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Stefanie Krick
Assistant Professor
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E-mail
skrick@uabmc.edu
skrick@uab.edu
Phone
205-975-5341
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Stefanie Krick
Assistant Professor
Positions
Assistant Professor (P)
,
Medicine - Pulmonary, Allergy, & Critical Care Medicine
,
Department of Medicine
2017 -
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
2017 -
Associate Scientist (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2020 -
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
2020 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2020
Targeting aging pathways in chronic obstructive pulmonary disease
.
International Journal of Molecular Sciences
. 21:1-17.
2020
2020
Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?
.
Frontiers in Medicine
. 7.
2020
2020
A fatal case of pneumocephalus during computed tomography-guided lung biopsy
.
American Journal of Respiratory and Critical Care Medicine
. 201:E83-E84.
2020
2020
The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance
.
Frontiers in Medicine
. 6.
2020
2020
Elexacafator/tezacaftor/ivacaftor resolves subfertility in females with CF: A two center case series
.
Journal of Cystic Fibrosis
.
2020
2019
O-GlcNAc transferase regulates angiogenesis in idiopathic pulmonary arterial hypertension
.
International Journal of Molecular Sciences
. 20.
2019
2019
Exercise Physiology Across the Lifespan in Cystic Fibrosis
.
Frontiers in Physiology
. 10.
2019
2019
Fibroblast growth factor 23 is associated with a frequent exacerbator phenotype in COPD: A cross-sectional pilot study
.
International Journal of Molecular Sciences
. 20.
2019
2019
How to detect tobacco-related vasculopathy: Are we there yet?
.
Annals of the American Thoracic Society
. 16:674-675.
2019
2019
Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis
2019
2018
Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases
.
International Journal of Molecular Sciences
. 19.
2018
2018
Fibroblast growth factor 23 and Klotho contribute to airway inflammation
.
European Respiratory Journal
. 52.
2018
2018
Impact of altered mineral metabolism on pathological cardiac remodeling in elevated fibroblast growth factor 23
.
Frontiers in Endocrinology
. 9.
2018
2018
Reply: We did this, and the patient improved: True, true, and unrelated?
.
Annals of the American Thoracic Society
. 15:269.
2018
2018
FGF23 Induction of O-Linked N-Acetylglucosamine Regulates IL-6 Secretion in Human Bronchial Epithelial Cells.
.
Frontiers in Endocrinology
. 9:708.
2018
2017
Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia
.
Scientific Reports
. 7.
2017
2017
Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells
.
Scientific Reports
. 7.
2017
2017
Going with the flow: Saddle pulmonary embolism complicated by severe hypoxemia without shock
.
Annals of the American Thoracic Society
. 14:1479-1484.
2017
2017
Use of aminocaproic acid in combination with extracorporeal membrane oxygenation in a case of leptospirosis pulmonary hemorrhage syndrome
.
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
. 11.
2017
2017
Fibroblast Growth Factor 23: Mineral Metabolism and beyond
.
Contributions to Nephrology
. 190:83-95.
2017
2016
All about Asthma: Association with Obstructive Sleep Apnea, Management, and Overlap with Chronic Obstructive Pulmonary Disease
.
American Journal of Respiratory and Critical Care Medicine
. 194:1423-1425.
2016
2016
Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
.
Kidney International
. 90:985-996.
2016
2016
Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H
2
O
2
Production
.
Journal of Biological Chemistry
. 291:6423-6432.
2016
2015
Roflumilast partially reverses smoke-induced mucociliary dysfunction
.
Respiratory Research
. 16.
2015
2015
Airway surface dehydration by transforming growth factor β (TGF-β) in cystic fibrosis is due to decreased function of a voltage-dependent potassium channel and can be rescued by the drug pirfenidone
.
Journal of Biological Chemistry
. 290:25710-25716.
2015
2014
Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro
2014
2013
High-frequency oscillatory ventilation, microRNAs in pulmonary hypertension, and gastric residual volumes.
.
American Journal of Respiratory and Critical Care Medicine
. 188:508-509.
2013
2011
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
.
Journal of Clinical Investigation
. 121:2013-2024.
2011
2010
BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation
.
PLoS ONE
. 5.
