Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synucleinNeurobiology of Disease.  110:68-81. 2018
2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's diseaseMolecular Brain.  10. 2017
2017 Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders: Randomized Controlled Trial Rationale and Protocol.JMIR Research Protocols.  6:e68. 2017
2016 Increased autophagic response in a population of metastatic breast cancer cellsOncology Letters.  12:523-529. 2016
2016 Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson DiseaseAnalytical Chemistry.  88:1856-1863. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
2015 HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuseJournal of Virology.  89:1024-1035. 2015
2014 ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative diseasePLoS ONE.  9. 2014
2014 Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient miceActa Neuropathologica Communications.  2. 2014
2013 Autophagy Modulation in Disease Therapy: Where Do We Stand?Current Pathobiology Reports.  1:239-245. 2013
2013 MHCII is required for α-Synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration 2013
2013 Mutant tristetraprolin: A potent inhibitor of malignant glioma cell growthJournal of Neuro-Oncology.  113:195-205. 2013
2013 A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagyMolecular Cancer Therapeutics.  12:663-674. 2013
2013 HIV-specific CD8+ T cells from elite controllers are primed for survivalJournal of Virology.  87:5170-5181. 2013
2012 Rotenone inhibits autophagic flux prior to inducing cell deathACS Chemical Neuroscience.  3:1063-1072. 2012
2012 Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosisExperimental and Molecular Pathology.  93:273-280. 2012
2012 Mouse models of neuronal ceroid lipofuscinoses: Useful pre-clinical tools to delineate disease pathophysiology and validate therapeuticsBrain Research Bulletin.  88:43-57. 2012
2012 Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy.  8:445-544. 2012
2010 Lysosome dysfunction triggers Atg7-dependent neural apoptosisJournal of Biological Chemistry.  285:10497-10507. 2010
2010 Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunctionJournal of Neurochemistry.  114:1193-1204. 2010
2009 Oxidative stress and autophagy in the regulation of lysosome-dependent neuron deathAntioxidants and Redox Signaling.  11:481-496. 2009
2009 Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.Science.  323:124-127. 2009
2008 Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brainNeuroscience.  155:818-832. 2008
2008 The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapyFrontiers in Bioscience.  13:718-736. 2008
2008 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesAutophagy.  4:151-175. 2008
2008 Antioxidants and free radical seavengers for the treatment of stroke, traumatic brain injury and agingCurrent Medicinal Chemistry.  15:404-414. 2008
2008 Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cellsCancer Research.  68:674-682. 2008
2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
2007 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 Cells by tyrosine-containing peptidesJournal of Biological Chemistry.  282:6324-6337. 2007
2007 Kainic acid induces early and transient autophagic stress in mouse hippocampusNeuroscience Letters.  414:57-60. 2007
2007 Cathepsin D deficiency induces persistent neurodegeneration in the absence of bax-dependent apoptosis 2007
2007 Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brainAutophagy.  3:222-229. 2007
2007 Cathepsin D deficiency and NCL/batten disease: There's more to death than apoptosisAutophagy.  3:474-476. 2007
2007 p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosisJournal of Neuropathology and Experimental Neurology.  66:66-74. 2007
2006 Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cellsCell Death and Differentiation.  13:1506-1514. 2006
2006 Bcl-2 family and the central nervous system: From rheostat to real complexCell Death and Differentiation.  13:1299-1304. 2006
2006 Autophagy, bafilomycin and cell death: The "A-B-Cs" of plecomacrolide-induced neuroprotectionAutophagy.  2:228-230. 2006
2006 Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neuronsMolecular Pharmacology.  69:1125-1136. 2006
2005 Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: Therapeutic implications 2005
2005 Cathepsin deficiency as a model for neuronal ceroid lipofuscinosesAmerican Journal of Pathology.  167:1473-1476. 2005
2004 Induction of motor neuron apoptosis by free 3-nitro-L-tyrosineJournal of Neurochemistry.  89:602-612. 2004
2002 Erythropoietin receptor signalling is required for normal brain development 2002
1998 Postnatal developmental regulation of neuronal nicotinic receptor subunit α7 and multiple α4 and β2 mRNA species in the rat 1998
1998 Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit α7, α4 and β2 messenger RNAs in the postnatal rat brainNeuroscience.  84:1151-1161. 1998
1997 Prenatal nicotine sex-dependently alters agonist-induced locomotion and stereotypyNeurotoxicology and Teratology.  19:467-476. 1997
1996 Central and peripheral anatomy of nicotinic sitesMedicinal Chemistry Research.  6:444-464. 1996

Chapter

Year Title Altmetric
2012 Lysosome storage disorders on the brain: The autophagy lysosome pathway contributes to disease pathophysiology and may be utilized for therapeutic benefit.  331-354. 2012
2009 Apoptosis in Neurodegenerative Disease.  531-537. 2009

Teaching Activities

Education And Training

  • Doctor of Philosophy in Pharmacology and Toxicology, Virginia Commonwealth University 1997
  • Full Name

  • John Shacka