Positions

Overview

  • Brian M. Sandroff is an Assistant Professor in the Department of Physical Therapy at the University of Alabama at Birmingham and is the Co-Director of the Exercise Neuroscience Research Laboratory. Prof. Sandroff earned his Bachelor’s, Master’s, and Ph.D. in Kinesiology at the University of Illinois at Urbana-Champaign, and further completed a postdoctoral fellowship at Kessler Foundation in Neuropsychology and Neuroscience. His research focuses on the intersection of exercise, cognition, and brain structure/function/connectivity in persons with multiple sclerosis and other neurological disorders. Prof. Sandroff has authored numerous publications in peer-reviewed journals, and has received over $2.5 million in grant funding as a principal investigator in this area.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Walking and cognitive performance in adults with multiple sclerosis: Do age and fatigability matter?Multiple Sclerosis and Related Disorders.  42. 2020
    2020 Quantitative Synthesis of Timed 25-Foot Walk Performance in Multiple SclerosisArchives of Physical Medicine and Rehabilitation.  101:524-534. 2020
    2020 Randomized controlled trial of physical activity intervention effects on fatigue and depression in multiple sclerosis: Secondary analysis of data from persons with elevated symptom statusContemporary Clinical Trials Communications.  17. 2020
    2020 Progressive resistance exercise training and changes in resting-state functional connectivity of the caudate in persons with multiple sclerosis and severe fatigue: A proof-of-concept studyNeuropsychological Rehabilitation.  30:54-66. 2020
    2020 Device-Measured Physical Activity and Cognitive Processing Speed Impairment in a Large Sample of Persons with Multiple SclerosisJournal of the International Neuropsychological Society2020
    2020 Do subcortical gray matter volumes and aerobic capacity account for cognitive-motor coupling in multiple sclerosis? 2020
    2020 Moving exercise research in multiple sclerosis forward (the MoXFo initiative): Developing consensus statements for research 2020
    2019 Protocol for a systematically-developed, phase I/II, single-blind randomized controlled trial of treadmill walking exercise training effects on cognition and brain function in persons with multiple sclerosisContemporary Clinical Trials.  87. 2019
    2019 Physical activity and walking performance across the lifespan among adults with multiple sclerosisMultiple Sclerosis and Related Disorders.  35:36-41. 2019
    2019 Self-efficacy and walking performance across the lifespan among adults with multiple sclerosis.Neurodegenerative Disease Management.  9:267-275. 2019
    2019 Changes in Cognitive Performance with Age in Adults with Multiple Sclerosis 2019
    2019 Use of the Godin leisure-time exercise questionnaire in multiple sclerosis research: a comprehensive narrative reviewDisability and Rehabilitation.  41:1243-1267. 2019
    2019 An intervention for changing sedentary behavior among African Americans with multiple sclerosis: ProtocolJournal of Medical Internet Research.  21. 2019
    2019 The Intersection of Physical Function, Cognitive Performance, Aging, and Multiple Sclerosis: A Cross-sectional Comparative Study 2019
    2019 Response heterogeneity in fitness, mobility and cognition with exercise-training in MSActa Neurologica Scandinavica.  139:183-191. 2019
    2019 Brain activation changes during balance- And attention-demanding tasks in middle- And older-aged adults with multiple sclerosisMotor Control.  23:498-517. 2019
    2019 Cardiorespiratory fitness and cognitive processing speed in multiple sclerosis: The possible roles of psychological symptomsMultiple Sclerosis and Related Disorders.  27:23-29. 2019
    2019 Energetic cost of walking and spasticity in persons with multiple sclerosis with moderate disability 2019
    2019 Will behavioral treatments for cognitive impairment in multiple sclerosis become standards-of-care?International Journal of Psychophysiology2019
    2018 The role of premotor areas in dual tasking in healthy controls and persons with multiple sclerosis: An fNIRS imaging studyFrontiers in Behavioral Neuroscience.  12. 2018
    2018 Rationale and design of a single-blind, randomised controlled trial of exercise training for managing learning and memory impairment in persons with multiple sclerosisBMJ Open.  8. 2018
