Steven Pogwizd

Steven Pogwizd
Professor

Senior Scientist (C), Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center (CAMBAC) , School of Medicine
Senior Scientist (C), Comprehensive Diabetes Center , School of Medicine
Senior Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Professor (P), Medicine - Cardiovascular Disease , Department of Medicine
Quality Officer for Cardiographics and Telemetry, Medicine - Cardiovascular Disease , Department of Medicine
Associate Director, Medicine - Cardiovascular Disease , Department of Medicine
Director, Medicine - Cardiovascular Disease , Department of Medicine
Professor (S), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments
Senior Scientist (C), Center for Exercise Medicine , Cell, Developmental and Integrative Biology (CDIB)
Professor (S), Biomedical Engineering , School of Engineering
Scientist (C), Biomatrix Eng Regen Med (BERM) Center , Biomedical Engineering

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy. Frontiers in Cardiovascular Medicine. 9. 2022
2021	Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Scientific Reports. 11. 2021
2021	Serine-threonine protein phosphatase regulation of Cx43 dephosphorylation in arrhythmogenic disorders. Cellular Signalling. 86. 2021
2021	Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure. Journal of Molecular and Cellular Cardiology. 158:72-81. 2021
2021	Atrial arrhythmia related outcomes in critically ill COVID-19 patients. Pacing and Clinical Electrophysiology. 44:814-823. 2021
2021	Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure 2021
2021	Alterations of housekeeping proteins in human aged and diseased hearts 2021
2020	A novel case of reverse Takotsubo cardiomyopathy following brain biopsy 2020
2020	Heart Failure with Preserved Ejection Fraction in a Postpartum Patient with Superimposed Preeclampsia and COVID-19. American Journal of Perinatology Reports. 10:E165-E168. 2020
2020	Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse model. Human Molecular Genetics. 29:369-381. 2020
2019	Dynamics of seizure-induced behavioral and autonomic arousal. Clinical Autonomic Research. 29:205-209. 2019
2019	Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure. Laboratory Investigation. 99:371-386. 2019
2019	Noninvasive Activation Imaging of Ventricular Arrhythmias by Spatial Gradient Sparse in Frequency Domain - Application to Mapping Reentrant Ventricular Tachycardia. IEEE Transactions on Medical Imaging. 38:525-539. 2019
2018	Evidence for a hyper-reductive redox in a sub-set of heart failure patients. Journal of Translational Medicine. 16. 2018
2018	Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and β-Adrenergic Effects on Delayed- and Inward-Rectifier Potassium Currents. Circulation: Arrhythmia and Electrophysiology. 11. 2018
2017	Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy. Scientific Reports. 7. 2017
2017	Regulation of cardiac gap junctions by protein phosphatases. Journal of Molecular and Cellular Cardiology. 107:52-57. 2017
2016	Reduced arrhythmia inducibility with calcium/ calmodulin-dependent protein kinase II inhibition in heart failure rabbits. Journal of Cardiovascular Pharmacology. 67:260-265. 2016
2015	Fibro-porous poliglecaprone/polycaprolactone conduits: Synergistic effect of composition and in vitro degradation on mechanical properties. Polymer International. 64:547-555. 2015
2015	Mitochondria-derived ROS bursts disturb Ca²⁺ cycling and induce abnormal automaticity in guinea pig cardiomyocytes: A theoretical study 2015
2015	Imaging cardiac activation sequence during ventricular tachycardia in a canine model of nonischemic heart failure 2015
2014	Sex differences in β-adrenergic responsiveness of action potentials and intracellular calcium handling in isolated rabbit hearts. PLoS One. 9. 2014
2014	Morning surge of ventricular arrhythmias in a new arrhythmogenic canine model of chronic heart failure is associated with attenuation of time-of-day dependence of heart rate and autonomic adaptation, and reduced cardiac chaos. PLoS One. 9. 2014
2014	Inhibiting Na⁺/K⁺ ATPase can impair mitochondrial energetics and induce abnormal Ca²⁺ cycling and automaticity in guinea pig cardiomyocytes. PLoS One. 9. 2014
