Terminal pro-b-Type natriuretic peptide and outcomes the reasons for geographic and racial differences in stroke (regards) studyJAMA Cardiology.  3:11-17. 2018
    2018 Refractory hypertension is not attributable to intravascular fluid retention as determined by intracardiac volumesHypertension.  72:343-349. 2018
    2018 THE CARDIOSPLENIC AXIS IS ESSENTIAL FOR THE PATHOGENESIS OF ISCHEMIC HEART FAILURETransactions- American Clinical and Climatological Association.  129:202-214. 2018
    2018 The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heartJournal of Molecular and Cellular Cardiology.  114:105-115. 2018
    2017 Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction HealingScientific Reports.  7. 2017
    2017 Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue EngineeringJournal of the American College of Cardiology.  70:766-775. 2017
    2017 Ticagrelor and Eptifibatide Bolus Versus Ticagrelor and Eptifibatide Bolus With 2-Hour Infusion in High-Risk Acute Coronary Syndromes Patients Undergoing Early Percutaneous Coronary InterventionJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  6. 2017
    2017 Continuous-Flow Left Ventricular Assist Device Support Improves Myocardial Supply:Demand in Chronic Heart FailureAnnals of Biomedical Engineering.  45:1475-1486. 2017
    2017 Immunomodulation is the key to cardiac repairCirculation Research.  120:1530-1532. 2017
    2017 Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophyBasic Research in Cardiology.  112. 2017
    2017 Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failureCirculation: Heart Failure.  10. 2017
    2017 Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failureBasic Research in Cardiology.  112. 2017
    2017 Myocardial ischemia/reperfusion impairs neurogenesis and hippocampal-dependent learning and memoryBrain, Behavior, and Immunity.  61:266-273. 2017
    2017 Lack of evidence of lower 30-day all-cause readmission in Medicare beneficiaries with heart failure and reduced ejection fraction discharged on spironolactoneInternational Journal of Cardiology.  227:462-466. 2017
    2017 Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutationJournal of Molecular and Cellular Cardiology.  102:83-93. 2017
    2017 Interaction of 12/15-lipoxygenase with fatty acids alters the leukocyte kinetics leading to improved postmyocardial infarction healingAJP - Heart and Circulatory Physiology.  313:H89-H102. 2017
    2017 Mononuclear phagocytes are dispensable for cardiac remodeling in established pressure-overload heart failurePLoS ONE.  12. 2017
    2016 Altered myocardial metabolic adaptation to increased fatty acid availability in cardiomyocyte-specific CLOCK mutant miceBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1861:1579-1595. 2016
    2016 Renin-Angiotensin System Inhibition and Lower 30-Day All-Cause Readmission in Medicare Beneficiaries with Heart FailureAmerican Journal of Medicine.  129:1067-1073. 2016
    2016 Effect of Left Ventricular Systolic Dysfunction on Response to WarfarinAmerican Journal of Cardiology.  118:232-236. 2016
    2016 The biological basis for cardiac repair after myocardial infarctionCirculation Research.  119:91-112. 2016
    2016 Acute metabolic influences on the natriuretic peptide system in humansJournal of the American College of Cardiology.  67:804-812. 2016
    2016 Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarctionAging.  8:2611-2634. 2016
    2016 Heme oxygenase-1 regulates mitochondrial quality control in the heart.JCI insight.  1:e85817. 2016
    2016 TNF receptor signaling inhibits cardiomyogenic differentiation of cardiac stem cells and promotes a neuroadrenergic-like fateAJP - Heart and Circulatory Physiology.  311:H1189-H1201. 2016
    2015 O-GlcNAcylation negatively regulates cardiomyogenic fate in adult mouse cardiac mesenchymal stromal cellsPLoS ONE.  10. 2015
    2015 Residential Proximity to Major Roadways Is Associated with Increased Levels of AC133+ Circulating Angiogenic CellsArteriosclerosis, Thrombosis, and Vascular Biology.  35:2468-2477. 2015
    2015 Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion InjuryCirculation Research.  117:437-449. 2015
    2015 Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular functionJournal of Molecular and Cellular Cardiology.  84:24-35. 2015
    2015 Glutathione S-transferase P protects against cyclophosphamide-induced cardiotoxicity in miceToxicology and Applied Pharmacology.  285:136-148. 2015
