Positions

Overview

  • Synaptic and cellular organization and processing in the neocortex and thalamus, with an emphasis on sensory systems
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Publisher Correction: Two dynamically distinct circuits drive inhibition in the sensory thalamus (Nature, (2020), 583, 7818, (813-818), 10.1038/s41586-020-2512-5)Nature.  585:E13. 2020
    2020 Two dynamically distinct circuits drive inhibition in the sensory thalamusNature.  583:813-818. 2020
    2017 Infrabarrels Are Layer 6 Circuit Modules in the Barrel Cortex that Link Long-Range Inputs and OutputsCell Reports.  21:3065-3078. 2017
    2015 A Corticothalamic Switch: Controlling the Thalamus with Dynamic SynapsesNeuron.  86:768-782. 2015
    2012 Thalamic control of layer 1 circuits in prefrontal cortex 2012
    2010 Electrical and chemical synapses between relay neurons in developing thalamus 2010
    2010 Pathway-Specific Feedforward Circuits between Thalamus and Neocortex Revealed by Selective Optical Stimulation of AxonsNeuron.  65:230-245. 2010
    2009 Stability of electrical coupling despite massive developmental changes of intrinsic neuronal physiology 2009
    2008 Neuroscience: State-sanctioned synchronyNature.  454:839-840. 2008
    2007 Bypassing interneurons: Inhibition in neocortexNature Neuroscience.  10:808-810. 2007
    2007 Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortexNature Neuroscience.  10:462-468. 2007
    2005 Connexon connexions in the thalamocortical systemProgress in Brain Research.  149:41-57. 2005
    2005 Abrupt maturation of a spike-synchronizing mechanism in neocortex 2005
    2004 Potent block of Cx36 and Cx50 gap junction channels by mefloquine 2004
    2002 Auditory thalamocortical synaptic transmission in vitroJournal of Neurophysiology.  87:361-384. 2002
    2001 Parvalbumin and calbindin are differentially distributed within primary and secondary subregions of the mouse auditory forebrainNeuroscience.  105:553-569. 2001
    2001 In vivo Hebbian and basal forebrain stimulation treatment in morphologically identified auditory cortical cellsBrain Research.  891:78-93. 2001
    2000 Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonistBrain Research.  880:51-64. 2000
    1999 Thalamocortical inputs trigger a propagating envelope of gamma-band activity in auditory cortex in vitroExperimental Brain Research.  126:160-174. 1999
    1996 Evidence for the Hebbian hypothesis in experience-dependent physiological plasticity of neocortex: A critical reviewBrain Research Reviews.  22:191-228. 1996
    1996 Receptive-field plasticity in the adult auditory cortex induced by Hebbian covariance 1996
    1992 Stimulation at a Site of Auditory-Somatosensory Convergence in the Medial Geniculate Nucleus Is an Effective Unconditioned Stimulus for Fear ConditioningBehavioral Neuroscience.  106:471-483. 1992

    Research Overview

  • Dr. Cruikshank studies synaptic and sensory processing in neural circuits of the neocortex and thalamus. Clarifying how these structures bidirectionally control one another will be an important part of understanding mammalian information processing. His work involves neurophysiology in intact animals and in vitro, pharmacology, anatomy, behavior and optogenetics. He often combines whole-cell recordings from genetically-identified neurons with optical control. An overarching goal is to identify basic principles of cortical-thalamic processing, including interactions with brain state.
  • Principal Investigator On

    Teaching Overview

  • Prior to arriving at UAB in 2020, Dr. Cruikshank was a non-tenure track professor at Brown University, where he participated in courses in neuroscience and one-on-one advising of students within research laboratories. The course work included lectures on neural systems to medical students (auditory and trigeminal systems) and on cellular and synaptic topics to neuroscience graduate students and undergraduates (including gap junctions and synaptic inhibition). He also taught at the Woods Hole MBL instructing Brown University graduate students in intensive practical courses in neuroscience techniques, running the in vitro neurophysiology and optogenetics section. Finally he has mentored numerous undergraduate and graduate students in research laboratories, including co-advising two recent Ph.D. recipients (degrees awarded in 2015 and 2019).
  • Education And Training

  • Brown University Neuroscience, Postdoctoral Research 2006
  • University of California, Irvine Department of Neurobiology & Behavior, Postdoctoral Research 2001
  • Doctor of Philosophy in Biology / Biological Sciences, University of California System : Irvine 1997
  • Full Name

  • Scott Cruikshank