Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Rare MDM2 amplification in a fat-predominant angiomyolipoma 2020
2020 Comparison of tissue molecular biomarker testing turnaround times and concordance between standard of care and the biocartis idylla platform in patients with colorectal cancerAmerican Journal of Clinical Pathology.  154:266-276. 2020
2020 Randomized trial of weight loss in primary breast cancer: Impact on body composition, circulating biomarkers and tumor characteristicsInternational Journal of Cancer.  146:2784-2796. 2020
2020 Identification of ALDH1A3 as a Viable Therapeutic Target in Breast Cancer Metastasis-Initiating CellsMolecular Cancer Therapeutics.  19:1134-1147. 2020
2020 An Overview of Molecular Genetic Diagnosis TechniquesCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.].  105. 2020
2020 Validation of the Spartan RXCYP2C19 Genotyping Assay Utilizing Blood SamplesClinical and Translational Science.  13:260-264. 2020
2020 Gastric Sclerosing Epithelioid Fibrosarcoma Harboring a Rare FUS-CREM FusionInternational Journal of Surgical Pathology2020
2020 Molecular Pathology of Colorectal CancerAdvances in Anatomic Pathology.  27:20-26. 2020
2019 Adamantinoma-Like Ewing Sarcoma of the Thyroid: A Case Report and Review of the LiteratureHead and Neck Pathology.  13:618-623. 2019
2019 Clear cell papillary renal cell carcinoma: molecular profile and virtual karyotypeHuman Pathology.  91:52-60. 2019
2019 Effects of Improved DNA Integrity by Punch from Tissue Blocks as Compared to Pinpoint Extraction from Unstained Slides on Next-Generation Sequencing Quality MetricsAmerican Journal of Clinical Pathology.  152:27-35. 2019
2019 Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Next-Generation Sequencing StudyHead and Neck Pathology.  13:162-168. 2019
2018 First-line treatment of widely metastatic BRAF-mutated salivary duct carcinoma with combined BRAF and MEK inhibition 2018
2018 Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary InterventionJACC: Cardiovascular Interventions.  11:181-191. 2018
2017 Comparison of two point-of-care cyp2c19 genotyping assays for genotype-guided antiplatelet therapyAnnals of Clinical and Laboratory Science.  47:738-743. 2017
2017 Precision Medicine at the University of Alabama at Birmingham: Laying the Foundational Processes Through Implementation of Genotype-Guided Antiplatelet TherapyClinical Pharmacology and Therapeutics.  102:493-501. 2017
2017 Immunogenomics: using genomics to personalize cancer immunotherapy 2017
2017 Detection of chromosomal translocation in hematologic malignancies by a novel DNA-based Looped Ligation Assay (LOLA) 2017
2017 Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas 2017
2017 Alchemy: A web 2.0 real-time quality assurance platform for human immunodeficiency Virus, hepatitis C Virus, and BK Virus quantitation assaysJournal of Pathology Informatics.  8. 2017
2017 Differential gene expression in ductal carcinoma in situ of the breast based on ERBB2 statusCancer Control : Journal of the Moffitt Cancer Center.  24:102-110. 2017
2017 Hepatitis C virus Genie: A web 2.0 interpretation and analytics platform for the Versant Hepatitis C virus genotype Line Probe Assay version 2.0Journal of Pathology Informatics.  8. 2017
2017 Implementation and utilization of the molecular tumor board to guide precision medicineOncotarget.  8:57845-57854. 2017
2016 Primary Colon Adenosquamous Carcinoma in a Patient with Lynch Syndrome: A New Histologic Subtype Associated with Microsatellite Instability?International Journal of Surgical Pathology.  24:653-655. 2016
2016 Is low positive JAK2 V617F mutation test result clinically significant?: Multi-institutional studyApplied Immunohistochemistry and Molecular Morphology.  24:589-594. 2016
2016 ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breastOncotarget.  7:80655-80663. 2016
2015 Poor cell block adequacy rate for molecular testing improved with the addition of Diff-Quik-stained smears: Need for better cell block processingCancer Cytopathology.  123:480-487. 2015
2015 Frozen section: Guiding the hands of surgeons?Annals of Diagnostic Pathology.  19:326-329. 2015
2015 The utility of phosphohistone H3 in breast cancer gradingApplied Immunohistochemistry and Molecular Morphology.  23:689-695. 2015
2014 Clinicopathological and molecular features of myeloid sarcoma as initial presentation of therapy-related myeloid neoplasms: a single institution experienceInternational Journal of Hematology.  100:457-463. 2014
2013 Overview of molecular genetic diagnosisCurrent protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]2013
2013 RNA isolation from mammalian samplesCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2013
2013 DNA isolation from Mammalian samplesCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]2013
