Positions

Selected Publications

Academic Article

Year Title Altmetric
2021 PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons 2021
2021 PARIS farnesylation prevents neurodegeneration in models of Parkinson's diseaseScience Translational Medicine.  13. 2021
2021 Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosisCell Death and Disease.  12. 2021
2021 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1Autophagy.  17:1-382. 2021
2021 Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotectiveAutophagy.  17:1330-1348. 2021
2020 Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019Frontiers in Pharmacology.  11. 2020
2020 AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSFCell Reports.  33. 2020
2020 Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine NeuronsStem Cell Reports.  15:629-645. 2020
2020 Quantitative mass spectrometric analysis of the mouse cerebral cortex after ischemic strokePLoS ONE.  15. 2020
2019 Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1 +/−/ODC transgenic miceScientific Reports.  9. 2019
2019 Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosisRedox Biology.  26. 2019
2019 The AAA + ATPase Thorase is neuroprotective against ischemic injuryJournal of Cerebral Blood Flow and Metabolism.  39:1836-1848. 2019
2019 SULT4A1 protects against oxidative-stress induced mitochondrial dysfunction in neuronal cellsDrug Metabolism and Disposition.  47:949-953. 2019
2018 DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disordersTranslational Psychiatry.  8. 2018
2018 Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s diseaseScience.  362. 2018
2018 Sirt3 regulation under cellular stress: Making sense of the ups and downsFrontiers in Neuroscience.  12. 2018
2018 Short communication generation and characterization of SULT4A1 mutant mouse modelsDrug Metabolism and Disposition.  46:41-45. 2018
2017 Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by PerampanelScience Translational Medicine.  9. 2017
2017 Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosisJournal of Cerebral Blood Flow and Metabolism.  37:1982-1993. 2017
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1Science.  354. 2016
2016 A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1Science.  354. 2016
2016 LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicityJournal of Chemical Neuroanatomy.  76:90-97. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3Science.  353. 2016
2016 High-content genome-wide rnai screen reveals ccr3 as a key mediator of neuronal cell deatheNeuro.  3. 2016
2016 PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasisCancer Research.  76:4430-4442. 2016
2016 Adult conditional knockout of PGC-1α leads to loss of dopamine neuronseNeuro.  3. 2016
2015 Parkin loss leads to Paris-dependent declines in mitochondrial mass and respiration 2015
2014 Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain 2014
2014 Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins 2014
2014 Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis 2014
2014 Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in parkinson's diseaseCell.  157:472-485. 2014
2013 Urocortin 1 administered into the hypothalamic supraoptic nucleus inhibits food intake in freely fed and food-deprived ratsAmino Acids.  44:879-885. 2013
2012 Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's diseaseScience Translational Medicine.  4. 2012
2011 Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage 2011
2011 Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell deathNature Medicine.  17:692-699. 2011
2011 Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)Science Signaling.  4. 2011
2011 Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activationPLoS ONE.  6. 2011
2010 Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemiaJournal of Neurochemistry.  113:1012-1022. 2010
2009 Parthanatos, A messenger of deathFrontiers in Bioscience.  14:1116-1128. 2009
2007 Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brainNeuroscience.  148:198-211. 2007
2007 Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicityHuman Molecular Genetics.  16:223-232. 2007
2007 Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleusNeuroscience.  144:56-65. 2007
2006 Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death 2006
2006 Poly(ADP-ribose) (PAR) polymer is a signal 2006
2006 Localization of LRRK2 to membranous and vesicular structures in mammalian brainAnnals of Neurology.  60:557-569. 2006
2006 Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathy 2006
2006 Blood-brain barrier permeability to the neuroprotectant oxyresveratrolNeuroscience Letters.  393:113-118. 2006
2005 Nitric oxide applications prior and simultaneous to potentially excitotoxic NMDA-evoked calcium transients: Cell death or survivalBrain Research.  1060:1-15. 2005
2004 Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemiaBrain Research.  1017:98-107. 2004
2004 Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin.The FASEB Journal.  18:869-871. 2004
LSO:Ce Inorganic Scintillators are Biocompatible with Neuronal and Circuit Function

Education And Training

  • Doctor of Philosophy Level Degree in Neurobiology and Neurosciences, Otto-von-Guericke University Magdeburg 2005
  • Full Name

  • Syed Shaida Andrabi