    2018 Supra-Spinal Modulation of Walking in Healthy Individuals and Persons with Multiple Sclerosis: A fNIRS Mobile Imaging StudyConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.  2018-July:3156-3159. 2018
    2018 Energetic Cost of Walking and Its Physiological Correlates in Persons With Multiple Sclerosis Who Have Moderate Mobility DisabilityArchives of Physical Medicine and Rehabilitation.  99:2038-2044. 2018
    2018 Integrative CNS Plasticity With Exercise in MS: The PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) Conceptual FrameworkNeurorehabilitation and Neural Repair.  32:847-862. 2018
    2018 Naturally occurring change in Multiple Sclerosis Walking Scale-12 scores over time in multiple sclerosisNeurodegenerative Disease Management.  8:315-322. 2018
    2018 Phase-III, randomized controlled trial of the behavioral intervention for increasing physical activity in multiple sclerosis: Project BIPAMSContemporary Clinical Trials.  71:154-161. 2018
    2018 Physical Function in Older Adults with Multiple Sclerosis: An Application of the Short Physical Performance BatteryJournal Geriatric Physical Therapy.  41:155-160. 2018
    2018 Therapies for mobility disability in persons with multiple sclerosis 2018
    2018 Dual Task of Fine Motor Skill and Problem Solving in Individuals With Multiple Sclerosis: A Pilot StudyArchives of Physical Medicine and Rehabilitation.  99:635-640. 2018
    2018 Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple SclerosisJournal of the International Neuropsychological Society.  24:139-146. 2018
    2018 Validation of the godin leisure-time exercise questionnaire classification coding system using accelerometry in multiple sclerosisRehabilitation Psychology.  63:77-82. 2018
    2018 Exercise as a Countermeasure to Declining Central Nervous System Function in Multiple Sclerosis 2018
    2018 Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation.Multiple Sclerosis Journal - Experimental, Translational and Clinical.  4:2055217318760641. 2018
    2017 Motion sensors in multiple sclerosis: Narrative review and update of applicationsExpert Review of Medical Devices.  14:891-900. 2017
    2017 Dual task training in persons with Multiple Sclerosis: A feasability randomized controlled trialClinical Rehabilitation.  31:1322-1331. 2017
    2017 Exercise in patients with multiple sclerosisLancet Neurology.  16:848-856. 2017
    2017 Multimodal exercise training in multiple sclerosis: A randomized controlled trial in persons with substantial mobility disabilityContemporary Clinical Trials.  61:39-47. 2017
    2017 Preliminary Evidence For The Effects Of Aging And Multiple Sclerosis On Cognitive Performance: An Analysis Based On Effect Size EstimatesExperimental Aging Research.  43:346-354. 2017
    2017 Frontal brain activation changes due to dual-tasking under partial body weight support conditions in older adults with multiple sclerosisJournal of NeuroEngineering and Rehabilitation.  14. 2017
    2017 Physical activity, sedentary behavior, and aerobic capacity in persons with multiple sclerosisJournal of the Neurological Sciences.  372:342-346. 2017
    2017 Intensity of treadmill walking exercise on acute mood symptoms in persons with multiple sclerosisAnxiety, Stress and Coping.  30:15-25. 2017
    2017 Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography 2017
    2017 The influence of cognitive impairment on the fitness-cognition relationship in multiple sclerosisMedicine and Science in Sports and Exercise.  49:1184-1189. 2017
    2016 Brain activation changes during locomotion in middle-aged to older adults with multiple sclerosisJournal of the Neurological Sciences.  370:277-283. 2016
    2016 Measurement and maintenance of reserve in multiple sclerosisJournal of Neurology.  263:2158-2169. 2016
    2016 Systematic Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple SclerosisArchives of Physical Medicine and Rehabilitation.  97:e143-e143. 2016
    2016 Systematically developed pilot randomized controlled trial of exercise and cognition in persons with multiple sclerosisNeurocase.  22:443-450. 2016
    2016 Comprehensive Profile of Cardiopulmonary Exercise Testing in Ambulatory Persons with Multiple SclerosisSports Medicine.  46:1365-1379. 2016
    2016 Systematic, Evidence-Based Review of Exercise, Physical Activity, and Physical Fitness Effects on Cognition in Persons with Multiple SclerosisNeuropsychology Review.  26:271-294. 2016
