Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic DysfunctionAntioxidants and Redox Signaling.  32:1293-1312. 2020
2020 Progressive cardiac arrhythmias and ECG abnormalities in the Huntington's disease BACHD mouse modelHuman Molecular Genetics.  29:369-381. 2020
2020 Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral RegurgitationJACC: Basic to Translational Science.  5:109-122. 2020
2020 Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunctionPLoS ONE.  15. 2020
2019 Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in miceRedox Biology.  27. 2019
2019 Ascending Defibrillation Waveform Significantly Reduces Myocardial Morphological Damage and Injury CurrentJACC: Clinical Electrophysiology.  5:854-862. 2019
2019 Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological RemodelingFrontiers in Cardiovascular Medicine.  6. 2019
2019 Novel role of the ER/SR Ca2+ sensor STIM1 in the regulation of cardiac metabolism 2019
2019 Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failureLaboratory Investigation.  99:371-386. 2019
2019 Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease 2019
2018 Myocardial rupture after small acute myocardial infarction in the absence of coronary artery diseaseCardiovascular Pathology.  37:26-29. 2018
2018 Association of preexisting arterial intimal hyperplasia with arteriovenous fistula outcomesClinical Journal of the American Society of Nephrology.  13:1358-1363. 2018
2018 Idiopathic ventricular arrhythmias originating from the infundibular muscles prevalence, electrocardiographic and electrophysiological characteristics, and outcome of catheter ablationCirculation: Arrhythmia and Electrophysiology.  11. 2018
2017 Smoldering myocarditis following immune checkpoint blockadeJournal for ImmunoTherapy of Cancer.  5. 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heartJournal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 Idiopathic Ventricular Arrhythmias Originating from the Parietal Band: Electrocardiographic and Electrophysiological Characteristics and Outcome of Catheter AblationCirculation: Arrhythmia and Electrophysiology.  10. 2017
2017 Efficacy of an Anatomical Approach in Radiofrequency Catheter Ablation of Idiopathic Ventricular Arrhythmias Originating from the Left Ventricular Outflow TractCirculation: Arrhythmia and Electrophysiology.  10. 2017
2017 Induced pluripotent stem cell-derived endothelial cells overexpressing interleukin-8 receptors a/b and/or c-c chemokine receptors 2/5 inhibit vascular injury responseStem Cells Translational Medicine.  6:1168-1177. 2017
2016 Challenging Radiofrequency Catheter Ablation of Idiopathic Ventricular Arrhythmias Originating from the Left Ventricular Summit Near the Left Main Coronary ArteryCirculation: Arrhythmia and Electrophysiology.  9. 2016
2016 Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular functionJournal of Thoracic and Cardiovascular Surgery.  152:1059-1070.e2. 2016
2016 Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function 2016
2016 Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - Nomenclature and diagnostic criteriaCardiovascular Pathology.  25:247-257. 2016
2016 Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: A mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscleThe FASEB Journal.  30:1865-1879. 2016
2016 Preoperative vascular medial fibrosis and arteriovenous fistula developmentClinical Journal of the American Society of Nephrology.  11:1615-1623. 2016
2015 Letter from Yamada et al Regarding Article, "differentiation of Papillary Muscle from Fascicular and Mitral Annular Ventricular Arrhythmias in Patients with and Without Structural Heart Disease"Circulation: Arrhythmia and Electrophysiology.  8:1301. 2015
2015 Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseasesCardiovascular Pathology.  24:267-278. 2015
2015 Shone variant with large eustachian valve: Implication for repair and heart transplantationCardiovascular Pathology.  24:124-127. 2015
2015 Preoperative arterial microcalcification and clinical outcomes of arteriovenous fistulas for hemodialysisAmerican Journal of Kidney Diseases.  66:84-90. 2015
2014 High-fat, low-carbohydrate diet promotes arrhythmic death and increases myocardial ischemia-reperfusion injury in rats 2014
2014 Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function 2014
2014 Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dogPLoS ONE.  9. 2014
2014 Activation of AKT by O-linked N-Acetylglucosamine induces vascular calcification in diabetes mellitusCirculation Research.  114:1094-1102. 2014
2014 The transcription factor E26 transformation-specific sequence-1 mediates neointima formation in arteriovenous fistulaJournal of the American Society of Nephrology.  25:475-487. 2014
2014 Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: A feasibility studyTheranostics.  4:36-46. 2014
2014 Hemorrhagic shock one month following uncomplicated liver transplantationAmerican Journal of Transplantation.  14:1461-1463. 2014
2013 Correlation of pre-existing vascular pathology with arteriovenous graft outcomes in hemodialysis patientsAmerican Journal of Kidney Diseases.  62:1122-1129. 2013
2013 Prevalence and clinical, electrocardiographic, and electrophysiologic characteristics of ventricular arrhythmias originating from the noncoronary sinus of ValsalvaHeart Rhythm.  10:1605-1612. 2013
