John Shacka

John Shacka
Associate Professor

Program Director, Graduate School , The University of Alabama at Birmingham
Scientist (C), Center for AIDS Research , School of Medicine
Associate Scientist (C), Integrative Center for Aging Research , School of Medicine
Scholar (C), Center for Clinical and Translational Science (CCTS) , General Clinical Research Center
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Associate Scientist (C), Neurodegeneration and Experimental Therapeutics (CNET) , Neurology
Scientist (C), Alzheimer's Disease Center , Neurology
Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry
Associate Professor (P), Pharmacology and Toxicology , Academic Joint Departments
Assistant Professor (S), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹. Autophagy. 17:1-382. 2021
2021	Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 17:1330-1348. 2021
2018	The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein. Neurobiology of Disease. 110:68-81. 2018
2017	O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's disease. Molecular Brain. 10. 2017
2017	Testing a computerized cognitive training protocol in adults aging with HIV-associated neurocognitive disorders: Randomized controlled trial rationale and protocol. JMIR Research Protocols. 6. 2017
2016	Increased autophagic response in a population of metastatic breast cancer cells. Oncology Letters. 12:523-529. 2016
2016	Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson Disease. Analytical Chemistry. 88:1856-1863. 2016
2016	Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12:1-222. 2016
2016	Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356. Autophagy. 12:443. 2016
2015	HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuse. Journal of Virology. 89:1024-1035. 2015
2014	ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease. PLoS ONE. 9. 2014
2014	Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice. Acta Neuropathologica Communications. 2. 2014
2013	Autophagy Modulation in Disease Therapy: Where Do We Stand?. Current Pathobiology Reports. 1:239-245. 2013
2013	MHCII is required for α-Synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration 2013
2013	Mutant tristetraprolin: A potent inhibitor of malignant glioma cell growth. Journal of Neuro-Oncology. 113:195-205. 2013
2013	A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Molecular Cancer Therapeutics. 12:663-674. 2013
2013	HIV-specific CD8⁺ T cells from elite controllers are primed for survival. Journal of Virology. 87:5170-5181. 2013
2012	Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chemical Neuroscience. 3:1063-1072. 2012
2012	Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis. Experimental and Molecular Pathology. 93:273-280. 2012
2012	Mouse models of neuronal ceroid lipofuscinoses: Useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics. Brain Research Bulletin. 88:43-57. 2012
2012	Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8:445-544. 2012
2010	Lysosome dysfunction triggers Atg7-dependent neural apoptosis. Journal of Biological Chemistry. 285:10497-10507. 2010
2010	Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of Neurochemistry. 114:1193-1204. 2010
2009	Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death. Antioxidants and Redox Signaling. 11:481-496. 2009
2009	Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science. 323:124-127. 2009
2009	Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.. Science. 323:124-127. 2009
2008	Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brain. Neuroscience. 155:818-832. 2008
2008	Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4:151-175. 2008
2008	Antioxidants and free radical seavengers for the treatment of stroke, traumatic brain injury and aging. Current Medicinal Chemistry. 15:404-414. 2008
2008	Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Research. 68:674-682. 2008
2008	Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.. Molecular Brain. 1:17. 2008
2008	The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapy. Frontiers in Bioscience. 13:718-736. 2008
2007	Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 Cells by tyrosine-containing peptides. Journal of Biological Chemistry. 282:6324-6337. 2007
2007	Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neuroscience Letters. 414:57-60. 2007
2007	Cathepsin D deficiency induces persistent neurodegeneration in the absence of bax-dependent apoptosis 2007
2007	Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy. 3:222-229. 2007
2007	Cathepsin D deficiency and NCL/batten disease: There's more to death than apoptosis. Autophagy. 3:474-476. 2007
2007	p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis. Journal of Neuropathology and Experimental Neurology. 66:66-74. 2007
2006	Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells. Cell Death and Differentiation. 13:1506-1514. 2006
2006	Bcl-2 family and the central nervous system: From rheostat to real complex. Cell Death and Differentiation. 13:1299-1304. 2006
2006	Autophagy, bafilomycin and cell death: The "A-B-Cs" of plecomacrolide-induced neuroprotection. Autophagy. 2:228-230. 2006
2006	Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Molecular Pharmacology. 69:1125-1136. 2006
2005	Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: Therapeutic implications 2005
2005	Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses. American Journal of Pathology. 167:1473-1476. 2005
2004	Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine. Journal of Neurochemistry. 89:602-612. 2004
2002	Erythropoietin receptor signalling is required for normal brain development 2002
1998	Postnatal developmental regulation of neuronal nicotinic receptor subunit α7 and multiple α4 and β2 mRNA species in the rat 1998
1998	Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit α7, α4 and β2 messenger RNAs in the postnatal rat brain. Neuroscience. 84:1151-1161. 1998
1997	Prenatal nicotine sex-dependently alters agonist-induced locomotion and stereotypy. Neurotoxicology and Teratology. 19:467-476. 1997
1996	Central and peripheral anatomy of nicotinic sites. Medicinal Chemistry Research. 6:444-464. 1996

Chapter

Year	Title	Altmetric
2012	Lysosome storage disorders on the brain: The autophagy lysosome pathway contributes to disease pathophysiology and may be utilized for therapeutic benefit. 331-354. 2012
2009	Apoptosis in Neurodegenerative Disease. 531-537. 2009