• Selwyn M. Vickers, M.D., FACS, has been Senior Vice President of Medicine and Dean of the University of Alabama at Birmingham (UAB) School of Medicine since October 2013. As dean, Dr. Vickers leads the UAB School of Medicine’s main campus in Birmingham as well as the school’s regional campuses in Montgomery, Huntsville, and Tuscaloosa. UAB School of Medicine is part of UAB Medicine, one of the 10 largest public academic medical centers and the third largest public hospital in the U.S. Dr. Vickers holds the James C. Lee Jr. Endowed Chair at the School of Medicine and is board chair of the University of Alabama Health Services Foundation, a faculty practice plan with over $1.4 billion in revenue. He also serves as chair of UAB Medicine’s Joint Operating Leadership Committee (JOLC).

    A world-renowned surgeon, pancreatic cancer researcher, and pioneer in health disparities research, Dr. Vickers is a member of the National Academy of Medicine (Institute of Medicine) and the Johns Hopkins Society of Scholars. He has served on the Johns Hopkins School of Medicine Board of Trustees and Johns Hopkins University Board of Trustees. In addition, he has served as president of the Society for Surgery of the Alimentary Tract and the Southern Surgical Association, and is President-Elect of the American Surgical Association, the oldest and most prestigious surgical society.

    Dr. Vickers has played an important advisory role since the onset of the COVID-19 (SARS-CoV-2) pandemic in 2020. He serves on the Executive Committee of Alabama Governor Kay Ivey’s Coronavirus Task Force and as co-chair of The University of Alabama (UA) System Campus Health and Safety Task Force, which was charged with developing reentry plans for the System’s three campuses in Tuscaloosa, Birmingham, and Huntsville and other participating higher education institutions. To that end, he sponsored development of and was the contact PI for the $37 million federal grant for GuideSafeTM, a higher education reentry platform and testing program developed by a group of experts at UAB—working in partnership with entities that included Apple and Google—and made available first to all colleges and universities in Alabama, and later to any interested institution.

    Dr. Vickers earned baccalaureate and medical degrees from Johns Hopkins University and completed surgical training there, including a chief residency and surgical oncology fellowship. He completed two post-graduate research fellowships with the National Institutes of Health and training at John Radcliffe Hospital of Oxford University, England, and was an instructor of surgery at Johns Hopkins for one year. In 1994 he joined the UAB faculty as an assistant professor in the Department of Surgery. From 1995-1999, he was a Robert Wood Johnson Research Fellow. From 2000-2006, he directed the Section of Gastrointestinal Surgery. During his first tenure at UAB, Dr. Vickers received numerous honors, including numerous Argus Awards for Excellence in Teaching, the Best Clinical Professor award, and the President’s Award for Excellence in Teaching. In 2000, he became the first faculty member chosen by students as commencement speaker.

    In 2006, Dr. Vickers left Alabama to become the Jay Phillips Professor and Chair of the Department of Surgery at the University of Minnesota Medical School, one of the oldest, most prestigious departments in the country. He was the fourth chair in the department’s 115-year history. While at Minnesota, Dr. Vickers’ lab was instrumental in the development of an injectable cancer drug, Minnelide, which entered phase II for the treatment of pancreatic & GI Cancer testing in September 2013. Dr. Vickers has a financial interest in the pharmaceutical company licensed to develop the drug, Minneamrita Therapeutics LLC.

    Dr. Vickers continues to see patients and conduct research. He has had continuous NIH extramural funding for the past 25 years. His major research interests include gene therapy as an application in the treatment of pancreatobiliary tumors, the role of growth factors and receptors in the oncogenesis of pancreatic cancer, the implications of FAS expressions and Tamoxifen in the growth and treatment of cholangiocarcinoma, assessment of clinical outcomes in the surgical treatment of pancreatobiliary tumors, and the role of death receptors in the treatment of pancreatic cancer.

