Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein 2020
2020 Structural Consequences of the 1,2,3-Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX-809 and VX-770 2020
2019 Structures of the substrate-binding protein YfeA in apo and zinc-reconstituted holo formsActa Crystallographica. Section d, Structural Biology.  75:831-840. 2019
2019 Evaluation of 1,2,3-Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX-770 and VX-809 2019
2018 Allosteric Role of Substrate Occupancy Toward the Alignment of P-glycoprotein Nucleotide Binding DomainsScientific Reports.  8. 2018
2018 Correction: In vitro evolution and affinity-maturation with coliphage Qβ display (PLoS ONE (2018) 13:6 (e0199953) DOI: 10.1371/journal.pone.0113069) )PLoS ONE.  13. 2018
2018 Essential metal uptake in gram-negative bacteria: X-ray fluorescence, radioisotopes, and cell fractionationJournal of Visualized Experiments.  2018. 2018
2017 The crystal structure of the Yersinia pestis iron chaperone YiuA reveals a basic triad binding motif for the chelated metalActa Crystallographica. Section d, Structural Biology.  73:921-939. 2017
2017 Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal-binding sitesActa Crystallographica. Section d, Structural Biology.  73:557-572. 2017
2016 Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loopJournal of Biological Chemistry.  291:1854-1865. 2016
2015 ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actininOncogene.  34:1553-1562. 2015
2015 Equilibrated atomic models of outward-facing P-glycoprotein and effect of ATP binding on structural dynamicsScientific Reports.  5. 2015
2015 Tools and procedures for visualization of proteins and other biomoleculesCurrent protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].  2015:19.12.1-19.12.47. 2015
2014 In vitro evolution and affinity-maturation with Coliphage Qβ displayPLoS ONE.  9. 2014
2014 Refined structures of mouse P-glycoproteinProtein Science.  23:34-46. 2014
2009 Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel 2009
2009 Structure of P-glycoprotein reveals a molecular basis for poly-specific drug bindingScience.  323:1718-1722. 2009
2009 Three-dimensional structure of the human copper transporter hCTR1 2009
2007 A structural perspective on copper uptake in eukaryotes 2007
2006 Mercury toxicity in the shark (Squalus acanthias) rectal gland: Apical CFTR chloride channels are inhibited by mercuric chlorideJournal of Experimental Zoology Part A: Comparative Experimental Biology.  305:259-267. 2006
2006 Projection structure of the human copper transporter CTR1 at 6-Å resolution reveals a compact trimer with a novel channel-like architecture 2006
2006 Mercury and zinc differentially inhibit shark and human CFTR orthologues: Involvement of shark cysteine 102 2006
2004 Eukaryotic CTR copper uptake transporters require two faces of the third transmembrane domain for helix packing, oligomerization, and functionJournal of Biological Chemistry.  279:53435-53441. 2004
2002 The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria 2002
2002 Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion 2002
1999 Molecular and functional characterization of s-KCNQ1 potassium channel from rectal gland of Squalus acanthias 1999
1999 Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland.American Journal of Physiology.  276:C442-C449. 1999
1999 Cloning, characterization, and functional expression of a CNP receptor regulating CFTR in the shark rectal gland 1999
1998 Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias: Acute regulation of CFTR trafficking in an intact epitheliumJournal of Clinical Investigation.  101:737-745. 1998
1997 Cadmium disrupts the signal transduction pathway of both inhibitory and stimulatory receptors regulating chloride secretion in the shark rectal glandJournal of Experimental Zoology.  279:530-536. 1997

Education And Training

  • Doctor of Philosophy in Molecular Biophysics, Yale University 2006
  • The Scripps Research Institute, Postdoctoral Fellowship 2009
  • Full Name

  • Stephen Aller