2010
2009
TβRI independently activates Smad- and CD2AP-dependent pathways in podocytes
.
Journal of the American Society of Nephrology
. 20:2127-2137.
2009
2009
Donor toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation
2009
2009
Renal gene and protein expression signatures for prediction of kidney disease progression
.
American Journal of Pathology
. 174:2073-2085.
2009
2008
Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension
.
Pulmonary Pharmacology and Therapeutics
. 21:824-832.
2008
2008
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
2008
2006
Favorable Effects of Inhaled Treprostinil in Severe Pulmonary Hypertension. Results From Randomized Controlled Pilot Studies
.
Journal of the American College of Cardiology
. 48:1672-1681.
2006
2006
Impact of HIF-1α and HIF-2α on proliferation and migration of human pulmonary artery fibroblasts in hypoxia
.
The FASEB Journal
. 20:163-165.
2006
2005
Transforming growth factor-β-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent
.
Journal of Pharmacology and Experimental Therapeutics
. 315:1005-1012.
2005
2005
Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration
.
Respiratory Research
. 6.
2005
2005
Hypoxia-driven proliferation of human pulmonary artery fibroblasts: Cross-talk between HIF-1α and an autocrine angiotensin system
.
The FASEB Journal
. 19:857-859.
2005
2005
Role of hypoxia-inducible factor-1α in hypoxia-induced apoptosis of primary alveolar epithelial type II cells
.
American Journal of Respiratory Cell and Molecular Biology
. 32:395-403.
2005
2003
RNA interference for HIF-1± inhibits its downstream signalling and affects cellular proliferation
.
Biochemical and Biophysical Research Communications
. 312:571-577.
2003
2002
Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors.
.
The FASEB Journal
. 16:1660-1661.
2002
2002
Nitric oxide induces apoptosis by activating K
+
channels in pulmonary vascular smooth muscle cells
2002
2001
c-Jun decreases voltage-gated K
+
channel activity in pulmonary artery smooth muscle cells
.
Circulation
. 104:1557-1563.
2001
2001
Activation of K
+
channels induces apoptosis in vascular smooth muscle cells
2001
2001
Anorexic effect of K
+
channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells
2001
2001
Augmented K
+
currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis
2001
2001
Bcl-2 decreases voltage-gated K
+
channel activity and enhances survival in vascular smooth muscle cells
2001
2001
Capacitative ca
2+
entry in agonist-induced pulmonary vasoconstriction
2001
2001
Chronic hypoxia decreases K
v
channel expression and function in pulmonary artery myocytes
2001
2000
Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation
2000
Research
Principal Investigator On
The Role of Fibrosis Growth Factor Receptor Signaling and Inflammation in Chronic Bronchitis
awarded by
Flight Attendant Medical Research Institute
2016 - 2021
Fibroblast Growth Factor 23/Klotho Crosstalk and Airway Epithelial Senescence in COPD
awarded by
National Institute on Aging/NIH/DHHS
2018 - 2020
The Role of FGF Receptor Signaling in Cystic Fibrosis
awarded by
Cystic Fibrosis Foundation ^
2016 - 2018
Investigator On
Metabolic Landscape of the Aging Lung
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2020 - 2024
UAB Research and Development Program
awarded by
Cystic Fibrosis Foundation ^
2019 - 2023
Private Grant
awarded by
TRANSLATE BIO, INC ^
2021 - 2022
A Prospective Study to Evaluate Biological and Clinical Effects of Significantly Corrected CFTR Function (the PROMISE Study)
awarded by
SEATTLE CHILDREN'S RESEARCH INSTITUTE
2018 - 2021
Private Grant
awarded by
TRANSLATE BIO, INC ^
2019 - 2021
Standardized Treatment of Pulmonary Exacerbations II
awarded by
SEATTLE CHILDREN'S HOSPITAL
2016 - 2019
Background
Education And Training
Doctor of Philosophy in Biomedical Sciences,
Justus Liebig University Giessen
2004
Doctor of Medicine,
Justus Liebig University Giessen
2003
Jackson Memorial Hospital, Residency
2012
Jackson Memorial Hospital, Postdoctoral Fellowship
2015
Contact
Full Name
Stefanie
Krick