Sixto Leal

Sixto Leal
Assistant Professor

Associate Scientist (C), UWIRC Microbiome Center , School of Medicine
Assistant Professor (S), Ophthalmology , School of Medicine
Associate Scientist (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Assistant Professor (S), Microbiology , Academic Joint Departments
Assistant Professor (P), Laboratory Medicine , Clinical Pathology
Associate Division Director of Laboratory Medicine, Laboratory Medicine , Clinical Pathology

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Maternal and Perinatal Outcomes Associated With the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Obstetrics and Gynecology. 140:262-265. 2022
2022	COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging. 2022
2022	Meta-analysis of the robustness of COVID-19 diagnostic kit performance during the early pandemic. BMJ Open. 12. 2022
2022	Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection. 2022
2021	Maternal and Perinatal Outcomes Associated With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta (B.1.617.2) Variant. Obstetrics and Gynecology. 138:842-844. 2021
2021	Decreasing High-risk Exposures for Healthcare Workers through Universal Masking and Universal Severe Acute Respiratory Syndrome Coronavirus 2 Testing on Entry to a Tertiary Care Facility. Clinical Infectious Diseases. 73:E3113-E3115. 2021
2021	Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging Infectious Diseases. 27:2454-2458. 2021
2021	Diagnosis of Clostridioides difficile infection by analysis of volatile organic compounds in breath, plasma, and stool: A cross-sectional proof-of-concept study. PLoS One. 16. 2021
2021	Recognition of Diagnostic Gaps for Laboratory Diagnosis of Fungal Diseases: Expert Opinion from the Fungal Diagnostics Laboratories Consortium (FDLC). Journal of Clinical Microbiology. 59:e0178420. 2021
2021	Practical guidance for clinical microbiology laboratories: Diagnosis of ocular infections. Clinical Microbiology Reviews. 34. 2021
2021	Meta-Analysis of Robustness of COVID-19 Diagnostic Kits During Early Pandemic. 2021
2020	Hyperammonemia syndrome due to Ureaplasma urealyticum in a kidney transplant recipient: A case of disseminated disease from a fluoroquinolone-resistant isolate. Transplant Infectious Disease. 22. 2020
2020	In vitro activities of eravacycline and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrobial Agents and Chemotherapy. 64. 2020
2020	Perioperative and critical care management of a patient with severe acute respiratory syndrome Corona virus 2 infection and aneurysmal subarachnoid hemorrhage. Neurosurgery. 87:E243-E244. 2020
2020	Evaluation of commercial molecular diagnostic methods for detection and determination of macrolide resistance in mycoplasma pneumoniae. Journal of Clinical Microbiology. 58. 2020
2020	Prospective evaluation of molecular assays for diagnosis of vaginitis. Journal of Clinical Microbiology. 58. 2020
2019	Disseminated metacestode versteria species infection in woman, pennsylvania, usa. Emerging Infectious Diseases. 25:1429-1431. 2019
2019	Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil–derived acidic mammalian chitinase. European Journal of Immunology. 49:918-927. 2019
2019	Evaluation of the ELITe InGenius PCR platform for detection of Mycoplasma pneumoniae. Journal of Clinical Microbiology. 57. 2019
2019	Mycoplasma pneumoniae Carriage with De Novo Macrolide-Resistance and Breakthrough Pneumonia. Pediatrics. 144. 2019
2018	Quantitative thresholds enable accurate identification of clostridium difficile infection by the luminex xTAG gastrointestinal pathogen panel. Journal of Clinical Microbiology. 56. 2018
2017	Current and Emerging Molecular Tests for Human Papillomavirus–Related Neoplasia in the Genomic Era. The Journal of Molecular Diagnostics. 19:366-377. 2017
2016	Clinical significance of commensal gram-positive rods routinely isolated from patient samples. Journal of Clinical Microbiology. 54:2928-2936. 2016
2016	Closing the brief case: Recurrent granulomatous mastitis due to corynebacterium kroppenstedtii. Journal of Clinical Microbiology. 54:2212. 2016
2016	Recurrent granulomatous mastitis due to corynebacterium kroppenstedtii. Journal of Clinical Microbiology. 54:1938-1941. 2016
2016	Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence. 7:465-476. 2016
2015	Erratum: Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2 (Nat. Immunol., 14, (143-151)). Nature Immunology. 16:214. 2015
2014	Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils. Journal of Immunology. 192:3319-3327. 2014
2014	Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses. Glycobiology. 24:262-271. 2014
2014	Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2. Nature Immunology. 15:143-151. 2014
2014	Fatal metacestode infection in Bornean orangutan caused by unknown Versteria species.. Emerging Infectious Diseases. 20:109-113. 2014
2013	The rodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo. Journal of Immunology. 191:2581-2588. 2013
2013	Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathogens. 9. 2013
2013	Host Response and Bacterial Virulence Factor Expression in Pseudomonas aeruginosa and Streptococcus pneumoniae Corneal Ulcers. PLoS One. 8. 2013
2012	Fungal antioxidant pathways promote survival against neutrophils during infection. Journal of Clinical Investigation. 122:2482-2498. 2012
2012	The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models. Cytokine. 58:107-111. 2012
2011	Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or Fusarium. Journal of Infectious Diseases. 204:942-950. 2011
2011	Co-regulation of β-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa. Journal of Medical Microbiology. 60:147-156. 2011
2010	Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. PLoS Pathogens. 6:1-16. 2010
2008	Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system. Journal of Medical Microbiology. 57:809-813. 2008

Book

Year	Title	Altmetric
2010	Encyclopedia of the Eye 2010

Chapter

Year	Title	Altmetric
2010	Pathogenesis of fungal keratitis. 268-272. 2010
2010	Pathogenesis of fungal keratitis. 268-272. 2010

Research Overview

Development of novel molecular assays to more accurately diagnose infectious diseases. Utilizing model systems to identify key mediators of microbial detection and killing by phagocytic cells.