2012 Molecular pathology and molecular markers of ductal carcinoma in-situCurrent Cancer Therapy Reviews.  8:197-204. 2012
2012 A virtual pyrogram generator to resolve complex pyrosequencing results 2012
2011 Analysis of hematopoietic stem cell transplant engraftment: Use of loss or gain of microsatellite alleles to identify residual hematopoietic malignancyDiagnostic Molecular Pathology.  20:194-202. 2011
2011 EGFR and KRAS mutations in metastatic lung adenocarcinomasHuman Pathology.  42:1447-1453. 2011
2011 The significance of HER-2/neu receptor positivity and immunophenotype in ductal carcinoma in situ with early invasive diseaseJournal of Surgical Oncology.  104:458-465. 2011
2011 Genomic changes in gliomas detected using single nucleotide polymorphism array in formalin-fixed, paraffin-embedded tissue: Superior results compared with microsatellite analysis 2011
2011 Δ-PCR, a simple method to detect translocations and insertion/deletion mutations 2011
2010 Specimen identity testing using deoxyribonucleic acid analysis in clinical and surgical pathology settingPathology Case Reviews.  15:116-120. 2010
2008 Biomarker Enables Molecular Specific Optical Detection of Transplant Rejection.IFMBE Proceedings2008
2008 Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleenAnnals of Diagnostic Pathology.  12:212-216. 2008
2000 Grb-2 associated binder-1 (Gab1) is involved in insulin-induced egr-1 gene expression through its PI3’-kinase binding site.DNA and Cell Biol.2000
1999 Mechanisms of nuclear translocation of insulinCell Biochemistry and Biophysics.  31:307-319. 1999
1998 Insulin-induced protein tyrosine phosphorylation cascade and signaling molecules are enriched in membrane caveolae in hepatoma cells.Cellular Signalling1998
1996 Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.Journal of Biological Chemistry.  271:30222-30226. 1996
1996 The expression of and insulin binding to cellular thyroid hormone binding protein, but not insulin degrading enzyme, is increased during 3T3-L1 adipocytes differentiation.Biochem Biophys Res Commun.1996
1996 Dexamethasone Inhibits Insulin Binding to Insulin-Degrading Enzyme and Cytosolic Insulin-Binding Protein p82Biochemical and Biophysical Research Communications.  218:154-158. 1996
1995 Insulin-induced egr-1 expression in Chinese hamster ovary cells is insulin receptor and insulin receptor substrate-1 phosphorylation-independent. Evidence of an alternative signal transduction pathway.Journal of Biological Chemistry.  270:26632-26638. 1995
1995 Roles of insulin internalization and other signaling pathways in the pleiotropic effects of insulinIntern Rec Cytol.1995
1995 Insulin endocytosis and other alternative pathways in the insulin signal transduction network.Antibody, Immunoconjugates, and Radiopharmaceuticals1995
1995 Demonstration of specific insulin binding to cytosolic proteins in H35 hepatoma cells, rat liver and skeletal muscle.Biochemical Journal.  306 ( Pt 1):21-28. 1995
1994 Electron microscopic demonstration of insulin translocation to the cytoplasm and nuclei of intact H35 hepatoma cells using covalently linked Nanogold-insulin.Endocrinology1994
1994 The paradoxical effect of 1,10-phenanthroline on nuclear accumulation of insulin and gene expression stimulated by insulin.DNA and Cell Biol.1994
1993 Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway.Endocrinology.  132:2293-2298. 1993
1992 Risk factors for progression of diabetic retinopathy after an improvement in glycemic control.Proc of the 6th Japan-Korea Symposium on Diabetes Mellitus1992
1992 Nuclear insulin is associated with g33 and c-fos transcription in trypsin-treated H35 hepatoma cells.Proc Nat Acad Sci USA1992
1992 Non-receptor mediated nuclear accumulation of insulin in H35 rat hepatoma cells.J Cellular Physiol.1992
1990 Low serum 1,5-anhydroglucitol concentrations in patients with chronic renal failure.J Japan Diab Soc1990
1990 Clinical Investigation of cases with hypothyroidism misdiagnosed as other diseases.Modern Physician.  10:1335-1338. 1990
1988 A case with hyperglycemic hyperosmolar nonketotic state incidentally diagnosed just before coma.Practice.  5:257-259. 1988

Book

Year Title Altmetric
2015 DNA and RNA extractions from mammalian samples. A book chapter in “Sample Preparation Techniques for Soil, Plant, and Animal Samples. 2015

Chapter

Year Title Altmetric
2015 Molecular pathology of osteosarcoma.  213-222. 2015

Education And Training

  • Doctor of Medicine, The University of Tokyo 1985
  • Hahnemann University Hospital, Residency 2008
  • University of Tokyo Faculty of Medicine, Residency 1987
  • Johns Hopkins Hospital, Postdoctoral Fellowship 2011
  • University of Pennsylvania Hospital, Postdoctoral Fellowship 2009
  • University of Tokyo Faculty of Medicine, Postdoctoral Fellowship 1990
  • Full Name

  • Shuko Harada