    Dr. Vickers was born in Demopolis, Alabama, and grew up in Tuscaloosa and Huntsville. He and his wife, Janice, who also is from Alabama, have been married since 1988. They have four children: Lauren, Adrienne, Lydia, and Benjamin.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Are We Undertreating Black Patients with Nonfunctional Pancreatic Neuroendocrine Tumors? Critical Analysis of Current Surveillance Guidelines by RaceJournal of The American College of Surgeons.  234:599-606. 2022
    2022 Racial Disparity Between Whites and African Americans in Incidence and Outcome of Pancreatic Cancer: Have We Made a Difference?Gastroenterology.  162:1346-1348.e3. 2022
    2022 Does race affect the long-term survival benefit of systemic therapy in pancreatic adenocarcinoma? 2022
    2022 External validation of four Pancreatic Fistula Risk Score models in the Deep South US: Do racial disparities affect pancreatic fistula prediction? 2022
    2022 The Fate of Resectable Pancreatic Adenocarcinoma after Neoadjuvant ChemotherapyPancreas.  51:100-105. 2022
    2021 Barriers to Advancement in Academic Medicine: the Perception Gap Between Majority Men and Other FacultyJournal of General Internal Medicine.  36:1937-1943. 2021
    2021 Preoperative anthropomorphic radiographic measurements can predict postoperative pancreatic fistula formation following pancreatoduodenectomy 2021
    2021 Ending Racial Bias in American Medicine: A Call for Help from the AMA, NMA, AAMC, and the Rest of UsAmerican Journal of Medicine.  134:565-568. 2021
    2021 Implementation of virtual focus groups for qualitative data collection in a global pandemic 2021
    2021 Perceived Institutional Barriers Among Clinical and Research Professionals: Minority Participation in Oncology Clinical Trials 2021
    2021 Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure 2021
    2021 Invited CommentaryJournal of The American College of Surgeons.  232:360. 2021
    2021 Prognostic Impact of Tumor Size on Pancreatic Neuroendocrine Tumor Recurrence May Have Racial VariancePancreas.  50:347-352. 2021
    2021 New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of DiscoveriesFrontiers in Immunology.  12. 2021
    2021 Returning to Growth: One Academic Medical Center's Successful Five-Step Approach to Change ManagementAcademic Medicine.  1401-1407. 2021
    2020 Benchmarking Accomplishments of Leaders in American Surgery and Justification for Enhancing Diversity and InclusionAnnals of Surgery.  272:897-903. 2020
    2020 COVID-19 Is Disproportionately High in African Americans. This Will Come as No Surprise…American Journal of Medicine.  133:e544-e545. 2020
    2020 COVID-19's Impact on the African American Community: A Stakeholder Engagement Approach to Increase Public Awareness through Virtual Town HallsHealth Equity.  4:320-325. 2020
    2020 Recognizing and Addressing the Disparities in Research Funding for Underrepresented Minorities and WomenAnnals of Surgery.  272:30-31. 2020
    2020 Erratum: Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors (American Journal of Physiology - Gastrointestinal and Liver Physiology (2011) 300 (G948-G955) DOI: 10.1152/ajpgi.00346.2010) 2020
    2020 Judge Frank Minis Johnson Jr: Impactful History FigureJournal of The American College of Surgeons.  230:720-723. 2020
    2020 Bias and stereotyping among research and clinical professionals: Perspectives on minority recruitment for oncology clinical trialsCancer.  126:1958-1968. 2020
    2019 Correction to: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia (Journal of Translational Medicine (2019) 17 (163 ) DOI: 10.1186/s12967-019-1901-8)Journal of Translational Medicine.  17. 2019
    2019 Correction: Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1 (Journal of Biological Chemistry (2013) 288 (33927-33938) DOI: 10.1074/jbc.M113.500983)Journal of Biological Chemistry.  294:10739. 2019
    2019 Neoadjuvant modified FOLFIRINOX or gemcitabine-nab paclitaxel followed by stereotactic body radiotherapy for patients with locally advanced pancreatic cancerAnnals of Oncology.  30:iv67. 2019
    2019 Stereotactic body radiotherapy in locally advanced pancreatic adenocarcinoma: A single institution experienceAnnals of Oncology.  30:iv89. 2019
    2019 Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemiaJournal of Translational Medicine.  17. 2019
    2019 Non-Hepatic Abdominal Surgery in Patients with Cirrhotic Liver DiseaseJournal of Gastrointestinal Surgery.  23:634-642. 2019
    2019 Training Needs of Clinical and Research Professionals to Optimize Minority Recruitment and Retention in Cancer Clinical TrialsJournal of Cancer Education.  34:26-34. 2019
    2019 O-GlcNAc modification of Sox2 regulates self-renewal in pancreatic cancer by promoting its stabilityTheranostics.  9:3410-3424. 2019
    2018 African American Men's Health: Research, Practice, and PolicyAmerican Journal of Preventive Medicine.  55:S1-S4. 2018
    2018 NFκB in Pancreatic Stellate Cells Reduces Infiltration of Tumors by Cytotoxic T Cells and Killing of Cancer Cells, via Up-regulation of CXCL12Gastroenterology.  155:880-891.e8. 2018
    2018 Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune ResponseGastroenterology.  155:33-37.e6. 2018
    2018 Strategic Partnerships in Surgery: A Model for the USJournal of The American College of Surgeons.  226:345-354. 2018
