Positions

Overview

  • Dr. Krick is an Assistant Professor of Medicine at the University of Alabama at Birmingham (UAB). Following her fellowship training and internships at Jackson Memorial Hospital/University of Miami and Mount Sinai Medical Center, she worked as an assistant professor of medicine at the Miller School of Medicine's Division of Pulmonary and Critical Care Medicine. She has completed training in internal medicine, molecular biology, pulmonary medicine, critical care and vascular medicine.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice.  Theranostics.  12:530-541. 2022
    2021 ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.  Frontiers in Immunology.  12. 2021
    2021 Elexacafator/tezacaftor/ivacaftor resolves subfertility in females with CF: A two center case series.  Journal of Cystic Fibrosis.  20:399-401. 2021
    2021 Cystic Fibrosis Lung Disease in the Aging Population.  Frontiers in Pharmacology.  12. 2021
    2020 Targeting aging pathways in chronic obstructive pulmonary disease.  International Journal of Molecular Sciences.  21:1-17. 2020
    2020 Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?.  Frontiers in Medicine.  7. 2020
    2020 A fatal case of pneumocephalus during computed tomography-guided lung biopsy.  American Journal of Respiratory and Critical Care Medicine.  201:E83-E84. 2020
    2020 The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance.  Frontiers in Medicine.  6. 2020
    2019 O-GlcNAc transferase regulates angiogenesis in idiopathic pulmonary arterial hypertension.  International Journal of Molecular Sciences.  20. 2019
    2019 Exercise Physiology Across the Lifespan in Cystic Fibrosis.  Frontiers in Physiology.  10. 2019
    2019 Fibroblast growth factor 23 is associated with a frequent exacerbator phenotype in COPD: A cross-sectional pilot study.  International Journal of Molecular Sciences.  20. 2019
    2019 How to detect tobacco-related vasculopathy: Are we there yet?.  Annals of the American Thoracic Society.  16:674-675. 2019
    2019 Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis 2019
    2018 FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells.  Frontiers in Endocrinology.  9. 2018
    2018 Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases.  International Journal of Molecular Sciences.  19. 2018
    2018 Fibroblast growth factor 23 and Klotho contribute to airway inflammation.  European Respiratory Journal.  52. 2018
    2018 Impact of altered mineral metabolism on pathological cardiac remodeling in elevated fibroblast growth factor 23.  Frontiers in Endocrinology.  9. 2018
    2018 Reply: We did this, and the patient improved: True, true, and unrelated?.  Annals of the American Thoracic Society.  15:269. 2018
    2017 Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia.  Scientific Reports.  7. 2017
    2017 Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells.  Scientific Reports.  7. 2017
    2017 Going with the flow: Saddle pulmonary embolism complicated by severe hypoxemia without shock.  Annals of the American Thoracic Society.  14:1479-1484. 2017
    2017 Use of aminocaproic acid in combination with extracorporeal membrane oxygenation in a case of leptospirosis pulmonary hemorrhage syndrome.  Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine.  11. 2017
    2017 Fibroblast Growth Factor 23: Mineral Metabolism and beyond.  Contributions to Nephrology.  190:83-95. 2017
    2016 All about Asthma: Association with Obstructive Sleep Apnea, Management, and Overlap with Chronic Obstructive Pulmonary Disease.  American Journal of Respiratory and Critical Care Medicine.  194:1423-1425. 2016
    2016 Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.  Kidney International.  90:985-996. 2016
    2016 Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production.  Journal of Biological Chemistry.  291:6423-6432. 2016
    2015 Roflumilast partially reverses smoke-induced mucociliary dysfunction.  Respiratory Research.  16. 2015
    2015 Airway surface dehydration by transforming growth factor β (TGF-β) in cystic fibrosis is due to decreased function of a voltage-dependent potassium channel and can be rescued by the drug pirfenidone.  Journal of Biological Chemistry.  290:25710-25716. 2015
    2014 Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro 2014
    2013 High-frequency oscillatory ventilation, microRNAs in pulmonary hypertension, and gastric residual volumes..  American Journal of Respiratory and Critical Care Medicine.  188:508-509. 2013
    2011 COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.  Journal of Clinical Investigation.  121:2013-2024. 2011
    2010 BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation.  PLoS ONE.  5. 2010
    2009 TβRI independently activates Smad- and CD2AP-dependent pathways in podocytes.  Journal of the American Society of Nephrology.  20:2127-2137. 2009
    2009 Donor toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation 2009
    2009 Renal gene and protein expression signatures for prediction of kidney disease progression.  American Journal of Pathology.  174:2073-2085. 2009
    2008 Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension.  Pulmonary Pharmacology and Therapeutics.  21:824-832. 2008
    2008 Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease 2008
    2006 Favorable Effects of Inhaled Treprostinil in Severe Pulmonary Hypertension. Results From Randomized Controlled Pilot Studies.  Journal of the American College of Cardiology.  48:1672-1681. 2006
    2006 Impact of HIF-1α and HIF-2α on proliferation and migration of human pulmonary artery fibroblasts in hypoxia.  The FASEB Journal.  20:163-165. 2006
    2005 Transforming growth factor-β-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent.  Journal of Pharmacology and Experimental Therapeutics.  315:1005-1012. 2005
    2005 Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration.  Respiratory Research.  6. 2005
    2005 Hypoxia-driven proliferation of human pulmonary artery fibroblasts: Cross-talk between HIF-1α and an autocrine angiotensin system.  The FASEB Journal.  19:857-859. 2005
    2005 Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells.  American Journal of Respiratory Cell and Molecular Biology.  32:395-403. 2005
    2003 RNA interference for HIF-1± inhibits its downstream signalling and affects cellular proliferation.  Biochemical and Biophysical Research Communications.  312:571-577. 2003
    2002 Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors..  The FASEB Journal.  16:1660-1661. 2002
    2002 Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells 2002
    2001 c-Jun decreases voltage-gated K+ channel activity in pulmonary artery smooth muscle cells.  Circulation.  104:1557-1563. 2001
    2001 Activation of K+ channels induces apoptosis in vascular smooth muscle cells 2001
    2001 Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells 2001
    2001 Augmented K+ currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis 2001
    2001 Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells 2001
    2001 Capacitative ca2+ entry in agonist-induced pulmonary vasoconstriction 2001
    2001 Chronic hypoxia decreases Kv channel expression and function in pulmonary artery myocytes 2001
    2000 Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation 2000

    Research Overview

  • Dr. Krick’s research is focused on fibroblast growth factor signaling and the role of pannexins in lung diseases such as cystic fibrosis, COPD and pulmonary fibrosis, with several of her more recent works being published in the likes of the Journal of Clinical Investigation, Annals of the American Thoracic Society, PNAS and the Journal of Biological Chemistry.

    • Principal Investigator On

    Investigator On

    Education And Training

  • Jackson Memorial Hospital, Residency
  • Jackson Memorial Hospital, Postdoctoral Fellowship
  • Doctor of Philosophy in Biomedical Sciences, Justus Liebig University Giessen 2004
  • Doctor of Medicine, Justus Liebig University Giessen 2003

    • Full Name

  • Stefanie Krick