    2015 Pretransplant coagulopathy and in-hospital outcomes among heart transplant recipients: A propensity-matched nationwide inpatient sample studyClinical Cardiology.  38:300-308. 2015
    2015 Beta-blocker use and 30-day all-cause readmission in medicare beneficiaries with systolic heart failureAmerican Journal of Medicine.  128:715-721. 2015
    2015 Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammationAJP - Heart and Circulatory Physiology.  309:H1827-H1836. 2015
    2015 Characteristics and outcomes of patients with advanced chronic systolic heart failure receiving care at the veterans affairs versus other hospitals insights from the Beta-blocker Evaluation of Survival Trial (BEST)Circulation: Heart Failure.  8:17-24. 2015
    2015 Reply: Upgrade Ambulatory Extra-Aortic Counterpulsation to Full-Support LVADJACC: Heart Failure.  3:343-344. 2015
    2014 Impact of atrial fibrillation and heart failure, independent of each other and in combination, on mortality in community-dwelling older adultsAmerican Journal of Cardiology.  114:909-913. 2014
    2014 Spironolactone use and higher hospital readmission for medicare beneficiaries with heart failure, left ventricular ejection fraction <45%, and estimated glomerular filtration rate <45 ml/min/1.73 m2American Journal of Cardiology.  114:79-82. 2014
    2014 Inhibiting Na+/K+ ATPase can impair mitochondrial energetics and induce abnormal Ca2+ cycling and automaticity in guinea pig cardiomyocytesPLoS ONE.  9. 2014
    2014 Digoxin and 30-day all-cause hospital admission in older patients with chronic diastolic heart failureAmerican Journal of Medicine.  127:132-139. 2014
    2014 Acrolein exposure is associated with increased cardiovascular disease riskJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  3. 2014
    2014 Ambulatory extra-aortic counterpulsation in patients with moderate to severe chronic heart failureJACC: Heart Failure.  2:526-533. 2014
    2014 Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarctionSTEM CELLS.  32:2502-2515. 2014
    2014 Impact of atrial fibrillation and heart failure, independent of each other and in combination, on mortality in community-dwelling older adults.American Journal of Cardiology.  114:909-913. 2014
    2014 Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarctionBasic Research in Cardiology.  109. 2014
    2014 It takes two to tango: Monocyte and macrophage duality in the infarcted heartCirculation Research.  114:1558-1560. 2014
    2014 Metabolomic analysis of pressure-overloaded and infarcted mouse heartsCirculation: Heart Failure.  7:634-642. 2014
    2014 Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure critical importance of the cardiosplenic axisCirculation Research.  114:266-282. 2014
    2013 Bovine Model of Chronic Ischemic Cardiomyopathy: Implications for Ventricular Assist Device ResearchArtificial Organs.  37. 2013
    2013 Cardiac immune cell remodeling after myocardial infarctionJournal of Molecular and Cellular Cardiology.  62:142-143. 2013
    2013 Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinaseLaboratory Investigation.  93:868-879. 2013
    2013 Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cellsSTEM CELLS.  31:765-775. 2013
    2013 H2S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthaseCirculation.  127:1116-1127. 2013
    2012 Reply to the editorJournal of Thoracic and Cardiovascular Surgery.  144:1531-1533. 2012
    2012 Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusionBasic Research in Cardiology.  107. 2012
    2012 Mechanism of myocardial ischemia with an anomalous left coronary artery from the right sinus of ValsalvaJournal of Thoracic and Cardiovascular Surgery.  144:402-408. 2012
    2012 O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophyAJP - Heart and Circulatory Physiology.  302. 2012
    2012 Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase c/nicotinamide adenine dinucleotide phosphate oxidase-dependent mannerJournal of the American College of Cardiology.  59:1477-1486. 2012
    2012 Statistical Analysis of Repeated MicroRNA High-Throughput Data with Application to Human Heart Failure: A Review of Methodology.Open Access Medical Statistics.  2012:21-31. 2012
    2012 Animal models of heart failure a scientific statement from the American Heart AssociationCirculation Research.  111:131-150. 2012
    2012 Direct measurement of blood flow in microvessels grown in Matrigel in vivoJournal of Surgical Research.  172. 2012
    2011 Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathyAJP - Heart and Circulatory Physiology.  301. 2011