    2018 Inactivation of cancer-associated-fibroblasts disrupts oncogenic signaling in pancreatic cancer cells and promotes its regressionCancer Research.  78:1321-1333. 2018
    2018 GRIT and ResilienceAnnals of Surgery.  267:S22-S25. 2018
    2017 A Qualitative Study of Motivations for Minority Recruitment in Cancer Clinical Trials Across Five NCI-Designated Cancer CentersJournal of Racial and Ethnic Health Disparities.  4:992-998. 2017
    2017 Erratum to: A Qualitative Study of Motivations for Minority Recruitment in Cancer Clinical Trials Across Five NCI-Designated Cancer Centers (Journal of Racial and Ethnic Health Disparities, (2017), 4, 5, (992-998), 10.1007/s40615-016-0303-3)Journal of Racial and Ethnic Health Disparities.  4:999. 2017
    2017 Increased pancreatic cancer survival with greater lymph node retrieval in the National Cancer Data Base 2017
    2017 Racial disparities in length-of-stay persist even with no postoperative complicationsJournal of Surgical Research.  214:14-22. 2017
    2017 Enhanced Recovery After Surgery (ERAS) Eliminates Racial Disparities in Postoperative Length of Stay After Colorectal SurgeryAnnals of Surgery2017
    2017 A participatory evaluation framework in the establishment and implementation of transdisciplinary collaborative centers for health disparities researchEvaluation and Program Planning.  60:37-45. 2017
    2017 Lessons Learned from Mentors and Heroes on Leadership and Surgical ResilienceJournal of Gastrointestinal Surgery.  21. 2017
    2016 Pancreatic cancer survivors’ preferences, barriers, and facilitators related to physical activity and diet interventionsJournal of Cancer Survivorship.  10:981-989. 2016
    2016 RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4Molecular Oncology.  10:1169-1182. 2016
    2016 Patient navigation as a model to increase participation of African Americans in cancer clinical trialsJournal of Oncology Practice.  12:556-563. 2016
    2016 Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Healthy and Pancreatic Cancer Compromised HumansChemical Research in Toxicology.  29:352-358. 2016
    2015 Targeting acidity in pancreatic Adenocarcinoma: Multispectral Optoacoustic tomography detects ph-low insertion peptide probes in vivoClinical Cancer Research.  21:4576-4585. 2015
    2015 Primary and liver metastasis-derived cell lines from Kras G12D; Trp53 R172H; Pdx-1 cre animals undergo apoptosis in response to triptolidePancreas.  44:583-589. 2015
    2015 Oncolytic adenovirus expressing interferon alpha in a syngeneic Syrian hamster model for the treatment of pancreatic cancerSurgery.  157:888-898. 2015
    2015 CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancerOncotarget.  6:8313-8322. 2015
    2014 Islet size index as a predictor of outcomes in clinical islet autotransplantationTransplantation.  97:1286-1291. 2014
    2014 Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells 2014
    2014 CD133+ tumor initiating cells in a syngenic murine model of pancreatic cancer respond to minnelideClinical Cancer Research.  20:2388-2399. 2014
    2014 An overview of EMPaCT and fundamental issues affecting minority participation in cancer clinical trials: enhancing minority participation in clinical trials (EMPaCT): laying the groundwork for improving minority clinical trial accrual.Cancer.  120 Suppl 7:1087-1090. 2014
    2014 Five National Cancer Institute-designated cancer centers' data collection on racial/ethnic minority participation in therapeutic trials: a current view and opportunities for improvement.Cancer.  120 Suppl 7:1113-1121. 2014
    2014 Long-term outcomes of total pancreatectomy and islet auto transplantation for hereditary/genetic pancreatitisJournal of The American College of Surgeons.  218:530-543. 2014
    2014 Neoadjuvant interferon-based chemoradiation for borderline resectable and locally advanced pancreas cancer: A Phase II pilot study 2014
    2014 Operative report teaching and synoptic operative reports: A national survey of surgical program directorsJournal of The American College of Surgeons.  218:113-118. 2014
    2014 Sorafenib and triptolide as combination therapy for hepatocellular carcinomaSurgery.  156:270-279. 2014
    2014 Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: Indication, surgical techniques, postoperative management, and long-term outcomesAnnals of Surgery.  260:56-64. 2014
    2014 Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathwayCancer Letters.  348:156-166. 2014
    2013 Triptolide-induced cell death in Pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1Journal of Biological Chemistry.  288:33927-33938. 2013
    2013 Minnelide: A Novel Therapeutic That Promotes Apoptosis in Non-Small Cell Lung Carcinoma In VivoPLoS ONE.  8. 2013
    2013 A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock 2013
    2013 Severely fibrotic pancreases from young patients with chronic pancreatitis: Evidence for a ductal origin of islet neogenesis 2013
    2013 MiR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell deathMolecular Cancer.  12. 2013
    2013 Total pancreatectomy with islet autotransplantation in patients with malignancy: Are we there yet?Annals of Surgery.  258:219-220. 2013
    2013 Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancerInternational Journal of Cancer.  133:88-97. 2013