    2016 Exercise Training and Cognitive RehabilitationNeurorehabilitation and Neural Repair.  30:499-511. 2016
    2016 Validity of the Timed Up and Go Test as a Measure of Functional Mobility in Persons with Multiple SclerosisArchives of Physical Medicine and Rehabilitation.  97:1072-1077. 2016
    2016 Free-living Walking Behavior in Persons with Multiple Sclerosis at Increased and Normal Fall Risk: 838 Board #154 June 1, 2: 00 PM - 3: 30 PM.Medicine and Science in Sports and Exercise.  48:233. 2016
    2016 Step-rate cut-points for physical activity intensity in patients with multiple sclerosis: The effect of disability statusJournal of the Neurological Sciences.  361:95-100. 2016
    2016 Acute effects of varying intensities of treadmill walking exercise on inhibitory control in persons with multiple sclerosis: A pilot investigationPhysiology and Behavior.  154:20-27. 2016
    2016 Effects of single bouts of walking exercise and yoga on acute mood symptoms in people with multiple sclerosisInternational Journal of Ms Care.  18:1-8. 2016
    2016 Effects of vigorous walking exercise on core body temperature and inhibitory control in thermosensitive persons with multiple sclerosisNeurodegenerative Disease Management.  6:13-21. 2016
    2016 Prediction of oxygen uptake during walking in ambulatory persons with multiple sclerosisJournal of Rehabilitation Research and Development.  53:199-206. 2016
    2015 Benefits of Exercise Training in Multiple SclerosisCurrent Neurology and Neuroscience Reports.  15:1-9. 2015
    2015 Relationships among Physical Inactivity, Deconditioning, and Walking Impairment in Persons with Multiple SclerosisJournal of Neurologic Physical Therapy.  39:103-110. 2015
    2015 Association between physical fitness and cognitive function in multiple sclerosis: Does disability status matter?Neurorehabilitation and Neural Repair.  29:214-223. 2015
    2015 Acute effects of walking, cycling, and yoga exercise on cognition in persons with relapsing-remitting multiple sclerosis without impaired cognitive processing speedJournal of Clinical and Experimental Neuropsychology.  37:209-219. 2015
    2015 Aerobic Fitness Is Associated with Inhibitory Control in Persons with Multiple SclerosisArchives of Clinical Neuropsychology.  30:329-340. 2015
    2015 Descriptive epidemiology of physical activity rates in multiple sclerosisActa Neurologica Scandinavica.  131:422-425. 2015
    2015 Does the six-minute walk test measure walking performance or physical fitness in persons with multiple sclerosis? 2015
    2015 Exercise and cognition in multiple sclerosis: The importance of acute exercise for developing better interventionsNeuroscience and Biobehavioral Reviews.  59:173-183. 2015
    2015 Further validation of the Six-Spot Step Test as a measure of ambulation in multiple sclerosisGait and Posture.  41:222-227. 2015
    2015 Impairment and disability in persons with MS: Do functional performance or functional limitations matter?Psychology, Health and Medicine.  20:646-652. 2015
    2015 No association between body composition and cognition in ambulatory persons with multiple sclerosis: A brief reportJournal of Rehabilitation Research and Development.  52:301-308. 2015
    2015 Nonsignificant Associations between Measures of Inhibitory Control and Walking while Thinking in Persons with Multiple SclerosisArchives of Physical Medicine and Rehabilitation.  96:1518-1524. 2015
    2015 Physical fitness assessment across the disability spectrum in persons with multiple sclerosis: A comparison of testing modalitiesJournal of Neurologic Physical Therapy.  39:241-249. 2015
    2014 Accelerometer cut-points derived during over-ground walking in persons with mild, moderate, and severe multiple sclerosisJournal of the Neurological Sciences.  340:50-57. 2014
    2014 Blood-flow Restriction Training Does Not Increase Muscular Gains in Persons with Multiple SclerosisMedicine and Science in Sports and Exercise.  46:551-551. 2014
    2014 Accuracy of StepWatch™ and ActiGraph accelerometers for measuring steps taken among persons with multiple sclerosisPLoS ONE.  9. 2014
    2014 Accelerometer measured physical activity and the integrity of the anterior visual pathway in multiple sclerosisMultiple Sclerosis and Related Disorders.  3:117-122. 2014
    2014 Cognitive motor interference during walking in multiple sclerosis using an alternate-letter alphabet taskArchives of Physical Medicine and Rehabilitation.  95:1498-1503. 2014