2013 Preoperative venous intimal hyperplasia, postoperative arteriovenous fistula stenosis, and clinical fistula outcomesClinical Journal of the American Society of Nephrology.  8:1750-1755. 2013
2013 Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: Systematic analysisRheumatology.  52:1529-1533. 2013
2013 Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinaseLaboratory Investigation.  93:868-879. 2013
2013 Identification of a high-mannose ICAM-1 glycoform: Effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signaling 2013
2013 Cationic peptide mR18L with lipid lowering properties inhibits LPS-induced systemic and liver inflammation in ratsBiochemical and Biophysical Research Communications.  436:705-710. 2013
2013 Evaluation of acute cardiac and chest wall damage after shocks with a subcutaneous implantable cardioverter defibrillator in swinePacing and Clinical Electrophysiology.  36:1265-1272. 2013
2013 Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to SepsisPLoS ONE.  8. 2013
2013 Histologic analysis of a covered stent implanted for pseudoaneurysm in a coronary arteryCardiovascular Pathology.  22. 2013
2012 In vivo Intravascular Ultrasound-guided Photoacoustic Imaging of Lipid in Plaques Using an Animal Model of AtherosclerosisUltrasound in Medicine and Biology.  38:2098-2103. 2012
2012 Coronary artery fistula after cardiac transplantationCirculation.  126:2144-2145. 2012
2012 Multiorgan failure and bone marrow necrosis in three adults with sickle cell-β +-thalassemiaAmerican Journal of Hematology.  87:621-624. 2012
2012 Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal bloodOptics Letters.  37:1244-1246. 2012
2012 Pathologic features of dilated cardiomyopathy with localized noncompaction in a child with deletion 1p36 syndromeCongenital Heart Disease.  7:59-61. 2012
2011 Medial fibrosis, vascular calcification, intimal hyperplasia, and arteriovenous fistula maturationAmerican Journal of Kidney Diseases.  58:437-443. 2011
2011 Oxidative stress and myocardial remodeling in chronic mitral regurgitationAmerican Journal of the Medical Sciences.  342:114-119. 2011
2011 Quantification of myocardial viability distribution with Gd(DTPA) bolus-enhanced, signal intensity-based percent infarct mappingMagnetic Resonance Imaging.  29:650-658. 2011
2010 Differentiation of acute and four-week old myocardial infarct with Gd(ABE-DTTA)-enhanced CMRJournal of Cardiovascular Magnetic Resonance.  12. 2010
2010 Electrocardiographic and electrophysiological characteristics in idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle relevance for catheter ablationCirculation: Arrhythmia and Electrophysiology.  3:324-331. 2010
2010 Bradycardia and syncope as a presentation of cardiac allograft rejection involving the conducting systemCardiovascular Pathology.  19:117-120. 2010
2010 Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imagingOptics Express.  18:4889-4897. 2010
2010 Increased Oxidative Stress and Cardiomyocyte Myofibrillar Degeneration in Patients With Chronic Isolated Mitral Regurgitation and Ejection Fraction >60%Journal of the American College of Cardiology.  55:671-679. 2010
2010 Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal miceAtherosclerosis.  208:90-96. 2010
2009 Myocardial strain in sub-acute peri-infarct myocardium 2009
2009 On the possibility to detect lipid in atherosclerotic plaques using intravascular photoacoustic imagingProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009.  4767-4770. 2009
2009 X-ray angiography and magnetic resonance imaging to distinguish interarterial from septal courses of anomalous left coronary artery: an ex vivo heart model.Journal of Invasive Cardiology.  21:648-652. 2009
2008 Statins improve human coronary atherosclerotic plaque morphologyTexas Heart Institute Journal.  35:99-103. 2008
2008 Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaquesOptics Express.  16:3362-3367. 2008
2008 Comparison of intracoronary and transendocardial delivery of allogeneic mesenchymal cells in a canine model of acute myocardial infarctionJournal of Molecular and Cellular Cardiology.  44:486-495. 2008
2008 Histomorphometric analysis of intramyocardial vessels in primary and senile amyloidosis: epicardium versus endocardiumCardiovascular Pathology.  17:65-71. 2008
2008 Automated multidetector computed tomography evaluation of subacutely infarcted myocardiumJournal of Cardiovascular Computed Tomography.  2:26-32. 2008
2008 The left ventricular ostium: an anatomic concept relevant to idiopathic ventricular arrhythmias.Circulation: Arrhythmia and Electrophysiology.  1:396-404. 2008
2007 Ex vivo characterization of atherosclerosis using intravascular photoacoustic imagingOptics Express.  15:16657-16666. 2007
2007 In reply [2]Archives of Pathology and Laboratory Medicine.  131:1766-1767. 2007
2007 Systemic infections cause exaggerated local inflammation in atherosclerotic coronary arteries: Clues to the triggering effect of acute infections on acute coronary syndromesTexas Heart Institute Journal.  34:11-18. 2007
2007 The role of periadventitial fat in atherosclerosis.Archives of Pathology and Laboratory Medicine.  131:481-487. 2007