    2013 Triptolide induces the expression of miR-142-3p: A negative regulator of heat shock protein 70 and pancreatic cancer cell proliferationMolecular Cancer Therapeutics.  12:1266-1275. 2013
    2013 Disparities in pancreas cancer careAnnals of Surgical Oncology.  20:2078-2087. 2013
    2013 Effect of insurance status on the surgical treatment of early-stage non-small cell lung cancerAnnals of Thoracic Surgery.  95:1221-1226. 2013
    2013 Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity 2013
    2013 Cancer surgery among American IndiansJAMA Surgery.  148:277-284. 2013
    2013 Does enrollment in cancer trials improve survival?Journal of The American College of Surgeons.  216:774-780. 2013
    2013 Infectivity-selective oncolytic adenovirus developed by high-throughput screening of adenovirus-formatted libraryMolecular Therapy.  21:139-148. 2013
    2013 Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancerCancer Medicine.  2:925-932. 2013
    2013 Surgical care and career opportunities in a changing practice paradigmJournal of The American College of Surgeons.  217. 2013
    2012 Generation of a novel, cyclooxygenase-2-targeted, interferon-expressing, conditionally replicative adenovirus for pancreatic cancer therapy 2012
    2012 Rurality and cancer surgery in the United States 2012
    2012 A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancerScience Translational Medicine.  4. 2012
    2012 Are Cancer Trials Valid and Useful for the General Surgeon and Surgical Oncologist?Advances in Surgery.  46:269-281. 2012
    2012 MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilizationPLoS ONE.  7. 2012
    2012 Delivery of interferon alpha using a novel Cox2-controlled adenovirus for pancreatic cancer therapySurgery.  152:114-122. 2012
    2012 Total pancreatectomy and islet autotransplantation for chronic pancreatitisJournal of The American College of Surgeons.  214:409-424. 2012
    2012 What happens to racial and ethnic minorities after cancer surgery at american college of surgeons national surgical quality improvement program hospitals?Journal of The American College of Surgeons.  214:539-547. 2012
    2012 Neoadjuvant interferon-based chemoradiation for locally advanced pancreas cancer: A phase II pilot study.Journal of Clinical Oncology.  30:266. 2012
    2012 Governors' Committee on Socioeconomic Issues.Bulletin of the American College of Surgeons.  97:51-53. 2012
    2012 Who receives their complex cancer surgery at low-volume hospitals?Journal of The American College of Surgeons.  214:81-87. 2012
    2011 A 17-year-old female with right upper quadrant abdominal pain and NauseaJournal of surgical radiology.  2:310-315. 2011
    2011 Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathwayCancer Letters.  308:181-188. 2011
    2011 Cancer trials versus the real world in the United StatesAnnals of Surgery.  254:438-443. 2011
    2011 Quality of Life Improves for Pediatric Patients After Total Pancreatectomy and Islet Autotransplant for Chronic PancreatitisClinical Gastroenterology and Hepatology.  9:793-799. 2011
    2011 Molecular targeted approaches for treatment of pancreatic cancerCurrent Pharmaceutical Design.  17:2221-2238. 2011
    2011 Enhanced recovery programs: Major benefits demonstrated againArchives of Surgery.  146:577-578. 2011
    2011 A phase i study evaluating the role of the anti-epidermal growth factor receptor (EGFR) antibody cetuximab as a radiosensitizer with chemoradiation for locally advanced pancreatic cancerCancer Chemotherapy and Pharmacology.  67:891-897. 2011
    2011 Autoimmune pancreatitis mimicking pancreatic cancerJournal of Hepato-Biliary-Pancreatic Sciences.  18:162-169. 2011
    2011 Serum biomarker panels for the detection of pancreatic cancerClinical Cancer Research.  17:805-816. 2011
    2011 The reality of pancreas cancer care from access to delivery.Journal of Clinical Oncology.  29:241. 2011
    2011 Guideline recommended gastric cancer care in the elderly: Insights into the applicability of cancer trials to real worldAnnals of Surgical Oncology.  18:26-33. 2011
    2011 Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors 2011
    2010 The maximally invasive hepatobiliary surgeon: A dying breed?Archives of Surgery.  145:1118. 2010
    2010 Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinomaJournal of Surgical Research.  163:244-249. 2010
    2010 Role of Hsp-70 in triptolide-mediated cell death of neuroblastomaJournal of Surgical Research.  163:72-78. 2010
    2010 A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancerPancreas.  39:913-922. 2010
    2010 Extremity soft tissue sarcoma care in the elderly: Insights into the generalizability of NCI cancer trialsAnnals of Surgical Oncology.  17:1732-1738. 2010
    2010 Resectability of pancreatic adenocarcinoma in patients with locally advanced disease downstaged by preoperative therapy: A challenge for MDCTAmerican Journal of Roentgenology.  194:615-622. 2010
    2010 In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacyCancer Science.  101:474-481. 2010
    2010 Major cancer surgery in the elderly: Results from the american college of surgeons national surgical quality improvement programAnnals of Surgery.  251:311-318. 2010
    2010 TRAIL and triptolide: An effective combination that induces apoptosis in pancreatic cancer cellsJournal of Gastrointestinal Surgery.  14:252-260. 2010
    2010 Variations in gastric cancer care: A trend beyond racial disparitiesCancer.  116:465-475. 2010