    2014 Comparing two conditions of administering the six-minute walk test in people with multiple sclerosisInternational Journal of Ms Care.  16:48-54. 2014
    2014 Internet-delivered lifestyle physical activity intervention improves body composition in multiple sclerosis: Preliminary evidence from a randomized controlled trialArchives of Physical Medicine and Rehabilitation.  95:1283-1288. 2014
    2014 Leg spasticity and ambulation in multiple sclerosis.Multiple Sclerosis International.  2014:649390. 2014
    2014 Mobility and cognitive correlates of dual task cost of walking in persons with multiple sclerosisDisability and Rehabilitation.  36:205-209. 2014
    2014 Oxygen cost of walking in persons with multiple sclerosis: disability matters, but why?Multiple Sclerosis International.  2014:162765. 2014
    2014 Physical activity is associated with cognitive processing speed in persons with multiple sclerosisMultiple Sclerosis and Related Disorders.  3:123-128. 2014
    2014 Randomized controlled trial of a behavioral intervention targeting symptoms and physical activity in multiple sclerosis 2014
    2014 Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosisJournal of Neurology.  261:363-372. 2014
    2014 Walking and cognition, but not symptoms, correlate with dual task cost of walking in multiple sclerosisGait and Posture.  39:870-874. 2014
    2013 Cognitive processing speed has minimal influence on the construct validity of Multiple Sclerosis Walking Scale-12 scoresJournal of the Neurological Sciences.  335:169-173. 2013
    2013 Objectively quantified physical activity in persons with multiple sclerosisArchives of Physical Medicine and Rehabilitation.  94:2342-2348. 2013
    2013 Gait and six-minute walk performance in persons with multiple sclerosisJournal of the Neurological Sciences.  334:72-76. 2013
    2013 Physical activity and information processing speed in persons with multiple sclerosis: A prospective studyMental Health and Physical Activity.  6:205-211. 2013
    2013 Psychometric properties of the Fatigue Severity Scale and the Modified Fatigue Impact ScaleJournal of the Neurological Sciences.  331:102-107. 2013
    2013 Cognitive processing speed is related to fall frequency in older adults with multiple sclerosisArchives of Physical Medicine and Rehabilitation.  94:1567-1572. 2013
    2013 Footfall placement variability and falls in multiple sclerosisAnnals of Biomedical Engineering.  41:1740-1747. 2013
    2013 Longitudinal change in physical activity and its correlates in relapsing-remitting multiple sclerosisPhysical Therapy.  93:1037-1048. 2013
    2013 Steps per day among persons with multiple sclerosis: Variation by demographic, clinical, and device characteristicsArchives of Physical Medicine and Rehabilitation.  94:1534-1539. 2013
    2013 Accelerometry as a measure of walking behavior in multiple sclerosisActa Neurologica Scandinavica.  127:384-390. 2013
    2013 Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosisBMC Neurology.  13. 2013
    2013 Physical fitness, walking performance, and gait in multiple sclerosisJournal of the Neurological Sciences.  328:70-76. 2013
    2013 Comparison of ActiGraph activity monitors in persons with multiple sclerosis and controlsDisability and Rehabilitation.  35:725-731. 2013
    2013 Gait variability and disability in multiple sclerosisGait and Posture.  38:51-55. 2013
    2013 Rationale and design of a randomized controlled, clinical trial investigating a comprehensive exercise stimulus for improving mobility disability outcomes in persons with multiple sclerosisContemporary Clinical Trials.  35:151-158. 2013
    2013 Further validation of multiple sclerosis walking scale-12 scores based on spatiotemporal gait parametersArchives of Physical Medicine and Rehabilitation.  94:575-578. 2013
    2013 Physical activity, self-efficacy, and health-related quality of life in persons with multiple sclerosis: Analysis of associations between individual-level changes over one yearQuality of Life Research.  22:253-261. 2013
    2013 Symptomatic correlates of six-minute walk performance in persons with multiple sclerosisEuropean Journal of Physical and Rehabilitation Medicine.  49:59-66. 2013
    2013 The dynamics of finger tremor in multiple sclerosis is affected by whole body positionJournal of the Neurological Sciences.  324:84-89. 2013
