• Selene Meza-Perez, Ph.D., is an Instructor of Medicine in the Division of Clinical Immunology and Rheumatology. She received her B.S. in Biology from the National Autonoma University of Mexico (UNAM) and her masters and Ph.D. degree in Immunology at the National Polytechnique Institute (IPN) in Mexico in 2010, where her thesis theme was dedicated to study the role of intestinal dendritic cells immune response against bacterial and viral infections.

    In February 2011, she joined the laboratory of Dr. William Agace at Lund University in Sweden as a postdoctoral fellow studying the interaction of intestinal dendritic cells and eosinophils in parasitic infections and the role of eosinophils in controlling immune and physiological responses in adipose tissue. In 2013, she moved to the University of Alabama in Birmingham (UAB) to join the laboratory of Dr. Troy Randall where she started describing the role of the omentum (adipose tissue) in the immune response in the context of ovarian cancer metastasis.

    Currently, she is investigating the impact of microbiota in the immune responses of the tumor microenvironment. She has been actively involved in teaching at the GBS program and also in training clinical fellows in cancer research due to her collaboration with the O’Neal Comprehensive Cancer Center at UAB.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Specialized immune responses in the peritoneal cavity and omentumJournal of Leukocyte Biology.  109:717-729. 2021
    2021 Neutralization of TGFβ improves tumor immunity and reduces tumor progression in ovarian carcinomaMolecular Cancer Therapeutics.  20:602-611. 2021
    2021 Manipulating the Wnt/β-catenin signaling pathway to promote anti-tumor immune infiltration into the TME to sensitize ovarian cancer to ICB therapyGynecologic Oncology.  160:285-294. 2021
    2020 Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice. 2020
    2020 Inhibiting WNT ligand production for improved immune recognition in the Ovarian tumor microenvironmentCancers.  12. 2020
    2020 Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer 2020
    2019 Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosisRedox Biology.  26. 2019
    2019 Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune ResponsesImmunity.  51:155-168.e5. 2019
    2019 The expression of MHC class II molecules on murine breast tumors delays T-cell exhaustion, expands the T-cell repertoire, and slows tumor growth 2019
    2018 The antitumor effects of entinostat in ovarian cancer require adaptive immunityCancer.  124:4657-4666. 2018
    2018 Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid OrganizationsMethods in Molecular Biology.  1845:1-15. 2018
    2017 Immunological Functions of the Omentum 2017
    2017 Eosinophils are key regulators of perivascular adipose tissue and vascular functionalityScientific Reports.  7. 2017
    2017 Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growthOncotarget.  8:44159-44170. 2017
    2016 IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in miceJournal of Ovarian Research.  9:70. 2016
    2016 IL-12 Expressing oncolytic herpes simplex virus promotes anti-tumor activity and immunologic control of metastatic ovarian cancer in miceJournal of Ovarian Research.  9:1-11. 2016

    Education And Training

  • Doctor of Science in Immunology, National Polytechnic Institute 2010
  • Full Name

  • Selene Meza-Perez