    2010 Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathwaysGastroenterology.  139:598-608. 2010
    2009 Laparoscopic Distal PancreatectomyJournal of The American College of Surgeons.  209:758-765. 2009
    2009 Therapeutic pancreatic endoscopy after Whipple resection requires rendezvous accessEndoscopy.  41:898-901. 2009
    2009 Lymph node evaluation is associated with improved survival after surgery for early stage gallbladder cancerSurgery.  146:706-713. 2009
    2009 Anti-ERBB2 sh-RNA suppress both cell growth and tumor growth in ERBB2-overexpressing upper gastrointestinal adenocarcinomasJournal of Gastrointestinal Surgery.  13:1754-1761. 2009
    2009 ERBB2 suppression decreases cell growth via apoptosis in gastrointestinal adenocarcinomasSurgery.  146:213-219. 2009
    2009 Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivoSurgery.  146:282-290. 2009
    2009 The role of heat shock proteins in gastrointestinal diseasesGut.  58:1000-1009. 2009
    2009 Endoscopic ultrasound-guided fine-needle aspiration diagnosis of clear-cell pancreatic endocrine neoplasm in a patient with von Hippel-Lindau disease: A case reportDiagnostic Cytopathology.  37:365-372. 2009
    2009 A critical analysis of the surgical management of early-stage gallbladder cancer in the united statesJournal of Gastrointestinal Surgery.  13:722-727. 2009
    2009 Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent MechanismsGastroenterology.  136:1772-1782. 2009
    2008 Molecular targeted therapies for pancreatic cancer 2008
    2008 Multicystic adenomatoid hamartoma of the pancreas: A hitherto undescribed pancreatic tumor occurring in a 3-year-old boyPediatric and Developmental Pathology.  11:314-320. 2008
    2008 Genetically designing a more potent antipancreatic cancer agent by simultaneously co-targeting human IL13 and EGF receptors in a mouse xenograft modelGut.  57:634-641. 2008
    2008 Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model 2008
    2008 Strength of the evidence: Adjuvant therapy for resected pancreatic cancerJournal of Gastrointestinal Surgery.  12:657-661. 2008
    2008 Primary colonic lymphomaAmerican Surgeon.  74:214-216. 2008
    2008 Multidetector Computed Tomography During Combined Therapy for Pancreatic AdenocarcinomaClinical Gastroenterology and Hepatology.  6. 2008
    2007 Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: Implications for the molecular analysis of clinically available biopsiesDiagnostic Molecular Pathology.  16:229-237. 2007
    2007 TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growthMolecular Cancer Therapeutics.  6:3198-3207. 2007
    2007 EGFR Genomic Gain and Aberrant Pathway Signaling in Pancreatic Cancer PatientsJournal of Surgical Research.  143:20-26. 2007
    2007 Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70Cancer Research.  67:9407-9416. 2007
    2007 Combination treatment with TRA-8 anti-death receptor 5 antibody and CPT-11 induces tumor regression in an orthotopic model of pancreatic cancerClinical Cancer Research.  13. 2007
    2007 Inactivation of Smad4 accelerates KrasG12D-mediated pancreatic neoplasiaCancer Research.  67:8121-8130. 2007
    2007 A prospective evaluation of an algorithm incorporating routine preoperative endoscopic ultrasound-guided fine needle aspiration in suspected pancreatic cancerJournal of Gastrointestinal Surgery.  11:813-819. 2007
    2007 Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib responseAnnals of Surgical Oncology.  14:2150-2158. 2007
    2007 Incorporating Laparoscopic Fellowship Does Not Increase Morbidity or Mortality in a University-Based Bariatric PracticeJournal of The American College of Surgeons.  204:824-828. 2007
    2007 Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancerSurgery.  141:464-469. 2007
    2007 Surgical treatment of pancreatic endocrine neoplasms 2007
    2007 ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinibCancer Biology and Therapy.  6:548-554. 2007
    2007 ReplyGastroenterology.  132:2608-2609. 2007
    2006 Incidence of vitamin deficiency after laparoscopic Roux-en-Y gastric bypass in a university hospital settingAmerican Surgeon.  72:1196-1202. 2006
    2006 Treatment With Gemcitabine and TRA-8 Anti-Death Receptor-5 mAb Reduces Pancreatic Adenocarcinoma Cell Viability In Vitro and Growth In VivoJournal of Gastrointestinal Surgery.  10:1291-1300. 2006
    2006 Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates.American Journal of Clinical Pathology.  126:572-579. 2006
    2006 Prognostic factors for survival in pancreatic cancer: a population-based study 2006
    2006 Outcomes of cholecystectomy after endoscopic sphincterotomy for choledocholithiasisJournal of Gastrointestinal Surgery.  10:292-296. 2006
    2006 Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates: A translational research applicationAmerican Journal of Clinical Pathology.  126:572-579. 2006
    2006 Multiple gene expression analyses in paraffin-embedded tissues by TaqMan low-density array. Application to Hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma 2006
    2005 Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: Clinical implications of abscopal effectsClinical Cancer Research.  11:8773-8781. 2005
    2005 Obesity status and use of general surgery resourcesAmerican Surgeon.  71:963-969. 2005