    2011 Tumor necrosis factor receptor 2 signaling limits β-adrenergic receptor-mediated cardiac hypertrophy in vivoBasic Research in Cardiology.  106:1193-1205. 2011
    2011 Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophyJournal of Molecular and Cellular Cardiology.  50:928-938. 2011
    2011 Heart transplant vs left ventricular assist device in heart transplant-eligible patientsAnnals of Thoracic Surgery.  91:1330-1334. 2011
    2011 Endothelial cell culture model for replication of physiological profiles of pressure, flow, stretch, and shear stress in vitroAnalytical Chemistry.  83:3170-3177. 2011
    2011 Bovine model of doxorubicin-induced cardiomyopathyJournal of Biomedicine and Biotechnology.  2011. 2011
    2011 Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failureCardiovascular Research.  89:129-138. 2011
    2011 Endothelial cell culture model of carotid artery atherosclerosis.Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.  186-189. 2011
    2011 Environmental pollutants and heart failureIssues in Toxicology.  177-197. 2011
    2011 Microfluidic endothelial cell culture model to replicate disturbed flow conditions seen in atherosclerosis susceptible regionsBiomicrofluidics.  5. 2011
    2011 Mitral valve prolapse after long-term mechanical ventricular unloadingThe Journal of heart transplantation.  30:1067-1068. 2011
    2011 Response to Letter to the Editor: A Novel Subcutaneous Counterpulsation Device: Acute Hemodynamic Efficacy During Pharmacologically Induced Hypertension, Hypotension, and Heart FailureArtificial Organs.  35:93-95. 2011
    2010 O-linked β-N-acetylglucosamine transferase is indispensable in the failing heartProceedings of the National Academy of Sciences.  107:17797-17802. 2010
    2010 Chronic AMD3100 antagonism of SDF-1α-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarctionJournal of Molecular and Cellular Cardiology.  49:587-597. 2010
    2010 EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-ΚB andMKK7/JNK/AP-1 signalingJournal of Molecular and Cellular Cardiology.  49:655-663. 2010
    2010 Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-κB activationAJP - Heart and Circulatory Physiology.  299. 2010
    2010 Microfluidic Cardiac Cell Culture Model (μCCCM)Analytical Chemistry.  82:7581-7587. 2010
    2010 Hemodynamic responses to continuous versus pulsatile mechanical unloading of the failing left ventricleASAIO Journal.  56:410-416. 2010
    2010 Mitochondrial dysfunction may explain the cardiomyopathy of chronic iron overloadFree Radical Biology and Medicine.  49:401-407. 2010
    2010 Erythropoietin and ventricular remodelling: A VEGF-dependent neovascularityCardiovascular Research.  87:6-7. 2010
    2010 Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heartCirculation.  121:1912-1925. 2010
    2010 WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte deathCellular Signalling.  22:809-820. 2010
    2010 A novel subcutaneous counterpulsation device: Acute hemodynamic efficacy during pharmacologically induced hypertension, hypotension, and heart failureArtificial Organs.  34:537-545. 2010
    2009 Microfluidic cardiac circulation model (μCCM) for functional cardiomyocyte studiesProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009.  1060-1063. 2009
    2009 O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte deathAJP - Heart and Circulatory Physiology.  297. 2009
    2009 Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injuryJournal of Biological Chemistry.  284:7853-7865. 2009
    2009 Divergent tumor necrosis factor receptor-related remodeling responses in heart failure:Role of nuclear factor-κB and inflammatory activationCirculation.  119:1386-1397. 2009
    2009 Intraoperative Evaluation of the HeartMate II Flow EstimatorThe Journal of heart transplantation.  28:39-43. 2009
    2008 Human, Bovine and Porcine Systematic Vascular Input Impedances Are Not Equivalent: Implications for Device Testing and Xenotransplantation in Heart FailureThe Journal of heart transplantation.  27:1340-1347. 2008
    2008 Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transitionCirculation.  118:1970-1978. 2008
    2008 Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac functionASAIO Journal.  54:578-584. 2008
    2008 Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-κB/PTEN suppressionJournal of Biological Chemistry.  283:24889-24898. 2008