    2013 Effects of walking direction and cognitive challenges on gait in persons with multiple sclerosis.Multiple Sclerosis International.  2013:859323. 2013
    2013 Integrity of the anterior visual pathway and its association with ambulatory performance in multiple sclerosis.Multiple Sclerosis International.  2013:481035. 2013
    2013 The reliability, precision and clinically meaningful change of walking assessments in multiple sclerosis 2013
    2012 Premorbid physical activity predicts disability progression in relapsing-remitting multiple sclerosisJournal of the Neurological Sciences.  323:123-127. 2012
    2012 Accelerometer output and its association with energy expenditure in persons with multiple sclerosisJournal of Rehabilitation Research and Development.  49:467-476. 2012
    2012 Does a waist-worn ActiGraph accelerometer quantify community ambulation in persons with multiple sclerosis?Journal of Rehabilitation Research and Development.  49:1405-1410. 2012
    2012 Fitness and cognitive processing speed in persons with multiple sclerosis: A cross-sectional investigationJournal of Clinical and Experimental Neuropsychology.  34:1041-1052. 2012
    2012 Internet-delivered behavioral intervention to increase physical activity in persons with multiple sclerosis: Sustainability and secondary outcomesPsychology, Health and Medicine.  17:636-651. 2012
    2012 Energy cost of walking and its association with gait parameters, daily activity, and fatigue in persons with mild multiple sclerosisNeurorehabilitation and Neural Repair.  26:1015-1021. 2012
    2012 Physical activity and multiple sclerosis: New insights regarding inactivityActa Neurologica Scandinavica.  126:256-262. 2012
    2012 Commercially available accelerometry as an ecologically valid measure of ambulation in individuals with multiple sclerosis 2012
    2012 Accelerometry is associated with walking mobility, not physical activity, in persons with multiple sclerosisMedical Engineering and Physics.  34:590-597. 2012
    2012 Quantifying gait abnormalities in persons with multiple sclerosis with minimal disabilityGait and Posture.  36:154-156. 2012
    2012 Postural control in multiple sclerosis: Effects of disability status and dual taskJournal of the Neurological Sciences.  315:44-48. 2012
    2012 Evidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosisBMC Neurology.  12. 2012
    2012 Physical activity, social support, and depression: Possible independent and indirect associations in persons with multiple sclerosisPsychology, Health and Medicine.  17:196-206. 2012
    2012 Falls and physical activity in persons with multiple sclerosis.Multiple Sclerosis International.  2012:315620. 2012
    2012 Fatigue, depression, and physical activity in relapsing-remitting multiple sclerosis: Results from a prospective, 18-month studyMultiple Sclerosis and Related Disorders.  1:43-48. 2012
    2012 Perceived impact of spasticity is associated with spatial and temporal parameters of gait in multiple sclerosis.ISRN Neurology.  2012:675431. 2012
    2011 Walking and thinking in persons with multiple sclerosis who vary in disabilityArchives of Physical Medicine and Rehabilitation.  92:2028-2033. 2011
    2011 Mobility, balance and falls in persons with multiple sclerosisPLoS ONE.  6. 2011
    2011 Cognitive dysfunction and multiple sclerosis: Developing a rationale for considering the efficacy of exercise training 2011
    2011 Social cognitive correlates of physical activity: Findings from a cross-sectional study of adults with relapsing-remitting multiple sclerosisJournal of Physical Activity and Health.  8:626-635. 2011
    2010 Objective monitoring of physical activity behavior in multiple sclerosisPhysical Therapy Reviews.  15:204-211. 2010
    An Intervention for Changing Sedentary Behavior Among African Americans With Multiple Sclerosis: Protocol (Preprint)

    Book

    Year Title Altmetric
    2018 Cognition and behavior in multiple sclerosis. 2018

    Chapter

    Year Title Altmetric
    Exercise, physical activity, physical fitness, and cognition in multiple sclerosis..  293-319.

    Education And Training

  • Doctor of Philosophy in Kinesiology and Exercise Science, University of Illinois at Urbana - Champaign 2015
  • Master of Science in Kinesiology and Exercise Science, University of Illinois at Urbana - Champaign 2012
  • Kessler Foundation, Postdoctoral Fellowship 2016
  • Full Name

  • Brian Sandroff