    2005 Water-soluble upper GI based on clinical findings is reliable to detect anastomotic leaks after laparoscopic gastric bypassAmerican Surgeon.  71:916-918. 2005
    2005 Cytologic grade independently predicts survival of patients with pancreatic adenocarcinomaAmerican Journal of Clinical Pathology.  124:697-707. 2005
    2005 Impact of obesity on resource utilization for general surgical proceduresAnnals of Surgery.  241:821-828. 2005
    2005 SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells.American Journal of Pathology.  166:1379-1392. 2005
    2005 Regulators of apoptosis in cholangiocarcinomaArchives of Pathology and Laboratory Medicine.  129:481-486. 2005
    2005 Oncolytic adenoviral therapy in gallbladder carcinomaSurgery.  137:527-535. 2005
    2005 Pancreatic adenocarcinoma: Clinical Practice Guidelines in Oncology 2005
    2005 SCFβ-TrCP1 controls Smad4 protein stability in pancreatic cancer cellsAmerican Journal of Pathology.  166:1379-1392. 2005
    2004 DiscussionAmerican Surgeon.  70:11-12. 2004
    2004 Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cellsJournal of Gastrointestinal Surgery.  8:960-970. 2004
    2004 Retrospective analysis of capecitabine and radiation therapy in the treatment of pancreatic cancerJournal of Applied Research in Clinical and Experimental Therapeutics.  4:635-646. 2004
    2004 Serum lactic acid determines the outcomes of CT diagnosis of pneumatosis of the gastrointestinal tractAmerican Surgeon.  70:19-23. 2004
    2004 Endoscopic ultrasound-guided fine-needle aspiration biopsy: A powerful tool to obtain samples from small lesionsCancer.  102:239-246. 2004
    2004 UAB's experience with concurrent capecitabine (CAP) and radiotherapy (RT) in Pts with resected (RES) or locally advanced (LA) pancreatic cancer (Pan Ca).Journal of Clinical Oncology.  22:4188. 2004
    2004 Incidence of clinically evident deep venous thrombosis after laparoscopic Roux-en-Y gastric bypass 2004
    2004 Smad4 Protein Stability Is Regulated by Ubiquitin Ligase SCF β-TrCP1Journal of Biological Chemistry.  279:14484-14487. 2004
    2004 Endoscopic ultrasound-guided fine needle aspiration biopsy of suspected cholangiocarcinomaClinical Gastroenterology and Hepatology.  2:209-213. 2004
    2004 Adenoviral gene therapy for pancreatic adenocarcinoma. 2004
    2004 Current status of gene therapy for pancreatic cancer 2004
    2004 Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinomaJournal of Gastrointestinal Surgery.  8:812-823. 2004
    2004 Regulatory cells. 2004
    2003 Endoscopic ultrasound-guided fine needle aspiration biopsy of patients with suspected pancreatic cancer: diagnostic accuracy and acute and 30-day complications.American Journal of Gastroenterology.  98:2663-2668. 2003
    2003 Prevalence and significance of periduodenal venous collaterals in patients evaluated for pancreaticobiliary disorders by endosonographyEndoscopy.  35:1015-1019. 2003
    2003 Recurrent Metastatic Klatskin's Carcinoid Tumor to Celiac Lymph Nodes in a Teenager: Diagnosis by Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy with Immunocytochemical CorrelationDigestive Diseases and Sciences.  48:2301-2305. 2003
    2003 Results of long-term follow-up for transanal excision for rectal cancerAmerican Surgeon.  69:675-678. 2003
    2003 Yield of endoscopic ultrasound-guided fine-needle aspiration biopsy in patients with suspected pancreatic carcinoma: Emphasis on atypical, suspicious, and false-negative aspiratesCancer.  99:285-292. 2003
    2003 Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancerGastroenterology.  125:1203-1218. 2003
    2003 Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibodyJournal of Surgical Research.  111:274-283. 2003
    2003 Common Bile Duct Transection in Blunt Abdominal Trauma: Case Report Emphasizing Mechanism of Injury and Therapeutic Management 2003
    2003 Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancementJournal of Gastrointestinal Surgery.  7:364-371. 2003
    2003 Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy of Patients with Suspected Pancreatic Cancer: Diagnostic Accuracy and Acute and 30-Day ComplicationsAmerican Journal of Gastroenterology.  98:2663-2668. 2003
    2003 Laparoscopic vs conventional ileocolectomy for primary Crohn diseaseArchives of Surgery.  138:76-79. 2003
    2002 Ligand activation of alternatively spliced fibroblast growth factor receptor-1 modulates pancreatic adenocarcinoma cell malignancyJournal of Gastrointestinal Surgery.  6:546-553. 2002
    2002 Endoscopic ultrasound-guided fine-needle aspiration biopsy: A study of 103 casesCancer.  96:232-239. 2002
    2002 IFN-gammaupregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma.International Journal of Cancer.  100:445-451. 2002
    2002 Application of molecular biology studies to gene therapy treatment strategiesWorld Journal of Surgery.  26:854-860. 2002
    2002 Tamoxifen (TMX)/Fas induced growth inhibition of human cholangiocarcinoma (HCC) by gamma interferon (IFN-γ)Annals of Surgery.  235:872-878. 2002
    2002 Quantitation of cytosine deaminase mRNA by real-time reverse transcription polymerase chain reaction: A sensitive method for assessing 5-fluorocytosine toxicity in VitroAnalytical Biochemistry.  301:189-199. 2002
    2002 Extrahepatic biliary cystadenoma localized to the common bile ductSurgery.  131:587-588. 2002
    2001 Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinomaCancer Gene Therapy.  8:990-996. 2001