2007 The role of periadventitial fat in atherosclerosis: An adipose subset with potential diagnostic and therapeutic implicationsArchives of Pathology and Laboratory Medicine.  131:481-487. 2007
2007 Xenograft calcification in Reiter's syndrome 2007
2006 Pulmonary atresia with intact ventricular septum associated with congenitally corrected transpositionPediatric Cardiology.  27:741-745. 2006
2006 Acute take-off of the right coronary artery with long intra-aortic wall course presenting as chronic coronary ostium occlusion in a patient with end-stage heart failure 2006
2005 Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model.Circulation.  111:150-156. 2005
2005 Of mice and men: Mouse models and the molecular mechanisms of post-transplant coronary artery disease 2005
2004 Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cellsJournal of the American Chemical Society.  126:15638-15639. 2004
2004 Finding vulnerable atherosclerotic plaques is it worth the effort? 2004
2004 Influenza vaccination: An emerging opportunity to prevent cardiovascular diseaseInternational Congress Series.  1263:678-681. 2004
2004 Influenza and Cardiovascular Disease: Is There a Causal Relationship?Texas Heart Institute Journal.  31:4-13. 2004
2004 Changes in magnetocardiogram patterns of infarcted-reperfused myocardium after injection of superparamagnetic contrast media 2004
2004 Changes in magnetocardiogram patterns of infarcted-reperfused myocardium after injection of superparamagnetic contrast media. 2004
2003 Influenza and Cardiovascular Disease: A New Opportunity for Prevention and the Need for Further StudiesCirculation.  108:2730-2736. 2003
2003 From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part IICirculation.  108:1772-1778. 2003
2003 From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part ICirculation.  108:1664-1672. 2003
2003 Thermography basket catheter: In vivo measurement of the temperature of atherosclerotic plaques for detection of vulnerable plaquesCatheterization and Cardiovascular Interventions.  59:52-59. 2003
2003 Superparamagnetic iron oxide-based method for quantifying recruitment of monocytes to mouse atherosclerotic lesions in vivo: Enhancement by tissue necrosis factor-α, interleukin-1β, and interferon-γCirculation.  107:1545-1549. 2003
2003 Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient miceCirculation.  107:762-768. 2003
2002 Thermal detection of vulnerable plaque.American Journal of Cardiology.  90:36L-39L. 2002
2002 pH heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaqueAtherosclerosis.  164:27-35. 2002
2001 Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactorsGenes and Development.  15:839-844. 2001
2000 Absent pulmonary valve with tricuspid atresia or severe tricuspid stenosis: report of three cases and review of the literature.Pediatric and Developmental Pathology.  3:353-366. 2000
2000 FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardiumCell.  101:729-739. 2000
1999 Truncus arteriosus with anomalous pulmonary venous connectionAmerican Journal of Cardiology.  83:801-804. 1999
1998 Clinicopathologic heterogeneity in hypertrophic cardiomyopathy with regard to age, asymmetric septal hypertrophy, and concentric hypertrophy beyond the pediatric age groupArchives of Pathology and Laboratory Medicine.  122:434-441. 1998
1997 Myocardial protection of contractile function after global ischemia by physiologic estrogen replacement in the ovariectomized ratJournal of Molecular and Cellular Cardiology.  29:2403-2414. 1997
1996 Giant cell myocarditis: An entity distinct from sarcoidosis characterized by multiphasic myocyte destruction by cytotoxic T cells and histiocytic giant cellsModern Pathology.  9:1126-1134. 1996
1996 Effect of age, race, body surface area, heart weight and atherosclerosis on coronary artery dimensions in young malesAtherosclerosis.  123:243-250. 1996
1994 Effect of early versus delayed hypoxic environment on neonatal rabbits.Journal of Surgical Research.  57:264-267. 1994
1993 Mucin-positive epithelial mesothelioma and pseudomesotheliomatous adenocarcinoma [3]Archives of Pathology and Laboratory Medicine.  117:967. 1993
1991 Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cellsCirculation Research.  69:1427-1449. 1991
1990 Differences in the electrophysiological response to canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardiumCirculation Research.  67:615-627. 1990
1989 Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: Role of the transient outward currentJournal of the American College of Cardiology.  14:1053-1066. 1989
1988 Transient outward current prominent in canine ventricular epicardium but not endocardiumCirculation Research.  62:116-126. 1988

Chapter

Year Title Altmetric
2007 Adventitial and Periadventitial Fat Inflammation and Plaque Vulnerability.  95-104. 2007
2007 Intravascular Thermography.  263-272. 2007
2007 New Developments in Treatment of Vulnerable Plaques.  303-320. 2007

Education And Training

  • Doctor of Medicine, University of Buenos Aires 1977
  • Ramos Mejia Hospital, Internship 1980
  • SUNY Health Science Center at Syracuse, Residency 1994
  • Ramos Mejia Hospital, Residency 1984
  • Children's Hospital Boston, Postdoctoral Fellowship 2000
  • Children's Hospital Boston, Postdoctoral Fellowship 1999
  • Armed Forces Institute of Pathology, Postdoctoral Fellowship 1996
  • Full Name

  • Silvio Litovsky