2013	Long-duration ventricular fibrillation exhibits 2 distinct organized states. Circulation: Arrhythmia and Electrophysiology. 6:1192-1199. 2013
2013	Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart. Heart Rhythm. 10:1509-1515. 2013
2013	Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits 2013
2012	Role of RyR2 phosphorylation at S2814 during heart failure progression. Circulation Research. 110:1474-1483. 2012
2012	Focal initiation of sustained and nonsustained ventricular tachycardia in a canine model of ischemic cardiomyopathy. Journal of Cardiovascular Electrophysiology. 23:543-552. 2012
2012	Effect of chest compressions on ventricular activation. American Journal of Cardiology. 109:670-674. 2012
2012	Noninvasive reconstruction of the three-dimensional ventricular activation sequence during pacing and ventricular tachycardia in the canine heart 2012
2011	Noninvasive reconstruction of the three-dimensional ventricular activation sequence during pacing and ventricular tachycardia in the rabbit heart. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 1684-1687. 2011
2011	Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardioscience. 92:106-114. 2011
2011	Noninvasive imaging of three-dimensional cardiac activation sequence during pacing and ventricular tachycardia. Heart Rhythm. 8:1266-1272. 2011
2010	Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca²⁺-calmodulin-dependent protein kinase II. Journal of Molecular and Cellular Cardiology. 49:25-32. 2010
2010	Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts 2010
2010	Isoform- and tissue-specific regulation of the Ca²⁺-sensitive transcription factor NFAT in cardiac myocytes and heart failure 2010
2010	Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes. Cardioscience. 85:751-762. 2010
2009	Can mapping differentiate microreentry from a focus in the ventricle?. Heart Rhythm. 6:1666-1669. 2009
2009	Purkinje fibers and arrhythmias. Pacing and Clinical Electrophysiology. 32:283-285. 2009
2008	Noninvasive three-dimensional cardiac activation imaging from body surface potential maps: A computational and experimental study on a rabbit model. IEEE Transactions on Medical Imaging. 27:1622-1630. 2008
2008	Rabbit models of heart disease. Drug Discovery Today: Disease Models. 5:185-193. 2008
2008	Arrhythmogenic effects of β2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circulation Research. 102:1389-1397. 2008
2008	Ca2+/calmodulin-dependent protein kinase IIδ and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circulation Research. 102:695-702. 2008
2008	Mechanistic insights into ventricular arrhythmias from mapping studies in humans. Heart Rhythm. 5. 2008
2007	Iatrogenic hemolytic anemia and endocarditis in New Zealand White rabbits secondary to Achromobacter xylosoxidans infection 2007
2007	Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart. Circulation Research. 101:802-810. 2007
2007	Creating a cardiac pacemaker by gene therapy. Medical and Biological Engineering and Computing. 45:145-155. 2007
2006	Models of cardiovascular disease. Drug Discovery Today: Disease Models. 3:261. 2006
2006	Three-dimensional myocardial activation imaging in a rabbit model. IEEE Transactions on Biomedical Engineering. 53:1813-1820. 2006
2005	Ca²⁺/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca²⁺ leak in heart failure. Circulation Research. 97:1314-1322. 2005
2005	Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence 2005
2005	Expression and phosphorylation of the Na-pump regulatory subunit phospholemman in heart failure. Circulation Research. 97:558-565. 2005
2005	Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function. Circulation Research. 96:815-817. 2005
2005	Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circulation Research. 96:54-63. 2005
2004	Cellular basis of triggered arrhythmias in heart failure. Trends in Cardiovascular Medicine. 14:61-66. 2004
2003	Elevated sarcoplasmic reticulum Ca²⁺ leak in intact ventricular myocytes from rabbits in heart failure. Circulation Research. 93:592-594. 2003
