Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 A Novel G542X CFTR Rat Model of Cystic Fibrosis Is Sensitive to Nonsense Mediated DecayFrontiers in Physiology.  11. 2020
2020 Development of a Broadly Protective, Self-Adjuvanting Subunit Vaccine to Prevent Infections by Pseudomonas aeruginosaFrontiers in Immunology.  11. 2020
2020 Ivacaftor reverses airway mucus abnormalities in a rat model harboring a humanized G551D-CFTRAmerican Journal of Respiratory and Critical Care Medicine.  202:1271-1282. 2020
2020 Novel therapy of bicarbonate, glutathione, and ascorbic acid improves cystic fibrosis mucus transportAmerican Journal of Respiratory Cell and Molecular Biology.  63:362-373. 2020
2020 Excess mucus viscosity and airway dehydration impact COPD airway clearanceEuropean Respiratory Journal.  55. 2020
2019 A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucusJCI insight.  4. 2019
2018 Development of an airway mucus defect in the cystic fibrosis ratJCI insight.  3. 2018
2018 A clean sweep: Mucin bundles clear the airwayEuropean Respiratory Journal.  52. 2018
2017 Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography.JCI insight.  2:e91702. 2017
2017 Pneumocystis infection alters the activation state of pulmonary macrophagesImmunobiology.  222:188-197. 2017
2016 Particle-Tracking Microrheology Using Micro-Optical Coherence TomographyBiophysical Journal.  111:1053-1063. 2016
2016 In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomographyBiomedical Optics Express.  7:2494-2505. 2016
2016 Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy 2016
2015 Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungsAmerican Journal of Respiratory Cell and Molecular Biology.  52:683-694. 2015
2014 A functional anatomic defect of the cystic fibrosis airwayAmerican Journal of Respiratory and Critical Care Medicine.  190:421-432. 2014
2014 An autoregulatory mechanism governing mucociliary transport is sensitive to mucus loadAmerican Journal of Respiratory Cell and Molecular Biology.  51:485-493. 2014
2013 Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosaJournal of Antimicrobial Chemotherapy.  68:840-851. 2013
2010 Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with PseudomonasAntimicrobial Agents and Chemotherapy.  54:2437-2447. 2010
2007 Preparation and characterization of translocator/chaperone complexes and their component proteins from Shigella flexneriBiochemistry.  46:8128-8137. 2007
2007 Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipDJournal of Biological Chemistry.  282:4035-4044. 2007
2006 Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system 2006
2006 Characterization of the interaction of single tryptophan containing mutants of IpaC from Shigella flexneri with phospholipid membranesBiochemistry.  45:626-636. 2006

Principal Investigator On

  • Vaccines To Counter Emerging Antibiotic Resistance  awarded by University of Kansas 2018 - 2023
  • The Mechanisms Underlying the Muco-Inflammatory Cycle in the CF Lung  awarded by Cystic Fibrosis Foundation ^ 2020 - 2022
  • Abnormal Mucus as the Initiating Factor in P. Aeruginosa Infection in CF  awarded by Cystic Fibrosis Foundation ^ 2020 - 2022
  • The Mechanisms Underlying Abnormal Mucus and its Clearance in the Cystic Fibrosis Rat  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by ENTRINSIC HEALTH SOLUTIONS INC. 2020 - 2021
  • Mechanisms of and Therapies for Abnormal Mucus Adhesion and Clearance in CF  awarded by Cystic Fibrosis Foundation ^ 2020 - 2021
  • Development of A Broadly Protective Subunit Vaccine Against Pseudomonas Aeruginosa  awarded by University of Kansas 2019 - 2021
  • The CF Rat as an In Vivo Model of Airway Infection  awarded by Cystic Fibrosis Foundation ^ 2020 - 2021
  • Private Grant  awarded by ARCTURUS THERAPEUTICS INC. 2019 - 2020
  • Mechanisms of and Therapies for Abnormal Mucus Adhesion and Clearance in CF  awarded by Cystic Fibrosis Foundation ^ 2018 - 2020
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2017 - 2020
  • Development of Hyperinflammation in the Cystic Fibrosis Rat  awarded by Cystic Fibrosis Foundation ^ 2018 - 2020
  • Private Grant  awarded by ARCTURUS THERAPEUTICS INC. 2019
  • Private Grant  awarded by ENTERPRISE THERAPEUTICS 2018 - 2019
  • Private Grant  awarded by ENTERPRISE THERAPEUTICS 2018 - 2019
  • Private Grant  awarded by Gilead Sciences ^ 2017 - 2019
  • The Mucociliary Clearance Defect of the Cystic Fibrosis Rat  awarded by Cystic Fibrosis Foundation ^ 2016 - 2017
  • Education And Training

  • University of Kentucky, Other
  • Doctor of Philosophy in Pharmacy, Pharmaceutical Sciences, and Administration, University of Kentucky 2012
  • Full Name

  • Susan Birket