Dr. Mukhtar conducted his Ph.D. research on Arabidopsis transcriptional regulatory networks at the Max Planck Institute Cologne, Germany under the supervision of Dr. Imre Somssich. He was fortunate to continue his postdoctoral research in the laboratory of Dr. Jeff Dangl, a Howard Hughes Medical Institute investigator and a member of the National Academy of Sciences, at the University of North Carolina at Chapel Hill. He employed genomics, bioinformatics and computer-aided systems-level analyses to generate the first large-scale Arabidopsis-pathogens protein-protein interaction network in collaboration with the Dana Farber Cancer Institute & Center for Cancer Systems Biology, an affiliate of Harvard Medical School in Boston, MA. His four years long post-doc resulted in a first author publication in Science (The Arabidopsis-pathogens interactome; Mukhtar et al. Science 2011), as well as a number of co-authored high impact papers, including another large-scale network assembly (the Arabidopsis interactome map; Science 2011), global mapping of the G-protein interactions (Molecular Systems Biology 2011) and sequencing and assembly of 19 strains of pathogenic bacterium P. syringae using next-generation sequencing approaches (PLoS Pathogens 2011).
Dr. Mukhtar’s research at UAB focuses at the interface of bioinformatics and life sciences. He is broadly interested in interdisciplinary research projects focused on genomics/systems biology of host immunity using computational approaches. Specifically, he aims to understand how macromolecular networks are organized in the cells and how pathogen proteins perturb such networks to promote diseases. He has fifteen years of training and experience in various aspects of life sciences such as genetics and genomics as well as in handling large datasets and employing computational tools to answer key questions in plant systems biology. The Shahid Mukhtar Lab carries out a highly research-active program with graduate and undergraduate students working on a wide range of bioinformatics/genomics projects.
Genomics is the study of the entire genome, usually starting with whole genome sequencing. In the recent years, genomics and proteomics have become powerful tools for revealing gene function and genomic organization in large scale. Functional genomics relies on using the sequence data to explore how DNA and proteins work with each other and the environment to create complex, dynamic living systems.
The long-term goal of the Shahid Mukhtar Lab is to understand how macromolecular networks control biological processes and how environmental perturbations in such networks can explain diverse phenotypes. The current projects under investigation include:
Dynamics of Transcriptional Regulatory Networks in Plant Defense Microbial Community Transcriptional Networks Predictive Modelling to Identify Key Functionalities in Host-Pathogen Interactions Exploring the Phytohormone-mediated Dynamic Properties of Network Modules Systems Analyses to Identify Host Cell Metabolism Functional Modules.
For details about these projects, please check out the Shahid Mukhtar Lab.
Systems Biology, Functional Genomics, Bioinformatics, Plant Immune Networks