    2008 Metallothionein Suppresses Angiotensin II-Induced Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation, Nitrosative Stress, Apoptosis, and Pathological Remodeling in the Diabetic HeartJournal of the American College of Cardiology.  52:655-666. 2008
    2008 Postnatal intermittent hypoxia and developmental programming of hypertension in spontaneously hypertensive Rats: The role of reactive oxygen species and L-Ca 2+ channelsHypertension.  52:156-162. 2008
    2008 Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotectionJournal of Molecular and Cellular Cardiology.  44:1016-1022. 2008
    2008 Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblastsAJP - Heart and Circulatory Physiology.  294. 2008
    2008 A True Emergency?American Journal of Medicine.  121:290-292. 2008
    2007 Mechanisms of acrolein-induced myocardial dysfunction: Implications for environmental and endogenous aldehyde exposureAJP - Heart and Circulatory Physiology.  293. 2007
    2007 Diabetic cardiomyopathy in OVE26 mice shows mitochondrial ROS production and divergence between in vivo and in vitro contractilityReview of Diabetic Studies.  4:159-168. 2007
    2007 Downregulation of CuZn-superoxide dismutase contributes to β-adrenergic receptor-mediated oxidative stress in the heartCardiovascular Research.  74:445-455. 2007
    2007 Altered left ventricular-arterial coupling precedes pump dysfunction in early heart failureHeart and Vessels.  22:170-177. 2007
    2007 Vascular pulsatility in patients with a pulsatile- or continuous-flow ventricular assist deviceJournal of Thoracic and Cardiovascular Surgery.  133:517-524. 2007
    2006 Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular functionCirculation Research.  98:1098-1105. 2006
    2006 Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementationCirculation.  113:544-554. 2006
    2006 Prolonged oxidative stress inverts the cardiac force-frequency relation: Role of altered calcium handling and myofilament calcium responsivenessJournal of Molecular and Cellular Cardiology.  40:64-75. 2006
    2005 Allopurinol and heart failure: A new use for an old drug?Journal of Molecular and Cellular Cardiology.  39:407-409. 2005
    2005 Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac functionProceedings of the National Academy of Sciences.  102:3766-3771. 2005
    2005 Post-infarction ventricular remodeling: An array of molecular eventsJournal of Molecular and Cellular Cardiology.  38:547-550. 2005
    2004 Cytokine-induced modulation of cardiac functionCirculation Research.  95:1140-1153. 2004
    2004 Cardiac functional analysis by electrocardiography, echocardiography and in situ hemodynamics in streptozotocin-induced diabetic miceJournal of Health Science -Tokyo-.  50:356-365. 2004
    2004 β-Adrenergic stimulation induces interleukin-18 expression via β2-AR, PI3K, Akt, IKK, and NF-κBBiochemical and Biophysical Research Communications.  319:304-311. 2004
    2004 Nitric oxide protects against pathological ventricular remodeling: Reconsideration of the role of NO in the failing heartCirculation Research.  94:1155-1157. 2004
    2004 Strategies for Developing Biomarkers of Heart FailureClinical Chemistry.  50:265-278. 2004
    2003 Cardiac Toxic Effects of Trans-2-Hexenal are Mediated by Induction of Cardiomyocyte Apoptotic PathwaysCardiovascular Toxicology.  3:341-351. 2003
    2003 Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium.Journal of Molecular and Cellular Cardiology.  35:483-493. 2003
    2003 β-Adrenergic receptor blockade modulates Bcl-XS expression and reduces apoptosis in failing myocardiumJournal of Molecular and Cellular Cardiology.  35:483-493. 2003
    2003 Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanismCirculation Research.  92:741-748. 2003
    2002 Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: Role of aldose reductaseAJP - Heart and Circulatory Physiology.  283. 2002
    2002 Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase.AJP - Heart and Circulatory Physiology.  283:H2612-H2619. 2002
    2002 Images in cardiology: Anomalous origin of a diseased left main coronary artery from the right sinus of ValsalvaClinical Cardiology.  25:489. 2002
    2002 Gene dosage-dependent effects of cardiac-specific overexpression of the A3 adenosine receptorCirculation Research.  91:165-172. 2002
    2000 Chronic β-adrenergic stimulation induces myocardial proinflammatory cytokine expressionCirculation.  101:2338-2341. 2000
    2000 beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling.Circulation.  101:2103-2109. 2000