    2001 Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors 2001
    2001 Acidic fibroblast growth factor (FGF-1) signaling inhibits peroxynitrite-induced cell death during pancreatic tumorigenesisFree Radical Biology and Medicine.  30:957-966. 2001
    2001 Improved Reduction in Pain in Chronic Pancreatitis with Combined Intraoperative Celiac Axis Plexus Block and Lateral Pancreaticojejunostomy 2001
    2001 Colorectal hepatic metastases: Resection, local ablation, and hepatic artery infusion pump are associated with prolonged survivalArchives of Surgery.  136:318-323. 2001
    2001 Invited critiqueArchives of Surgery.  136:69. 2001
    2000 Combined intraoperative alcohol celiac ablation and lateral pancreaticojejunostomy for chronic pancreatitis. 2000
    2000 Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinomaArchives of Biochemistry and Biophysics.  377:350-356. 2000
    2000 Carcinoid tumor of the hepatic duct presenting as a Klatskin tumor in an adolescent and review of world literature 2000
    2000 Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models 2000
    1999 The role of pancreaticoduodenectomy in the treatment of severe chronic pancreatitisAmerican Surgeon.  65:1108-1112. 1999
    1999 Solitary malignant peripheral nerve sheath tumor of the pancreas 1999
    1999 An unusual etiology of biliary hilar obstruction and the potential role of acidic fibroblast growth factor in the development of a biliary neuromaAmerican Surgeon.  65:47-51. 1999
    1999 Apoptosis and tumorigenesis in human cholangiocarcinoma cells: Involvement of Fas/APO-1 (CD95) and calmodulinAmerican Journal of Pathology.  155:193-203. 1999
    1999 Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancerArchives of Surgery.  134:245-251. 1999
    1999 Cytosine deaminase and herpes simplex virus thymidine kinase gene expression via adenoviral infection of human cholangiocarcinoma cells occurs in the presence of human bileTumor Targeting.  4:29-36. 1999
    1999 Fas Expression Prevents Cholangiocarcinoma Tumor GrowthJournal of Gastrointestinal Surgery.  3:374-382. 1999
    1999 Organized pancreatic necrosis: Endoscopic, radiologic, and pathologic features of a distinct clinical entityPancreas.  19:105-108. 1999
    1998 The surgical management of chronic pancreatitis (ductal strictures)Seminars in Gastrointestinal Disease.  9:80-83. 1998
    1998 Combined Cytosine Deaminase Expression, 5-Fluorocytosine Exposure, and Radiotherapy Increases Cytotoxicity to Cholangiocarcinoma CellsJournal of Gastrointestinal Surgery.  2:283-291. 1998
    1998 Directed antisense therapy confirms the role of protein kinase C-α in the tumorigenicity of pancreatic cancerSurgery.  124:218-224. 1998
    1998 Endoscopic transgastric drainage of a retroperitoneal lymphoceleGastrointestinal Endoscopy.  48:309-311. 1998
    1998 Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 geneSurgery.  124:143-151. 1998
    1998 Immunoaffinity localization of the enzyme xanthine oxidase on the outside surface of the endothelial cell plasma membraneSurgery.  124:551-560. 1998
    1998 Surgical gastrostomy placement as access for diagnostic and therapeutic ERCPGastrointestinal Endoscopy.  48:640-641. 1998
    1997 Pancreatic carcinoma cell killing via adenoviral mediated delivery of the herpes simplex virus thymidine kinase geneAnnals of Surgery.  225:609-620. 1997
    1997 Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivoCancer Research.  57:4325-4332. 1997
    1997 Hodgkin's disease associated with neurologic paraneoplastic syndromeSouthern Medical Journal.  90:839-844. 1997
    1997 Solitary breast metastasis to the ampulla and distal common bile ductAmerican Surgeon.  63:512-515. 1997
    1997 Tamoxifen-mediated growth inhibition of human cholangiocarcinomaCancer Research.  57:1743-1749. 1997
    1997 Adenoviral vector infection of the human exocrine pancreasArchives of Surgery.  132:1006-1009. 1997
    1997 Receptor-Dependent Growth Inhibition of Human Pancreatic Cancer by 9-cis Retinoic AcidJournal of Gastrointestinal Surgery.  1:174-181. 1997
    1996 In vivo gene transfer to the human biliary tract 1996
    1996 Economics of pancreatoduodenectomy in the elderlySurgery.  120:620-626. 1996
    1995 Perixiphoid extension of the midline incisionJournal of The American College of Surgeons.  180:739-741. 1995
    1992 Mesenteric vasoconstriction in cardiogenic shock in pigsGastroenterology.  102:1968-1979. 1992
    1990 Molecular biology of circulatory shock. Part II. Expression of four groups of hepatic genes is enhanced after resuscitation from cardiogenic shockSurgery.  108:559-566. 1990


    Year Title Altmetric
    2012 Adjunctive procedures in intestinal surgery 2012
    2004 Pancreatitis and Its Complications.  223-272. 2004
    1997 Archives of Surgery.  909-910. 1997

    Research Overview

  • Dr. Vickers continues to see patients and conduct research. His major research interests include gene therapy as an application in the treatment of pancreatobiliary tumors, the role of growth factors and receptors in the oncogenesis of pancreatic cancer, the implications of FAS expressions and Tamoxifen in the growth and treatment of cholangiocarcinoma, assessment of clinical outcomes in the surgical treatment of pancreatobiliary tumors and the role of death receptors in the treatment of pancreatic cancer.