2003	Prevention of ischemia-induced reentrant ventricular arrhythmias by a peptide that enhances gap junctional conductance. Journal of Cardiovascular Electrophysiology. 14:521-523. 2003
2003	Intracellular Na in animal models of hypertrophy and heart failure: Contractile function and arrhythmogenesis. Cardioscience. 57:887-896. 2003
2003	Clinical potential of sodium-calcium exchanger inhibitors as antiarrhythmic agents. Drugs. 63:439-452. 2003
2003	Gene therapy to develop a genetically engineered cardiac pacemaker. Journal of Cardiovascular Nursing. 18:330-336. 2003
2002	Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Research in Cardiology. 97. 2002
2002	Intracellular Na⁺ concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 105:2543-2548. 2002
2002	Intracellular [Na⁺] and Na⁺ pump rate in rat and rabbit ventricular myocytes 2002
2002	Calcium cycling in heart failure: The arrhythmia connection. Journal of Cardiovascular Electrophysiology. 13:88-91. 2002
2002	Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts 2002
2001	Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic responsiveness. Circulation Research. 88:1159-1167. 2001
2000	Increased NA⁺-CA²⁺ exchanger in the failing heart. Circulation Research. 87:641-643. 2000
2000	Cycle length dynamics during ventricular tachycardia in the infarcted heart. Journal of Cardiovascular Electrophysiology. 11:545-546. 2000
1999	Upregulation of Na⁺/Ca²⁺ exchanger expression and-function in an arrhythmogenic rabbit model of heart failure. Circulation Research. 85:1009-1019. 1999
1998	Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy. Circulation. 98:2404-2414. 1998
1997	Termination of ventricular tachycardia in the human heart: Insights from three-dimensional mapping of nonsustained and sustained ventricular tachycardias. Circulation. 95:2528-2540. 1997
1997	Three-dimensional mapping of the initiation of nonsustained ventricular tachycardia in the human heart. Circulation. 95:2517-2527. 1997
1997	Transmyocardial laser treatment denervates canine myocardium. Journal of Thoracic and Cardiovascular Surgery. 114:883-890. 1997
1995	Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits. Circulation. 92:1034-1048. 1995
1994	Focal mechanisms underlying ventricular tachycardia during prolonged ischemic cardiomyopathy. Circulation. 90:1441-1458. 1994
1992	Contribution of myocardium responsible for ventricular tachycardia to abnormalities detected by analysis of signal-averaged ECGs. Circulation. 86:1888-1901. 1992
1992	Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart. Circulation. 86:1872-1887. 1992
1991	Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart. Journal of Molecular and Cellular Cardiology. 23:11-22. 1991
1990	Mechanisms Underlying Ventricular Tachycardia and Fibrillation in the Ischemic Heart: Relation to Nonlinear Dynamics. Annals of the New York Academy of Sciences. 591:278-300. 1990
1990	Mechanisms underlying the development of ventricular fibrillation during early myocardial ischemia. Circulation Research. 66:672-695. 1990
1988	Mechanisms contributing to arrhythmogenesis during early myocardial ischemia, subsequent reperfusion, and chronic infarction. Angiology. 39:684-699. 1988
1987	Electrophysiologic mechanisms underlying arrhythmias due to reperfusion of ischemic myocardium. Circulation. 76:404-426. 1987
1987	Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: Results using three-dimensional mapping. Circulation Research. 61:352-371. 1987
1986	Induction of delayed afterdepolarizations and triggered activity in canine Purkinje fibers by lysophosphoglycerides. Circulation Research. 59:416-426. 1986
1986	Mechanisms of arrhythmogenes is during myocardial ischemia and reperfusion:A perspective of our current understanding. Journal of Molecular and Cellular Cardiology. 18:43-47. 1986
1982	Influences of labetalol a combined α- and β-adrenergic blocking agent on the dysrhythmias induced by coronary occlusion and reperfusion. Cardioscience. 16:398-407. 1982
1976	In vitro activity of gentamicin, amikacin, and netilmicin alone and in combination with carbenicillin against Serratia marcescens. Antimicrobial Agents and Chemotherapy. 10:878-884. 1976