Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synucleinNeurobiology of Disease.  110:68-81. 2018
2017 O-GlcNAc regulation of autophagy and α-synuclein homeostasis; Implications for Parkinson's diseaseMolecular Brain.  10. 2017
2017 Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders: Randomized Controlled Trial Rationale and Protocol.JMIR Research Protocols.  6:e68. 2017
2016 Increased autophagic response in a population of metastatic breast cancer cellsOncology Letters.  12:523-529. 2016
2016 Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson DiseaseAnalytical Chemistry.  88:1856-1863. 2016
2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy.  12:1-222. 2016
2016 Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356Autophagy.  12:443. 2016
2015 HIV-1 and morphine regulation of autophagy in microglia: Limited interactions in the context of HIV-1 infection and opioid abuseJournal of Virology.  89:1024-1035. 2015
2014 ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative diseasePLoS ONE.  9. 2014
2014 Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient miceActa Neuropathologica Communications.  2. 2014
2013 Autophagy Modulation in Disease Therapy: Where Do We Stand?Current Pathobiology Reports.  1:239-245. 2013
2013 MHCII is required for α-Synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegenerationJournal of Neuroscience.  33:9592-9600. 2013
2013 Mutant tristetraprolin: A potent inhibitor of malignant glioma cell growthJournal of Neuro-Oncology.  113:195-205. 2013
2013 A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagyMolecular Cancer Therapeutics.  12:663-674. 2013
2013 HIV-specific CD8+ T cells from elite controllers are primed for survivalJournal of Virology.  87:5170-5181. 2013
2012 Rotenone inhibits autophagic flux prior to inducing cell deathACS Chemical Neuroscience.  3:1063-1072. 2012
2012 Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosisExperimental and Molecular Pathology.  93:273-280. 2012
2012 Mouse models of neuronal ceroid lipofuscinoses: Useful pre-clinical tools to delineate disease pathophysiology and validate therapeuticsBrain Research Bulletin.  88:43-57. 2012
2012 Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy.  8:445-544. 2012
2010 Lysosome dysfunction triggers Atg7-dependent neural apoptosisJournal of Biological Chemistry.  285:10497-10507. 2010
2010 Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunctionJournal of Neurochemistry.  114:1193-1204. 2010
2009 Oxidative stress and autophagy in the regulation of lysosome-dependent neuron deathAntioxidants and Redox Signaling.  11:481-496. 2009
2009 Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.Science.  323:124-127. 2009
2008 Localization of electrogenic Na/bicarbonate cotransporter NBCe1 variants in rat brainNeuroscience.  155:818-832. 2008
2008 The autophagy-lysosomal degradation pathway: Role in neurodegenerative disease and therapyFrontiers in Bioscience.  13:718-736. 2008
2008 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesAutophagy.  4:151-175. 2008
2008 Antioxidants and free radical seavengers for the treatment of stroke, traumatic brain injury and agingCurrent Medicinal Chemistry.  15:404-414. 2008
2008 Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cellsCancer Research.  68:674-682. 2008
2008 Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Molecular Brain.  1:17. 2008
2007 Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 Cells by tyrosine-containing peptidesJournal of Biological Chemistry.  282:6324-6337. 2007
2007 Kainic acid induces early and transient autophagic stress in mouse hippocampusNeuroscience Letters.  414:57-60. 2007
2007 Cathepsin D deficiency induces persistent neurodegeneration in the absence of bax-dependent apoptosisJournal of Neuroscience.  27:2081-2090. 2007
2007 Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brainAutophagy.  3:222-229. 2007
2007 Cathepsin D deficiency and NCL/batten disease: There's more to death than apoptosisAutophagy.  3:474-476. 2007
2007 p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosisJournal of Neuropathology and Experimental Neurology.  66:66-74. 2007
2006 Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cellsCell Death and Differentiation.  13:1506-1514. 2006
2006 Bcl-2 family and the central nervous system: From rheostat to real complexCell Death and Differentiation.  13:1299-1304. 2006
2006 Autophagy, bafilomycin and cell death: The "A-B-Cs" of plecomacrolide-induced neuroprotectionAutophagy.  2:228-230. 2006
2006 Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neuronsMolecular Pharmacology.  69:1125-1136. 2006
2005 Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: Therapeutic implicationsCurrent Drug Targets -Cns and Neurological Disorders-.  4:25-39. 2005
2005 Cathepsin deficiency as a model for neuronal ceroid lipofuscinosesAmerican Journal of Pathology.  167:1473-1476. 2005
2004 Induction of motor neuron apoptosis by free 3-nitro-L-tyrosineJournal of Neurochemistry.  89:602-612. 2004
2002 Erythropoietin receptor signalling is required for normal brain developmentDevelopment.  129:505-516. 2002
1998 Postnatal developmental regulation of neuronal nicotinic receptor subunit α7 and multiple α4 and β2 mRNA species in the ratDevelopmental Brain Research.  109:67-75. 1998
1998 Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit α7, α4 and β2 messenger RNAs in the postnatal rat brainNeuroscience.  84:1151-1161. 1998
1997 Prenatal nicotine sex-dependently alters agonist-induced locomotion and stereotypyNeurotoxicology and Teratology.  19:467-476. 1997
1996 Central and peripheral anatomy of nicotinic sitesMedicinal Chemistry Research.  6:444-464. 1996

Chapter

Year Title Altmetric
2012 Lysosome storage disorders on the brain: The autophagy lysosome pathway contributes to disease pathophysiology and may be utilized for therapeutic benefit.  331-354. 2012
2009 Apoptosis in Neurodegenerative Disease.  531-537. 2009

Education And Training

  • Doctor of Philosophy in Pharmacology and Toxicology, Virginia Commonwealth University 1997
  • Full Name

  • John Shacka