    2000 β-Adrenergic blockade in developing heart failure: Effects on myocardial inflammatory cytokines, nitric oxide, and remodelingCirculation.  101:2103-2109. 2000
    2000 Altered LV inotropic reserve and mechanoenergetics early in the development of heart failureAJP - Heart and Circulatory Physiology.  278. 2000
    2000 Altered LV inotropic reserve and mechanoenergetics early in the development of heart failure.AJP - Heart and Circulatory Physiology.  278:H698-H705. 2000
    1999 Hemodynamic effects of nitric oxide synthase inhibition at steady state and following tumor necrosis factor-α-induced myodepressionCardiovascular Research.  44:527-535. 1999
    1999 Load sensitivity of left ventricular relaxation in normal and failing hearts: Evidence of a nonlinear biphasic responseCardiovascular Research.  43:354-363. 1999
    1999 Nitric oxide effects on myocardial function and force-interval relations: Regulation of twitch durationJournal of Molecular and Cellular Cardiology.  31:2077-2085. 1999
    1998 Ryanodine and the left ventricular force-interval and relaxation- interval relations in closed-chest dogs: Insights on calcium handlingCardiovascular Research.  40:483-491. 1998
    1997 Ryanodine and left ventricular function in intact dogs: Dissociation of force-based and velocity-based indexesAJP - Heart and Circulatory Physiology.  273. 1997
    1997 Ryanodine and left ventricular function in intact dogs: dissociation of force-based and velocity-based indexes.American Journal of Physiology.  273:H1561-H1568. 1997
    1997 Syncope: current diagnosis and treatment.Current Problems in Cardiology.  22:242-296. 1997
    1997 Syncope: Current diagnosis and treatmentCurrent Problems in Cardiology.  22:237-296. 1997
    1997 Syncope: Current diagnosis and treatmentCurrent Problems in Cardiology.  22:237-296. 1997
    1996 Proliferative properties of smc cultures derived from de novo and restenotic human coronary lesionsFederation proceedings.  10. 1996
    1995 Postextrasystolic mechanical restitution in closed-chest dogs: Effect of heart failureCirculation.  92:2652-2659. 1995
    1995 Effect of tachycardia heart failure on the restitution of left ventricular function in closed-chest dogsCirculation.  91:176-185. 1995
    1993 Left ventricular energetics in closed-chest dogs.American Journal of Physiology.  265:H1048-H1055. 1993
    1993 An analysis of variability of left ventricular pressure decayAmerican Journal of Physiology.  264. 1993
    1993 An analysis of variability of left ventricular pressure decay.American Journal of Physiology.  264:H262-H268. 1993
    1993 Determination of ventricular elastance with echocardiography: A reality?American Heart Journal.  126:500-502. 1993
    1993 Left ventricular energetics in closed-chest dogsAmerican Journal of Physiology.  265. 1993
    1992 Kinetics of restitution of left ventricular relaxationCirculation Research.  70:29-38. 1992
    1990 Reactive disulfide compounds induce Ca2+ release from cardiac sarcoplasmic reticulumArchives of Biochemistry and Biophysics.  282:275-283. 1990
    1990 The heavy metal ions Ag+ and Hg2+ trigger calcium release from cardiac sarcoplasmic reticulumArchives of Biochemistry and Biophysics.  277:47-55. 1990

    Chapter

    Year Title Altmetric
    2014 Pharmacological Models of Hypertrophy and Failure.  170-6. 2014
    2012 Chest Pain.  259-272. 2012
    2011 Environmental Pollutants and Heart Failure.  177-197. 2011
    2005 Chest Pain.  219-229. 2005
    1998 Faintness and syncope.  952-957. 1998
    1998 Palpitations.  130-131. 1998
    1997 Mitral Valve Prolapse.  10.1-10.18. 1997
    1996 Elastance based mechanical restitution provides data from the intact heart not available from any other technique.  293-300. 1996
    1995 Observations on the relation of PVA and MVO2 in closed-chest dogs.  79-89. 1995
    1994 Cardiovascular physiology.  2-14. 1994
    1993 Diseases of the heart.  18-89. 1993

    Research Overview

  • Dr. Prabhu's research focus has been to understand the fundamental mechanisms of pathological remodeling in the failing heart, with a particular focus on inflammatory pathways (tumor necrosis factor, nuclear factor-kappaB) and immune cells (e.g., macrophages, T-cells). He is also interested in the interplay between inflammatory signaling and stem cell-mediated repair of the failing heart. Clinical studies include profiling immune cell networks in human heart failure, and defining the effects of mechanical circulatory support on forward and reverse remodeling.