  • Education And Training

  • National Institutes of Health (NIH), Bethesda Biologies of the Food and Drug Administration, Predoctoral Fellowship
  • National Institutes of Health (NIH), Bethesda Gerontology Research Center, Predoctoral Fellowship
  • Johns Hopkins Hospital, Internship
  • Johns Hopkins Hospital, Residency
  • Johns Hopkins Medical Centers, Residency
  • Johns Hopkins Hospital, Postdoctoral Fellowship
  • Johns Hopkins Hospital, Baltimore, Postdoctoral Fellowship
  • Johns Hopkins School of Medicine, Postdoctoral Fellowship
  • Doctor of Medicine, Johns Hopkins University 1986
  • Awards And Honors

  • Southern Surgical Association President, 2017
  • Best Doctors in America, 2017
  • Southern Surgical Association President, 2016
  • Society for Surgery of the Alimentary Tract (SSAT) Board of Trustees Chair, 2016
  • University of Minnesota Clinical Research Award, 2016
  • Best Doctors in America, 2016
  • Society for Surgery of the Alimentary Tract (SSAT) President, 2015
  • Best Doctors in America, 2015
  • Best Doctors in America, 2014
  • Johns Hopkins Society of Scholars, 2013
  • Best Doctors in America, 2013
  • Minneapolis / St. Paul Top Doctors, 2013
  • Best Doctors in America, 2012
  • America’s Top Doctors, 2012
  • Minneapolis / St. Paul Top Doctors, 2012
  • America’s Top Doctors, 2011
  • America’s Top Surgeons, 2011
  • America’s Top Doctors, 2010
  • America’s Top Surgeons, 2010
  • America’s Top Doctors, 2009
  • National Academy of Medicine (Section 6), 2009
  • Distinguished Faculty, 2009
  • America’s Top Doctors, 2008
  • America’s Leading Doctors, 2008
  • America’s Top Doctors, 2007
  • Best Doctors in America, 2006
  • Best Doctor in Birmingham Magazine Annual Best Doctors Issue, 2006
  • America’s Top Doctors, 2006
  • Who’s Who in Black Birmingham, 2006
  • Best Doctor in Birmingham Magazine Annual Best Doctors Issue, 2005
  • UAB Argus Society Excellence in Teaching Award, 2004
  • UAB Argus Society Excellence in Teaching Award, 2003
  • Best Doctors in America, 2003
  • Best Doctor in Annual Best Regional Doctors, 2003
  • UAB Argus Society Excellence in Teaching Award, 2002
  • UAB Argus Society Excellence in Teaching Award, 2001
  • James IV Fellow, 2001
  • AOA, 2001
  • UAB Argus Society Excellence in Teaching Award, 2000
  • UAB Argus Society Excellence in Teaching Award, 1999
  • Robert Wood Johnson Research Fellow, 1999
  • Society for Surgery of the Alimentary Tract Young Clinician Award, 1999
  • UAB Argus Society Excellence in Teaching Award, 1998
  • Robert Wood Johnson Research Fellow, 1998
  • UAB Argus Society Excellence in Teaching Award, 1997
  • Robert Wood Johnson Research Fellow, 1997
  • Best Clinical Professor, 1997
  • Presidents Award for Excellence in Teaching, 1997
  • UAB Argus Society Excellence in Teaching Award, 1996
  • Robert Wood Johnson Research Fellow, 1996
  • UAB Argus Society Excellence in Teaching Award, 1995
  • Robert Wood Johnson Research Fellow, 1995
  • UAB Argus Society Excellence in Teaching Award, 1994
  • Baltimore Academy of Surgery Resident Research Award, 1990
  • Recipient of Johns Hopkins Hospital Department of Surgery, George D. Zuidiema Resident Research Award, 1989
  • The National Medical Commonwealth Outstanding Minority Medical Student ($5,000), 1986
  • J.F. Reed Four-year Academic Medical Scholarship, 1982
  • Full Name

  • Selwyn Vickers
  • Fax

  • 205-975-6190