  • Principal Investigator On

  • Private Grant  awarded by TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D 2015 - 2023
  • Basic and Translational Science in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Macrophage Circadian Clock Disruption and Inflammation in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2020
  • Cardiomyocyte-Mediated Mechanisms of Ischemia  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2020
  • Genomic Analysis of Enhanced Response to Heart Failure Therapy in African America  awarded by University of Pittsburgh 2015 - 2020
  • Splenic Marginal Zone Macrophages in Chronic Ischemic Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • Private Grant  awarded by AASTROM BIOSCIENCES, INC. 2013 - 2018
  • Private Grant  awarded by ABBOTT LABORATORIES 2018
  • 6th Annual Comprehensive Cardiovascular Center (CCVC) Symposium: Focus on Cardiovascular Electrophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2018
  • Relationship between Coronary Flow Reserve, Myocardial Structure/Function and Glomerular Filtration Rates: Mechanistic Insights and Outcomes  awarded by American College of Cardiology 2018
  • Private Grant  awarded by BIOSENSE WEBSTER, INC. 2017
  • Private Grant  awarded by MEDTRONIC, INC. 2017
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION 2017
  • Protection of Ischemic Myocardium: Tumor Necrosis Factor Modulation of CPCs  awarded by University of Louisville 2011 - 2016
  • Role of T-Regulatory Lymphocytes in Pathological Cardiac Remodeling and Heart Failure  awarded by American Heart Association (Southeast Affiliate) 2014 - 2016
  • Obesity, Salt-Sensitivity, and Natriuretic Peptides  awarded by VANDERBILT UNIVERSITY 2015 - 2016
  • Role of Glutathione S-Transferase P in Heart Failure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2012 - 2015
  • Role of Macrophages in Diabetic Cardiomyopathy  awarded by American Heart Association 2013 - 2014
  • Private Grant  awarded by UNITED THERAPEUTICS CORPORATION 2012
  • Private Grant  awarded by THORATEC CORPORATION 2012
  • Private Grant  awarded by Gilead Sciences 2012
  • Investigator On

  • Metabolic Rhythm Alterations as a Cause for Obesity Cardiomyopathy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2023
  • Lipoxygenase Signaling in Heart Failure Pathology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2023
  • Integrated Cellular and Tissue Engineering for Ischemic Heart Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2023
  • Cardiac Mesenchymal Stem Cells and Myocardial Fibrosis: Role of Platelet Derived Growth Factor Receptor Signaling  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2021
  • Patient Oriented Research in Personalized Antithrombotic Therapy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by ZOLL SERVICES, LLC 2018 - 2021
  • Resolution of Inflammation in Heart Failure Post-Myocardial Infarction  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by HEARTWARE, INC. 2014 - 2021
  • Private Grant  awarded by GE HEALTHCARE 2016 - 2020
  • Beta-hydroxybutyrate Protects Mitochondria During Cardiac lschemia Reperfusion Injury  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2018 - 2020
  • Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support  awarded by Northwestern University 2015 - 2020
  • Mitochondria-SR Redox Signaling and Ca2+ Handling in Healthy and Failing Hearts  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2020
  • Private Grant  awarded by LUNG BIOTECHNOLOGY PBC 2013 - 2019
  • Private Grant  awarded by Pfizer Pharmaceuticals 2014 - 2018
  • Pathological TNFR1 Expressing CD4+ T-Cells are Critical for HF Progression  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2018
  • Reductive Stress Induces Proteotoxic Cardiac Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2018
  • Role of Lipoxins in Resolution of Inflammation Following Myocardial Infarction  awarded by American Heart Association (Southeast Affiliate) 2016 - 2018
  • Private Grant  awarded by GENO LLC 2015 - 2016
  • Private Grant  awarded by ARENA PHARMACEUTICALS, INC. 2014 - 2016
  • Private Grant  awarded by ARENA PHARMACEUTICALS, INC. 2014 - 2016
  • Private Grant  awarded by SUNSHINE HEART, INC. 2013 - 2016
  • Private Grant  awarded by CARDIACASSIST, INC 2015 - 2016
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2014 - 2015
  • Private Grant  awarded by Actelion Pharmaceuticals Ltd. 2013 - 2015
  • Private Grant  awarded by GENO LLC 2015
  • Training Program in Cardiovascular Pathophysiology  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2015
  • Role of Heme Oxygenase-1 in Doxorubicin-Induced Cardiac Toxicity  awarded by American Heart Association 2013 - 2015
  • Randomized Evaluation of VAD Intervention before Inotropic Therapy (REVIVE-IT) Pilot Trial  awarded by University of Michigan 2013 - 2015
  • Education And Training

  • Doctor of Medicine, Thomas Jefferson University 1985
  • University of Pittsburgh, Internship 1986
  • University of Pittsburgh, Residency 1988
  • University of Texas Health Science Center, Postdoctoral Fellowship 1992
  • University of Pittsburgh, Postdoctoral Fellowship 1989
  • Full Name

  • Sumanth Prabhu